公开(公告)号：WO2010004173A1

公开(公告)日：2010-01-14

申请号：PCT/FR2009/051216

申请日：2009-06-25

Applicant: HORIBA ABX SAS ,  MERCHEZ, Benoît ,  BRUNEL, Patrick ,  NERIN, Philippe

Inventor： MERCHEZ, Benoît ,  BRUNEL, Patrick ,  NERIN, Philippe

IPC: G01N15/14 ,  G01N15/12

CPC classification number: G01N15/1434 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1037 ,  G01N2201/1241

Abstract: L'invention concerne un dispositif d'analyse biologique (100) par mesure de photoluminescence dans un fluide présent dans une cuve de mesure (111). Ce dispositif (100) comprend au moins deux sources lumineuses (121,131) aptes à émettre dans des zones spectrales différentes convenant pour la réalisation de mesures, respectivement, d'absorption et de fluorescence, et un dispositif de détection (140), comprenant un détecteur (141), un système optique (142) et des moyens de filtrages (144), ces trois derniers éléments étant mutualisés, selon l'invention, pour permettre la mesure des signaux d'absorption et/ou de fluorescence. Selon l'invention, le détecteur (141) est en outre configurable en gain interne afin de permettre de réaliser les mesures de fluorescence et les mesures d'absorption de manière séquentielle.

Abstract translation: 本发明涉及一种用于测量存在于测量单元（111）中的流体中的光致发光的生物分析装置（100）。 该装置（100）包括能够分别适于进行吸收和荧光测量的能够在不同光谱范围内发射的至少两个光源（121,131），以及检测装置（140），包括检测器（141），光学 系统（142）和过滤装置（144），根据本发明，这三个后续组件被相互设计，以允许测量吸收和/或荧光信号。 根据本发明，检测器（141）也可以处于内部增益配置，以便顺序执行荧光测量和吸收测量。

公开(公告)号：WO2014170016A1

公开(公告)日：2014-10-23

申请号：PCT/EP2014/001009

申请日：2014-04-15

Applicant: DRÄGER SAFETY AG & CO. KGAA

Inventor： ROSTALSKI, Philipp ,  HANSMANN, Hans-Ullrich ,  MOHRMANN, Andreas ,  TRÖLLSCH, Arne ,  HILTAWSKY, Karsten

IPC: G01N21/78 ,  G01N21/27

CPC classification number: G01N21/783 ,  G01N21/272 ,  G01N31/223 ,  G01N33/0013 ,  G01N33/0031 ,  G01N33/0073 ,  G01N2201/1241 ,  G01N2201/1242 ,  G01N2201/1248

Abstract: Die Erfindung bezieht sich auf eine Messvorrichtung (10) sowie ein entsprechendes Messverfahren zur Messung einer Konzentration von gas- und/oder aerosolförmigen Komponenten eines Gasgemisches für einen Reaktionsträger (14), mit einem Strömungskanal (42), der eine Reaktionskammer (46) mit einem Reaktionsstoff (48) bildet, welcher ausgebildet ist, um mit zumindest einer zu messenden Komponente des Gasgemisches oder einem Reaktionsprodukt der zu messenden Komponente eine optisch detektierbare Reaktion einzugehen. Die Messvorrichtung (12) umfasst eine Gasförderbaugruppe (2) mit einer Gasfördereinrichtung (28) zur Förderung des Gasgemisches durch den Gasabflusskanal (18), und eine Detektionsbaugruppe (3) mit einer Beleuchtungseinrichtung (37) zur Beleuchtung der Reaktionskammer (46) des Reaktionsträgers (14), einem optischen Sensor (38) zur Erfassung der optisch detektierbaren Reaktion, und eine Auswertungseinheit (4) zu Auswertung der vom optischen Sensor erfassten Daten der optisch detektierbaren Reaktion und Bestimmung einer Konzentration der Komponente des Gasgemisches. Die Detektionsbaugruppe (3) ist ausgebildet, um eine Geschwindigkeit einer sich in Strömungsrichtung in der Reaktionskammer (46) ausbreitenden Reaktionsfront (6) zu erfassen und aus der Geschwindigkeit der Reaktionsfront (6) eine vorläufige Konzentration zu bestimmen.

Abstract translation: 本发明涉及一种测量装置（10）和用于测量一个反应载体（14）的气体混合物的气体和/或气溶胶状成分的浓度，用具有反应室（46）的流动通道（42）的相应的测量方法具有 其被设计成向至少一个部件响应反应物（48）的气体混合物的被测量或所述组分的反应产物将被测量到的光学可检测的反应。 的测量装置（12）包括具有气体通过气体流出通道（18）输送所述气体混合物输送装置（28）用于照亮所述反应载体的反应室（46）的气体输送组件（2），并与照明装置（37）的检测组件（3）（ 14），用于检测所述光学可检测反应的光学传感器（38），以及评估单元从所述光学可检测的反应的光传感器数据的检测，并且确定所述气体混合物的成分的浓度的（4）的评价。 所述检测组件（3）被适配成检测的速度在反应室（46）传播的反应前的流动方向（6）和从反应前（6），一个初步浓度的速度来确定。

公开(公告)号：WO2004036196A1

公开(公告)日：2004-04-29

申请号：PCT/US2003/032081

申请日：2003-10-08

Applicant: APPLERA CORPORATION

Inventor： SAGATELYAN, Dmitry, M. ,  SLETTNES, Tor

IPC: G01N21/64

CPC classification number: G01N21/274 ,  G01J1/42 ,  G01N21/645 ,  G01N2201/1241 ,  H03F3/08 ,  H04N5/235 ,  H04N5/2353 ,  H04N5/2355 ,  H04N5/243 ,  H04N5/35581

Abstract: A photo-detector 122 generated signal 125 is measured as a sample set 192 comprising a long signal and a short signal. The short signal is scaled to the value of the long signal if the long signal exceeds a dynamic range 131 associated with the photo detector 122. In one embodiment, the short signal is obtained during a short time interval that is at the approximate middle of a long time interval such that the short and long intervals share a common median time value 194. Given such symmetry, an approximately linear signal 190 yields a proportionality parameter between the long and short signals thereby allowing the short signal to be scaled. The proportionality parameter facilitates determination of an integration independent component of the photo detector signal that should be removed from the measured long and short signals before scaling. A plurality of sample sets 260 can also be processed such that each sample set overlaps with its neighboring sample set, thereby increasing the effective number of sample sets.

Abstract translation: 光检测器122产生的信号125被测量为包括长信号和短信号的采样组192。 如果长信号超过与光电检测器122相关联的动态范围131，则短信号被缩放到长信号的值。在一个实施例中，在短时间间隔内获得短信号，该短信号在大约中间 长时间间隔使得短和长间隔共享公共中值时间值194.给定这样的对称性，近似线性信号190在长信号和短信号之间产生比例参数，从而允许缩短短信号。 比例参数有助于确定光电探测器信号的积分独立分量，该分量在缩放之前应从测量的长信号和短信号中去除。 还可以处理多个样本集合260，使得每个样本集合与其相邻样本集重叠，从而增加样本集合的有效数量。

公开(公告)号：WO2019060375A1

公开(公告)日：2019-03-28

申请号：PCT/US2018/051682

申请日：2018-09-19

Applicant: BECKMAN COULTER, INC. ,  KOZICKI, Brian ,  THOMPSON, Creigh ,  WOLF, Richard

Inventor： KOZICKI, Brian ,  THOMPSON, Creigh ,  WOLF, Richard ,  HOLMES, Laura ,  SORRENTINO, David

IPC: G01N21/76 ,  G01N33/53 ,  G01N35/00 ,  G01J1/00 ,  G01N21/27 ,  G01N21/13

CPC classification number: G01N21/76 ,  G01J1/44 ,  G01N21/27 ,  G01N33/5302 ,  G01N2021/135 ,  G01N2201/022 ,  G01N2201/1241 ,  G01N2201/127 ,  G01N2201/12753

Abstract: Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).

公开(公告)号：WO2019060373A1

公开(公告)日：2019-03-28

申请号：PCT/US2018/051679

申请日：2018-09-19

Applicant: BECKMAN COULTER, INC. ,  WOLF, Richard

Inventor： WOLF, Richard ,  SORRENTINO, David ,  MIZUTANI, Takayuki ,  DAVIS, Glenn

IPC: G01J1/00 ,  G01N21/27 ,  G01N21/76 ,  G01N33/53 ,  G01N35/00 ,  G01N21/13

CPC classification number: G01N21/76 ,  G01J1/44 ,  G01N21/27 ,  G01N33/5302 ,  G01N2021/135 ,  G01N2201/022 ,  G01N2201/1241 ,  G01N2201/127 ,  G01N2201/12753

Abstract: A luminometer (400) includes a light detector (630) configured to sense photons (135). The luminometer (400) includes an analog circuit (915a) configured to provide an analog signal (965) based on the photons (135) emitted from assay reactions over a time period and a counter circuit (915b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).

公开(公告)号：US09933404B2

公开(公告)日：2018-04-03

申请号：US14784726

申请日：2014-04-15

Applicant: Dräger Safety AG & Co. KGaA

Inventor： Hans-Ullrich Hansmann ,  Philipp Rostalski ,  Andreas Mohrmann

IPC: G01N33/00 ,  G01N21/78 ,  G01N21/27

CPC classification number: G01N33/0073 ,  G01N21/272 ,  G01N21/783 ,  G01N33/0013 ,  G01N2201/1241

Abstract: A measuring device (10) and a measuring method measure a concentration of gaseous and/or aerosol components of a gas mixture. A reaction carrier (14) has a flow channel (42) defining a reaction chamber (46) with an optically detectable reaction material (48) to react with at least one component or with a reaction product of the component. The measuring device (12) includes a gas delivery unit (2) and detection unit (3) having a lighting device (37) for lighting the reaction chamber (46). An optical sensor (38) detects the reaction. An evaluation unit (4) evaluates data of the optical sensor (38) to determines a concentration. The gas delivery unit (2) includes a gas delivering device (28) delivering the gas mixture through the gas outlet channel (18) and a control/regulation unit (31) which controls/regulates a flow of the gas mixture through the flow channel (42) depending on at least one reaction speed parameter.

公开(公告)号：US20170370828A1

公开(公告)日：2017-12-28

申请号：US15194829

申请日：2016-06-28

Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION

Inventor： Arifin Arifin ,  Cheng-Gang Xie

IPC: G01N21/31 ,  G01N15/02 ,  G01P5/26

CPC classification number: G01N21/31 ,  G01N15/0205 ,  G01N15/06 ,  G01N21/359 ,  G01N21/532 ,  G01N2015/0011 ,  G01N2015/0053 ,  G01N2015/0693 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0694 ,  G01N2201/12 ,  G01N2201/1241 ,  G01P5/26

Abstract: An apparatus includes a pipe through which a multiphase fluid flows, with a transparent window structure formed in the pipe. A collimated light source emits light through the transparent window structure into the pipe having a wavelength at which a component of a desired phase of the multiphase fluid is absorptive. A photodetector is positioned such that the emitted light passes through the multiphase fluid in the pipe to impinge upon the photodetector. The photodetector has an actual dynamic range for collimated light detection. Processing circuitry is configured to continuously adjust a power of the collimated light source dependent upon an output level of the photodetector so as to cause measurement of the emitted light over an effective dynamic range greater than the actual dynamic range, and determine a property of the multiphase fluid as a function of the power of the collimated light source.

公开(公告)号：US08134698B1

公开(公告)日：2012-03-13

申请号：US12049091

申请日：2008-03-14

Applicant: Christian Wolters ,  Anatoly Romanovsky ,  Daniel Kavaldjiev ,  Bret Whiteside

Inventor： Christian Wolters ,  Anatoly Romanovsky ,  Daniel Kavaldjiev ,  Bret Whiteside

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  G01N2201/1241

Abstract: In one embodiment, a surface analyzer system comprises a radiation targeting assembly to target a radiation beam onto a surface; and a scattered radiation collecting assembly that collects radiation scattered from the surface. The radiation targeting assembly generates primary and secondary beams. Data collected from the reflections of the primary and secondary beams may be used in a dynamic range extension routine, alone or in combination with a power attenuation routine.

Abstract translation: 在一个实施例中，表面分析器系统包括将辐射束对准到表面上的辐射瞄准组件; 以及收集从表面散射的辐射的散射的辐射收集组件。 辐射瞄准组件产生主光束和次光束。 从主波束和次波束的反射中收集的数据可以单独使用或者与功率衰减程序组合在动态范围扩展程序中使用。

公开(公告)号：US07847928B2

公开(公告)日：2010-12-07

申请号：US12130488

申请日：2008-05-30

Applicant: Koichi Taniguchi ,  Masayuki Ochi ,  Shuichi Chikamatsu ,  Shigehisa Nozawa

Inventor： Koichi Taniguchi ,  Masayuki Ochi ,  Shuichi Chikamatsu ,  Shigehisa Nozawa

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  G01N2021/8887 ,  G01N2021/8896 ,  G01N2201/1241

Abstract: An inspection device for inspecting defects of an inspection object including a light source for irradiating a luminous flux to the inspection object; an optical system for guiding reflected light from the inspection object; a photoelectric image sensor having a plurality of photoelectric cells arranged, for converting the light guided to detection signals; a detection signal transfer unit having channels each constituted by a signal correction unit, a converter and an image formation unit, and corresponding to each of a plurality of regions formed by dividing the photoelectric image sensor, respectively; and an image synthesis unit for forming an image of the surface of the object by synthesizing partial images outputted; the inspection device inspecting defects of the object by processing the synthesized image; whereby it becomes possible to correct a detection signal from said photoelectric cell close to a predetermined reference target value.

Abstract translation: 一种检查装置，用于检查包括用于向检查对象照射光通量的光源的检查对象的缺陷; 用于引导来自检查对象的反射光的光学系统; 光电图像传感器，其具有布置用于将被引导的光转换成检测信号的多个光电单元; 检测信号传送单元，其具有各自由信号校正单元，转换器和图像形成单元构成的信道，并且分别对应于通过划分光电图像传感器形成的多个区域中的每一个; 以及图像合成单元，用于通过合成输出的部分图像来形成对象的表面的图像; 检查装置通过处理合成图像来检查物体的缺陷; 从而可以将来自所述光电单元的检测信号校正为接近预定的基准目标值。

公开(公告)号：US20080161206A1

公开(公告)日：2008-07-03

申请号：US12005542

申请日：2007-12-26

Applicant: John F. Corson ,  Scott D. Connell ,  Srinka Ghosh

Inventor： John F. Corson ,  Scott D. Connell ,  Srinka Ghosh

IPC: C40B60/10 ,  G01N33/50

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N2201/1241

Abstract: Biopolymeric array scanners that are capable of automatically selecting a dye specific scale factor to employ for a plurality of different dyes, as wells as methods for making and using the same, are provided. In many embodiments, the actual dye specific scale factor automatically selected by the scanner is one that is equal to a preset “master” scale factor, so that the scanner reads any supported dye using the same constant scale factor. The dye specific scale factor selection is typically made by reference to a collection of nominal scale factors for each member of the plurality of dyes. In using the subject scanners, a user simply inputs the one or more dyes being used in a given array assay, and the scanner automatically reads the array using an automatically chosen dye specific scale factor for the selected dyes. Also provided are methods of obtaining collections of nominal scale factors and computer readable mediums comprising the same. The subject invention finds use in a variety of different applications, including both genomics and proteomics applications.