公开(公告)号：WO1993004626A1

公开(公告)日：1993-03-18

申请号：PCT/US1992007283

申请日：1992-08-27

Applicant: BAXTER INTERNATIONAL INC. ,  UNIVERSITY OF UTAH

Inventor： BAXTER INTERNATIONAL INC. ,  UNIVERSITY OF UTAH ,  BOBO, Donald, E., Jr. ,  BAKER, Phillip, D. ,  WESTENSKOW, Dwayne, R.

IPC: A61B05/021

CPC classification number: A61B5/021

Abstract: There is disclosed herein a method of obtaining certain information about the blood pressure of a given patient by means of a particular blood pressure technique, specifically by means of oscillometry, in which the pressurizable pressure transducing bladder (18) located adjacent and cooperating with a particular artery of the patient (12), is used in combination with means (24) for pressurizing the bladder (18) in a controlled way in order to provide the desired information. The particular artery used is the patient's supraorbital artery (14) which is readily accessible in a specific area just above the eyebrow of substantially all patients. There is also disclosed herein a blood pressure transducing bladder assembly (16) which is specifically designed to easily access the supraorbital artery (14) of substantially all patients using the eyebrow and nose of each patient as a frame of reference.

公开(公告)号：WO1991014396A1

公开(公告)日：1991-10-03

申请号：PCT/EP1991000570

申请日：1991-03-25

Applicant: TYMIEC, Marian

IPC: A61B05/021

CPC classification number: A61B5/02225 ,  A61B5/02125 ,  A61B5/022

Abstract: In conventional processes for measuring blood pressure, a pressure cuff is applied to an extremety such as the upper arm or a finger and all the blood vessels supplying this extremity are completely or partially compressed for the entire duration of the blood pressure measurement or at least periodically. Until now, it has not been possible to measure blood pressure continously without considerable damage to the patient. The process for measuring blood pressure according to the invention is monoarterial and therefore the supply to the corresponding extremity is never cut off. To determine the blood pressure curve, given characteristic values, such as maximum amplitude, for consecutive blood pressure pulses are compared and used to determine the true pulse pressure curve.

公开(公告)号：WO1997009927A2

公开(公告)日：1997-03-20

申请号：PCT/US1996014477

申请日：1996-09-10

Applicant: NOLAN, James, A. ,  MOODY, Trevor, J.

IPC: A61B05/021

CPC classification number: A61B1/2275 ,  A61B5/0002 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/6817 ,  A61B2560/0223

Abstract: Continuous, non-invasive method and apparatus for measuring blood pressure parameters and the like are disclosed. The apparatus includes an earpiece (10) for sealing an individual's ear canal so that arterial blood pressure changes adjacent the sealed ear canal (12) produce air pressure changes in the sealed ear canal (12). The apparatus further includes pressure sensing means (24) for measuring the air pressure changes in the sealed ear canal (12) and producing a signal related to the measured air pressure changes. In addition, the apparatus preferably includes processing means (52) for processing the signal to measure blood pressure parameters, as well as means for displaying (58) and/or recording (50) the processed signal. The method may be used to determine heart rate, blood pressure, cardiac output, stroke volume, cardiac function, circulatory function, and other parameters. To obtain absolute pressure readings, two sensors (24a, 24b), one in each ear, may be used to monitor pulse time transit delay.

Abstract translation: 公开了用于测量血压参数的连续的非侵入性方法和装置等。 该装置包括用于密封个体耳道的听筒（10），使得邻近密封的耳道（12）的动脉血压变化产生密封的耳道（12）中的空气压力变化。 该装置还包括用于测量密封的耳道（12）中的空气压力变化并产生与所测量的空气压力变化相关的信号的压力感测装置（24）。 此外，该装置优选地包括用于处理信号以测量血压参数的处理装置（52），以及用于显示（58）和/或记录（50）处理的信号的装置。 该方法可用于确定心率，血压，心输出量，搏动体积，心脏功能，循环功能等参数。 为了获得绝对压力读数，可以使用每个耳朵中的两个传感器（24a，24b）来监测脉冲时间传递延迟。

公开(公告)号：WO1995016391A1

公开(公告)日：1995-06-22

申请号：PCT/US1994014612

申请日：1994-12-15

Applicant: PULSE METRIC, INC.

Inventor： PULSE METRIC, INC. ,  CHIO, Shiu-Shin

IPC: A61B05/021

CPC classification number: A61B5/02007 ,  A61B5/022 ,  A61B5/7239 ,  A61B5/742

Abstract: A method is disclosed for diagnosing, monitoring and treating cardiovascular pathologies. Among the hemodynamic parameters of interest are peripheral resistance, compliance, and cardiac (left ventricular) output. Peripheral resistance determined according to the present invention has been found to be a reliable indicator, not only of hypertension, but also of the cause of the hypertension. The determined peripheral resistance can be compared against a predetermined threshold value. This comparison helps to foster a diagnosis of a hypertensive condition.

Abstract translation: 公开了用于诊断，监测和治疗心血管病变的方法。 感兴趣的血液动力学参数是外周阻力，顺应性和心脏（左心室）输出。 已经发现根据本发明确定的外周阻力不仅是高血压，而且是高血压原因的可靠指标。 所确定的外围电阻可以与预定的阈值进行比较。 这种比较有助于促进高血压病症的诊断。

公开(公告)号：WO1994014372A1

公开(公告)日：1994-07-07

申请号：PCT/US1993012105

申请日：1993-12-16

Applicant: COHEN, Avi ,  RAICH, Yuval ,  FRANK, Eyal

Inventor： COHEN, Avi

IPC: A61B05/021

CPC classification number: A61B5/029 ,  A61B5/412 ,  A61B5/7239 ,  A61B5/7242

Abstract: A method and apparatus for continuously monitoring cardiac output and SVR of a patient by analyzing the blood pressure signal. The signal waveform is generated by a transducer (20) and can be measured directly by the use of catheters placed into various arteries, in particular a radial artery or a femoral artery, or non-invasive methods such as electrooptic methods, or methods using a piezoelectric transducer. Transducer (20) is connected to an A/D converter (30) which is in turn connected a low pass filter (40). The output of low pass filter (40) is connected to waveform analyzer (50). A calculator (60) receives inputs from waveform analyzer (50) and an input device (10). Various parameters are extracted from the blood pressure signal waveform in order to calculate the cardiac output of the patient and other hemodynamic data.

Abstract translation: 通过分析血压信号来连续监测患者的心输出量和SVR的方法和装置。 信号波形由换能器（20）产生，并且可以通过使用放置在各种动脉，特别是桡动脉或股动脉中的导管，或非侵入性方法（例如电光方法）或使用 压电换能器。 传感器（20）连接到A / D转换器（30），A / D转换器又连接低通滤波器（40）。 低通滤波器（40）的输出端连接到波形分析仪（50）。 计算器（60）接收来自波形分析器（50）和输入装置（10）的输入。 从血压信号波形中提取各种参数，以计算患者的心输出量和其他血液动力学数据。

公开(公告)号：WO1993004625A1

公开(公告)日：1993-03-18

申请号：PCT/US1992007279

申请日：1992-08-27

Applicant: BAXTER INTERNATIONAL INC. ,  UNIVERSITY OF UTAH

Inventor： BAXTER INTERNATIONAL INC. ,  UNIVERSITY OF UTAH ,  BORSANYI, Alexander ,  BAKER, Phillip, D. ,  WESTENSKOW, Dwayne, R. ,  SMITH, Nancy

IPC: A61B05/021

CPC classification number: A61B5/6814 ,  A61B5/02241 ,  A61B2562/168

Abstract: A noninvasive sensor assembly is provided for measuring the blood pressure in the patient's superficial temporal arteries. The device comprises generally a support base (10), a sensor bladder (12) disposed within the support base (10), a transducer (13), a holding bladder (16), and headband (62) for securing the device to the patient's head. Optionally, a compression plate (14) is provided, the compression plate (14) serving to form an improved contact surface between the support base (10) and the headband (62). The holding bladder (16) serves to attenuate noise and artifacts from exterior sources while isolating the support base (10) against the patient's scalp.

Abstract translation: 提供用于测量患者的浅表颞动脉血压的无创传感器组件。 该装置通常包括支撑基座（10），设置在支撑基座（10）内的传感器囊（12），换能器（13），保持囊（16）和头带（62），用于将装置固定到 病人的头。 可选地，提供压缩板（14），压缩板（14）用于在支撑基座（10）和头带（62）之间形成改进的接触表面。 保持囊（16）用于在将支撑基座（10）隔离患者头皮的同时，衰减来自外部源的噪声和伪像。

公开(公告)号：WO1997014355A2

公开(公告)日：1997-04-24

申请号：PCT/US1996015951

申请日：1996-10-03

Applicant: VITAL INSITE, INC.

Inventor： VITAL INSITE, INC. ,  CARO, Richard, G. ,  SHER, Mark, H. ,  FLAHERTY, Bryan, P. ,  WOHLTMANN, William, J.

IPC: A61B05/021

CPC classification number: A61B5/02007 ,  A61B5/021 ,  A61B5/02133 ,  A61B5/0507 ,  A61B5/6824 ,  A61B8/04 ,  A61B8/488

Abstract: An exciter-detector unit is disclosed which includes an exciter (104) and a detector (105) mounted on a common support (101) for inducing perturbations into the body and detecting the perturbations after they travel a distance through the body.

Abstract translation: 公开了一种激励器检测器单元，其包括安装在公共支撑件（101）上的激励器（104）和检测器（105），用于引导人体内的扰动，并在它们行进一段距离通过身体之后检测扰动。

公开(公告)号：WO1996029004A1

公开(公告)日：1996-09-26

申请号：PCT/AU1996000148

申请日：1996-03-15

Applicant: PWV MEDICAL PTY. LTD. ,  O'ROURKE, Michael, Francis

Inventor： PWV MEDICAL PTY. LTD.

IPC: A61B05/021

CPC classification number: A61B5/026 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/7257

Abstract: A method is disclosed for determining the aortic flow velocity waveform non-invasively. A calibrated ascending aorta pressure waveform can be derived from peripheral measurements, for example at the radial artery, and calibrated from conventional syphgmomanometry, for example at the brachial artery. From the calibrated ascending aorta pressure waveform the flow velocity waveform in the ascending aorta can be determined, by using the Fourier transform of the pressure waveform and the age-related phase and modulus values. The method can also be used for invasively measured pressure waveforms to provide a flow waveform.

Abstract translation: 公开了非侵入性地确定主动脉血流速度波形的方法。 校准的上升主动脉压力波形可以从周边测量得到，例如在桡动脉处，并且从常规的血压测量法例如在肱动脉上校准。 通过校准升主动脉压力波形，可以通过使用压力波形的傅里叶变换和与年龄有关的相位和模量值来确定升主动脉中的流速波形。 该方法还可用于入侵测量的压力波形以提供流量波形。

公开(公告)号：WO1994017728A1

公开(公告)日：1994-08-18

申请号：PCT/US1994001505

申请日：1994-02-14

Applicant: BIOSYSS CORPORATION

Inventor： BIOSYSS CORPORATION ,  BARNES, Jeffrey, T. ,  MOORE, J., Erik

IPC: A61B05/021

CPC classification number: A61B5/021 ,  A61B5/02108 ,  A61B2562/02

Abstract: A blood pressure instrument (10) and method in which analog blood pressure waveform signals are digitized and stored and used to determine blood pressure parameters to make physiological measurements based upon pattern recognition using information empirically obtained from clinical measurements. In a preferred embodiment, the analog waveform signals are obtained non-invasively using an external wrist-mounted displacement transducer (12).

Abstract translation: 一种血压仪器（10）以及其中模拟血压波形信号被数字化并存储并用于确定血压参数以根据从临床测量经验获得的信息基于模式识别进行生理测量的方法。 在优选实施例中，使用外部腕部置换换能器（12）非侵入地获得模拟波形信号。

公开(公告)号：WO1992011805A1

公开(公告)日：1992-07-23

申请号：PCT/US1991008710

申请日：1991-11-21

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  CHESNEY, Charles, F. ,  FINKELSTEIN, Stanley, M. ,  COHN, Jay, N.

IPC: A61B05/021

CPC classification number: A61B5/02007 ,  A61B5/021 ,  A61B5/029 ,  G06F19/00 ,  G09B23/28 ,  Y10S128/92

Abstract: A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.