公开(公告)号：WO1996034559A1

公开(公告)日：1996-11-07

申请号：PCT/US1996006133

申请日：1996-05-01

Applicant: CORDIS WEBSTER, INC.

Inventor： CORDIS WEBSTER, INC. ,  WEBSTER, Wilton, W., Jr.

IPC: A61B05/0402

CPC classification number: A61B5/6858 ,  A61B5/0422 ,  A61B2018/00041 ,  A61B2018/0016 ,  A61B2018/1465 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056

Abstract: An electrophysiological mapping device includes an outer catheter (8), an inner catheter (6) slidable within the outer catheter, and an electronic activation and recording device (4) for electrically activating electrodes (11) on the inner catheter and/or recording electric signals received by the electrodes. The distal end of the inner catheter comprises a plurality of arms (9) that cary electrodes. The arms bow outwardly upon extension of the inner catheter from the outer catheter to form a three-dimensional shape. Each arm has a spine (25) of a super-elastic material. Each spine is semicircular in section, and is disposed within a portion of a flexible sheath (18), the electrode lead wires being disposed in the rest of the sheath. The electrodes are formed from the ends of the insulated electrode lead wires (20) which pass through the sheath, are wrapped around the sheath and then stripped of their insulation.

Abstract translation: 电生理测绘装置包括外导管（8），可在外导管内滑动的内导管（6）和用于电激活内导管上的电极（11）和/或记录电的电子激活和记录装置（4） 由电极接收的信号。 内导管的远端包括多个臂（9），其是电极。 当内导管从外导管延伸时，臂向外。向，形成三维形状。 每个臂具有超弹性材料的脊柱（25）。 每个脊柱的剖面为半圆形，并且设置在柔性护套（18）的一部分内，电极引线设置在护套的其余部分中。 电极由穿过护套的绝缘电极引线（20）的端部形成，围绕护套缠绕，然后剥离其绝缘体。

公开(公告)号：WO1996025094A1

公开(公告)日：1996-08-22

申请号：PCT/US1996002034

申请日：1996-02-16

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  SWANSON, David, K. ,  PANESCU, Dorin ,  WHAYNE, James, G.

IPC: A61B05/0402

CPC classification number: A61N1/403 ,  A61B1/0051 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/6855 ,  A61B5/6858 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056

Abstract: Systems and methods analyze bio-potential morphologies in body tissue. The systems and methods use a template of a bio-potential event of known cause in body tissue. The systems and methods compare this template to a sample of a bio-potential event externally triggered in body tissue. The systems and methods generate an output based upon this comparison. The systems and methods can be used to compare an event specific to the template of a cardiac event (T(i)) of known diagnosis to a sample of a placed cardiac event (P(i)). The comparison yields a matching coefficient (MCOEFF(i)) indicating how alike the input sample is to the input template. The matching coefficient can be used by the physician, for example, to aid in the location of sites that are potentially appropriate for ablation.

Abstract translation: 系统和方法分析身体组织中的生物潜能形态。 系统和方法使用身体组织中已知原因的生物潜在事件的模板。 系统和方法将此模板与身体组织中外部触发的生物潜在事件的样本进行比较。 系统和方法基于此比较生成输出。 系统和方法可以用于将已知诊断的心脏事件（T（i））的模板特有的事件与放置的心脏事件（P（i））的样本进行比较。 比较产生一个匹配系数（MCOEFF（i）），表示输入样本与输入模板的相似度。 例如，医生可以使用匹配系数来帮助可能适合于消融的部位的位置。

公开(公告)号：WO1996014796A1

公开(公告)日：1996-05-23

申请号：PCT/US1995014889

申请日：1995-11-14

Applicant: CAMBRIDGE HEART, INC.

Inventor： CAMBRIDGE HEART, INC. ,  ALBRECHT, Paul ,  ARNOLD, Jeffrey, M. ,  JUDELL, Neil ,  COHEN, Richard, J.

IPC: A61B05/0402

CPC classification number: A61B5/0535 ,  A61B5/0408 ,  A61B5/04085 ,  A61B5/0452 ,  A61B5/222 ,  A61B5/4884 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/721 ,  Y10S128/901

Abstract: A method of reducing noise in a signal that represents a physiologic process includes obtaining multiple input signals (205), measuring a relationship between noise content of the input signals (210-225), and combining the input signals in consideration of the measured relationship to produce an output signal having a low noise content (230). The multiple input signals may include, for example, two or more primary physiologic input signals or one or more primary physiologic input signals and two or more secondary input signals that represent noise. The method may further include dividing one or more ECG input signals and secondary input signals into a set of segments, where each set of segments represents a beat of the ECG signal, measuring a relationship between noise content of corresponding points from successive sets of segments, and combining the input signals based on the measured relationship.

Abstract translation: 一种降低代表生理过程的信号中的噪声的方法包括获得多个输入信号（205），测量输入信号（210-225）的噪声含量之间的关系，以及将所测量的关系考虑到输入信号 产生具有低噪声含量的输出信号（230）。 多个输入信号可以包括例如两个或更多个原始生理输入信号或一个或多个原始生理输入信号以及表示噪声的两个或更多次级输入信号。 该方法还可以包括将一个或多个ECG输入信号和次要输入信号划分成一组段，其中每组段表示ECG信号的搏动，测量来自连续的段组的对应点的噪声含量之间的关系， 并根据所测量的关系组合输入信号。

公开(公告)号：WO1995016394A1

公开(公告)日：1995-06-22

申请号：PCT/US1994014257

申请日：1994-12-12

Applicant: MARQUETTE ELECTRONICS, INC.

Inventor： MARQUETTE ELECTRONICS, INC. ,  LUCZYK, William, J.

IPC: A61B05/0402

CPC classification number: A61B5/0468

Abstract: A cardiac monitoring system includes an acquisition module (12) for acquiring a plurality of analog cardiac signals through leads connected to predetermined locations on the body of a patient and for converting the cardiac signals to twelve standardized ECG lead signals. An arrhythmia monitor (18) analyzes a plurality of the ECG signals for determining the existence of rhythm abnormalities, and a twelve lead analyzer (14) analyzes both the rhythm and the contours of all of the ECG lead signals for rhythming conduction, infarction, hypertrophy and repolarization abnormalities. The arrhythmia monitor (18) and the twelve lead analyzers (14) are operated concurrently for the simultaneous analysis of the ECG signals so that the occurrence of a rhythm abnormality and its cause can be determined on a real time basis.

Abstract translation: 心脏监测系统包括：采集模块（12），用于通过连接到患者身体上的预定位置的引线获取多个模拟心脏信号，并将心脏信号转换成十二个标准化的ECG导联信号。 心律失常监测器（18）分析多个ECG信号以确定心律异常的存在，并且十二引导分析仪（14）分析所有ECG导联信号的节律和轮廓，用于节律传导，梗死，肥大 和复极异常。 心律失常监测器（18）和十二个引线分析仪（14）同时运行，以便对ECG信号进行同步分析，从而可以实时确定出节律异常及其原因。

公开(公告)号：WO1997047237A1

公开(公告)日：1997-12-18

申请号：PCT/DK1997000257

申请日：1997-06-12

Applicant: BANG & OLUFSEN TECHNOLOGY A/S ,  BÆKGAARD, Knud, Erik

Inventor： BANG & OLUFSEN TECHNOLOGY A/S

IPC: A61B05/0402

CPC classification number: A61B5/0245

Abstract: Basic research has shown that in connection with characteristic and critical changes in certain physiological conditions, e.g. critically decreasing blood sugar content with diabetic patients, there appear some preceding, marked changes in the pattern of the person's heart rate variations. According to the invention, advantage is taken of this in providing for an apparatus, e.g. shaped as a wrist watch, which currently detects the heartbeats of the person and forms an expression of the variation pattern of the last 10-50 heartbeats; the apparatus has a program unit coded with the expression that is premonitory of the relevant change and an alarm unit, which is activated if or when this expression happens to coincide with the corresponding detected expression. Hereby the person gets a chance to take countermeasures against the relevant change, which has thus been preadvised in real time. The apparatus is also applicable for indication of the stress condition of the body, which may provide useful information e.g. for strongly trained sportsmen for avoiding overtaxing.

Abstract translation: 基础研究表明，与某些生理条件的特征和关键变化有关。 糖尿病患者血糖含量显着降低，出现以前有一些人心率变化的模式发生明显变化。 根据本发明，优点在于提供一种装置，例如， 形成手表，其目前检测到人的心跳并形成最后10-50个心跳的变化模式的表达; 该装置具有用相关变化的预兆表达式编码的程序单元和报警单元，如果或者当该表达符合相应的检测到的表达式时，该单元被激活。 因此，该人有机会对相关变化采取对策，因此已经实时预先设置。 该装置还可用于指示身体的应激状况，其可以提供有用的信息，例如， 强力训练的运动员避免超负荷。

公开(公告)号：WO1996041569A1

公开(公告)日：1996-12-27

申请号：PCT/US1996009818

申请日：1996-06-07

Applicant: ENGINEERING & RESEARCH ASSOCIATES, INC. ,  TAYLOR, Junius, E.

Inventor： ENGINEERING & RESEARCH ASSOCIATES, INC.

IPC: A61B05/0402

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00041 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00738 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/124 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/403

Abstract: A catheter (14) for use in an electrophysiological procedure to ablate a site includes a metallic tip (30) having a first work function and energized by a source of RF energy (10). The RF energy return path is through a relatively large plate (34) of a metallic material having a second work function and disposed at a location removed from the ablation site. The difference in work functions of the tip and the plate, operating in the presence of an electrolyte represented by the intermediate tissue, produces an exchange of electrical charges through chemical reaction to create a galvanic cell. By loading the galvanic cell with a shunt resistor (R1), it becomes a current source providing a current linear with and highly dependent on the tissue temperature at the ablation site. This accurate representation of the tissue temperature at the ablation site is used to regulate the RF energy applied to maintain the tissue at the ablation site at a predetermined temperature during the ablation procedure.

Abstract translation: 用于电生理过程以消融部位的导管（14）包括具有第一功能并由RF能量源（10）激励的金属尖端（30）。 RF能量返回路径穿过具有第二功函数的金属材料的相对较大的板（34），并设置在从消融部位移除的位置。 在由中间组织代表的电解质的存在下操作的尖端和板的功能的差异通过化学反应产生电荷交换以产生电池。 通过用分流电阻（R1）负载电池，它成为电流源，提供与消融部位的组织温度成线性关系，并高度依赖于组织温度。 消融部位处的组织温度的这种准确表示用于调节在消融过程期间将消融部位处的组织保持在预定温度下的RF能量。

公开(公告)号：WO1996025097A1

公开(公告)日：1996-08-22

申请号：PCT/US1996002190

申请日：1996-02-16

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  SWANSON, David, K. ,  PANESCU, Dorin ,  WHAYNE, James, G.

IPC: A61B05/0402

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2090/065 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056

Abstract: Systems and methods use an array (20) of multiple electrodes (24) supported for operative association with a region of heart tissue, in tandem with a roving second electrode (36) supported for movement relative to the multiple electrodes for operative association with selected different regions of endocardial tissue within the heart. An analog or digital processing element (32) conditions one of the multiple electrodes and the roving electrode to emit a pacing signal while the other one of the multiple electrodes and the roving electrode records paced electro-grams occurring as a result of the pacing signal. A template of cardiac event of known diagnosis sensed using the array of multiple electrodes is input. A sample of a cardiac event acquired by pacing from at least one roving electrode and sensed with the array of multiple electrodes is input. The processing element and method electronically compare the sample to a template and generate an output.

Abstract translation: 系统和方法使用多个电极（24）的阵列（20），其被支撑用于与心脏组织的区域有效地相关联，与被支撑用于相对于多个电极移动的粗纱第二电极（36）串联，以与所选择的不同的 心脏内心脏组织的区域。 模拟或数字处理元件（32）调节多个电极和粗纱电极之一以发出起搏信号，而多个电极和粗纱电极中的另一个记录起搏电针作为起搏信号的结果。 输入使用多个电极阵列感测的已知诊断的心脏事件的模板。 输入通过起搏从至少一个粗纱电极获取的心脏事件的样本，并用多个电极的阵列感测。 处理元件和方法将样本与模板进行电子比较并生成输出。

公开(公告)号：WO1996025093A1

公开(公告)日：1996-08-22

申请号：PCT/US1996001977

申请日：1996-02-16

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  PANESCU, Dorin ,  WHAYNE, James, G. ,  SWANSON, David, K.

IPC: A61B05/0402

CPC classification number: H03H17/0263 ,  A61B5/0422 ,  A61B5/6855 ,  A61B5/6858 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/3702

Abstract: Systems and methods provide nonlinear, non-median filters (56) for signals derived from biological events. The systems and methods select a set of n sample values arranged with respect to time from the derived biological signal input. The systems and methods arrange the n sample values of the set into ordered positions following a predetermined permutation. The systems and methods select one of the ordered positions z within the permutation, where z is an odd positive integer greater or equal to one but less than or equal to n. The systems and methods generate a processed output (54) comprising the sample value occupying the ordered position z in the permutation.

Abstract translation: 系统和方法为来自生物事件的信号提供非线性非中值滤波器（56）。 系统和方法从衍生的生物信号输入中选择相对于时间排列的一组n个样本值。 系统和方法将集合的n个样本值排列在预定排列之后的有序位置。 系统和方法选择置换中的有序位置z之一，其中z是大于或等于1但小于或等于n的奇正整数。 系统和方法产生包括在排列中占据有序位置z的样本值的经处理的输出（54）。

公开(公告)号：WO1994026163A1

公开(公告)日：1994-11-24

申请号：PCT/US1994004846

申请日：1994-05-03

Applicant: HUTSON, William, H.

IPC: A61B05/0402

CPC classification number: G06K9/00503 ,  G01S3/802 ,  G01S7/20 ,  G01S7/6245 ,  G01S15/899 ,  G06F17/16 ,  G06F19/00 ,  G06K9/00523 ,  G16H10/60 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/70 ,  Y10S128/901

Abstract: This invention is a medical processing and display system including the algorithmic structures of preprocessing (12), sub-space selection (13), sub-space enhancement (14), signal processing (15), sub-space expansion (16), and a display (17). Medical data are collected and re-formatted into a two-dimensional matrix X. A history database and other priority information may be concatenated with the matrix. The concatenated matrix is decomposed using singular value decomposition (SVD) to obtain its corresponding left and right singular vectors L, R and singular values D.

Abstract translation: 本发明是一种包括预处理（12），子空间选择（13），子空间增强（14），信号处理（15），子空间扩展（16）的算法结构的医疗处理和显示系统，以及 显示器（17）。 医疗数据被收集并重新格式化为二维矩阵X.历史数据库和其他优先级信息可以与矩阵连接。 使用奇异值分解（SVD）分解级联矩阵以获得其相应的左和右奇异矢量L，R和奇异值D.

公开(公告)号：WO1994007412A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009059

申请日：1993-09-24

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  KORDIS, Thomas, F.

IPC: A61B05/0402

CPC classification number: A61B5/6852 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/05

Abstract: An electrode support for use in an intraventricular cardiac diagnosis and treatment includes at least one elongated spline (76) that carries at least one electrode (22). The spline has a rectangular cross section. It has a substantially greater width than thickness. The spline can be flexed in one vertical plane that passes through its longitudinal axis. The spline resists twisting and resists flexing in all other planes passing through the axis.

Abstract translation: 用于心室内心脏诊断和治疗的电极支撑件包括至少一个延伸的花键（76），其携带至少一个电极（22）。 花键具有矩形截面。 它具有比厚度大得多的宽度。 花键可以在穿过其纵向轴线的一个垂直平面中弯曲。 花键抵抗扭转并抵抗穿过轴线的所有其他平面的弯​​曲。