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公开(公告)号：HU230669B1
公开(公告)日：2017-07-28
申请号：HU1600483
申请日：2001-06-05
Applicant: UCB PHARMA SA
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12.发明专利
公开(公告)号：ES2600080T3
公开(公告)日：2017-02-07
申请号：ES10010795
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/13 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/21 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/08
Abstract: Una molécula de anticuerpo que tiene especificidad por el TNFα humano, que tiene una cadena ligera que tiene la secuencia dada en SEC ID NO:113 y una cadena pesada que tiene la secuencia dada en SEC ID NO:115 en donde una molécula efectora o reportera está unida al extremo C terminal de la cadena pesada.
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公开(公告)号：SI2308975T1
公开(公告)日：2016-11-30
申请号：SI200131056
申请日：2001-06-05
Applicant: UCB PHARMA SA
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公开(公告)号：NO334808B1
公开(公告)日：2014-06-02
申请号：NO20020554
申请日：2002-02-04
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C07K16/24 , A61K39/395 , C12N15/09 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: Oppfinnelsen vedrører antistoffmolekyler inneholdende minst ett CDR avledet fra et mus monoklonalt antistoff med en spesifisitet for human TNFce. Det er også omtalt et CDR podet antistoff hvor minst ett av CDRene er et hybrid CDR. Videre er det omtalt DNA sekvenser som koder for kjedene til antistoff molekylene, vektorer, transformerte vertsceller og anvendelse av antistoffmolekylene i behandlingen av sykdommer mediert ved TNFcc.
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公开(公告)号：AU2008232409B2
公开(公告)日：2013-06-20
申请号：AU2008232409
申请日：2008-03-21
Applicant: BIOGEN IDEC INC , UCB PHARMA SA
Inventor： GARBER ELLEN A , POPPLEWELL ANDREW GEORGE , TAYLOR FREDERICK R , ROBINSON MARTYN KIM , SU LIHE , FERRANT-ORGETTAS JANINE L , ADAMS RALPH , SHOCK ANTHONY , BURKLY LINDA C , HSU YEN-MING , BROWN DEREK THOMAS , TYSON KERRY LOUISE
IPC: C07K16/28 , A61K39/395 , C12N15/13 , C12N15/63
Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
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Patent Agency Ranking
公开(公告)号：UA100513C2
公开(公告)日：2013-01-10
申请号：UAA200910650
申请日：2008-03-21
Applicant: BIOGEN IDEC INC , UCB PHARMA SA
Inventor： BURKLY LINDA , FERRANT-ORGETTAS JANINE L , GARBER ELLEN A , HSU YEN-MING , SU LIHE , TAYLOR FREDERICH R , ADAMS RALPH , BROWN DEREK THOMAS , POPPLEWELL ANDREW GEORGE , ROBINSON MARTYN KIM , SHOK ANTHONY , TYSON KERRY LOUISE
IPC: C07K16/28 , A61K39/395 , A61P37/00 , C12N15/13 , C12P21/08
Abstract: Изобретениеотноситсяк CD 154-связывающемубелку (антитела), молекуленуклеиновойкислоты, котораяегокодирует, вектору, клетке-хозяину, способуполученияантитела, композициии применениюданногобелкав приготовлениилекарственногосредствадлялеченияилипрофилактикисостояния, нарушенияилизаболеваниячеловека, опосредствованногов целомиличастичносигнальнымпутемприучастии CD40.
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公开(公告)号：PL399351A1
公开(公告)日：2012-12-17
申请号：PL39935101
申请日：2001-06-05
Applicant: UCB PHARMA SA
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公开(公告)号：AU2003285578B2
公开(公告)日：2010-07-15
申请号：AU2003285578
申请日：2003-12-01
Applicant: UCB PHARMA SA
Inventor： CROMIE KAREN DOROTHY , GRIFFITHS MERYN RUTH , LIGHTWOOD DANIEL JOHN , BROWN DEREK THOMAS , BUTLER LISA , LAWSON ALASTAIR DAVID GRIFFITHS
IPC: C07K16/24 , G01N33/569 , G01N33/58 , G01N33/68
Abstract: The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antigen and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibody producing cell capable of producing an antibody which binds to the selected antigen.
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公开(公告)号：ES2337763T3
公开(公告)日：2010-04-29
申请号：ES01934209
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/13 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/21 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/08
Abstract: Se describen moléculas de anticuerpo que contienen al menos una CDR procedente de un anticuerpo monoclonal de ratón que tiene especificidad por el TNFa humano. También se describe un anticuerpo de CDR injertadas en el que al menos una de las CDR es una CDR híbrida. También se describen secuencias de ADN que codifican las cadenas de las moléculas de anticuerpo, vectores, células huésped transformadas y usos de las moléculas de anticuerpo en el tratamiento de enfermedades mediadas por TNFap.
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20.发明专利
公开(公告)号：DK1287140T3
公开(公告)日：2010-04-19
申请号：DK01934209
申请日：2001-06-05
Applicant: UCB PHARMA SA
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