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公开(公告)号：AU2012335496A1
公开(公告)日：2014-05-15
申请号：AU2012335496
申请日：2012-11-09
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.
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公开(公告)号：CA2856216A1
公开(公告)日：2013-05-16
申请号：CA2856216
申请日：2012-11-09
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.
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公开(公告)号：CA2855174A1
公开(公告)日：2013-05-16
申请号：CA2855174
申请日：2012-11-09
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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Patent Agency Ranking
公开(公告)号：CL2014001193A1
公开(公告)日：2014-12-26
申请号：CL2014001193
申请日：2014-05-07
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , HUMPHREYS DAVID PAUL , BHATTA PALLAVI , HEYWOOD SAM PHILLIP
IPC: A61K39/395 , C07K16/28 , C07K16/44 , C07K16/46
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公开(公告)号：PE19952014A1
公开(公告)日：2014-12-06
申请号：PE0006732014
申请日：2012-11-09
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: SE REFIERE A UNA PROTEINA DE FUSION QUE ES UN ANTICUERPO BIESPECIFICO, LA CUAL SE UNE A OX40 HUMANO Y A ALBUMINA DE SUERO HUMANO, QUE COMPRENDE: UNA CADENA PESADA QUE TIENE, EN SECUENCIA DESDE EL EXTREMO N-TERMINAL, UN PRIMER DOMINIO VARIABLE DE LA CADENA PESADA (VH1), UN DOMINIO CH1 Y UN SEGUNDO DOMINIO VARIABLE DE LA CADENA PESADA (VH2); Y UNA SEGUNDA CADENA LIGERA QUE TIENE, EN SECUENCIA DESDE EL EXTREMO N-TERMINAL, UN PRIMER DOMINIO VARIABLE DE LA CADENA LIGERA (VL1), UN DOMINIO CL Y UN SEGUNDO DOMINIO VARIABLE DE LA CADENA LIGERA (VL2). SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA, QUE ES UTIL PARA EL TRATAMIENTO DE UN TRASTORNO PATOLOGICO QUE ESTA MEDIADO POR OX40.
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公开(公告)号：MX2014005564A
公开(公告)日：2014-11-10
申请号：MX2014005564
申请日：2012-11-09
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP
Abstract: La invención se refiere a moléculas que son anticuerpos con especificidad por determinantes antigénicos de OX40 humano, a usos terapéuticos de las moléculas que son anticuerpos y a métodos para producir las moléculas que son anticuerpos.
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公开(公告)号：SG11201401649VA
公开(公告)日：2014-07-30
申请号：SG11201401649V
申请日：2012-11-09
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.
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公开(公告)号：SG11201402093RA
公开(公告)日：2014-06-27
申请号：SG11201402093R
申请日：2012-11-09
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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