公开(公告)号：WO1992003967A1

公开(公告)日：1992-03-19

申请号：PCT/US1991006914

申请日：1991-09-06

Applicant: SPACELABS, INC.

Inventor： SPACELABS, INC. ,  JONES, Paul, Harvey ,  WANG, Wei-Min

IPC: A61B05/021

公开(公告)号：WO1990011043A1

公开(公告)日：1990-10-04

申请号：PCT/US1990001612

申请日：1990-03-26

Applicant: EASTERN MEDICAL TESTING SERVICES, INC.

Inventor： EASTERN MEDICAL TESTING SERVICES, INC. ,  O'ROURKE, Michael, F.

IPC: A61B05/021

CPC classification number: A61B5/7257 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/7239

Abstract: The invention is a method for calculating from the contours of the pressure pulses in the brachial, carotid and radial arteries the absolute systolic pressure, the degree of augmentation, and the contour of the pressure pulse wave in the ascending aorta. The pressure in the ascending aorta is related to a combination of a primary pressure pulse and a secondary pressure wave which is a reflection of the primary pressure pulse from the periphery of the body. The maximum central arterial pressure can be determined from an analysis of the contour of the pressure pulses in the peripheral arteries, and the relationship between the peaks in the pulses relating to the maximum primary pressure and the maximum secondary wave pressure. The inventive system determines the positions of the two peaks and then analyses their amplitudes to ascertain the maximum systolic pressure in the central arteries and the amount of augmentation. Transfer functions relating the measured peripheral artery pressure pulses to the ascending aorta pressure pulses developed from an analysis of the pressure pulse waves of a number of individuals using Fourier transform techniques are used to determine the contour of the ascending aorta pressure pulse based on the measured peripheral pulses.

Abstract translation: 本发明是从肱动脉，颈动脉和桡动脉的压力脉冲的轮廓计算上升主动脉的绝对收缩压，增大程度和压力脉搏波轮廓的方法。 上升主动脉中的压力与初级压力脉冲和二次压力波的组合有关，二次压力波是来自身体周围的一次压力脉冲的反射。 最大中心动脉压可以根据外围动脉压力脉冲轮廓的分析以及与最大一次压力和最大二次波压有关的脉冲中的峰值之间的关系来确定。 本发明的系统确定两个峰的位置，然后分析其振幅以确定中心动脉中的最大收缩压和增加的量。 使用傅立叶变换技术对测量的外周动脉压力脉冲与从多个个体的压力脉搏波分析产生的上升主动脉压力脉冲相关的转移功能用于基于所测量的周边物质确定升主动脉压力脉搏的轮廓 脉冲。

公开(公告)号：WO1997011637A1

公开(公告)日：1997-04-03

申请号：PCT/US1996014968

申请日：1996-09-18

Applicant: DATA SCIENCES INTERNATIONAL, INC.

Inventor： DATA SCIENCES INTERNATIONAL, INC. ,  BROCKWAY, Brian, P. ,  BROCKWAY, Robert, V. ,  FUNDAKOWSKI, Richard, A.

IPC: A61B05/021

CPC classification number: A61B5/0816 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/7239 ,  G06F19/00

Abstract: A system and method obtains physiologic parameter information of an animal or human, such as respiratory rate, from a blood pressure signal from an implanted blood pressure sensor (11) in the animal or human (10, 12, 14). Specifically, the blood pressure signal is externally signal processed to develop an amplitude versus time waveform. A sequence of selected blood pressure features derived from individual cardiac cycles of the amplitude versus time waveform over a selected time interval are extracted from the developed amplitude versus time waveform. A mathematical model is fitted to the extracted sequence of selected blood pressure features to yield a fitted mathematical model. The physiologic parameter information is computed from the fitted mathematical model.

Abstract translation: 系统和方法根据来自动物或人类的植入式血压传感器（11）的血压信号，获得动物或人类的生理参数信息，如呼吸频率（10,12,14）。 具体地说，将血压信号从外部进行信号处理，以产生振幅对时间波形。 从所开发的振幅对时间波形中提取从所选择的时间间隔内的幅度对时间波形的各个心脏周期导出的选定血压特征的序列。 将数学模型拟合到所选择的血压特征的提取序列以产生拟合的数学模型。 从拟合数学模型计算生理参数信息。

公开(公告)号：WO1996039074A1

公开(公告)日：1996-12-12

申请号：PCT/AU1996000340

申请日：1996-06-05

Applicant: PWV MEDICAL PTY. LTD. ,  O'ROURKE, Michael, Francis

Inventor： PWV MEDICAL PTY. LTD.

IPC: A61B05/021

CPC classification number: A61B5/021 ,  A61B5/02108

Abstract: Disclosed is an improved arrangement for allowing more accurate automatic calibration for a system in which blood pressure pulses are derived for remote sites from a calibrated measurement and a waveform measurement, when these are made at different sites. Where a calibrated measurement is made, say, at the brachial artery (11), and a waveform recorded at the radial artery (12), a waveform is derived for the calibrated site using a known transfer function, this drived waveform is then calibrated by the measurements already made, and the calibrated waveform for any remote site, for example the ascending aorta (14), can be derived using a known transfer function.

Abstract translation: 公开了一种改进的布置，用于当这些系统在不同的位置进行时，允许针对远程站点的血压脉冲从校准的测量和波形测量得到的系统进行更准确的自动校准。 例如在肱动脉（11）和记录在桡动脉（12）处的波形进行校准测量时，使用已知的传递函数为校准位点导出波形，然后将该驱动波形通过 已经进行了测量，并且可以使用已知的传递函数导出任何远程站点的校准波形，例如升主动脉（14）。

公开(公告)号：WO1995013014A1

公开(公告)日：1995-05-18

申请号：PCT/US1994012800

申请日：1994-11-07

Applicant: MEDWAVE, INC. ,  ARCHIBALD, G., Kent ,  CURRAN, Timothy, G. ,  DANIELSON, Orland, H. ,  POLIAC, Marius, O. ,  THEDE, Roger, C.

Inventor： MEDWAVE, INC.

IPC: A61B05/021

CPC classification number: A61B5/02116 ,  A61B5/021 ,  A61B2562/0247

Abstract: A sensor (180) having a sensing surface (100) for sensing blood pressure within an underlying artery of a patient includes a transducer (96), a sidewall (184), a flexible diaphragm (186) and a fluid coupling medium (188). The sidewall (184) is distinct from transducer (96) and supports the transducer (96) above the underlying artery. The fluid coupling medium (188) is coupled between the sensing surface (100) of transducer (96) and the flexible diaphragm (186) and transmits blood pressure pulses within the underlying artery from the flexible diaphragm (186) to the sensing surface (100) of transducer (96). In one embodiment, the fluid coupling medium (188) is isolated from sidewall (184).

Abstract translation: 具有感测表面（100）的传感器（180），用于感测患者的下部动脉内的血压，包括换能器（96），侧壁（184），柔性隔膜（186）和流体耦合介质（188） 。 侧壁（184）不同于换能器（96）并且支撑在下面的动脉上方的换能器（96）。 流体耦合介质（188）耦合在换能器（96）的感测表面（100）和柔性隔膜（186）之间，并将下面的动脉内的血压脉冲从柔性隔膜（186）传递到感测表面（100） ）换能器（96）。 在一个实施例中，流体耦合介质（188）与侧壁（184）隔离。

公开(公告)号：WO1994020016A1

公开(公告)日：1994-09-15

申请号：PCT/US1994002094

申请日：1994-02-28

Applicant: MERIT MEDICAL SYSTEMS, INC.

Inventor： MERIT MEDICAL SYSTEMS, INC. ,  TRIPP, Carl, F. ,  LAMPROPOULOS, Fred,P. ,  TAYLOR, Steven, R. ,  PADILLA, William ,  DENTON, Marshall, T.

IPC: A61B05/021

CPC classification number: A61B5/0215 ,  A61B5/02156

Abstract: A novel pressure transducer apparatus (10) for medical pressure monitoring apparatus having a housing (14, 28) with a calibration port or well (38). The patient side of the transducer (60) senses fluid pressures to be monitored. The non-patient side of the transducer (60) is hermetically sealed in the housing (14, 28) of the apparatus (10). The housing (14, 28) has a female calibration well (38) communicating, via a pinhole (42), with the non-patient side of the transducer (60). The non-patient side of the transducer (60) can thus alternatively be vented to atmospheric pressure or be exposed to a vacuum calibration pressure.

Abstract translation: 一种用于医疗压力监测装置的新型压力传感器装置（10），具有具有校准端口或孔（38）的壳体（14,28）。 换能器（60）的患者侧感测待监测的流体压力。 换能器（60）的非病人侧气密地密封在装置（10）的壳体（14,28）中。 壳体（14,28）具有通过针孔（42）与换能器（60）的非病人侧连通的母校准孔（38）。 因此，换能器（60）的非患者侧可以替代地排放到大气压力或暴露于真空校准压力。

公开(公告)号：WO1992003087A1

公开(公告)日：1992-03-05

申请号：PCT/EP1991001358

申请日：1991-07-19

Applicant: SPEIDEL + KELLER GMBH + CO. KG ,  SPEIDEL, Blasius

Inventor： SPEIDEL + KELLER GMBH + CO. KG

IPC: A61B05/021

CPC classification number: A61B5/021

Abstract: The blood pressure measuring device (10) has a bowl-shaped casing (11) in which is arranged a pressure measuring system with measuring scale (13) and indicator. The casing (1) is closed at its upper edge by a transparent cover plate (25). This primary casing (11) is surrounded at a given distance on the outside by a protective housing (15), whereby the base (18) of the protective housing (15) is combined in one piece with the base (16) of the primary casing (11). The compressed air line is connected either through a hole (22) in the base (16) of the casing (11) or through the casing walls. In the latter case, there is a material bridge in the space between the wall of the primary casing (11) and of the protective housing (15).

Abstract translation: 一种用于测量血压的设备（10），包括一个其中具有测量标尺（13）和测量指示器的电压测量机构的转轮形壳体（11）。 壳体（11）的上边缘通过透明盖（25）封闭。 该主壳体（11）被由外保护壳体（15）确定的间隔围绕。 保护壳体（15）的底部（18）与主壳体（11）的底部（16）形成单个部件。 压缩空气管道通过形成在壳体的底部（16）中的孔口（22）或通过壳体的壁连接。 在后一种情况下，在通道开口的区域中，在主壳体（11）的壁和保护壳体（15）的壁之间的间隙中形成材料连接。

公开(公告)号：WO1990003145A1

公开(公告)日：1990-04-05

申请号：PCT/US1989003613

申请日：1989-08-22

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  COHN, Jay, N. ,  FINKELSTEIN, Stanley, M.

IPC: A61B05/021

CPC classification number: A61B5/021

Abstract: A method for diagnosing, treating and monitoring hypertension uses the parameter C2 (i.e. distal vascular compliance) of the modified Windkessel model as an indication of the hypertensive disease condition. Apparatus for determining the parameter C2 of the modified Windkessel model includes means for obtaining a pressure pulse contour and a cardiac output value and for determining the model parameters.

Abstract translation: 用于诊断，治疗和监测高血压的方法使用修改的Windkessel模型的参数C2（即远端血管顺应性）作为高血压疾病状况的指示。 用于确定修改的Windkessel模型的参数C2的装置包括用于获得压力脉冲轮廓和心输出值并用于确定模型参数的装置。