公开(公告)号：WO1998020026A1

公开(公告)日：1998-05-14

申请号：PCT/US1997020534

申请日：1997-11-07

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  JIMENEZ, Elsie, C. ,  OLIVERA, Baldomero, M. ,  GRAY, William, R. ,  CRUZ, Lourdes, J.

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION

IPC: C07K07/64

CPC classification number: C07K7/06 ,  A61K38/00

Abstract: The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan residues. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys (SEQ ID NO:1), wherein Xaa1 is Gly or des-Xaa1, Xaa2 is Pro or 4-trans-hydroxyproline and Xaa3 is D-Trp or L-Trp, preferably D-Trp. The present invention is further directed to the peptides contryphan R and des-Gly contryphan R. In contryphan R, Xaa1 is Gly and Xaa3 is D-Trp. These contryphans are useful as anticonvulsant or neuroprotective agents.

Abstract translation: 本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸残基。 更具体地，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是Gly或des-Xaa1，Xaa2是Pro 或4-反式 - 羟基脯氨酸，Xaa3是D-Trp或L-Trp，优选D-Trp。 本发明进一步针对R和des-Gly 1反式R的肽。相反，Raa，Xaa1是Gly，Xaa3是D-Trp。 这些拮抗剂可用作抗惊厥药或神经保护剂。

公开(公告)号：WO1998013063A1

公开(公告)日：1998-04-02

申请号：PCT/IB1997001376

申请日：1997-09-25

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  IRELAND, Chris, M. ,  FERNANDEZ, Annette

IPC: A61K38/12

CPC classification number: C07K7/08 ,  A61K38/00

Abstract: A purified bicyclic depsipeptide, vitilevuamide (1), from the ascidians Didemnum cuculliferum and Polysyncraton lithostrotum is disclosed. Vitilevuamide has antitumor activity as demonstrated by standard in vitro and in vivo assays. An anticancer composition is also disclosed, comprising an effective amount of vitilevuamide and an inert carrier. A method of treating cancer in also disclosed, comprising administering an anticancer composition comprising an effective amount of vitilevuamide and an inert carrier.

Abstract translation: 公开了一种来自海拔Didemnum cuculliferum和Polysyncrato litortrotrot的纯化的双环depsipeptide，vitilevuamide（1）。 Vitilevuamide具有抗肿瘤活性，如标准体外和体内测定所证明的。 还公开了一种抗癌组合物，其包含有效量的维甲酰胺和惰性载体。 还公开了一种治疗癌症的方法，包括施用包含有效量的维生素和惰性载体的抗癌组合物。

公开(公告)号：WO1998000556A1

公开(公告)日：1998-01-08

申请号：PCT/US1997012425

申请日：1997-07-03

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  KIM, Jin-Seok ,  MARUYAMA, Atsushi ,  AKAIKE, Toshihiro ,  KIM, Sung, Wan

IPC: C12N15/64

CPC classification number: C12N15/1135 ,  A61K38/00 ,  A61K47/645 ,  A61K47/6917 ,  C12N15/87 ,  C12N2310/3513 ,  Y10T428/2984

Abstract: A composition for delivery of a selected nucleic acid into a targeted host cell comprises a complex of a hydrophobized, positively charged, biocompatible polymer; a lipoprotein; and a selected nucleic acid. Hydrophobic and electrostatic interactions between the components provide for the formation of the condensed DNA-containing complex. Preferred embodiments of the complex have a slightly positive surface charge and an average diameter of about 200 nm. Plasmids and oligonucleotides can be efficiently delivered with such compositions. A method of delivering a selected nucleic acid to a host cell is also disclosed.

Abstract translation: 用于将选择的核酸递送至靶宿主细胞的组合物包含疏水化，带正电荷的生物相容性聚合物的复合物; 脂蛋白 和选择的核酸。 组分之间的疏水和静电相互作用提供了形成含缩合DNA的复合物。 络合物的优选实施方案具有略微正的表面电荷和约200nm的平均直径。 可以用这样的组合物有效地递送质粒和寡核苷酸。 还公开了将选择的核酸递送至宿主细胞的方法。

公开(公告)号：WO1997049329A1

公开(公告)日：1997-12-31

申请号：PCT/US1997011217

申请日：1997-06-26

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  ZHDANOV, Michael, S.

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION

IPC: A61B05/00

CPC classification number: A61B5/417 ,  A61B5/05 ,  G03H1/04

Abstract: A method of imaging an object, such as a diseased human heart or bone, in a nontransparent medium, such as the human body, involves placing an array of transmitters (12, 13) and receivers (14, 15) in operational association with the medium (16). The transmitters (12, 13) generate a harmonic (frequency domain) or pulse (time domain) primary EM field which propagates through the medium (16). The primary field interacts with the object to produce a scattered field, which is recorded by the receivers (14, 15). The scattered EM field components measured by the receivers (14, 15) are applied as an artificial EM field to generate a backscattering EM field. Cross power spectra of the primary and backscattering fields (in frequency domain) or cross correlation between these fields (in time domain) produce a numerical reconstruction of an EM hologram. The desired properties of the medium (16), such as conductivity or dielectric permittivity, are then derived from this hologram.

Abstract translation: 在非透明介质（例如人体）中对物体（例如患病的人的心脏或骨骼）进行成像的方法涉及将发射器阵列（12,13）和接收器（14,15）放置成与 中等（16）。 发射机（12,13）产生通过介质（16）传播的谐波（频域）或脉冲（时域）主EM场。 主场与对象交互以产生由接收器（14,15）记录的散射场。 由接收器（14,15）测量的散射EM场分量被应用为人造EM场以产生后向散射EM场。 主要和后向散射场（频域）的交叉功率谱或这些场（在时域）之间的互相关产生EM全息图的数值重建。 然后从该全息图导出介质（16）的期望性质，例如导电性或介电常数。

公开(公告)号：WO1997037317A1

公开(公告)日：1997-10-09

申请号：PCT/US1997005419

申请日：1997-04-01

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  THOMAS, Charles, L. ,  LEE, Cheol, H. ,  KAZA, Srinivas ,  GAFFNEY, Thomas, M.

IPC: G06F19/00

CPC classification number: G05B19/4099 ,  B29C64/386 ,  B33Y40/00 ,  B33Y50/02 ,  G05B2219/49011 ,  G05B2219/49014 ,  Y02P90/265

Abstract: A rapid prototype modeling system (20) operates to first electronically decompose a discrete part represented by an STL file into electronic layers, using a paradigm characterized by a higher than zero order of fit with respect to the surface of the part. Physical layers are generated from the electronic layers by mechanical devices constructed and arranged to operate in accordance with the paradigm. The physical layers are then stacked appropriately to create a physical model of the discrete part.

Abstract translation: 快速原型建模系统（20）操作，首先使用由相对于零件表面高于零的配合顺序的特征模型将由STL文件表示的分立部分电子分解成电子层。 通过构造和布置为根据范例操作的机械装置从电子层产生物理层。 然后将物理层适当地堆叠以创建离散部分的物理模型。

公开(公告)号：WO1997035176A1

公开(公告)日：1997-09-25

申请号：PCT/US1997004398

申请日：1997-03-19

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  HERRON, James, A. ,  CHRISTENSEN, Douglas, A. ,  POLLAK, Victor, A. ,  McEACHERN, Richard, D. ,  SIMON, Eric, M.

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION

IPC: G01N21/00

CPC classification number: G01N21/0303 ,  G01N2021/058

Abstract: Improvements in a biosensor of the type having reservoirs or wells for analyzing a biological liquid are disclosed. A biosensor (190) includes a waveguide (164) placed between a plurality of members such as plates (100, 186), at least one of the members (100) being formed to define the walls (132, 134, 136) of the reservoirs where the liquid is biologically analyzed. The walls of the reservoirs are made of an inert, opaque material such as a metal. Although the biosensor may include a gasket (162), the gasket is associated with the members and waveguide in such a way (e.g. by recessing the gasket into a channel formed into a metal plate) so that the gasket does not form any significant portion of the reservoir wall. Waveguides of varying composition (e.g. plastic, quartz or glass) may be associated with the members to form the biosensor. The metal plate of the biosensor has input and output ports for infusing, draining, or oscillating the liquid to be analyzed in the reaction reservoir. Also disclosed is a sled-shaped waveguide associated with a rear lens to couple light out of the waveguide to serve as a quality control measure thus insuring that the biosensor is properly placed and that the light is working.

Abstract translation: 公开了具有用于分析生物液体的储存器或孔的类型的生物传感器的改进。 生物传感器（190）包括布置在诸如板（100,186）之间的多个构件之间的波导（164），所述构件（100）中的至少一个被形成以限定所述壁（132,134,136） 生物分析液体的储层。 储存器的壁由惰性的不透明材料如金属制成。 虽然生物传感器可以包括垫圈（162），但是垫圈以这样的方式（例如通过将垫圈凹入形成金属板的通道）与构件和波导相关联，使得垫圈不形成任何重要的部分 水库墙。 不同成分的波导（例如塑料，石英或玻璃）可与成员相关联以形成生物传感器。 生物传感器的金属板具有输入和输出端口，用于在反应槽中输入，排出或振荡待分析液体。 还公开了一种与后透镜相关联的雪橇形波导，以将光从波导耦合以用作质量控制措施，从而确保生物传感器被正确放置并且光正在工作。

公开(公告)号：WO1997034913A1

公开(公告)日：1997-09-25

申请号：PCT/US1997005067

申请日：1997-03-21

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  COLE, Barry, C. ,  ATKIN, Curtis, L. ,  KNUDTSON, Kevin, L. ,  SAWITZKE, Allen, D.

IPC: C07H21/04

CPC classification number: C07K14/30 ,  A61K38/00 ,  C07H21/04

Abstract: The gene encoding the superantigen Mycoplasma arthritidis T-cell mitogen (MAM) was molecularly cloned. The mam gene was modified by site-directed mutagenesis to change UGA codons, which in mycoplasmas are read as tryptophan codons instead of universal stop codons, to UGG codons such that the gene could be expressed in standard expression systems. Recombinant MAM, including extra amino acid residues at the - and C-termini, were expressed and discovered to be biologically active. Certain amino acid substitutions in active regions of the protein also yield biologically active MAM proteins. A method of diagnosing rheumatoid arthritis using recombinant MAM protein in an ELISA assay is disclosed.

Abstract translation: 编码超抗原支原体支原体T细胞有丝分裂原（MAM）的基因被分子克隆。 通过定点诱变修饰mam基因，以将UGA密码子改变为UGA密码子，其将支原体作为色氨酸密码子而不是通用终止密码子读取到UGG密码子，使得该基因可以在标准表达系统中表达。 表达并发现重组MAM，包括 - 和C-末端的额外的氨基酸残基具有生物活性。 蛋白质活性区域中的某些氨基酸取代也产生生物活性的MAM蛋白质。 公开了一种在ELISA测定中使用重组MAM蛋白诊断类风湿性关节炎的方法。

公开(公告)号：WO1997010847A1

公开(公告)日：1997-03-27

申请号：PCT/US1996015219

申请日：1996-09-20

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  JACOBS, Harvey ,  KIM, Sung, Wan ,  MENARD, Virginie

IPC: A61K39/44

CPC classification number: C07K16/40 ,  A61K38/00 ,  A61K39/44 ,  A61K47/60 ,  A61K47/6871 ,  C07K2317/55

Abstract: A method for delaying onset of insulin dependent diabetes mellitus (IDDM) in an individual predisposed to developing the disease is disclosed. The method comprises administering a composition comprising an immunologically effective monoclonal antibody or fragment thereof against glutamic acid decarboxylase (GAD) coupled to a nonimmunogenic hydrophilic polymer that provides a hydration shell around the monoclonal antibody for inhibiting immune recognition thereof. Poly(ethylene glycol) is a preferred polymer. A method of reducing insulitis in an IDDM patient and a composition therefor are also described.

Abstract translation: 公开了一种在发生该疾病的个体中延缓胰岛素依赖性糖尿病（IDDM）发病的方法。 该方法包括施用包含免疫有效的单克隆抗体或其片段的组合物，其抗体与非免疫原性亲水性聚合物偶联的谷氨酸脱羧酶（GAD），所述非免疫原性亲水性聚合物在单克隆抗体周围提供水合壳以抑制其免疫识别。 聚（乙二醇）是优选的聚合物。 还描述了减少IDDM患者的胰岛炎的方法及其组合物。

公开(公告)号：WO1996004844A1

公开(公告)日：1996-02-22

申请号：PCT/US1995010191

申请日：1995-08-11

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  BRADSHAW, Kenneth, M. ,  GLOVER, Gary, H. ,  HADLEY, J., Rock ,  SCHWEIZER, Martin, P.

IPC: A61B05/055

CPC classification number: G01R33/465 ,  G01R33/443 ,  G01R33/563 ,  G01R33/58

Abstract: A magnetic resonance sensitive (MRS) element, notably boron (B), is compounded in a carrier, such as borocaptate sodium (22). A subject, typically a patient (21) with a brain tumor (24), is positioned in the imaging field of a magnetic resonance imaging machine, along with a reference (38) containing a known concentration of the MRS element. The magnetic resonance imaging machine is operated to produce a signal encoded by a reconstruction method that takes data immediately following the transverse RF pulse. The data is reconstructed to provide, for example, a subject image and a reference image. The subject image is calibrated from the reference image to derive a data matrix relating the concentration of the MRS element in the subject to locations within the subject. The data matrix may then be displayed as an image or downloaded to a computer for controlling radiation dosage during neutron therapy.

Abstract translation: 磁共振敏感（MRS）元素，特别是硼（B））在载体如硼酸盐钠（22）中复合。 通常具有脑肿瘤（24）的患者（21）被放置在磁共振成像机的成像领域中，以及包含已知浓度的MRS元件的参考（38）。 磁共振成像机被操作以产生由采用横向RF脉冲之后的数据的重建方法编码的信号。 重建数据以提供例如对象图像和参考图像。 从参考图像校准被摄体图像以导出将受检者中的MRS元件的浓度与受试者内的位置相关联的数据矩阵。 然后可以将数据矩阵显示为图像或下载到计算机以控制中子治疗期间的辐射剂量。

公开(公告)号：WO1993001601A1

公开(公告)日：1993-01-21

申请号：PCT/US1992005717

申请日：1992-07-08

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  CEDZYNSKA, Krystyna ,  LINTON, Denton, C. ,  WILL, Fritz, G.

IPC: G21B01/00

CPC classification number: G21B3/00 ,  Y02E30/18

Abstract: Isotopic hydrogen is electrolytically loaded into a palladium or palladium alloy electrode (22) by alternately charging and discharging the electrode in a plurality of cycles, each cycle including charging the electrode with isotopic hydrogen approximately to a saturation level and then discharging the electrode to a predetermined retention level. The electrode can be palladized by electrodeposition of a thin coating of Pd black, then pre-loaded in deuterium gas at atmospheric pressure, then transferred to an electrochemical cell (20) where the alternate charging and discharging takes place for a total of 4-5 times.

Abstract translation: 通过以多个周期交替地对电极进行充电和放电，将同位素氢电解负载到钯或钯合金电极（22）中，每个循环包括将电极与同位素氢充分接近饱和水平，然后将电极放电到预定的 保留水平。 电极可以通过电沉积Pd黑的薄涂层来沉积，然后在大气压下预加载在氘气中，然后转移到电化学电池（20），其中交替充电和放电发生总共4-5 倍。