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    DETECTION OF PROTEASE AND PROTEASE ACTIVITY USING A SINGLE NANOSCRESCENT SERS PROBE
    3.
    发明专利
    DETECTION OF PROTEASE AND PROTEASE ACTIVITY USING A SINGLE NANOSCRESCENT SERS PROBE 未知

    公开(公告)号：CA2679707A1

    公开(公告)日：2008-02-14

    申请号：CA2679707

    申请日：2007-05-02

    Applicant: UNIV CALIFORNIA

    Inventor： LIU GANG L ,  ELLMAN JONATHAN A ,  LEE LUKE P ,  CHEN FANQING FRANK

    IPC: A01N37/18 ,  A61K38/00

    Abstract: This invention pertains to the in vitro detection of proteases using a si ngle peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease a nd a Raman tag attached to the peptide.

    METALLIC NANOSTRUCTURES ADAPTED FOR ELECTROMAGNETIC FIELD ENHANCEMENT
    4.
    发明申请
    METALLIC NANOSTRUCTURES ADAPTED FOR ELECTROMAGNETIC FIELD ENHANCEMENT 审中-公开
    适用于电磁场增强的金属纳米结构

    公开(公告)号：WO2006099494A3

    公开(公告)日：2009-04-30

    申请号：PCT/US2006009339

    申请日：2006-03-14

    Applicant: UNIV CALIFORNIA ,  LEE LUKE P ,  LU YU ,  LIU GANG ,  KIM JAEYOUN

    Inventor： LEE LUKE P ,  LU YU ,  LIU GANG ,  KIM JAEYOUN

    IPC: G02B26/00 ,  G02F1/37 ,  H01L51/10

    CPC classification number: G01N21/658 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00

    Abstract: The disclosure relates to metallic nanophotonic crescent structures, or "nanocrescent SERS probes," that enhance detectable signals to facilitate molecular detections. More particularly, the nanocrescent SERS probes of the disclosure possess specialized geometries, including an edge surrounding the opening that is capable of enhancing local electromagnetic fields. Nanosystems utilizing such structures are particularly useful in the medical field for detecting rare molecular targets, biomolecular cellular imaging, and in molecular medicine.

    Abstract translation: 本公开涉及金属纳米光子月牙结构或“纳米新SERS探针”，其增强可检测信号以促进分子检测。 更具体地，本公开的纳米新SERS探针具有专门的几何形状，包括围绕开口的能够增强局部电磁场的边缘。 利用这种结构的纳米系统在用于检测稀有分子靶标，生物分子细胞成像和分子医学的医学领域中特别有用。

    DETECTION OF PROTEASE AND PROTEASE ACTIVITY USING A SINGLE NANOCRESCENT SERS PROBE
    6.
    发明公开
    DETECTION OF PROTEASE AND PROTEASE ACTIVITY USING A SINGLE NANOCRESCENT SERS PROBE 有权
    NACHWEIS VON蛋白酶和蛋白酶 - AKTIVITÄTMITHILFE EINER EINZEL-NANOSTEIGERUNGS-SERS-SONDE

    公开(公告)号：EP2019587A4

    公开(公告)日：2009-06-10

    申请号：EP07835744

    申请日：2007-05-02

    Applicant: UNIV CALIFORNIA

    Inventor： LIU GANG L ,  ELLMAN JONATHAN A ,  LEE LUKE P ,  CHEN FANQING FRANK

    IPC: A01N37/18 ,  A61K38/00

    CPC classification number: C12Q1/37 ,  G01N33/57434 ,  G01N33/587 ,  G01N2333/96433 ,  G01N2333/96466 ,  G01N2333/974

    Abstract: This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease and a Raman tag attached to the peptide.

    Abstract translation: 本发明涉及使用具有至少纳摩尔灵敏度的单肽缀合纳米新月形表面增强拉曼散射（SERS）探针体外检测蛋白酶。 该探针能够以极小的体积和低浓度检测蛋白水解活性。 在某些实施方案中，所述探针包含用于检测活性蛋白酶的指示剂，其中所述指示剂包含附着于肽的纳米新月，其中所述肽包含蛋白酶的识别位点和附着于肽的拉曼标签。

    DIGITAL FLUID SAMPLE SEPARATION APPARATUS AND METHODS FOR ONE-STEP QUANTITATIVE SAMPLE ANALYSIS
    7.
    发明公开
    DIGITAL FLUID SAMPLE SEPARATION APPARATUS AND METHODS FOR ONE-STEP QUANTITATIVE SAMPLE ANALYSIS 审中-公开
    装置：用于单级样品定量分析DIGITAL流体样品分离和方法

    公开(公告)号：EP3030908A4

    公开(公告)日：2017-04-19

    申请号：EP14834471

    申请日：2014-08-08

    Applicant: UNIV CALIFORNIA

    Inventor： LEE LUKE P ,  YEH ERH-CHIA

    IPC: C12Q1/68 ,  G01N35/08

    CPC classification number: B01L3/502753 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/049 ,  C12Q1/6806 ,  C12Q1/6851 ,  C12Q1/689 ,  C12Q1/703 ,  C12Q2565/629 ,  C12Q2600/158 ,  G01N2035/00158

    Abstract: A Digital Separation (DS) chip for separating, digitizing and analyzing a fluid sample is presented. The DS chip includes a fluidic layer that prepares and compartmentalizes the fluid sample for analysis. Cliff structures that are adjacent to wells skim the fluid sample and prevent particles, which may interfere with fluid sample analysis, from entering the wells. Skimmed fluid sample analysis occurs in the wells and endpoint data can be collected and used to determine an original concentration of a desired component in the fluid sample very quickly. Using the described apparatus and methods, a fluid sample can be prepared, digitized, compartmentalized, assayed and the endpoint data collected in ˜30 minutes. The apparatus and methods can easily be adapted to provide parallel processing of a sample.

    Abstract translation: 一种数字分离（DS）芯片，用于分离，数字化和分析流体样品的呈现。 的DS芯片包括流体层做准备并为间隔化分析流体样品。 悬崖结构做了相邻孔脱脂流体样品和防止颗粒，其可与流体样本的分析干扰，从进入孔中。 发生在井脱脂流体试样分析用和端点数据可被收集并用于将流体样品中的所希望组分的初始浓度的确定性矿非常快。 使用所描述的装置和方法，流体样品可以制备，数字化，区室化，测定并在约30分钟收集端点的数据。 该装置和方法能够容易地angepasst提供样本的并行处理。

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