公开(公告)号：WO1996025096A1

公开(公告)日：1996-08-22

申请号：PCT/US1996002092

申请日：1996-02-16

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  SWANSON, David, K. ,  WHAYNE, James, G. ,  PANESCU, Dorin

IPC: A61B05/0402

CPC classification number: A61N1/056 ,  A61B1/0051 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/6855 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2562/0209 ,  A61B2562/043

Abstract: Systems and methods acquire electrocardiograms using a first electrode (24) associated with a region of heart tissue and a second body surface electrode. An analog or digital processing element (32) is coupled to the first and second electrodes for conditioning the first electrode to emit a pacing signal (48) and for conditioning the second electrode to sense paced electrocardiograms occurring as a result of the pacing signal. The systems and methods also employ a template of an electrocardiogram of a cardiac event of known diagnosis; for example an arrhythmia that the physician seeks to treat. The systems and methods compare this event-specific template to a sample of a paced electrocardiogram. The comparison yields a matching coefficient indicating how alike the input sample is to the input template. The matching coefficient can be used by the physician, for example to aid in the location of sites that are potentially appropriate for ablation (46).

Abstract translation: 系统和方法使用与心脏组织区域和第二体表电极相关联的第一电极（24）获取心电图。 模拟或数字处理元件（32）耦合到第一和第二电极，用于调节第一电极以发出起搏信号（48），并用于调节第二电极以感测由于起搏信号而产生的起搏心电图。 系统和方法还采用已知诊断的心脏事件的心电图的模板; 例如医师寻求治疗的心律失常。 系统和方法将此事件特定的模板与起搏心电图的样本进行比较。 比较产生一个表示输入样本与输入模板相似度的匹配系数。 匹配系数可由医生使用，例如帮助位置可能适合消融的位置（46​​）。

公开(公告)号：WO1994007413A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009091

申请日：1993-09-24

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  HOUSER, Russell, A. ,  EDWARDS, Stuart, D. ,  KORDIS, Thomas, F.

IPC: A61B05/0402

CPC classification number: A61B5/6852 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/0091 ,  A61B2018/1861 ,  A61B2218/002 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056

Abstract: A system and method for cardiac diagnosis and treatment inserts the distal end of a catheter (18) into a heart chamber. The distal end of the catheter (18) supports at least one electrode (22). The catheter (18) has a fluid flow conduit (62) extending through it. The conduit (62) has a valve (156) that prevents fluid flow from the heart chamber into the conduit (62) in response to in vivo pressure generated during heart systole and diastole. The valve (156) permits fluid flow from the conduit (62) into the heart at a pressure above the in vivo pressure. In use, the catheter (18) locates the electrode (22) in contact with a portion of the endocardium, and fluid is conducted from an external source through the conduit (62) at a pressure above the in vivo pressure to flush the area surrounding the electrode (22).

Abstract translation: 用于心脏诊断和治疗的系统和方法将导管（18）的远端插入心室。 导管（18）的远端支撑至少一个电极（22）。 导管（18）具有延伸通过其的流体流动导管（62）。 导管（62）具有阀（156），其响应于在心脏收缩和舒张期期间产生的体内压力而阻止流体从心室流入导管（62）。 阀（156）允许流体在高于体内压力的压力下从导管（62）流入心脏。 在使用中，导管（18）将电极（22）定位成与心内膜的一部分接触，并且流体在高于体内压力的压力下从外部源通过导管（62）传导以冲洗周围的区域 电极（22）。

公开(公告)号：WO1993001746A1

公开(公告)日：1993-02-04

申请号：PCT/US1992005515

申请日：1992-07-02

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  KWAK, Yoon, T. ,  KOPOLOW, Stephen, L. ,  TAZI, Mohammed

IPC: A61B05/0402

CPC classification number: A61K47/32 ,  A61B5/04087 ,  A61K9/0014

Abstract: What is provided herein is an electrically conductive gel composition for use in establishing a low resistance contact between an electrode and a biological body, comprising a clear, aqueous solution of about 0.1 to 3 % by weight of a crosslinked, neutralized copolymer of maleic anhydride and a C1-C5 alkyl vinyl ether. In the preferred form of the invention, the composition contains about 0.1 to 3 % by weight of the crosslinked, neutralized copolymer which contains about 1 to 5 mole % based on the alkyl vinyl ether of a crosslinking agent.

公开(公告)号：WO1992017112A1

公开(公告)日：1992-10-15

申请号：PCT/US1992002361

申请日：1992-03-26

Applicant: ALLEGHENY-SINGER RESEARCH INSTITUTE

Inventor： ALLEGHENY-SINGER RESEARCH INSTITUTE ,  CANO, Gerald, G.

IPC: A61B05/0402

CPC classification number: A61B5/04087

Abstract: The present invention is directed to an electrode (1) for use in measuring low level signals amidst competing noise signals. The electrode (1) includes an electrically non-conductive substrate (2) having a closed loop (3) of electrical conductive and adhesive material carried by the substrate (2) which defines therein an open area on the substrate (2). A first electrically conductive terminal (4) is embedded within the closed loop (3) of electrically conductive and adhesive material. Within the open area is an inner mass (6) of electrically conductive and adhesive material. The inner mass (6) of electrically conductive and adhesive material is spaced from the closed loop (3). The electrode (1) also includes a second electrically conductive terminal (5) which is embedded with the inner mass (6) of electrically conductive and adhesive material. The electrode (1) includes a first contract device (3) for making electrical contact with the first terminal (4) and a second contact device (7) for making electrical contact with the second terminal (5).

公开(公告)号：WO1998019595A1

公开(公告)日：1998-05-14

申请号：PCT/US1997020067

申请日：1997-11-06

Applicant: NOVOSTE CORPORATION

Inventor： NOVOSTE CORPORATION ,  LARSEN, Charles, E. ,  TRIP, Roelof ,  JOHNSON, Cheryl, R.

IPC: A61B05/0402

CPC classification number: H01L35/00 ,  A61B5/0422 ,  A61B18/02 ,  A61B18/1492 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2018/00047 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/0212 ,  A61B2018/0237 ,  A61B2018/0243 ,  A61N1/28

Abstract: Methods and apparatus are disclosed for use in procedures related to the electrophysiology of the heart, such as identifying or evaluating the electrical activity of the heart, diagnosing and/or treating conditions associated with the electrophysiology of the heart. An apparatus (200) having thermocouple elements (206, 208) of different electromotive potential conductively connected at a junction (210) is introduced into the interior of the heart and a section of heart tissue is contacted with the junction (210). An electrical current is passed through the thermocouple elements (206, 208) to reduce the temperature of the junction in accordance with the Peltier effect and thereby cool contacted heart tissue. The effect of the cooling may be monitored and, if desired, the section of heart tissue may be treated.

Abstract translation: 公开了用于与心脏电生理学有关的方法的方法和装置，例如鉴​​定或评估心脏的电活动，诊断和/或治疗与心脏的电生理学相关的病症。 具有在结（210）处导电连接的不同电动势的热电偶元件（206,208）的装置（200）被引入到心脏的内部，心脏组织的一部分与结点（210）接触。 电流通过热电偶元件（206,208），以根据珀尔帖效应降低结点的温度，从而冷却接触的心脏组织。 可以监测冷却的效果，并且如果需要，可以处理心脏组织的部分。

公开(公告)号：WO1997024060A1

公开(公告)日：1997-07-10

申请号：PCT/US1996005635

申请日：1996-04-22

Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY

Inventor： MINNESOTA MINING AND MANUFACTURING COMPANY ,  CARIM, Hatim, M. ,  BURTON, Scott, A.

IPC: A61B05/0402

CPC classification number: A61B5/411 ,  A61B5/04025 ,  A61B2562/0215 ,  A61B2562/0217

Abstract: Systems and methods of conditioning skin (10) by passing electrical energy through a medical electrode (12A, 12B, 12C). A method of reconditioning a medical electrode by passing electric energy through the electrode. An electrode having electrolyte including an agent to reduce skin discomfort.

Abstract translation: 通过使电能通过医疗电极（12A，12B，12C）来调理皮肤（10）的系统和方法。 一种通过使电能通过电极来修复医用电极的方法。 一种具有电解质的电极，包括用于减轻皮肤不适的药剂。

公开(公告)号：WO1996025095A1

公开(公告)日：1996-08-22

申请号：PCT/US1996002090

申请日：1996-02-14

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  SWANSON, David, K. ,  PANESCU, Dorin

IPC: A61B05/0402

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/6858 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056 ,  A61N1/3702 ,  A61N1/403

Abstract: Analog or digital systems (10) and methods generate a composite signal derived from a biological event in a time sequential fashion. A first set of signals derived from a biological event using a first group of sensors (20) during a first time interval is input. A second set of signals derived from the biological event during a second time interval sequentially after the first time interval using a second group of sensors (36) is input. The second group of sensors has at least one common sensor that is part of the first group and other sensors that are not part of the first group. The first and second sets of signals are time aligned using signals sensed by the at least one common sensor, thereby generating the composite signal. The time alignment is done by shifting the first and second sets of signals either with or without computing a time difference between them.

Abstract translation: 模拟或数字系统（10）和方法以时间顺序的方式产生从生物事件导出的复合信号。 输入在第一时间间隔期间使用第一组传感器（20）从生物事件导出的第一组信号。 输入使用第二组传感器（36）在第一时间间隔之后的第二时间间隔期间从生物事件导出的第二组信号。 第二组传感器具有至少一个共同的传感器，其是第一组的一部分和不是第一组的一部分的其它传感器。 使用由至少一个公共传感器感测的信号来对第一和第二组信号进行时间对准，从而产生复合信号。 时间对准是通过移动第一和第二组信号来完成的，无论是否计算它们之间的时间差。

公开(公告)号：WO1994007411A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009055

申请日：1993-09-24

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  EDWARDS, Stuart, D. ,  KORDIS, Thomas, F. ,  SWANSON, David, K.

IPC: A61B05/0402

CPC classification number: A61B5/6856 ,  A61B5/0422 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6859 ,  A61B18/14 ,  A61B18/18 ,  A61B2562/0209 ,  A61B2562/043 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  A61N1/056 ,  Y10T29/49002 ,  Y10T29/49117 ,  C08L1/02

Abstract: An electrode assembly for use in inter-ventricular cardiac mapping includes one or more elongated splines (76) each of which carries a plurality of spaced apart electrodes (22) thereon. The body of each spline is formed of a plurality of alternating electrically conductive layers (86, 98) and the electrically nonconductive layers (88, 100). A separate electrically conductive pathway (94, 102) is provided to connect each of the electrodes to a different one of the conductive layers. Each of the layers is electrically connected to an electrical signal processing device (92) so that signals provided by each of the electrodes can be processed.

Abstract translation: 用于心室间心脏图像的电极组件包括一个或多个细长花键（76），每个细长花键在其上承载有多个间隔开的电极（22）。 每个花键的主体由多个交替导电层（86,98）和非导电层（88,100）形成。 提供单独的导电路径（94,102）以将每个电极连接到不同的一个导电层。 每个层电连接到电信号处理装置（92），使得可以处理由每个电极提供的信号。

公开(公告)号：WO1998022791A3

公开(公告)日：1998-05-28

申请号：PCT/IL1997000362

申请日：1997-11-10

Applicant: CARDIOSOL LTD. ,  KLETSKIN, Solomon

Inventor： CARDIOSOL LTD.

IPC: A61B05/0402

公开(公告)号：WO1997004703A1

公开(公告)日：1997-02-13

申请号：PCT/US1996012100

申请日：1996-07-23

Applicant: CARDIOTRONICS INTERNATIONAL, INC.

Inventor： CARDIOTRONICS INTERNATIONAL, INC. ,  KELLY, Robert, J. ,  LAVINE, Thomas

IPC: A61B05/0402

CPC classification number: A61B5/04085

Abstract: A disposable electro-dermal connector device (10) comprising a flexible non-conductive sheet (11) having a fixed array of electrical strips (12) affixed thereon, and positioned in a specific size configuration normally used for electro-cardia recording, is disclosed. The connector strips (12) have a receptor pad end (22) adapted for electrical connection with the skin for receiving electrical impulses, and a terminal connection end (23) which is adapted for connection with an electrocardiology measuring apparatus. Receptor pads (V1)(V2) are attached approximately over the sternum at the fourth intercostal space, and receptor pads (V3)(V4) are attached over the ribs, the distance between (V1)(V2), (V2)(V3)(V4) is 1.75 inches plus or minus 0.56 inch.

Abstract translation: 公开了一种一次性电皮肤连接器装置（10），其包括具有固定在其上的电条（12）的固定阵列的柔性非导电片（11），并定位在通常用于电灼记录的特定尺寸配置中 。 连接器条（12）具有适于与皮肤电连接以接收电脉冲的接收器垫端（22）和适于与心电图测量装置连接的端子连接端（23）。 受体垫（V1）（V2）在第四肋间距大致位于胸骨周围，受体垫（V3）（V4）附着在肋上，（V1）（V2），（V2）（V3 ）（V4）为1.75英寸加或减0.56英寸。