公开(公告)号：WO1998022126A1

公开(公告)日：1998-05-28

申请号：PCT/US1997020669

申请日：1997-11-17

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  McINTOSH, J., Michael ,  OLIVERA, Baldomero, M. ,  YOSHIKAMI, Doju

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION

IPC: A61K38/10

CPC classification number: A61K38/17

Abstract: The present invention is directed to the use of ImI and MII conotoxin peptides, and derivatives thereof, as cardiovascular agents including, but not limited to, heart rate regulating agents, blood pressure regulating agents and anti-arrhythmia agents.

Abstract translation: 本发明涉及ImI和MII芋螺毒素肽及其衍生物作为心血管药物的用途，包括但不限于心率调节剂，血压调节剂和抗心律不齐剂。

公开(公告)号：WO1998005338A2

公开(公告)日：1998-02-12

申请号：PCT/US1997012954

申请日：1997-07-31

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  ARANEO, Barbara, A.

IPC: A61K31/565

CPC classification number: A61K31/569 ,  A61K31/568 ,  A61K31/57 ,  A61K31/573 ,  A61K31/575 ,  A61K31/58

Abstract: The present invention relates to the use of a dehydroepiandrosterone (DHEA) derivative as described herein or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for accelerating re-epithelialization or re-endothelialization of tissue in a subject in need thereof. Examples of re-epithelialization in which the invention is particularly suited include, but are not limited to, re-epithelialization of (a) skin following surgical wounds; (b) skin abrasions caused by mechanical trauma, caustic agents or burns; (c) cornea following cataract surgery or corneal transplants; (d) mucosal epithelium (respiratory, gastrointestinal, genitourinary, mammary, oral cavity, ocular tissue, liver and kidney) following infection, nonpathological etiologies or drug therapy; (e) skin following grafting; and (f) renal tubule following acute tubular necrosis. Examples of re-endothelialization in which the invention is particularly suited include, but are not limited to, re-endothelialization (or regrowth of endothelium) in blood vessels following angioplasty, and the lysis of fibrin clots or lysis or mechanical disruption of thrombi in coronary arteries. In accordance with the present invention, the time to complete re-epithelialization or re-endothelialization is enhanced or accelerated by administering a dehydroepiandrosterone (DHEA) derivative.

Abstract translation: 本发明涉及如本文所述的脱氢表雄酮（DHEA）衍生物或其药学上可接受的盐在制备用于加速有需要的受试者中组织再上皮化或再内皮化的药物组合物中的应用。 本发明特别适合的再上皮化的实例包括但不限于（a）外科伤口后皮肤的再上皮化; （b）由机械创伤，苛性剂或烧伤引起的皮肤擦伤; （c）白内障手术或角膜移植后的角膜; （d）感染，非病理性病因或药物治疗后的粘膜上皮（呼吸道，胃肠道，泌尿生殖道，乳腺，口腔，眼组织，肝和肾） （e）嫁接后的皮肤; 和（f）急性肾小管坏死后的肾小管。 本发明特别适合的再内皮化的实例包括但不限于血管成形术后的血管中的内皮细胞再生（或内皮再生长），以及纤维蛋白凝块的裂解或冠状动脉血栓的裂解或机械破裂 动脉。 根据本发明，通过施用脱氢表雄酮（DHEA）衍生物来增强或加速完成再上皮细胞化或再内皮化的时间。

公开(公告)号：WO1998000155A1

公开(公告)日：1998-01-08

申请号：PCT/US1997011355

申请日：1997-06-27

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  BAUDYS, Miroslav ,  KIM, Sung, Wan

IPC: A61K38/00

CPC classification number: A61K38/23

Abstract: Compositions and methods for stabilization and oral delivery of human calcitonin are described. An aqueous liquid composition for stable storage of human calcitonin comprises an aqueous mixture of SDS and an organic acid. A nonaqueous liquid composition for stable storage of human calcitonin comprises about 90-100 % by volume of a mixture of C8/C10 mono- and di-glycerides and about 0-10 % by volume of a polar, nonaqueous solvent. Both of these stabilized human calcitonin formulations provide significant intestinal absorption of calcitonin.

Abstract translation: 描述了人类降钙素稳定和口服递送的组合物和方法。 用于稳定储存人降钙素的水性液体组合物包括SDS和有机酸的水性混合物。 用于稳定储存人降钙素的非水液体组合物包含约90-100体积％的C8 / C10单甘油酯和二甘油酯的混合物和约0-10体积％的极性非水溶剂。 这两种稳定的降钙素制剂都能提供显着的降钙素吸收。

公开(公告)号：WO1997004292A1

公开(公告)日：1997-02-06

申请号：PCT/US1996012008

申请日：1996-07-19

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  GAO, Dachun ,  SILCOX, Geoffrey, D.

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION

IPC: G01J05/60

CPC classification number: G01J5/602

Abstract: A method of using multiple single-color pyrometers to correct for the effects of reflected radiation when optically measuring the temperature of a relatively cool surface in hotter surroundings is disclosed. The method includes obtaining pyrometric readings from the surface at two or more wavelengths and thereafter utilizing the readings together with the emissivity of the surface to calculate the surface temperature. In one version of the method the emissivity of the surface being measured is determined by a method which includes heating the surface in an insulated environment and thereafter obtaining readings pyrometrically from the surface once the insulation of the surface is removed. The readings are then utilized to calculate the emissivity by extrapolating the readings to a time zero. In those versions of the method which utilze pyrometric readings taken over three or more wavelengths, emissivity may be calculated through the use of relevant mathematical expressions.

Abstract translation: 公开了一种使用多个单色高温计来校正反射辐射的影响的方法，当光学测量较热的环境中较冷的表面的温度时。 该方法包括从两个或多个波长的表面获得高温测量读数，然后利用读数与表面的发射率一起计算表面温度。 在该方法的一个版本中，所测量的表面的发射率由包括在绝缘环境中加热表面的方法确定，然后一旦表面的绝缘被去除，就从表面获得高温表面的读数。 然后通过将读数推算为零时，读数被用于计算发射率。 在利用三个或更多波长的高温测量读数的方法的这些版本中，发射率可以通过使用相关的数学表达式来计算。

公开(公告)号：WO1996033206A1

公开(公告)日：1996-10-24

申请号：PCT/US1996005262

申请日：1996-04-17

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  SHON, Ki-Joon ,  GRILLEY, Michelle, M. ,  OLIVERA, Baldomero, M. ,  YOSHIKAMI, Doju ,  MARSH, Maren ,  CRUZ, Lourdes, J. ,  HILLYARD, David, R.

IPC: C07H21/04

CPC classification number: C07K14/435 ,  A61K38/00

Abstract: The present invention is directed to conotoxin peptides, specifically delta -conotoxin PVIA and mu -conotoxin PIIIA. delta -conotoxin PVIA is found in the Eastern Pacific fish hunting species of cone snails Conus purpurascens. It consists of 29 amino acid residues of the sequence: Glu-Ala-Cys-Tyr-Ala-Xaa1-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa2-Gly-Leu-Cys- Cys-Ser-Glu-Phe-Cys-Leu-Pro-Gly-Val-Cys-Pro-Gly (SEQ ID NO:1) where Xaa1 or Xaa2 is Pro or 4-trans-hydroxyproline. The C-terminus may be free or amidated. delta -conotoxin PVIA is vertebrate specific and targets voltage-sensitive Na channels. mu -conotoxin PIIIA is also found in Conus purpurascens. It consists of 22 amino acid residues of the sequence: Xaa1-Arg-Leu-Cys-Cys-Gly-Phe-Xaa2-Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys- Xaa2-His-Arg-Cys-Cys (SEQ ID NO:2) where Xaa1 represents pyroglutamate or glutamine and Xaa2 represents 4-trans-hydroxyproline or proline. This latter peptide targets sodium channels.

Abstract translation: 本发明涉及芋螺毒素肽，特别是δ-毒素PVIA和μ-毒素PIIIA。 δ-毒素PVIA发现于东太平洋狩猎鱼类锥锥螺旋体中。 它由序列的29个氨基酸残基组成：Glu-Ala-Cys-Tyr-Ala-Xaa1-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa2-Gly-Leu-Cys-Cys-Ser-Glu -Phe-Cys-Leu-Pro-Gly-Val-Cys-Pro-Gly（SEQ ID NO：1），其中Xaa1或Xaa2是Pro或4-反式 - 羟基脯氨酸。 C末端可以是免费的或酰胺化的。 δ-毒素PVIA是脊椎动物特异性的，并且靶向电压敏感的Na +通道。 红曲霉素PIIIA也存在于紫锥菊（Conus purpurascens）中。 它由序列的22个氨基酸残基组成：Xaa1-Arg-Leu-Cys-Cys-Gly-Phe-Xaa2-Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys-Xaa2-His-Arg -Cys-Cys（SEQ ID NO：2），其中Xaa1表示焦谷氨酸或谷氨酰胺，Xaa2表示4-反式 - 羟基脯氨酸或脯氨酸。 后一种肽靶向钠通道。

公开(公告)号：WO1995015981A1

公开(公告)日：1995-06-15

申请号：PCT/US1994006166

申请日：1994-06-01

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  WEI, Ai-Ping ,  HERRON, James, W.

IPC: C07K15/12

CPC classification number: C07K14/59 ,  G01N33/542

Abstract: An improved oligopeptide composition for use in a fluorescent polarization immunoassay for a high molecular weight analyte is disclosed, along with a kit and a method using the composition. The composition comprises an oligopeptide selected by a screening procedure in which a plurality of different oligopeptides having respective amino acid sequences that represent sequential overlapping segments of the analyte amino acid sequence, and a fluorescent label bound thereto. The screening process further includes screening to select a composition which exhibits fluorescence enhancement upon binding the analyte. A preferred embodiment of the oligopeptide is one having an amino acid sequence which does not form internal disulfide bridges. Such a preferred oligopeptide will generally have no more than one cysteine residue. In a further preferred embodiment, the fluorescent label is tetramethylrhodamine or a cyanine dye. The kit may be packaged with instructions directing a user to prepare an assay solution containing the monoclonal antibody and the oligopeptide in certain respective concentrations. The composition, method and kit are constructed to detect nanomolar concentrations of the analyte.

Abstract translation: 公开了用于高分子量分析物的荧光偏振免疫测定法的改进的寡肽组合物以及试剂盒和使用该组合物的方法。 该组合物包含通过筛选方法选择的寡肽，其中多个具有代表分析物氨基酸序列的顺序重叠片段的氨基酸序列的不同寡肽和与其结合的荧光标记。 筛选方法还包括筛选以选择在结合分析物时显示荧光增强的组合物。 寡肽的优选实施方案是具有不形成内部二硫键的氨基酸序列的寡肽。 这种优选的寡肽通常具有不超过一个半胱氨酸残基。 在另一优选实施方案中，荧光标记是四甲基罗丹明或花青染料。 试剂盒可以包装，指示用户在某些相应浓度下制备含有单克隆抗体和寡肽的测定溶液。 构建组合物，方法和试剂盒以检测分析物的纳摩尔浓度。

公开(公告)号：WO1995011256A1

公开(公告)日：1995-04-27

申请号：PCT/US1994011927

申请日：1994-10-19

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  OLIVERA, Baldomero, M. ,  CRUZ, Lourdes, J. ,  HILLYARD, David, R. ,  McINTOSH, J., Michael ,  SANTOS, Ameurfina, D.

IPC: C07K07/08

CPC classification number: C07K14/43504 ,  A61K38/00 ,  A61K39/00 ,  C07K14/435

Abstract: The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the alpha -conotoxin peptides. The A-lineage conotoxin peptides include the alpha -conotoxin peptides, the alpha -conotoxin-like peptides and the kappa -conotoxin peptides, described further below. The alpha -conotoxinpeptides generally share a "core" sequence motif. This core sequence is termed the alpha 3/5 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:1). The alpha -conotoxin-like peptides generally share a core sequence termed the alpha 4/7 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:2). The kappa -conotoxin peptides generally have a core sequence termed the kappa 7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO:3).

Abstract translation: 本发明涉及A系血凝素毒素肽，其是在编码这些肽的基因的信号序列和3'非翻译区与α-毒素肽序列中具有强同源性的芋螺毒素肽。 A系血凝素毒素肽包括下文进一步描述的α-毒素肽，α-毒素样肽和κ-毒素肽。 α-核黄素肽通常共有“核心”序列基序。 该核心序列称为α3/ 5核，并表示为Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys（SEQ ID NO：1）。 α-类毒素样肽通常共有称为α4/7核心的核心序列，并表示为Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa -Cys（SEQ ID NO：2）。 κ-毒素肽通常具有称为kappa 7/2/1/3核心的核心序列，并且表示为Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys -Xaa-Cys-Xaa-Xaa-Xaa-Cys（SEQ ID NO：3）。

公开(公告)号：WO1995001436A1

公开(公告)日：1995-01-12

申请号：PCT/US1994007194

申请日：1994-06-27

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  OLIVERA, Baldomero, M. ,  RIVIER, Jean, E., F. ,  CRUZ, Lourdes, J. ,  ABOGADIE, Fe ,  HOPKINS, Chris, E. ,  DYKERT, John ,  TORRES, Josep, L.

IPC: C12N15/12

CPC classification number: C07K14/43504 ,  A61K38/00 ,  A61K39/00 ,  C07K14/435

Abstract: Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defense genes into plant species of interest.

Abstract translation: 提供基本上纯的芋螺毒素，其抑制神经肌肉接头处的突触传递，并且其在体内和分析中都是有用的，因为它们特异性靶向特定受体，例如乙酰胆碱受体和离子通道。 肽的长度可以通过化学合成制成。 它们也可以使用重组DNA技术制备，并且编码具有杀虫性质的这种芋螺毒素的DNA可以作为植物防御基因并入感兴趣的植物物种中。

公开(公告)号：WO1994008048A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009136

申请日：1993-09-29

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  INSERM

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  INSERM ,  LALOUEL, Jean-Marc ,  JEUNEMAITRE, Xavier ,  LIFTON, Richard, P. ,  SOUBRIER, Florent ,  KOTELEVTSEV, Youri ,  CORVOL, Pierre

IPC: C12Q01/68

CPC classification number: C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172 ,  Y10T436/143333

Abstract: The association of molecular variants of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to hypertension, especially essential hypertension and pregnancy-induced hypertension (preeclampsia).

Abstract translation: 公开了血管紧张素原基因的分子变体与人高血压的关联。 确定这种关联可以筛选出具有高血压倾向的人，特别是原发性高血压和妊娠高血压（先兆子痫）。

公开(公告)号：WO1991003271A1

公开(公告)日：1991-03-21

申请号：PCT/US1990004368

申请日：1990-08-03

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  STANLEY, Theodore, H.

IPC: A61M37/00

CPC classification number: A61K9/703 ,  A23G3/368 ,  A61K9/0056 ,  A61K9/7084 ,  A61K31/465

Abstract: Apparatus and method for the dose-to-effect transmucosal administration of medicaments are disclosed. The invention relates to a disk-shaped control member (22) defining a plurality of openings (24) on one semicircle of the control member (22), positioned adjacent the medicament chamber base (14). An adhesive material (26) located on the control member (22) rotates relative to housing (12) to increase or decrease the effective area of medicament chamber opening (18).

Abstract translation: 公开了用于剂量效应的经粘膜给药的装置和方法。 本发明涉及在控制构件（22）的一个半圆上限定多个开口（24）的盘形控制构件（22），其位于邻近药剂室底座（14）处。 位于控制构件（22）上的粘合剂材料（26）相对于壳体（12）旋转以增加或减少药物室开口（18）的有效面积。