公开(公告)号：WO2017011919A1

公开(公告)日：2017-01-26

申请号：PCT/CA2016/050864

申请日：2016-07-22

Applicant: UNIVERSITY OF SASKATCHEWAN ,  KENYA AGRICULTURE AND LIVESTOCK RESEARCH ORGANIZATION (KALRO) ,  INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE (ILRI)

Inventor： POTTER, Andrew ,  GERDTS, Volker ,  PEREZ-CASAL, Jose ,  WANG, Yejun ,  WESONGA, Hezron ,  SOI, Reuben ,  NAESSENS, Jan ,  JORES, Joerg

IPC: C12N15/31 ,  A61K39/02 ,  A61K39/385 ,  A61P31/04 ,  A61P37/04 ,  C07K14/30 ,  C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  C12N15/70

CPC classification number: C07K14/30 ,  A61K39/0241 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/00

Abstract: Immunogenic proteins comprising Mycoplasma mycoides subsp. mycoides and M. mycoides subsp. capri proteins, encoding polynucleotides, a method for producing said proteins, and use of compositions to prevent M. mycoides subsp. mycoides infections are disclosed.

Abstract translation: 免疫原性蛋白质，包括支原体支原体亚种 金丝桃和M.cocoides subsp。 编码多核苷酸的capri蛋白，用于产生所述蛋白质的方法，以及使用组合物来防止M.mycoides subsp。 披露了金丝雀感染。

公开(公告)号：WO2003091279A3

公开(公告)日：2003-11-06

申请号：PCT/CA2003/000586

申请日：2003-04-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： BOLTON, Alexandra, J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew, A.

IPC: C07K14/315

Abstract: The use of GapC plasmin binding proteins from Streptococcus dysgalactiae (S. dysgalactiae) , Streptococcus agalactiae (S. agalactiae) , Streptococcus uberis (S. uberis) , Streptococcus parauberis (S. parauberis) , and Streptococcus iniae (S. iniae) in combination with CAMP factors is described, to prevent or treat bacterial infections in general, and mastitis in particular.

公开(公告)号：WO2003091279A2

公开(公告)日：2003-11-06

申请号：PCT/CA2003/000586

申请日：2003-04-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： BOLTON, Alexandra, J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew, A.

IPC: C07K14/315

CPC classification number: C07K14/315 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/02 ,  Y10S530/825

Abstract: The use of GapC plasmin binding proteins from Streptococcus dysgalactiae (S. dysgalactiae) , Streptococcus agalactiae (S. agalactiae) , Streptococcus uberis (S. uberis) , Streptococcus parauberis (S. parauberis) , and Streptococcus iniae (S. iniae) in combination with CAMP factors is described, to prevent or treat bacterial infections in general, and mastitis in particular.

Abstract translation: 结合使用来自无乳链球菌（乳酸乳球菌），无乳链球菌（无乳链球菌），乳房链球菌（S.auberis），乳链球菌（S. parauberis）和链球菌（S.iniae）的组合的GapC纤溶酶结合蛋白 描述了CAMP因子，以预防或治疗一般的细菌感染，特别是乳腺炎。

公开(公告)号：WO2017011918A1

公开(公告)日：2017-01-26

申请号：PCT/CA2016/050863

申请日：2016-07-22

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： PEREZ-CASAL, Jose ,  POTTER, Andrew ,  GERDTS, Volker ,  WANG, Yejun

IPC: C12N15/31 ,  A61K39/02 ,  A61P31/04 ,  A61P37/04 ,  C07K14/30 ,  C12N15/63 ,  C12N15/70 ,  C12P21/02

CPC classification number: C07K14/30 ,  A61K39/0241 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/00

Abstract: Mycoplasma bovis antigens for use in subunit vaccine compositions to elicit immune responses against M. bovis , polynucleotides encoding therefor, and use of said compositions to prevent Mycoplasma bovis infections.

Abstract translation: 用于亚单位疫苗组合物中的支原体牛抗原用于引发针对牛枝原体的免疫应答，编码该多核苷酸的多核苷酸以及使用所述组合物来预防牛支原体感染。

公开(公告)号：WO2003091437A1

公开(公告)日：2003-11-06

申请号：PCT/CA2003/000587

申请日：2003-04-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： POTTER, Andrew, A. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  SONG, Xinming

IPC: C12N15/31

CPC classification number: C07K14/315 ,  A61K39/00 ,  C07K2319/02

Abstract: The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial species. The CAMP factors and chimeras including the same can be used in immunogenic compositions for the prevention and treatment of bacterial infections.

Abstract translation: 描述了乳房链球菌（乳房链球菌）的CAMP因子基因，以及从其重组产生CAMP因子。 还公开了嵌合CAMP因子构建体，包括来自多于一种细菌种的CAMP因子表位。 包括其的CAMP因子和嵌合体可用于免疫原性组合物中用于预防和治疗细菌感染。

公开(公告)号：EP1332155A2

公开(公告)日：2003-08-06

申请号：EP01949115.8

申请日：2001-06-11

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： BOLTON, Alexandra, J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew, A.

IPC: C07K14/315 ,  C12N15/31 ,  C12N15/70 ,  C12N1/21 ,  A61K39/09 ,  C07K16/12 ,  A61P31/04 ,  A61K31/7088 ,  G01N33/569 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K14/315 ,  A61K39/00 ,  A61K2039/53

Abstract: The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S.iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1294771A2

公开(公告)日：2003-03-26

申请号：EP01944803.4

申请日：2001-06-11

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： POTTER, Andrew, A. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael

IPC: C07K19/00 ,  C12N15/62 ,  C12N15/70 ,  C12N1/21 ,  A61K39/09 ,  C07K16/12 ,  G01N33/569 ,  A61P31/04 ,  A61K31/7088 ,  G01N33/68

CPC classification number: G01N33/56944 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/315 ,  C07K2319/00 ,  G01N2469/20

Abstract: The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.

公开(公告)号：EP1294771B1

公开(公告)日：2008-10-29

申请号：EP01944803.4

申请日：2001-06-11

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： POTTER, Andrew, A. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael

IPC: C07K19/00 ,  C12N15/62 ,  C12N15/70 ,  C12N1/21 ,  A61K39/09 ,  C07K16/12 ,  G01N33/569 ,  A61P31/04 ,  A61K31/7088 ,  G01N33/68

CPC classification number: G01N33/56944 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/315 ,  C07K2319/00 ,  G01N2469/20

公开(公告)号：EP1499634A2

公开(公告)日：2005-01-26

申请号：EP03722115.7

申请日：2003-04-24

Applicant: University of Saskatchewan

Inventor： BOLTON, Alexandra J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew A.

IPC: C07K14/315 ,  A61K39/09

CPC classification number: C07K14/315 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/02 ,  Y10S530/825

Abstract: The use of GapC plasmin binding proteins from Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S. iniae) in combination with CAMP factors is described, to prevent or treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1332155B1

公开(公告)日：2006-10-25

申请号：EP01949115.8

申请日：2001-06-11

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： BOLTON, Alexandra, J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew, A.

IPC: C07K14/315 ,  C12N15/31 ,  C12N15/70 ,  C12N1/21 ,  A61K39/09 ,  C07K16/12 ,  A61P31/04 ,  A61K31/7088 ,  G01N33/569 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K14/315 ,  A61K39/00 ,  A61K2039/53

Abstract: The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S.iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.