公开(公告)号：WO2009012589A1

公开(公告)日：2009-01-29

申请号：PCT/CA2008/001354

申请日：2008-07-23

Applicant: UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  FERNANDO, Ursla

Inventor： POTTER, Andrew, A. ,  FERNANDO, Ursla

IPC: A61K39/02 ,  A61K39/106 ,  A61P31/04 ,  A61P37/04 ,  A61K39/39

CPC classification number: A61K39/105 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55566 ,  Y02A50/47

Abstract: Methods for the treatment or prevention of Gram negative bacterial infection in a vertebrate subject are provided. The methods provide administering an antagonist of bacterial flagellar protein biosynthesis to the vertebrate subject in an amount effective to reduce or eliminate the bacterial infection. Methods for the treatment or prevention of Campylobacter jejuni infection in an avian species or a mammalian species are provided.

Abstract translation: 提供了在脊椎动物受试者中治疗或预防革兰氏阴性细菌感染的方法。 所述方法提供以有效减少或消除细菌感染的量向脊椎动物受试者施用细菌鞭毛蛋白生物合成拮抗剂。 提供了用于治疗或预防禽类物种或哺乳动物物种的空肠弯曲杆菌感染的方法。

公开(公告)号：WO1993008290A1

公开(公告)日：1993-04-29

申请号：PCT/CA1992000449

申请日：1992-10-15

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  REDMOND, Mark, J. ,  HUGHES, Huw, P., A.

IPC: C12N15/62

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/0006 ,  A61K47/62 ,  A61K47/646 ,  A61K47/6829 ,  A61K47/6833 ,  A61K2039/6037 ,  C07K5/1019 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/23 ,  C07K14/285 ,  C07K14/655 ,  C07K16/26 ,  C07K2319/00 ,  C12N2720/12322

Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.

Abstract translation: 公开了新的免疫载体系统，编码相同的DNA以及这些系统的使用。 载体体系包括嵌合蛋白，其包含与选定抗原融合的白细胞毒素多肽。 白细胞毒素用于增加融合在其上的抗原的免疫原性。

公开(公告)号：WO1994010316A1

公开(公告)日：1994-05-11

申请号：PCT/CA1993000448

申请日：1993-11-03

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  GERLACH, Gerald, F. ,  WILLSON, Philip, J. ,  ROSSI-CAMPOS, Amalia ,  POTTER, Andrew, A.

IPC: C12N15/31

CPC classification number: C07K14/285 ,  A61K39/00 ,  Y10S424/825 ,  Y10S435/851

Abstract: Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one Actinobacillus pleuropneumoniae outer membrane lipoprotein A, or an immunogenic fragment thereof. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.

Abstract translation: 公开了用于针对放线杆菌胸膜肺炎放线芽孢杆菌的新型疫苗。 疫苗含有至少一种胸膜肺炎放线芽孢杆菌外膜脂蛋白A或其免疫原性片段。 还公开了编码这些蛋白质的DNA序列，包括这些序列的载体和用这些载体转化的宿主细胞。 疫苗可用于治疗或预防猪呼吸道感染。

公开(公告)号：WO1993021323A1

公开(公告)日：1993-10-28

申请号：PCT/CA1993000135

申请日：1993-04-05

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  PONTAROLLO, Reno, A. ,  PFEIFFER, Cheryl, G. ,  THEISEN, Michael ,  HARLAND, Richard, J. ,  RIOUX, Clement

IPC: C12N15/31

CPC classification number: C07K14/285 ,  A61K39/00 ,  C07K2319/40 ,  C07K2319/55

Abstract: Novel Haemophilus somnus immunogenic proteins are disclosed. The proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections. The proteins are conveniently produced using recombinant technology.

Abstract translation: 公开了新型嗜血杆菌somnus免疫原性蛋白。 这些蛋白质可用于预防和治疗嗜睡睡眠感染的疫苗组合物中。 使用重组技术便利地生产蛋白质。

公开(公告)号：WO1993008283A1

公开(公告)日：1993-04-29

申请号：PCT/CA1992000460

申请日：1992-10-21

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  GERLACH, Gerald, F. ,  WILLSON, Philip, J. ,  ROSSI-CAMPOS, Amalia

IPC: C12N15/31

CPC classification number: C07K14/285 ,  A61K39/00

Abstract: Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one A. pleuropneumoniae transferrin binding protein and/or one A. pleuropneumoniae cytolysin and/or one A. pleuropneumoniae APP4. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.

Abstract translation: 公开了用于针对放线杆菌胸膜肺炎放线芽孢杆菌的新型疫苗。 疫苗含有至少一种胸膜肺炎放线芽孢杆菌转运蛋白结合蛋白和/或一种胸膜肺炎放线芽孢杆菌细胞溶解素和/或一种胸膜肺炎放线菌APP4。 还公开了编码这些蛋白质的DNA序列，包括这些序列的载体和用这些载体转化的宿主细胞。 疫苗可用于治疗或预防猪呼吸道感染。

公开(公告)号：WO2003091437A1

公开(公告)日：2003-11-06

申请号：PCT/CA2003/000587

申请日：2003-04-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： POTTER, Andrew, A. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  SONG, Xinming

IPC: C12N15/31

CPC classification number: C07K14/315 ,  A61K39/00 ,  C07K2319/02

Abstract: The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial species. The CAMP factors and chimeras including the same can be used in immunogenic compositions for the prevention and treatment of bacterial infections.

Abstract translation: 描述了乳房链球菌（乳房链球菌）的CAMP因子基因，以及从其重组产生CAMP因子。 还公开了嵌合CAMP因子构建体，包括来自多于一种细菌种的CAMP因子表位。 包括其的CAMP因子和嵌合体可用于免疫原性组合物中用于预防和治疗细菌感染。

公开(公告)号：WO1996041879A1

公开(公告)日：1996-12-27

申请号：PCT/CA1996000377

申请日：1996-06-07

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  JIANG, Min ,  POTTER, Andrew, A. ,  MACLACHLAN, Philip, Ronald

IPC: C12N15/31

CPC classification number: C07K14/315 ,  A61K39/00 ,  Y10S930/29

Abstract: The CAMP factor gen of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the prevention and treatment of bacterial infections.

Abstract translation: 描述了乳房链球菌（乳房链球菌）的CAMP因子基因，以及从其重组产生CAMP因子。 CAMP因子可用于预防和治疗细菌感染的疫苗组合物中。

公开(公告)号：WO1994005326A1

公开(公告)日：1994-03-17

申请号：PCT/CA1993000365

申请日：1993-09-03

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  ALLAN, Brenda, J. ,  POTTER, Andrew, A.

IPC: A61K39/108

CPC classification number: C07K14/245 ,  A61K39/00

Abstract: Vaccines are provided for vaccinating an animal against pathogenic bacteria, including E. coli. The invention also encompasses methods of preparing and methods of use of vaccine strains and compositions that result from or are used in these methods.

Abstract translation: 提供疫苗以接种疫苗以对抗致病细菌，包括大肠杆菌。 本发明还包括由这些方法产生或被使用的疫苗菌株和组合物的制备方法和使用方法。

公开(公告)号：WO1991015237A1

公开(公告)日：1991-10-17

申请号：PCT/CA1990000170

申请日：1990-05-25

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC: A61K39/102

CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

Abstract: New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50 K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.

Abstract translation: 公开了用于刺激抗呼吸系统疾病例如肺炎的免疫的解脲索氏溶血杆菌的新蛋白质和亚基抗原，包括运​​送发热性肺炎。 亚单位抗原包括解脲葡萄球菌菌毛蛋白，溶血性解纤维细胞溶血素受体蛋白和溶血性解水多糖50K外膜蛋白和解放军溶血白细胞毒素的免疫原性氨基酸序列。 抗原可以单独或组合地用于疫苗组合物中。 还公开了接种疫苗的方法以及制备疫苗中使用的亚基抗原的方法。

公开(公告)号：WO1998021231A2

公开(公告)日：1998-05-22

申请号：PCT/CA1997000867

申请日：1997-11-14

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  JIANG, Min ,  POTTER, Andrew, A. ,  MACLACHLAN, Philip, Ronald

IPC: C07K14/00

CPC classification number: C07K14/315 ,  A61K39/00

Abstract: The bovine lactoferrin (bLF) binding protein of Streptococcus uberis (S. uberis) is described, as well as the gene encoding the bLF (1bp). LF-binding proteins can be used in vaccine compositions for the prevention and treatment of S. uberis infections, particularly mastitis, as well as in diagnostic methods for determining the presence of S. uberis infections. Also disclosed is a regulatory region adjacent to 1bp, termed mga.

Abstract translation: 描述了乳房链球菌（S.auberis）的牛乳铁蛋白（bLF）结合蛋白，以及编码bLF（1bp）的基因。 LF结合蛋白可用于预防和治疗乳房链球菌感染，特别是乳腺炎的疫苗组合物，以及用于确定乳房链球菌感染存在的诊断方法。 还公开了与1bp相邻的调节区，称为mga。