公开(公告)号：WO1994005287A1

公开(公告)日：1994-03-17

申请号：PCT/US1993007698

申请日：1993-08-17

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  HOTCHKISS, Richard, Samuel ,  KARL, Irene, Elsie ,  ACKERMAN, Joseph, John, Henry ,  SONG, Sheng-Kwei

IPC: A61K31/415

CPC classification number: A61K31/415 ,  A61K31/42

Abstract: A method of preventing and treating sepsis in a human or other mammal afflicted with sepsis comprising the administration of a safe and effective amount of a compound that inhibits the release of calcium from the sarcoplasmic and/or endoplasmic reticula, preferably dantrolene sodium or azumolene sodium.

Abstract translation: 一种预防和治疗患有败血症的人或其他哺乳动物的败血症的方法，包括施用安全有效量的抑制钙从肌质和/或内质网释放的化合物，优选丹曲林钠或azumolene钠。

公开(公告)号：WO1994000468A1

公开(公告)日：1994-01-06

申请号：PCT/US1993005832

申请日：1993-06-17

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  OLIVO, Paul, D.

IPC: C07H17/00

CPC classification number: C12N9/0093 ,  C12Q1/04 ,  C12Q1/6897 ,  C12Q1/705 ,  G01N33/5091 ,  G01N2333/90209 ,  G01N2333/924 ,  G01N2333/938

Abstract: A diagnostic assay for detecting the presence of an infectious herpes virus in a specimen and a genetically engineered cell line for use in such assay are disclosed. The cell line used in the assay expresses a reporter gene only if infectious herpes virus is present in the specimen. The assay involves inoculating a DNA-transfected cell line with a specimen suspected of containing a herpes virus, allowing a sufficient period of time for the herpes virus infectious cycle to proceed, and detecting and quantifying the number of herpes virus-infected cells to determine the number of infectious herpes virus virions in the specimen. The cell line is a DNA-transfected cell line susceptible to infection by a herpes virus which is stably transformed with a chimeric gene comprising a herpes virus inducible promoter and a gene coding for an enzyme, the expression of the enzyme being dependent upon and quantitatively proportional to the presence of herpes virus. A kit for such assay is also provided.

Abstract translation: 公开了用于检测样品中的感染性疱疹病毒的存在的诊断测定法和用于此类测定中的基因工程细胞系。 只有在感染性疱疹病毒存在于样本中时，测定中使用的细胞系才能表达报告基因。 该测定涉及将DNA转染的细胞系接种到怀疑含有疱疹病毒的标本，允许疱疹病毒感染循环的足够的时间进行，并且检测和定量疱疹病毒感染细胞的数量以确定 样本中感染性疱疹病毒颗粒数。 细胞系是由疱疹病毒感染易感染的DNA转染细胞系，其用包含疱疹病毒诱导型启动子和编码酶的基因的嵌合基因稳定转化，酶的表达依赖于和定量比例 对疱疹病毒的存在。 还提供了用于这种测定的试剂盒。

公开(公告)号：WO1993026107A1

公开(公告)日：1993-12-23

申请号：PCT/US1993005322

申请日：1993-06-03

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  GADDIS, Michael, E. ,  BUBENIK, Richard, G. ,  COSTA, Pierre ,  MATSUURA, Noritaka

IPC: H04L12/46

CPC classification number: H04Q11/0478 ,  H04L12/4608 ,  H04L12/5601 ,  H04L12/66 ,  H04L49/90 ,  H04L49/901 ,  H04L2012/561 ,  H04L2012/5618 ,  H04L2012/5665

Abstract: An ATM-Ethernet portel/concentrator (Figure 3) permits a transparent interconnection between Ethernet segments over an ATM network to provide remote connectivity for Ethernet segments. The portal includes an Ethernet controllor (22) and an ATM cell processor, both of which receive and transmit data to and from a dual port shared memory (24) under control of a direct memory access controller. A control microprocessor (20) monitors and controls the shifting of data through the dual port memory (24). In this scheme, original data is written and read directly into and out of the dual port memory (24) to thereby eliminate any requirement for copying of data, to thereby significantly increase the data throughput capability of the portal. In the concentrator embodiment (Figure 12), a plurality of Ethernet controllers, each of which is connected to its own associated Ethernet segment, is multiplexed through the concentrator to an ATM network to thereby provide remote connectivity for each of the Ethernet segments.

Abstract translation: ATM-Ethernet Portel /集中器（图3）允许在ATM网络上的以太网段之间进行透明互连，为以太网段提供远程连接。 门户包括以太网控制器（22）和ATM信元处理器，两者都在直接存储器访问控制器的控制下接收和传送数据到双端口共享存储器（24）。 控制微处理器（20）监视和控制数据通过双端口存储器（24）的移位。 在该方案中，将原始数据直接写入和读出双端口存储器（24），从而消除对数据复制的任何要求，从而显着提高门户的数据吞吐能力。 在集中器实施例（图12）中，通过集线器将多个连接到其自己的相关联的以太网段的以太网控制器多路复用到ATM网络，从而为每个以太网段提供远程连接。

公开(公告)号：WO1993003555A1

公开(公告)日：1993-02-18

申请号：PCT/US1992006331

申请日：1992-07-30

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  TURNER, Jonathan, S.

IPC: H04J03/14

CPC classification number: H04L12/5602 ,  H04J3/247 ,  H04L2012/563 ,  H04L2012/5632 ,  H04L2012/5636 ,  H04L2012/5642 ,  H04L2012/5678 ,  H04Q11/0478

Abstract: A bandwidth management and congestion control scheme for a multicast ATM network includes a buffer reservation mechanism (60) comprised of a state machine associated with each virtual circuit, the state machine adapted to monitor the number of available buffer slots at a data link (40, 42, 46) and an encoding scheme for cells of data in order to control switching from active to idle states. A state dependent token pool mechanism (70) associated with each virtual circuit generates tokens at varying rates which are 'used' by transmitted data in order to monitor the average data rate passing through a link (40, 42, 46) over a virtual circuit. By thus monitoring and controlling the peak and average data rates, the bandwidth for each data link (40, 42, 46) is efficiently managed to maximize throughput and minimize loss of cells. Means for determining the availability of capacity on a data link (40, 42, 46) for establishing a virtual circuit is also disclosed.

公开(公告)号：WO1993003375A1

公开(公告)日：1993-02-18

申请号：PCT/US1992006545

申请日：1992-08-07

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  PESTRONK, Alan

IPC: G01N33/564

CPC classification number: G01N33/564 ,  A01K67/027 ,  C07K14/47 ,  C07K16/18 ,  G01N33/6854 ,  G01N33/6875 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/285 ,  Y10S436/811

Abstract: The present invention relates to methods of diagnosing peripheral neuropathies which comprises the steps of determining the titer of autoantibodies directed toward particular nervous system antigens. It also provides for substantially purified preparations of specific antigens, namely neuroprotein-1, neuroprotein-2, neuroprotein-3, neuroprotein-4, neuroprotein-5, neuroprotein-9 and histone H3 which may be used in such diagnostic methods.

Abstract translation: 本发明涉及诊断周围神经病变的方法，其包括确定针对特定神经系统抗原的自身抗体滴度的步骤。 它还提供可用于这种诊断方法的特异抗原的基本上纯化的制剂，即神经蛋白-1，神经蛋白-2，神经蛋白-3，神经蛋白-4，神经蛋白-5，神经蛋白-9和组蛋白H3。

公开(公告)号：WO1992017990A1

公开(公告)日：1992-10-15

申请号：PCT/US1992002038

申请日：1992-03-12

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  TURNER, Jonathan, S.

IPC: H04Q11/04

CPC classification number: H04L49/1515 ,  H04L49/201 ,  H04L49/254

Abstract: A multi-cast switching system comprised of a pair of high speed data networks, each of said data networks being either a Benes network, a Clos network, or a Cantor network, and configured to provide point-to-point switching only in the first network and multi-cast switching in the second network, may be non-blocking for adding a multi-cast connection and re-arrangeably non-blocking for augmenting an existing multi-cast connection using the algorithm which essentially consists of identifying the most lightly loaded middle stage switch (Z), connecting the input to the middle stage switch (Z), and connecting the outputs to the middle stage switch (Z). A minimal speed advantage for each type of network is presented and thereby reduces the cost of each network in order to achieve non-blocking operation.

公开(公告)号：WO1992013871A1

公开(公告)日：1992-08-20

申请号：PCT/US1992000863

申请日：1992-01-31

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  NORMARK, Staffan ,  JONSSON, Ann-Beth

IPC: C07H21/00

CPC classification number: C07K16/1217 ,  A61K39/00 ,  C07K14/22

Abstract: We have isolated and characterized a novel protein of pathogenic forms of Neisseria. We have also isolated and characterized genes which encode PilC, i.e., the pilC loci. Portions of the DNA sequences of the pilC genes are useful as probes to diagnose the presence of the relevant microorganisms containing type 4 pilin, for example, Neisseria in samples. These DNAs also make available polypeptide sequences of immunoreactive epitopes encoded within the loci, thus permitting the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. Antibodies, both monoclonal and purified polyclonal, directed against PilC epitopes are also useful for diagnostic test and as therapeutic agents for passive immunization. In addition, by utilizing probes derived from the DNA sequences, it is possible to isolate and sequence other portions of the pilC loci from species and strains of interest.

Abstract translation: 我们已经分离和鉴定了一种新型的奈瑟氏球菌病原体蛋白质。 我们还有编码PilC，即pilC基因座的分离和表征的基因。 pilC基因的DNA序列的一部分可用作诊断含有4型皮林的相关微生物的存在的探针，例如样品中的奈瑟氏球菌。 这些DNA还制备了在基因座内编码的免疫反应性表位的多肽序列，从而允许产生在诊断测试和/或疫苗组分中可用作标准品或试剂的多肽。 针对PilC抗原决定簇的单克隆抗体和纯化多克隆抗体也可用于诊断试验和用作被动免疫的治疗剂。 此外，通过利用衍生自DNA序列的探针，可以从感兴趣的物种和菌株中分离并序列pilC基因座的其他部分。

公开(公告)号：WO1991015829A1

公开(公告)日：1991-10-17

申请号：PCT/US1991002405

申请日：1991-04-10

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  WONG, John, Wai-Chu ,  LEUNG, Tin, Chi ,  GRAHAM, Mary, Vogelsang

IPC: G06F15/66

CPC classification number: G06T5/006

Abstract: A method and apparatus for generating a single, composite, anatomically aligned radiographic image from a prescription or reference image and a plurality of separate radiographic images includes an electronic display (30), a general purpose computer (20), a hard disk drive (22) for storing electronic data representative of the individual image and a mouse (28) to permit the on-screen designation of anatomical points for each image by an operator. The method includes the steps of designating a plurality of landmark points on each image, aligning the image to correlate to a reference image through alignment of the landmark points, scanning the image to detect the irradiated area, creating a summary image, and displaying the summary image over the reference image.

Abstract translation: 一种用于从处方或参考图像和多个单独的放射线照相图像生成单个，复合的，解剖学对准的放射线照相图像的方法和装置，包括电子显示器（30），通用计算机（20），硬盘驱动器（22） ），用于存储代表单独图像的电子数据和鼠标（28），以允许操作者对每个图像的解剖点进行屏幕上指定。 该方法包括以下步骤：在每个图像上指定多个地标点，使图像对齐，通过对地标点进行对齐，扫描图像以检测照射区域，创建摘要图像，并显示摘要 图像参考图像。

公开(公告)号：WO1991015793A1

公开(公告)日：1991-10-17

申请号：PCT/US1991002404

申请日：1991-04-10

Applicant: WASHINGTON UNIVERSITY ,  FIBER IMAGING, INC.

Inventor： WASHINGTON UNIVERSITY ,  FIBER IMAGING, INC. ,  ACCSTA, George, M. ,  BINNS, W., Robert ,  EPSTEIN, John, W.

IPC: G02B23/26

CPC classification number: A61B1/07 ,  A61B1/0017 ,  G02B6/06

Abstract: An endoscope (20) is disclosed which incorporates a plastic multi-fiber optic bundle assembly (22) for both illuminating and imaging tissue specimens. The bundle assembly (22) is comprised of a plastic multi-fiber optic bundle (28) surrounded by an individually cladded plastic optical fiber (30), with the bundle assembly (22) having a cross-section matching that of a single opening (24) extending through the length of the catheter (26) to thereby minimize the cross-sectional area of the catheter itself and optimize its flexibility. A multi-fiber optical bundle (28) used for imaging and apparatus and methods for forming the bundle (28) with arrays of individually cladded fibers (30) is disclosed. Several embodiments are disclosed of varying geometrical arrangements. An alternative embodiment is disclosed wherein a square multi-fiber imaging bundle (78) and four round illuminating fibers (80) are inserted through a generally circular opening (24) in the catheter (26). In still another embodiment, a mirror (86) or beam splitter (92) may be used to transmit illuminating as well as imaging light through a single multi-fiber bundle (84). In still another embodiment, a multi-fiber annular shaped guide (100) is used to transmit the illuminating light, and a method for forming it from a plurality of individually cladded plastic fibers (102) is disclosed.

Abstract translation: 公开了一种内窥镜（20），其包括用于照射和成像组织标本的塑料多光纤束组件（22）。 束组件（22）包括由单独包覆的塑料光纤（30）围绕的塑料多光纤束（28），束组件（22）的横截面与单个开口（22）的横截面相匹配 24）延伸穿过导管（26）的长度，从而最小化导管本身的横截面积并优化其柔性。 公开了一种用于成像的多纤维光束（28）以及用于形成具有单独包层纤维（30）的阵列的束（28）的装置和方法。 公开了改变几何布置的几个实施例。 公开了一种替代实施例，其中方形多纤维成像束（78）和四个圆形照明纤维（80）通过导管（26）中的大致圆形的开口（24）插入。 在另一个实施例中，反射镜（86）或分束器（92）可用于通过单个多纤维束（84）传输照明以及成像光。 在另一个实施例中，公开了一种多纤维环形引导件（100）来传递照明光，并且公开了一种从多个单独包覆的塑料纤维（102）形成的方法。

公开(公告)号：WO1991015785A1

公开(公告)日：1991-10-17

申请号：PCT/US1991002444

申请日：1991-04-09

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  BINNS, W., Robert ,  EPSTEIN, John, W. ,  KLARMANN, Joseph ,  WONG, John, Wai-Chu

IPC: G02B06/06

CPC classification number: B29C55/00 ,  B29D11/00663 ,  B29L2011/0075 ,  G02B6/06

Abstract: Apparatus for generating a reduced-scale optical image of an x-ray beam pattern or the like. The apparatus includes an optical fiber assembly (38) which forms a two-dimensional input array (42) and whose output ends form a reduced-scale two-dimensional output array (44). A beam converter (34) in the apparatus converts the irradiation beam (29) to a corresponding electron beam, and this beam is converted to a two-dimensional light image of the beam which is directed onto the input array (42). In one embodiment, the optical fibers form a fiber assembly constructed of an array (38) of multifiber reducers (40) which are tapered on progressing between input (48) and output ends (50). In another embodiment, the input array (78) is formed by the elongate input fiber regions of fibers (77) having a parallel, side-by-side arrangement, and the two-dimensional image is produced by scanning a linear electron beam and light-generating strip (76) transversely along the length of the array. In a third embodiment, the input array (113) is also formed by elongate input fiber regions (115) of a group of side-by-side fibers (114), where the two-dimensional image is generated by rotating the array (113) below a full-area electron beam.

Abstract translation: 用于产生X射线束图案等的缩小尺度光学图像的装置。 该装置包括形成二维输入阵列（42）的光纤组件（38），其输出端形成缩小的二维输出阵列（44）。 设备中的光束转换器（34）将照射光束（29）转换成相应的电子束，并将该光束转换成被引导到输入阵列（42）上的光束的二维光图像。 在一个实施例中，光纤形成由多光纤减速器（40）的阵列（38）构成的光纤组件，其在输入（48）和输出端（50）之间进行渐缩。 在另一个实施例中，输入阵列（78）由具有平行并排布置的纤维（77）的细长输入光纤区域形成，并且通过扫描线性电子束和光产生二维图像 沿着阵列的长度横向生成带（76）。 在第三实施例中，输入阵列（113）还由一组并排光纤（114）的细长的输入光纤区域（115）形成，其中通过旋转阵列（113）产生二维图像 ）在全面电子束之下。