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1.
公开(公告)号:WO2013068563A3
公开(公告)日:2013-06-27
申请号:PCT/EP2012072325
申请日:2012-11-09
Applicant: UCB PHARMA SA
Inventor: ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及用于产生所述抗体分子的方法。
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2.
公开(公告)号:WO2013068563A9
公开(公告)日:2014-06-19
申请号:PCT/EP2012072325
申请日:2012-11-09
Applicant: UCB PHARMA SA
Inventor: ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号:PE20141995A1
公开(公告)日:2014-12-06
申请号:PE2014000673
申请日:2012-11-09
Applicant: UCB PHARMA SA
Inventor: ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
Abstract: SE REFIERE A UNA PROTEINA DE FUSION QUE ES UN ANTICUERPO BIESPECIFICO, LA CUAL SE UNE A OX40 HUMANO Y A ALBUMINA DE SUERO HUMANO, QUE COMPRENDE: UNA CADENA PESADA QUE TIENE, EN SECUENCIA DESDE EL EXTREMO N-TERMINAL, UN PRIMER DOMINIO VARIABLE DE LA CADENA PESADA (VH1), UN DOMINIO CH1 Y UN SEGUNDO DOMINIO VARIABLE DE LA CADENA PESADA (VH2); Y UNA SEGUNDA CADENA LIGERA QUE TIENE, EN SECUENCIA DESDE EL EXTREMO N-TERMINAL, UN PRIMER DOMINIO VARIABLE DE LA CADENA LIGERA (VL1), UN DOMINIO CL Y UN SEGUNDO DOMINIO VARIABLE DE LA CADENA LIGERA (VL2). SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA, QUE ES UTIL PARA EL TRATAMIENTO DE UN TRASTORNO PATOLOGICO QUE ESTA MEDIADO POR OX40.
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公开(公告)号:CO7010784A2
公开(公告)日:2014-07-31
申请号:CO14099147
申请日:2014-05-08
Applicant: UCB PHARMA SA
Inventor: ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
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公开(公告)号:CA2855174C
公开(公告)日:2021-11-02
申请号:CA2855174
申请日:2012-11-09
Applicant: UCB PHARMA SA
Inventor: ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, including a bispecific antibody fusion protein that binds OX40 and human scrum albumin, wherein the antigen bound by the first antigen binding site is human OX40, and the antigen bound by the second antigen binding site is human serum albumin. The invention also relates to therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号:CA2856216C
公开(公告)日:2021-01-12
申请号:CA2856216
申请日:2012-11-09
Applicant: UCB PHARMA SA
Inventor: ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.
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公开(公告)号:IN3451DEN2014A
公开(公告)日:2015-06-05
申请号:IN3451DEN2014
申请日:2014-04-30
Applicant: UCB PHARMA SA
Inventor: ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4 in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.
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公开(公告)号:MX2014005546A
公开(公告)日:2014-06-04
申请号:MX2014005546
申请日:2012-11-09
Applicant: UCB PHARMA SA
Inventor: HUMPHREYS DAVID PAUL , ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP
Abstract: Un anticuerpo de unión a albúmina de suero o fragmento del mismo que comprende un dominio variable de cadena pesada que tiene la secuencia dada en SEQ ID NO: 1 o SEQ ID NO:2 y/o que comprende un dominio variable de cadena ligera que tiene la secuencia dada en SEQ ID NO:3 o SEQ ID NO:4, en particular que comprende un dominio variable de cadena pesada y un dominio variable de cadena ligera que tiene la secuencia dada en SEQ ID NO: 1 y SEQ ID NO:3 o un dominio variable de cadena pesada y un dominio variable de cadena ligera que tiene la secuencia dada en SEQ ID NO: 2 y SEQ ID NO:4. La descripción también se extiende a polinucleótidos que codifican los anticuerpos o fragmentos, vectores que comprenden los mismos y células hospederas capaces de expresar los polinucleótidos. La descripción además incluye composiciones farmacéuticas que comprenden los anticuerpos o fragmentos y agentes terapéuticos usados de cualquiera de los mismos.
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公开(公告)号:AP2014007668A0
公开(公告)日:2014-05-31
申请号:AP2014007668
申请日:2012-11-09
Applicant: UCB PHARMA SA
Inventor: HEYWOOD SAM PHILLIP , BHATTA PALLAVI , ADAMS RALPH
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号:AU2012333997A1
公开(公告)日:2014-05-29
申请号:AU2012333997
申请日:2012-11-09
Applicant: UCB PHARMA SA
Inventor: ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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