Abstract:
A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.
Abstract:
A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.
Abstract:
Method and systems that provide improved cell handling and assays in microfluidic systems and devices particularly using lateral cell trapping and methods of fabrication of the same.
Abstract:
Soft capacitive pressure sensors for continuous wearable health monitoring applications are described herein. Wrinkled gold thin films on elastomeric substrates are used as robust parallel plate electrodes to create a robust integration with the polymer, allowing repeated normal force to deform the thin film without failure. By incorporating micro-ridged structures that support the counter electrodes to create air cavities within the elastomeric dielectric layer, pressure sensitivity is further increased. The pressure sensors are configured to measure human physiological signals such as pressure exerted from a radial pulse on a skin's surface. The radial pulse pressure detected by the sensor can be correlated to an arterial blood pressure. Calibration of said pressure sensors using a neural network allows for determination of absolute blood pressure.
Abstract:
Method and systems that provide improved cell handling and assays in microfluidic systems and devices particularly using lateral cell trapping and methods of fabrication of the same.
Abstract:
This invention provides a microwell array having a plurality of microwells on a hydrophobic surface wherein the microwells each is substantially proximate to each of its adjacent microwells, as well as methods to prepare arrays. Also provided is a plate that comprises at least one microarray, at least one input channel, at least one output channel, and a channel connecting the input and output channel.
Abstract:
Provided are sensors for detecting chemical and biological agents. The sensors include a heat-shrunk thermoplastic substrate and a film of metal disposed over the surface of the substrate, wherein the film of metal comprises a microstructure characterized by wrinkle-like features. Also provided are methods for making the sensors and methods for detecting chemical and biological agents with the sensors using backscattering spectrometry.
Abstract:
Light emitting devices are provided. The light emitting devices include a substrate, a first array of light emitting lines disposed over the substrate, and a second array of light emitting lines disposed over the first array, wherein one or more light emitting lines of the first array cross one or more light emitting lines of the second array to provide a pixel having an area of no more than 100 µm2. The light emitting lines may include quantum dots and the substrate may be formed of a thermoplastic material, such as polystyrene. Also provided are methods of making the light emitting devices using a stamp comprising a heat-shrunk thermoplastic substrate and a film of metal disposed over the surface of the heat-shrunk thermoplastic substrate, wherein the film of metal comprises a microstructure characterized by wrinkle-like features.
Abstract:
Method and systems that provide improved cell handling and assays in microfluidic systems and devices particularly using lateral cell trapping and methods of fabrication of the same.
Abstract:
A sensor apparatus including a flexible substrate and a wrinkled conductor disposed on the flexible substrate. In some embodiments, the conductor includes micro-scale invaginations. Also disclosed are methods of making a sensor apparatus, including: placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate. Also disclosed are methods of sensing a health condition of a user or patient. The methods include coupling a sensor apparatus to a surface of a user or patient overlying structures to be monitored. The sensor apparatus may include a crumpled conductor capable of detecting strain. Strain is detected by directing current through the sensor apparatus during flexing of the surface and measuring a characteristic of the sensor apparatus based on the strain to generate an output for a user, indicative of the condition of the user or patient.