公开(公告)号：WO1998006848A1

公开(公告)日：1998-02-19

申请号：PCT/CA1997000559

申请日：1997-08-08

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  MANNS, John, G.

IPC: C12N15/16

CPC classification number: A61K39/0006 ,  A61K39/00 ,  A61K47/62 ,  A61K47/646 ,  A61K47/6829 ,  A61K47/6833 ,  A61K2039/6037 ,  C07K5/1008 ,  C07K5/1019 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/23 ,  C07K14/005 ,  C07K14/285 ,  C07K14/655 ,  C07K16/26 ,  C07K2319/00 ,  C12N2720/12322

Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.

Abstract translation: 公开了新的免疫载体系统，编码相同的DNA以及这些系统的使用。 载体系统包括嵌合蛋白，其包含与一个或多个选定的GnRH多聚体融合的白细胞毒素多肽，所述GnRH多聚体包含至少一个重复的GnRH十肽序列，或至少一个对应于所选GnRH分子的至少一个表位的序列的重复单元。 根据本发明，所选择的GnRH序列可以全部相同，或者可以对应于GnRH的不同衍生物，类似物，变体或表位，只要GnRH序列能够引发免疫应答即可。 白细胞毒素用于增加与其融合的GnRH多聚体的免疫原性。

公开(公告)号：WO2010115278A8

公开(公告)日：2010-10-14

申请号：PCT/CA2010/000516

申请日：2010-04-06

Applicant: UNIVERSITY OF SASKATCHEWAN ,  Bioniche Life Sciences Inc. a Body corporate pursuant to the Laws of Canada ,  POTTER, Andrew, A. ,  ASPER, David ,  ROGAN, Dragan

Inventor： POTTER, Andrew, A. ,  ASPER, David ,  ROGAN, Dragan

IPC: C07K19/00 ,  A61K39/108 ,  A61K39/385 ,  A61P31/04 ,  A61P37/04 ,  C07K14/245

Abstract: Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least one of the STEC proteins generates antibodies that react with STEC 0157 and at least one other STEC serotype.

公开(公告)号：WO2003091279A3

公开(公告)日：2003-11-06

申请号：PCT/CA2003/000586

申请日：2003-04-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： BOLTON, Alexandra, J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew, A.

IPC: C07K14/315

Abstract: The use of GapC plasmin binding proteins from Streptococcus dysgalactiae (S. dysgalactiae) , Streptococcus agalactiae (S. agalactiae) , Streptococcus uberis (S. uberis) , Streptococcus parauberis (S. parauberis) , and Streptococcus iniae (S. iniae) in combination with CAMP factors is described, to prevent or treat bacterial infections in general, and mastitis in particular.

公开(公告)号：WO2003091279A2

公开(公告)日：2003-11-06

申请号：PCT/CA2003/000586

申请日：2003-04-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： BOLTON, Alexandra, J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew, A.

IPC: C07K14/315

CPC classification number: C07K14/315 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/02 ,  Y10S530/825

Abstract: The use of GapC plasmin binding proteins from Streptococcus dysgalactiae (S. dysgalactiae) , Streptococcus agalactiae (S. agalactiae) , Streptococcus uberis (S. uberis) , Streptococcus parauberis (S. parauberis) , and Streptococcus iniae (S. iniae) in combination with CAMP factors is described, to prevent or treat bacterial infections in general, and mastitis in particular.

Abstract translation: 结合使用来自无乳链球菌（乳酸乳球菌），无乳链球菌（无乳链球菌），乳房链球菌（S.auberis），乳链球菌（S. parauberis）和链球菌（S.iniae）的组合的GapC纤溶酶结合蛋白 描述了CAMP因子，以预防或治疗一般的细菌感染，特别是乳腺炎。

公开(公告)号：WO2002053181A1

公开(公告)日：2002-07-11

申请号：PCT/CA2002/000019

申请日：2002-01-03

Applicant: UNIVERSITY OF SASKATCHEWAN ,  UNIVERSITY OF BRITISH COLUMBIA ,  FINLAY, Brett ,  POTTER, Andrew, A.

Inventor： FINLAY, Brett ,  POTTER, Andrew, A.

IPC: A61K39/108

CPC classification number: A61K39/0258 ,  A61K2039/55566 ,  C07K14/245 ,  Y02A50/474

Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.

Abstract translation: 公开了用于刺激针对分泌的肠嗜酸性大肠杆菌（EHEC）抗原的免疫应答的组合物和方法。 该组合物包含EHEC细胞培养物上清液。

公开(公告)号：WO1996024675A1

公开(公告)日：1996-08-15

申请号：PCT/CA1996000049

申请日：1996-01-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  MANNS, John, G.

IPC: C12N15/62

CPC classification number: C07K5/1024 ,  A61K39/00 ,  A61K39/0006 ,  A61K47/62 ,  A61K47/646 ,  A61K47/6829 ,  A61K47/6833 ,  A61K2039/6037 ,  C07K5/1008 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/23 ,  C07K14/005 ,  C07K14/285 ,  C07K14/655 ,  C07K16/26 ,  C07K2319/00 ,  C12N2720/12322

Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected GnRH multimer which consists essentially of at least one repeating GnRH decapepetide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimer fused thereto.

Abstract translation: 公开了新的免疫载体系统，编码相同的DNA以及这些系统的使用。 载体体系包括嵌合蛋白，其包含与选定的GnRH多聚体融合的白细胞毒素多肽，所述GnRH多聚体基本上由至少一个重复的GnRH脱羧选择素序列组成，或至少一个对应于所选GnRH分子的至少一个表位的序列的重复单元。 根据本发明，所选择的GnRH序列可以全部相同，或者可以对应于GnRH的不同衍生物，类似物，变体或表位，只要GnRH序列能够引发免疫应答即可。 白细胞毒素的作用是增加与其融合的GnRH多聚体的免疫原性。

公开(公告)号：EP1292327B1

公开(公告)日：2007-03-21

申请号：EP01944804.2

申请日：2001-06-11

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： POTTER, Andrew, A. ,  BOLTON, Alexandra, J. ,  SONG, Xin, Ming

IPC: A61K39/09 ,  A61K48/00

CPC classification number: C07K14/315 ,  A61K39/00

Abstract: The Mig protein gene of Streptococcus dysgalactiae, and the corresponding amino acid sequence, is described, as is the use of the Mig protein in vaccine compositions to prevent and treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1332155A2

公开(公告)日：2003-08-06

申请号：EP01949115.8

申请日：2001-06-11

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： BOLTON, Alexandra, J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew, A.

IPC: C07K14/315 ,  C12N15/31 ,  C12N15/70 ,  C12N1/21 ,  A61K39/09 ,  C07K16/12 ,  A61P31/04 ,  A61K31/7088 ,  G01N33/569 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K14/315 ,  A61K39/00 ,  A61K2039/53

Abstract: The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S.iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1037909A2

公开(公告)日：2000-09-27

申请号：EP98959682.0

申请日：1998-12-11

Applicant: The University of Saskatchewan

Inventor： WANG, Li ,  BABIUK, Lorne, A. ,  POTTER, Andrew, A. ,  WILLSON, Philip

IPC: C07K14/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/552 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/10022 ,  C12N2750/10043 ,  C12Q1/701

Abstract: The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.

公开(公告)号：EP0527724B1

公开(公告)日：1997-08-27

申请号：EP90906831.4

申请日：1990-05-25

Applicant: The University of Saskatchewan

Inventor： ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC: A61K39/102 ,  C12N15/31

CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

Abstract: New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50 K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.