公开(公告)号：CA2778765A1

公开(公告)日：2011-05-19

申请号：CA2778765

申请日：2010-11-10

Applicant: TORAY INDUSTRIES

Inventor： TAKEUCHI NORIHIRO ,  MINEGISHI SHIN-ICHI ,  CHEON JIHOON ,  NISHIDA MAKOTO ,  MIMITSUKA TAKASHI ,  SUZUKI HIRONOBU ,  YAMADA KATSUSHIGE ,  SAWAI HIDEKI ,  KUMO ICHIRO

IPC: B01D63/04 ,  B01D63/00 ,  B01D71/34 ,  C12M1/12 ,  C12M3/06 ,  C12N15/09 ,  C12P7/56

Abstract: Disclosed is a hollow fiber membrane module (1) for use in the production of a chemical substance, which can be used in the continuous fermentation that comprises filtrating a fermentation culture of a microorganism or a cultured cell through a hollow fiber membrane, collecting a chemical substance from a filtrate, retaining a concentrated solution in the fermentation culture or refluxing the concentrated solution, and further adding a fermentation raw material to the fermentation culture. In the hollow fiber membrane module (1), multiple hollow fiber membrane bundles are accommodated in a tubular case, at least one end part of each of the hollow fiber membrane bundles is fixed onto the tubular case in such a manner that the end surface of each of the hollow fiber membranes is opened by means of a hollow-fiber-membrane-bundling material, and the hollow-fiber-membrane-bundling material comprises a synthetic resin that exhibits a hardness retention rate of 95% or more after the material is brought into contact with a saturated water vapor at 121°C for 24 hours. The hollow fiber membrane module (1) can keep substance productivity at a high level and can be used in the production of a chemical substance by a sterilizable continuous fermentation method.

公开(公告)号：ES2795837T3

公开(公告)日：2020-11-24

申请号：ES11825009

申请日：2011-09-05

Applicant: TORAY INDUSTRIES

Inventor： KOBAYASHI ATSUSHI ,  CHEON JIHOON ,  TAKEUCHI NORIHIRO ,  NISHIDA MAKOTO ,  TANAKA YUJI ,  MINEGISHI SHIN-ICHI

IPC: C12P1/00 ,  B01D61/18 ,  B01D63/02 ,  B01D65/02 ,  B01D65/06 ,  B01D71/34 ,  C12M1/00 ,  C12M1/26 ,  C12P7/40 ,  C12P7/56

Abstract: Un método para producir productos químicos mediante fermentación continua, comprendiendo el método: (a) generar productos químicos por fermentación con un medio de cultivo que contiene una materia prima de fermentación y microbios o células cultivadas a una temperatura de 15°C a 65°C en un fermentador; (b) filtrar el medio de cultivo a través de una membrana de separación; (c) recoger el producto químico del filtrado; (d) retener o refluir los restos sin filtrar en el fermentador, (e) añadir una materia prima de fermentación al medio de cultivo en el fermentador, y (f) lavar la membrana de separación con un líquido de lavado suministrado desde el lado del permeado de la membrana de separación durante la etapa (a) en un estado en el que la fermentación con los microbios o las células cultivadas continúa en el medio de cultivo en el fermentador; en donde el líquido de lavado es agua que tiene una temperatura al menos 5°C mayor que la temperatura del medio de cultivo en el fermentador de la etapa (a) hasta una temperatura máxima del agua de lavado de 100°C, y la concentración de los microbios en el fermentador se controla suministrando el líquido de lavado.

公开(公告)号：BR112013015179A2

公开(公告)日：2016-08-02

申请号：BR112013015179

申请日：2011-12-21

Applicant: TORAY INDUSTRIES

Inventor： KOBAYASHI ATSUSHI ,  CHEON JIHOON ,  NISHIDA MAKOTO ,  TAKEUCHI NORIHIRO ,  KANAMORI SATOKO

IPC: C12P1/00 ,  C12P7/56

Abstract: método para produzir um produto químico por fermentação contínua trata-se de um método para produzir um produto químico, em a membrana de separação podem ser lavadas eficientemente e a fermentação pode ser realizada estavelmente em um aparelho de fermentaçãocontínua para produzir continuamente um produto químico por fermentação usando membranas de separação. o método para produzir um produto químico por fermentação contínua de acordo com a presente invenção inclui uma etapa de fermentação para converter uma matéria prima de fermentação através de fermentação pelo cutivo de um microorganismo ou células de cultura, em um líquido fermentado contendop produto químico, e uma etapa de separação por membrana para coletar produto químico, como um filtrado, do líquido fermentado com o uso de dois ou mais módulos de membrana de seperação, e retornar o líquido não filtrado para o líquido fermentado, em que na etapa de separação por membrana, a temporização do tratamento com filtragem parada para cada módulo de membrana de separação é controlado quando uma operação de filtragem intermitente incluindo repetir alternadamente um tratamento de filtragem e um tratamento com filtragem parada é realizada com módulos de membrana de separação plurais.

公开(公告)号：AU2011345962B2

公开(公告)日：2016-05-19

申请号：AU2011345962

申请日：2011-12-21

Applicant: TORAY INDUSTRIES

Inventor： TAKEUCHI NORIHIRO ,  CHEON JIHOON ,  NISHIDA MAKOTO ,  KANAMORI SATOKO ,  KOBAYASHI ATSUSHI

IPC: C12P1/00 ,  C12P7/56

Abstract: Provided is a method for producing a chemical, whereby, in a continuous fermentation device for continuously producing a chemical by fermentation using separation membranes, the separation membranes can be efficiently washed and the fermentation can be stably carried out. The method for producing a chemical by continuous fermentation according to the present invention, which comprises: a fermentation step for converting a starting material to be fermented, through fermentation by culturing a microorganism or cells, into a fermented liquor containing the chemical; and a membrane separation step for collecting the chemical, as a filtrate, from the fermented liquor with the use of two or more separation membrane modules, and returning the non-filtered liquid to the fermented liquor, is characterized in that, in said membrane separation step, the multiple separation membrane modules are intermittently driven in such a manner that a filtration treatment and a filtration-stop treatment are alternately repeated, with controlling the timing of the filtration-stop treatment in each separation membrane module.

公开(公告)号：AU2010319104A1

公开(公告)日：2012-05-17

申请号：AU2010319104

申请日：2010-11-10

Applicant: TORAY INDUSTRIES

Inventor： TAKEUCHI NORIHIRO ,  MINEGISHI SHIN-ICHI ,  CHEON JIHOON ,  NISHIDA MAKOTO ,  MIMITSUKA TAKASHI ,  SUZUKI HIRONOBU ,  YAMADA KATSUSHIGE ,  SAWAI HIDEKI ,  KUMO ICHIRO

IPC: B01D63/04 ,  B01D63/00 ,  B01D71/34 ,  C12M1/12 ,  C12M3/06 ,  C12N15/09 ,  C12P7/56

Abstract: Disclosed is a hollow fiber membrane module (1) for use in the production of a chemical substance, which can be used in the continuous fermentation that comprises filtrating a fermentation culture of a microorganism or a cultured cell through a hollow fiber membrane, collecting a chemical substance from a filtrate, retaining a concentrated solution in the fermentation culture or refluxing the concentrated solution, and further adding a fermentation raw material to the fermentation culture. In the hollow fiber membrane module (1), multiple hollow fiber membrane bundles are accommodated in a tubular case, at least one end part of each of the hollow fiber membrane bundles is fixed onto the tubular case in such a manner that the end surface of each of the hollow fiber membranes is opened by means of a hollow-fiber-membrane-bundling material, and the hollow-fiber-membrane-bundling material comprises a synthetic resin that exhibits a hardness retention rate of 95% or more after the material is brought into contact with a saturated water vapor at 121°C for 24 hours. The hollow fiber membrane module (1) can keep substance productivity at a high level and can be used in the production of a chemical substance by a sterilizable continuous fermentation method.

公开(公告)号：AU2011304167B2

公开(公告)日：2015-05-21

申请号：AU2011304167

申请日：2011-09-05

Applicant: TORAY INDUSTRIES

Inventor： KOBAYASHI ATSUSHI ,  CHEON JIHOON ,  TAKEUCHI NORIHIRO ,  NISHIDA MAKOTO ,  TANAKA YUJI ,  MINEGISHI SHIN-ICHI

IPC: C12P1/00 ,  B01D65/02 ,  B01D65/06 ,  C12P7/40 ,  C12P7/56

Abstract: A production method for chemicals by continuous fermentation, comprising: filtering a culture medium containing a fermentation feedstock, chemicals, microbes, or cultured cells by a separation membrane; collecting the chemicals from the filtrate; retaining or refluxing the unfiltered remains in the culture medium; and supplying washing liquid from the permeate side of a membrane unit to wash the membrane in a continuous fermentation in which the fermentation feedstock is added to the culture medium, characterized in that the washing liquid has a higher temperature than the culture medium, and is high-temperature water of 150°C or lower, and a microbial concentration in a fermenter is controlled by supplying the washing liquid. By using the production method, the retention of the filtration property for high cell-density cultivation of microbial mixture and the control of the microbial concentration can be simultaneously performed, in the collection of products by the fermentation using the separation membrane.

公开(公告)号：AU2010319104B2

公开(公告)日：2015-05-07

申请号：AU2010319104

申请日：2010-11-10

Applicant: TORAY INDUSTRIES

Inventor： TAKEUCHI NORIHIRO ,  MINEGISHI SHIN-ICHI ,  CHEON JIHOON ,  NISHIDA MAKOTO ,  MIMITSUKA TAKASHI ,  SUZUKI HIRONOBU ,  YAMADA KATSUSHIGE ,  SAWAI HIDEKI ,  KUMO ICHIRO

IPC: B01D63/04 ,  B01D63/00 ,  B01D71/34 ,  C12M1/12 ,  C12M3/06 ,  C12N15/09 ,  C12P7/56

Abstract: Disclosed is a hollow fiber membrane module (1) for use in the production of a chemical substance, which can be used in the continuous fermentation that comprises filtrating a fermentation culture of a microorganism or a cultured cell through a hollow fiber membrane, collecting a chemical substance from a filtrate, retaining a concentrated solution in the fermentation culture or refluxing the concentrated solution, and further adding a fermentation raw material to the fermentation culture. In the hollow fiber membrane module (1), multiple hollow fiber membrane bundles are accommodated in a tubular case, at least one end part of each of the hollow fiber membrane bundles is fixed onto the tubular case in such a manner that the end surface of each of the hollow fiber membranes is opened by means of a hollow-fiber-membrane-bundling material, and the hollow-fiber-membrane-bundling material comprises a synthetic resin that exhibits a hardness retention rate of 95% or more after the material is brought into contact with a saturated water vapor at 121°C for 24 hours. The hollow fiber membrane module (1) can keep substance productivity at a high level and can be used in the production of a chemical substance by a sterilizable continuous fermentation method.

公开(公告)号：AU2011304167A1

公开(公告)日：2013-04-04

申请号：AU2011304167

申请日：2011-09-05

Applicant: TORAY INDUSTRIES

Inventor： KOBAYASHI ATSUSHI ,  CHEON JIHOON ,  TAKEUCHI NORIHIRO ,  NISHIDA MAKOTO ,  TANAKA YUJI ,  MINEGISHI SHIN-ICHI

IPC: C12P1/00 ,  B01D65/02 ,  B01D65/06 ,  C12P7/40 ,  C12P7/56

Abstract: A production method for chemicals by continuous fermentation, comprising: filtering a culture medium containing a fermentation feedstock, chemicals, microbes, or cultured cells by a separation membrane; collecting the chemicals from the filtrate; retaining or refluxing the unfiltered remains in the culture medium; and supplying washing liquid from the permeate side of a membrane unit to wash the membrane in a continuous fermentation in which the fermentation feedstock is added to the culture medium, characterized in that the washing liquid has a higher temperature than the culture medium, and is high-temperature water of 150°C or lower, and a microbial concentration in a fermenter is controlled by supplying the washing liquid. By using the production method, the retention of the filtration property for high cell-density cultivation of microbial mixture and the control of the microbial concentration can be simultaneously performed, in the collection of products by the fermentation using the separation membrane.

公开(公告)号：EP2500083A4

公开(公告)日：2014-08-13

申请号：EP10829942

申请日：2010-11-10

Applicant: TORAY INDUSTRIES

Inventor： TAKEUCHI NORIHIRO ,  MINEGISHI SHIN-ICHI ,  CHEON JIHOON ,  NISHIDA MAKOTO ,  MIMITSUKA TAKASHI ,  SUZUKI HIRONOBU ,  YAMADA KATSUSHIGE ,  SAWAI HIDEKI ,  KUMO ICHIRO

IPC: B01D63/04 ,  B01D63/00 ,  B01D65/02 ,  B01D71/34 ,  C12M1/12 ,  C12M3/06 ,  C12N15/09 ,  C12P7/56

CPC classification number: B01D63/04 ,  B01D63/022 ,  B01D63/023 ,  C12M29/16 ,  C12P7/56

公开(公告)号：EP2657343A4

公开(公告)日：2017-01-18

申请号：EP11850267

申请日：2011-12-21

Applicant: TORAY INDUSTRIES

Inventor： TAKEUCHI NORIHIRO ,  CHEON JIHOON ,  NISHIDA MAKOTO ,  KANAMORI SATOKO ,  KOBAYASHI ATSUSHI

IPC: C12P7/56 ,  C12M1/12 ,  C12M1/36

CPC classification number: C12P7/56 ,  C12M29/04 ,  C12M33/14

Abstract: Provided is a method for producing a chemical, wherein the separation membranes can be efficiently washed and the fermentation can be stably performed in a continuous fermentation apparatus for continuously producing a chemical by fermentation using separation membranes. The method for producing a chemical by continuous fermentation according to the present invention includes a fermentation step for converting a fermentation feedstock, through fermentation by culturing a microorganism or culture cells, into a fermented liquid containing the chemical, and a membrane separation step for collecting the chemical, as a filtrate, from the fermented liquid with the use of two or more separation membrane modules, and returning the non-filtered liquid to the fermented liquid, wherein in the membrane separation step, timing of the filtration-stop treatment for each separation membrane module is controlled when an intermittent filtration operation including alternately repeating a filtration treatment and a filtration-stop treatment is performed with plural separation membrane modules.