公开(公告)号：JPH0446266B2

公开(公告)日：1992-07-29

申请号：JP7759983

申请日：1983-05-04

Applicant: UBE INDUSTRIES

Inventor： FUKUI KYOSHI ,  KAKEYA NOBORU ,  TAGUCHI MITSUSHI

IPC: C07C243/28 ,  C07C67/00 ,  C07C241/00 ,  C07C241/04

公开(公告)号：JPS607987B2

公开(公告)日：1985-02-28

申请号：JP14040680

申请日：1980-10-09

Applicant: UBE INDUSTRIES

Inventor： FUKUI KYOSHI ,  KAKEYA NOBORU ,  JIBIKI HIROSHI ,  KITA JUNICHIRO

IPC: A01N43/50 ,  C07D233/78 ,  C07D233/96

公开(公告)号：JPS607985B2

公开(公告)日：1985-02-28

申请号：JP13522980

申请日：1980-09-30

Applicant: UBE INDUSTRIES

Inventor： FUKUI KYOSHI ,  KAKEYA NOBORU ,  JIBIKI HIROSHI ,  KITA JUNICHIRO

IPC: C07D233/96

公开(公告)号：JPS5890563A

公开(公告)日：1983-05-30

申请号：JP18689481

申请日：1981-11-24

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU ,  KAKEYA NOBORU ,  YOKOO YASUHIKO

IPC: C07D239/557 ,  C07D239/54

Abstract: PURPOSE:The reaction of an alkali metal salt of 5-carboxyorotic acid with a halogenating reagent is followed by treatment of the product with an acid to give the titled compound, especially 5-iodoorotic acid, used as a medicine or its starting material, in high yield. CONSTITUTION:A halogenating reagent is added as much, or in the form of an aqueous solution or solution in a inert organic solvent, to an aqueous solution of an alkali metal salt of 5-carboxyorotic acid of formulaI(M is Li, Na, K) and their reaction is effected by heating at 0-100 deg.C and the resultant reaction product is acidified with a mineral acid at 0-30 deg.C to give the objective compound. As a halogenating reagent, is used Br2, I2 or N-chlorosuccinimide. The compound of formulaIis obtained by making 3-amino-1,4-bis(alkoxycarbonyl) maleimide of formula III (R , R are 1-4C alkyl) react with an alkali hydroxide in water at room temperature or under heating and acidifying the reaction mixture with a mineral acid.

公开(公告)号：JPS5862175A

公开(公告)日：1983-04-13

申请号：JP15949981

申请日：1981-10-08

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KAKEYA NOBORU ,  JIBIKI HIROSHI ,  MATSUO FUMIO

IPC: C07D487/04 ,  A01N43/90

Abstract: NEW MATERIAL:An imidazopyrimidine shown by the formulaI[R is benzoyl, acetyl, or ethoxycarbonyl; R is 1-4C alkyl or a group shown by the formula II (R is 1-4C alkyl or 1-4C alkoxy; n is 0, 1, or 2)]. EXAMPLE:8-Benzoyl-2,6-diethyl-1,2,3,5,6,7-hexahydro-1,3,5,7-tetraoxoim idazo[1,5- C]pyrimidine. USE:An agricultural chemical, drug, or an intermediate for them. PROCESS:An alpha,beta-unsaturated-alpha-amino ethyl ester shown by the formula III is reacted with an isocyanate shown by the formula IV in the presence of a base to give a compound shown by the formulaI.

公开(公告)号：JP2001122852A

公开(公告)日：2001-05-08

申请号：JP29909099

申请日：1999-10-21

Applicant: UBE INDUSTRIES

Inventor： KAKEYA NOBORU ,  TAKAI TSUTOMU

IPC: C07D201/02

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing caprolactam from 1, 1'- peroxydicyclohexylamine without requiring a complex isolating operation in a high yield. SOLUTION: This method for producing caprolactam is to react 1, 1'- peroxydicyclohexylamine in a hydrocarbon solvent containing a salt of quaternary ammonium halide.

公开(公告)号：JP2001122851A

公开(公告)日：2001-05-08

申请号：JP29908999

申请日：1999-10-21

Applicant: UBE INDUSTRIES

Inventor： KAKEYA NOBORU ,  TAKAI TSUTOMU

IPC: C07D201/02

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing caprolactam from 1,1'- peroxydicyclohexylamine without requiring a complex isolating operation in a high yield. SOLUTION: This method for producing caprolactam is to react 1,1'- peroxydicyclohexylamine in a hydrocarbon solvent containing a salt of an element belonging to the IA and/or IIA group in the Periodic table and a tertiary phosphine oxide.

公开(公告)号：JP2001048869A

公开(公告)日：2001-02-20

申请号：JP22480399

申请日：1999-08-09

Applicant: UBE INDUSTRIES

Inventor： KAKEYA NOBORU

IPC: C07D273/01

Abstract: PROBLEM TO BE SOLVED: To readily and environmentally-friendly produce an oxaziridine compound useful as a raw material for various organic synthesis at a low cost by reacting a cycloalkanone with ammonia, and oxidizing the product. SOLUTION: A cycloalkanone (e.g. cyclohexanone and cyclododecanone) is reacted with ammonia, and the product is oxidized by an organic peroxide (e.g. performic acid and t-butyl hydroperoxide) and/or an inorganic peroxide (e.g. hydrogen potassium persulfate) to provide the objective 3,3- alkyleneoxaziridine. The amount of the used ammonia is preferably 0.5-200 molar times as much as that of the cycloalkane, and the amount of the used peroxide is preferably 0.5-5.0 eq. The reaction is preferably carried out in a solvent (e.g. methanol), and the amount of the solvent is 1-100 times as much as the weight of the cycloalkanone.

公开(公告)号：JP2001048862A

公开(公告)日：2001-02-20

申请号：JP22480499

申请日：1999-08-09

Applicant: UBE INDUSTRIES

Inventor： KAKEYA NOBORU

IPC: C07D201/02

Abstract: PROBLEM TO BE SOLVED: To simply obtain a lactam useful as a raw material for nylon fibers and resins in a high yield by making ammonia act on a cycloalkanone, oxidizing the resultant reactional liquid with an organic peroxide and/or an inorganic peroxide and then treating the produced intermediate with an isomerization catalyst without isolating the produced intermediate. SOLUTION: Ammonia in an equivalent amount of preferably 1 to 100 times based on a cycloalkanone (preferably cyclohexanone and cyclododecanone) is made to act on the cycloalkanone and the resultant reactional liquid is then oxidized with 1.0-3.0 equivalents of an organic peroxide and/or an inorganic peroxide preferably at -10 to 40 deg.C for 1-5 h in a reactional solvent. The produced intermediate is further treated with an isomerization catalyst without isolating the produced intermediate preferably at 50-150 deg.C for 5 min to 2 h. Thereby, a lactam is obtained. The reaction of the cycloalkanone with the ammonia is preferably conducted at -10 to 40 deg.C under atmospheric pressure or under a reactional pressure of 3-100 atm and a reactional temperature of -10 to 100 deg.C under pressurization. The reactional time is 1-3 h.

公开(公告)号：JPH0967328A

公开(公告)日：1997-03-11

申请号：JP22012995

申请日：1995-08-29

Applicant: UBE INDUSTRIES

Inventor： KAKEYA NOBORU ,  ABE KOJI

IPC: C07C249/10 ,  C07C251/38

Abstract: PROBLEM TO BE SOLVED: To easily produce the subject compound useful as a production raw material for hexamethylenediamine which is a raw material for nylon-66 from an easily available raw material in high yield. SOLUTION: The objective compound is produced by reacting (A) 1- formyloxy-2-nitrosocyclohexane or 1-hydroxy-2-nitrosocyclohexane with (B) an inorganic acid (e.g. hydrochloric acid) and/or (C) hydroxylamine. The reaction is preferably carried out by using 10 to 1 equivalent of the component B or 1-10 equivalent of the component C based on 1 equivalent of the component A at a reaction temperature of 70-100 deg.C in a solvent such as ethanol. The component A is preferably produced e.g. by the addition reaction of formyl nitrite to cyclohexene.