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    Detection of protease and protease activity using a single nanocrescent SERS probe
    11.
    发明专利
    Detection of protease and protease activity using a single nanocrescent SERS probe 未知

    公开(公告)号：AU2007282164A1

    公开(公告)日：2008-02-14

    申请号：AU2007282164

    申请日：2007-05-02

    Applicant: UNIV CALIFORNIA

    Inventor： LEE LUKE P ,  CHEN FANQING FRANK ,  LIU GANG L ,  ELLMAN JONATHAN A

    IPC: A01N37/18 ,  A61K38/00

    Abstract: This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease and a Raman tag attached to the peptide.

    DETECTION OF PROTEASE AND PROTEASE ACTIVITY USING A SINGLE NANOCRESCENT SERS PROBE
    13.
    发明申请
    DETECTION OF PROTEASE AND PROTEASE ACTIVITY USING A SINGLE NANOCRESCENT SERS PROBE 审中-公开
    用单一纳米SERS探针检测蛋白酶和蛋白酶活性

    公开(公告)号：WO2008018933A3

    公开(公告)日：2008-10-09

    申请号：PCT/US2007010722

    申请日：2007-05-02

    Applicant: UNIV CALIFORNIA ,  LIU GANG L ,  ELLMAN JONATHAN A ,  LEE LUKE P ,  CHEN FANQING FRANK

    Inventor： LIU GANG L ,  ELLMAN JONATHAN A ,  LEE LUKE P ,  CHEN FANQING FRANK

    IPC: A01N37/18 ,  A61K38/00

    CPC classification number: C12Q1/37 ,  G01N33/57434 ,  G01N33/587 ,  G01N2333/96433 ,  G01N2333/96466 ,  G01N2333/974

    Abstract: This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease and a Raman tag attached to the peptide.

    Abstract translation: 本发明涉及使用具有至少纳摩尔灵敏度的单肽缀合纳米新月形表面增强拉曼散射（SERS）探针体外检测蛋白酶。 该探针能够以极小的体积和低浓度检测蛋白水解活性。 在某些实施方案中，所述探针包含用于检测活性蛋白酶的指示剂，其中所述指示剂包含附着于肽的纳米新月，其中所述肽包含蛋白酶的识别位点和附着于肽的拉曼标签。

    Aparato para formación de cultivo celular
    14.
    发明专利
    Aparato para formación de cultivo celular 未知

    公开(公告)号：ES2865180T3

    公开(公告)日：2021-10-15

    申请号：ES16150645

    申请日：2006-07-06

    Applicant: UNIV CALIFORNIA

    Inventor： HUNG PAUL J ,  LEE PHILIP J ,  LEE LUKE P

    IPC: C12M3/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/34 ,  C12M3/06 ,  C12N5/071

    Abstract: Un sistema de cultivo de microfluidos capaz de proporcionar un entorno para el crecimiento biológico y/o análisis y/o manipulación que comprende: una pluralidad de unidades de área de microcultivo, comprendiendo al menos algunas de dichas unidades: un área de cultivo, teniendo dicha área una entrada de flujo fluídico que permite la carga de células u otros objetos de cultivo; un canal fluídico de sección transversal de medio /reactivo, proporcionando dicho canal un flujo deseado de un medio de cultivo y/o reactivo y/o proporcionando acceso a productos de cultivo; y una estructura de paso microfluídico, separando dicha estructura dicha área de cultivo y dicho canal al tiempo que proporciona una conexión fluídica entre dicha área de cultivo y dicho canal sin perturbar las células u otros objetos de cultivo; en el que el canal de medio/reactivo está dispuesto de tal manera que dicho medio de cultivo y/o reactivo en el canal de medio/reactivo fluye alrededor de las unidades de área de microcultivo sin ser forzado a fluir a través de las unidades de área de microcultivo.

    REMOTE OPTICAL SWITCH FOR LOCALIZED CONTROL OF GENE INTERFERENCE
    16.
    发明申请
    REMOTE OPTICAL SWITCH FOR LOCALIZED CONTROL OF GENE INTERFERENCE 审中-公开
    用于本地干扰的本地化控制的远程光学开关

    公开(公告)号：WO2010002949A3

    公开(公告)日：2010-04-08

    申请号：PCT/US2009049334

    申请日：2009-06-30

    Applicant: UNIV CALIFORNIA ,  LEE LUKE P ,  LIU GANG L ,  LEE EUNICE

    Inventor： LEE LUKE P ,  LIU GANG L ,  LEE EUNICE

    IPC: C12Q1/68 ,  B82B3/00 ,  G01N33/50

    CPC classification number: C12N15/111 ,  B82Y5/00 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/50

    Abstract: The disclosure provides a remote control switch of gene interference in living cells by using Oligonucleotides on a Nanoplasmonic Carrier-based Optical Switch (ONCOS) and a near infrared (NIR) laser transmitter. It is possible activate a variety of different nanoscale receivers by tuning optical transmission frequency, which is selectively determined by matching the resonant transmission frequency with the gold nanoplasmonic particle (GNP) carriers.

    Abstract translation: 本公开通过在基于纳米基质载体的光开关（ONCOS）和近红外（NIR）激光发射器上使用寡核苷酸提供了活细胞中基因干扰的遥控开关。 可以通过调谐光传输频率来激活各种不同的纳米级接收机，该传输频率通过将谐振传输频率与金纳米质子粒子（GNP）载体匹配来选择性地确定。

    APPARATUS AND METHOD FOR FORMING FIBERS
    18.
    发明申请
    APPARATUS AND METHOD FOR FORMING FIBERS 审中-公开
    用于形成纤维的装置和方法

    公开(公告)号：WO2007145989A3

    公开(公告)日：2008-02-28

    申请号：PCT/US2007013311

    申请日：2007-06-05

    Applicant: UNIV CALIFORNIA ,  BRESLAUER DAVID N ,  LEE LUKE P

    Inventor： BRESLAUER DAVID N ,  LEE LUKE P

    IPC: B29C47/00

    CPC classification number: D01F4/02 ,  D01D5/00 ,  D01D5/38 ,  D01D5/40 ,  D01F11/02

    Abstract: A method and apparatus for forming materials such as fiber and elongated shapes, including: a tapered flow channel; supply channels for the addition and removal of agents into the tapered flow channel; and a fiber outlet at the distal end of the tapering flow channel.

    Abstract translation: 一种用于形成诸如纤维和细长形状的材料的方法和装置，包括：锥形流动通道; 提供通道，用于将剂添加到锥形流动通道中; 以及在锥形流动通道的远端处的纤维出口。

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