公开(公告)号：US5330717A

公开(公告)日：1994-07-19

申请号：US697769

申请日：1991-05-09

Applicant: Alfred Berteloot ,  Michel Brunette

Inventor： Alfred Berteloot ,  Michel Brunette

IPC: G01N1/00 ,  G01N13/00 ,  G01N35/00 ,  G01N35/10 ,  G01N21/00 ,  B01L3/02 ,  G01N1/14 ,  G01N35/02

CPC classification number: G01N35/10 ,  G01N2035/00198 ,  G01N2035/00475 ,  G01N2035/0097 ,  G01N2201/122 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/12 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: An electropneumatic apparatus for sampling rapidly predetermined volumes of a mixture, to be connected to a computer. It comprises an injector provided with a detector connected to the computer for indicating activation of the injector; a reactor having a chamber provided with at least one aperture, the chamber being provided in its superior portion with an air inlet/outlet connected to a pressurized air system, the chamber having a bottom outlet provided with a flow sensor connected to the computer for indicating a volume of fluid exiting from the bottom outlet; the pressurized air system having an air channel provided with a first portion connected to an air source, and a second portion connected to the air inlet/outlet of the chamber, the air channel being provided with an air controlling device connected to the computer for producing a succession of positive and negative pressures inside the chamber, whereby the predetermined volumes of the mixture can be sampled from the bottom outlet under control of the computer; and a receiving system comprising a mobile manifold array for receiving successive samples exiting from the bottom outlet of the chamber.

Abstract translation: 一种电动气动装置，用于对要连接到计算机的快速预定体积的混合物进行采样。 它包括具有连接到计算机的用于指示喷射器的启动的检测器的喷射器; 具有设置有至少一个孔的室的反应器，所述室在其上部设置有连接到加压空气系统的空气入口/出口，所述室具有底部出口，所述底部出口设置有连接到计算机的流量传感器，用于指示 从底部出口排出的体积的体积; 所述加压空气系统具有设置有连接到空气源的第一部分的空气通道和连接到所述室的空气入口/出口的第二部分，所述空气通道设置有连接到所述计算机的空气控制装置，用于产生 室内的一系列正负压力，由此可以在计算机的控制下从底部出口采集预定体积的混合物; 以及接收系统，包括用于接收从所述室的底部出口离开的连续样品的移动歧管阵列。

公开(公告)号：US4889815A

公开(公告)日：1989-12-26

申请号：US922359

申请日：1986-10-23

Applicant: Arthur R. Bradwell ,  Ian Deverill

Inventor： Arthur R. Bradwell ,  Ian Deverill

IPC: G01N33/536 ,  G01N21/47 ,  G01N33/53 ,  G01N33/557

CPC classification number: G01N33/53 ,  G01N21/47 ,  G01N33/557 ,  G01N2201/122 ,  Y10S436/805 ,  Y10S436/825 ,  Y10S436/909

Abstract: A method and apparatus for use in quantifying, in a whole blood sample in which the red cells are lysed, a component which will react with a reagent to form an antigen-antibody complex, the method comprising mixing the sample with the reagent to obtain the complex, exposing the sample to a source of radiation and measuring the intensity of radiation scattered through a given angle by the complex, and the apparatus including a container for receiving the sample which has been treated with the reagent to the component, the container being transparent to radiation having a wavelength falling within a given band width, typically 460-530 nm. A source of radiation within this band width is provided together with a device for detecting the intensity of radiation scattered through a given angle by the sample.

Abstract translation: 一种用于定量在其中红细胞裂解的全血样品中的与试剂反应形成抗原 - 抗体复合物的成分的方法和装置，所述方法包括将样品与试剂混合以获得 复合物，将样品暴露于辐射源并测量由复合物散射到给定角度的辐射的强度，并且该装置包括用于接收已经用试剂处理到该部件的样品的容器，容器是透明的 具有波长落在给定带宽内的辐射，通常为460-530nm。 在该带宽内的辐射源与用于检测样品通过给定角度散射的辐射的强度的装置一起提供。

公开(公告)号：JP2018528436A

公开(公告)日：2018-09-27

申请号：JP2018515802

申请日：2016-09-27

Applicant: センシキュー テクノロジーズ インコーポレイテッド ,  SensiQ Technologies, Inc.

Inventor： マーティン, アーロン デビッド

IPC: G01N21/41

CPC classification number: G01N21/554 ,  G01N15/1404 ,  G01N21/05 ,  G01N21/4133 ,  G01N21/553 ,  G01N35/1095 ,  G01N2015/0092 ,  G01N2201/122 ,  G01N2201/129

Abstract: 分散勾配を準備するための方法、並びに競合分子の存在下で完全な化学反応速度論及び親和性分析を決定するためのSPR注入方法が開示される。このSPR注入は、2つ以上のサンプルの分散勾配をSPRフローセル及び検出器に提供する。 【選択図】 図1

公开(公告)号：JP2016538531A

公开(公告)日：2016-12-08

申请号：JP2016519914

申请日：2014-09-30

Applicant: レニショウ パブリック リミテッド カンパニーRenishaw Public Limited Company ,  レニショウ パブリック リミテッド カンパニーRenishaw Public Limited Company

Inventor： アンソニー メイソン トーマス ,  アンソニー メイソン トーマス

IPC: G01N21/65 ,  G01J3/18 ,  G01N21/27 ,  G01N21/64

CPC classification number: G01N21/65 ,  G01J3/0208 ,  G01J3/0237 ,  G01J3/0248 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/44 ,  G01J2003/2826 ,  G01N2201/025 ,  G01N2201/06113 ,  G01N2201/103 ,  G01N2201/11 ,  G01N2201/117 ,  G01N2201/122

Abstract: 本発明は、サンプル上に光プロファイル(110)を生成するように構成された光源(101)と、サンプルと光源(101)からの光の相互作用から生成される特性光を検出するための、少なくとも1つの受光素子(104)を有する受光器(103)と、サンプルを支持するための支持体(109)であって、光プロファイル(110)に対して移動可能である支持体(109)と、処理ユニット(121)とを備える分光装置に関する。処理ユニット(121)は、支持体(109)と光プロファイル(110)の間に発生したと予期される相対運動に基づいて、特定の時間において受光素子(104)によって記録されたスペクトル値と、特定の時間において受光素子(104)によって記録された特性光を生成したと予測されるサンプル上の点を関連づけるように構成されている。

Abstract translation: 本发明包括被配置为产生在样品上，样品和光源，用于检测从所述光从（101）的相互作用产生的特征的光的光分布（110）的光源（101）， 具有至少一个光接收元件（104）和（103），用于支撑样品（109）的支撑光检测器，所述载体是相对于光学轮廓（110）和（109）可动 涉及光谱设备和处理单元（121）。 所述处理单元（121），基于预期的所述支撑件（109）和所述光学轮廓（110）之间已经发生的相对运动，在特定的时间由所述光接收元件（104）所记录的频谱值， 它被配置为一个点上，预计由在特定时间的光接收元件（104）以产生所记录的特征的光的样品相关联。

公开(公告)号：WO1992013266A1

公开(公告)日：1992-08-06

申请号：PCT/US1991009510

申请日：1991-12-18

Applicant: EASTMAN KODAK COMPANY

Inventor： EASTMAN KODAK COMPANY ,  MARCUS, Michael, Alan

IPC: G01N21/75

CPC classification number: G01N21/648 ,  G01N21/1717 ,  G01N21/7703 ,  G01N2021/1725 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2021/7786 ,  G01N2201/122

Abstract: Apparatus and method are disclosed in which a beam of radiant energy (16) is passed into a medium at a wavelength selected to cause a response of an analyte in the medium or of a sensor (10, 14) exposed to the medium, the sensor comprising a reagent whose optical properties change in response to the presence of the analyte in the medium. A perturbing pulse of energy (22) is passed into the medium to alter the response of the analyte or reagent to the beam of radiation; and the time rates of change in the intensity of the transmitted radiant energy are measured (18, 24, 26, 28) while the response is changing due to the influence of the perturbing pulse, after the perturbing pulse starts or ends or both, such rates of change being proportional to the concentration of the analyte in the medium. Both the beam of radiant energy and the perturbing pulse may be passed through optic fibers into the medium or sensor.

Abstract translation: 公开了一种装置和方法，其中辐射能束（16）以选定的波长被传送到介质中，以引起介质或暴露于介质的传感器（10,14）中的分析物的响应，传感器 包括其光学性质响应于介质中分析物的存在而改变的试剂。 将扰动的能量脉冲（22）传递到介质中以改变分析物或试剂对辐射束的响应; 并且测量发射辐射能的强度的时间变化率（18,24,26,28），同时响应在扰动脉冲开始或结束之后由于扰动脉冲的影响而改变，这样的 变化率与培养基中分析物的浓度成比例。 辐射能量束和扰动脉冲都可以通过光纤传入介质或传感器。

公开(公告)号：WO1987003960A1

公开(公告)日：1987-07-02

申请号：PCT/US1986002776

申请日：1986-12-22

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  THEOBALD, Paul, E. ,  SEYMOUR, Daniel, B. ,  OKAWA, Dobson, M.

IPC: G01N21/47

CPC classification number: G01N21/82 ,  G01N21/47 ,  G01N2021/1748 ,  G01N2201/122 ,  G01N2201/125

Abstract: A scatter signal is produced from light scattered by a precipitate formed by a chemical reaction and non-specific scatter sources. A blanking signal is produced for a scatter signal from light scattered only by the non-specific scatter sources that contribute to the scatter signal, and the blanking signal is subtracted from the scatter signal to dynamically produce a signal indicative of the difference between the scatter signals to reduce the effects of non-specific scattering sources in determining the rate of change of the light scattered by the precipitate. One of the scatter signals may be stored and then combined with the other, or the signals may be measured simultaneously and then combined.

Abstract translation: 由通过化学反应和非特异性散射源形成的沉淀散射的光产生散射信号。 产生用于散射信号的消隐信号，该散射信号仅由有助于散射信号的非特定散射光散射，并且从散射信号中减去消隐信号，以动态产生指示散射信号之间的差异的信号 以减少非特异性散射源在确定由沉淀物散射的光的变化率的影响。 可以存储一个散射信号，然后与另一个散射信号组合，或者可以同时测量信号，然后组合。

公开(公告)号：US20160238533A1

公开(公告)日：2016-08-18

申请号：US15025464

申请日：2014-09-30

Applicant: RENISHAW PLC

Inventor： Thomas Anthony MASON

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01J3/0208 ,  G01J3/0237 ,  G01J3/0248 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/44 ,  G01J2003/2826 ,  G01N2201/025 ,  G01N2201/06113 ,  G01N2201/103 ,  G01N2201/11 ,  G01N2201/117 ,  G01N2201/122

Abstract: This invention concerns spectroscopy apparatus comprising a light source arranged to generate a light profile on a sample, a photodetector having at least one photodetector element for detecting characteristic light generated from interaction of the sample with light from the light source, a support for supporting the sample, the support movable relative to the light profile, and a processing unit. The processing unit is arranged to associate a spectral value recorded by the photodetector element at a particular time with a point on the sample predicted to have generated the characteristic light recorded by the photodetector element at the particular time based on relative motion anticipated to have occurred between the support and the light profile.

Abstract translation: 本发明涉及光谱装置，其包括被配置为在样品上产生光分布的光源，具有至少一个光电探测元件的光电检测器，该光电检测元件用于检测由样品与来自光源的光的相互作用产生的特征光;支撑样品 ，相对于光轮廓可移动的支撑件，以及处理单元。 处理单元被布置为将由特定时间的光电检测器元件记录的光谱值与预测的样品上的点相关联，以在特定时间基于由光电检测器元件记录的特征光，基于预期发生在 支持和光线。

公开(公告)号：US5238809A

公开(公告)日：1993-08-24

申请号：US711270

申请日：1991-06-04

Applicant: Otto S. Wolfbeis

Inventor： Otto S. Wolfbeis

IPC: C12Q1/00 ,  C12Q1/34 ,  C12Q1/40 ,  G01N21/77 ,  G01N33/58

CPC classification number: G01N33/581 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/40 ,  G01N21/7703 ,  G01N2021/6434 ,  G01N2021/772 ,  G01N2201/122 ,  Y10S435/805 ,  Y10S435/808

Abstract: For optical determination of the catalytic enzyme activity of a sample by means of enzyme reactants which are split under the influence of the enzyme to be measured, the enzyme reactant is placed at the end of an optical fiber and brought into contact with the sample to be determined. The measurements are carried out by observing the rate of change in spectral characteristics of the enzyme reactant, or its reaction products, resulting from the enzyme reaction. The method permits measurements of undiluted blood and in-vivo determinations of enzyme activities.

Abstract translation: 为了通过在待测酶的影响下分裂的酶反应物对样品的催化酶活性进行光学测定，将酶反应物置于光纤末端并与样品接触以进行接触 决心。 通过观察由酶反应产生的酶反应物或其反应产物的光谱特征的变化速率来进行测量。 该方法允许测量未稀释的血液和体内酶活性测定。

公开(公告)号：US5051901A

公开(公告)日：1991-09-24

申请号：US570078

申请日：1990-08-20

Applicant: Hirotoshi Endo

Inventor： Hirotoshi Endo

IPC: G01N21/75 ,  G01N21/78 ,  G01N21/86 ,  G01N33/48

CPC classification number: G01N21/8483 ,  G01N33/48 ,  G01N2201/122 ,  G01N2201/1241 ,  G01N2201/127

Abstract: Errors in applying liquid sample are judged during biochemical analysis wherein a droplet of liquid sample is applied to an analysis medium containing a reagent, which chemically reacts with a specific constitutent in the liquid sample, the analysis medium is then incubated, the optical densities of the analysis medium are determined, and concentration of the specific constituent in the liquid sample is determined from the optical densities of the analysis medium thus determined. The method for judging errors in applying a liquid sample comprises the steps of determining the optical density of the analysis medium plural times with the passage of time while the analysis medium is being incubated, and calculating the difference between the maximum value and the minimum value of the optical densities thus determined for the analysis medium. The difference is compared with a predetermined threshold value. In cases the difference is smaller than the threshold value, it is judged that errors occurred in applying a liquid sample to the analysis medium.

Abstract translation: 在生物化学分析中判断应用液体样品的错误，其中将液体样品液滴施加到含有与液体样品中的特定成分发生化学反应的试剂的分析介质上，然后将分析介质温育， 确定分析介质，并根据如此确定的分析介质的光密度确定液体样品中特定成分的浓度。 用于判断应用液体样品的误差的方法包括以下步骤：在分析介质被培养的同时，随着时间的推移多次确定分析介质的光密度，并计算最大值与最小值之差 因此为分析介质确定的光密度。 将该差异与预定阈值进行比较。 在差异小于阈值的情况下，判定在将液体样品应用于分析介质时发生错误。

公开(公告)号：US5029583A

公开(公告)日：1991-07-09

申请号：US431914

申请日：1989-11-06

Applicant: Peter M. Meserol ,  Thomas Palmieri

Inventor： Peter M. Meserol ,  Thomas Palmieri

IPC: A61B5/00 ,  A61B5/15 ,  G01N21/03 ,  G01N21/25 ,  G01N21/78

CPC classification number: A61B5/157 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150633 ,  A61B5/150702 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/15194 ,  G01N21/251 ,  G01N2021/0371 ,  G01N21/78 ,  G01N2201/122 ,  G01N2201/126

Abstract: An optical analyzer for determining an analyte in a fluid of interest such as a body fluid of interest satisfying the foregoing need and embodying the present invention may include a housing; combination optically transparent cuvette and lancet mounted removably in the housing, the cuvette may receive an optically transparent reagent test system for reacting with the body fluid to produce a change in at least one optical transmissive characteristic of the system indicative of the analyte; a cuvette carrier mounted slidably in the housing and for removably receiving the cuvette; a spring actuator mounted in the housing and connected to the cuvette carrier, the spring actuator may be compressed and released to advance the carrier and thereby advance the lancet into engagement with a portion of a body to produce the body fluid; depth control apparatus for controlling the depth of penetration of the lancet into the body portion; an electrooptical system mounted in the housing in optical engagement with the cuvette and for passing a light beam through the cuvette and the reagent system and for receiving the light beam modified by the change in optical transmissive characteristic of the system and for transmitting computation signals indicative of the analyte to a computer; a computer mounted in the housing for receiving the computation signals and for comparing the computation signals against predetermined data to produce display signals indicative of the analyte; a display mounted in the housing and for receiving the display signals and for providing a vehicle display indicative of the analyte; and control switches mounted in the housing and connected to the computer for controlling the operation of the computer.

Abstract translation: 用于确定感兴趣的流体（例如满足上述需要的体液的分析物）并体现本发明的光学分析仪可以包括壳体; 组合的光学透明比色杯和可拆卸地安装在壳体中的刺血针，反应杯可以接收光学透明的试剂测试系统，用于与体液反应以产生指示分析物的系统的至少一个光学透射特性的变化; 比色杯托架，其可滑动地安装在所述壳体中并用于可移除地接收所述比色皿; 安装在壳体中并连接到比色杯托架的弹簧致动器可以压缩和释放弹簧致动器以使托架前进，从而使刺血针与身体的一部分接合以产生体液; 深度控制装置，用于控制刺血针穿入体部的深度; 安装在壳体中的电光学系统与比色皿光学接合并使光束通过比色杯和试剂系统，并用于接收由系统的光学透射特性的改变而修改的光束，并且用于发射指示 分析物到计算机; 安装在壳体中用于接收计算信号并用于将计算信号与预定数据进行比较以产生指示分析物的显示信号的计算机; 安装在壳体中并用于接收显示信号并提供指示分析物的车辆显示器的显示器; 以及安装在壳体中并连接到计算机以控制计算机的操作的控制开关。