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公开(公告)号：CA2754539C
公开(公告)日：2017-09-12
申请号：CA2754539
申请日：2010-03-10
Applicant: UCB PHARMA SA
Inventor： GOZZARD NEIL , LAWSON ALASTAIR DAVID GRIFFITHS , LIGHTWOOD DANIEL JOHN , PALFRAMAN ROGER THOMAS , SMITH BRYAN JOHN , TYSON KERRY LOUISE
IPC: C07K16/24 , A61K39/395 , A61P11/06 , C07K16/46 , C12N15/13
Abstract: Antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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2.发明专利
公开(公告)号：PE15472014A1
公开(公告)日：2014-10-25
申请号：PE0003532014
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVE KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
CPC classification number: C07K16/1282 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/56911 , G01N33/573 , G01N33/6854 , G01N2333/91097
Abstract: SE REFIERE A UN ANTICUERPO MONOCLONAL ESPECIFICO FRENTE AL ANTIGENO TCDA O TCDB, QUE COMPRENDE UNA CADENA PESADA EN EL DOMINIO VARIABLE QUE TIENE UNA CDR QUE COMPRENDE LA SECUENCIA DADA EN SEQ ID NO: 44 PARA CDR-H1, UNA CDR EN SEQ ID NO: 45 PARA CDR-H2 Y UNA CDR EN SEQ ID NO: 46 PARA CDR-H3; Y UNA CADENA LIGERA EN EL DOMINIO VARIABLE QUE TIENE UNA CDR QUE COMPRENDE LA SECUENCIA DADA EN SEQ ID NO: 41 PARA CDR-L1, UNA CDR EN SEQ ID NO: 42 PARA CDR-L2 Y UNA CDR EN SEQ ID NO:43 PARA CDR-L3. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO O LA PROFILAXIS DE LA INFECCION POR CLOSTRIDIUM DIFFICILE.
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3.发明专利
公开(公告)号：CO6930310A2
公开(公告)日：2014-04-28
申请号：CO14082286
申请日：2014-04-15
Applicant: UCB PHARMA SA
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公开(公告)号：PT1570267E
公开(公告)日：2012-01-03
申请号：PT03778577
申请日：2003-12-01
Applicant: UCB PHARMA SA
Inventor： BROWN DEREK THOMAS , BUTLER LISA , CROMIE KAREN DOROTHY , GRIFFITHS MERYN RUTH , LAWSON ALASTAIR D G , LIGHTWOOD DANIEL JOHN
IPC: C07K16/24 , G01N33/52 , G01N33/569 , G01N33/58 , G01N33/68
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公开(公告)号：AT528648T
公开(公告)日：2011-10-15
申请号：AT03778577
申请日：2003-12-01
Applicant: UCB PHARMA SA
Inventor： BROWN DEREK THOMAS , BUTLER LISA , CROMIE KAREN DOROTHY , GRIFFITHS MERYN RUTH , LAWSON ALASTAIR D G , LIGHTWOOD DANIEL JOHN
IPC: G01N33/52 , C07K16/24 , G01N33/569 , G01N33/58 , G01N33/68
Abstract: The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antigen and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibody producing cell capable of producing an antibody which binds to the selected antigen.
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Patent Agency Ranking
公开(公告)号：AT459652T
公开(公告)日：2010-03-15
申请号：AT04734554
申请日：2004-05-24
Applicant: UCB PHARMA SA
Inventor： LAWSON ALASTAIR DAVID GRIFFITHS , LIGHTWOOD DANIEL JOHN
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公开(公告)号：SG10201701055WA
公开(公告)日：2017-03-30
申请号：SG10201701055W
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVÉ KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.
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公开(公告)号：NZ623293A
公开(公告)日：2016-05-27
申请号：NZ62329312
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVÉ KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: Disclosed is a pharmaceutical composition comprising a monoclonal antibody suitable for reducing the duration and/or severity of diarrhoea or morbidity and/or mortality in a patient with Clostridium difficile infection or at risk of said infection wherein the antibody is specific to: antigen Clostridium difficile toxin A (TcdA) and binds 3 or more times in the range S1827-D2249 or G2205-R2608 of SEQ ID NO: 171 with an EC50 in the range 0.1 to 10 ng/ml when toxin is used at an LD80 or higher.
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公开(公告)号：TN2014000101A1
公开(公告)日：2015-07-01
申请号：TN2014000101
申请日：2014-03-07
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVE KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.
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公开(公告)号：AU2010222693B2
公开(公告)日：2014-12-04
申请号：AU2010222693
申请日：2010-03-10
Applicant: UCB PHARMA SA
Inventor： GOZZARD NEIL , LAWSON ALASTAIR DAVID GRIFFITHS , LIGHTWOOD DANIEL JOHN , PALFRAMAN ROGER THOMAS , SMITH BRYAN JOHN , TYSON KERRY LOUISE
IPC: C07K16/24 , A61K39/395 , A61P11/06 , C07K16/46 , C12N15/13
Abstract: Antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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