公开(公告)号：WO2021040519A1

公开(公告)日：2021-03-04

申请号：PCT/NL2020/050527

申请日：2020-08-26

Applicant: STICHTING VUMC ,  STICHTING VU

Inventor： RUIJTER, Eelco ,  RONG, Mark Karsten ,  SPEER, Alexander ,  BITTER, Wilhelmus ,  COLE, Stewart Thomas

IPC: C07D285/08 ,  C07D417/04 ,  A61K31/4436 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/506 ,  A61P31/04 ,  A61P31/06

Abstract: The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as a Mycobacterium tuberculosis infection, e.g., in a respiratory system and/or extrapulmonic. The invention further relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds as chemotherapeutic agents. Also, the invention relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds for inhibiting mycobacterial type VII secretion. The compounds have the following formula (Ia), wherein Q and X are, respectively, CH and C, CR2 and C, CH and N, CR2 and N, or N and C; R1 is hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms; R2 is independently selected from hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms, and R3 is optionally substituted linear or branched alkoxy having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms, n-propyl, 2-propenyl, 2-propynyl, or n-pentyl, or a pharmaceutically acceptable salt of the compound, for use in the prevention or treatment of a bacterial infection.

公开(公告)号：WO2020149742A1

公开(公告)日：2020-07-23

申请号：PCT/NL2020/050024

申请日：2020-01-17

Applicant: STICHTING VU

Inventor： IANNUZZI, Davide ,  SCHELTES, Julien Serge

IPC: H04R1/10 ,  H04R1/08

Abstract: The present invention relates to a headphone for use with an audio or mobile communication device, comprising at least one earbud, a microphone, and a wire. The headphone further comprises a stiffening mechanism, which is constructed to be arranged in an actuated state, in which the stiffening mechanism has a first bending stiffness and in which the stiffening mechanism is in a stiff configuration, and in a relaxed state, in which the stiffening mechanism has a second bending stiffness and in which the stiffening mechanism is in a free-hanging configuration. The first bending stiffness is larger than the second bending stiffness. The invention further relates to a method for communicating by means of a headphone, which comprises the steps of arranging, at the onset of communication, a stiffening mechanism of the headphone in an actuated state, in order to position a microphone of the headphone in front of a mouth of the user, and arranging, at the end of communication, the stiffening mechanism in a relaxed state, in order to freely suspend the microphone.

公开(公告)号：WO2020080944A1

公开(公告)日：2020-04-23

申请号：PCT/NL2019/050686

申请日：2019-10-18

Applicant: STICHTING VU

Inventor： AMITONOVA, Liubov Vladimirovna ,  DE BOER, Johannes Fitzgerald

IPC: G01D5/353 ,  G01D5/34 ,  G01H9/00 ,  G01L1/24 ,  G02B27/48 ,  F21V8/00 ,  A61B1/07 ,  A61B1/00 ,  G02B6/036 ,  G01N21/47

Abstract: An imaging system (100) comprises a multimode waveguide (Wm) configured to receive input light (Li) from a light source (20) into its proximal side (13p) and output a corresponding speckle pattern (Pn) based on the input light (Li) out of its distal side (13d) for illuminating a sample (S) to be imaged. A single -mode waveguide (Ws) is connected to the multimode waveguide (Wm) for coupling the input light (Li) from the light source (20) to the multimode waveguide (Wm). The multimode waveguide (Wm) has a relatively short length (Zm) and relatively high flexural rigidity (R) for maintaining a unique relation between the input characteristic (λ,Α) of the input light (Li) into the multimode waveguide (Wm) and a spatial distribution (Ixy) of the speckle pattern (Pn). The single-mode waveguide (Ws) may be relatively long and flexible (F) for allowing movement of the short rigid multimode waveguide (Wm).

公开(公告)号：WO2018224251A1

公开(公告)日：2018-12-13

申请号：PCT/EP2018/062557

申请日：2018-05-15

Applicant: STICHTING VU ,  STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN ,  UNIVERSITEIT VAN AMSTERDAM ,  ASML NETHERLANDS B.V.

Inventor： WITTE, Stefan, Michiel ,  ANTONCECCHI, Alessandro ,  ZHANG, Hao ,  EDWARD, Stephen ,  PLANKEN, Paulus, Clemens, Maria ,  GOORDEN, Sebastianus, Adrianus ,  HUISMAN, Simon, Reinald ,  SETIJA, Irwan, Dani ,  VLES, David, Ferdinand

IPC: G03F9/00

Abstract: A method for determining a characteristic of a feature in an object, the feature being disposed below a surface of the object is disclosed. The surface of the object is irradiated with a pulsed pump radiation beam so as to produce an acoustic wave in the object. The surface of the object is then irradiated with a measurement radiation beam. A portion of the measurement radiation beam scattered from the surface is received and a characteristic of the feature in the object is determined from at least a portion of the measurement radiation beam scattered from the surface within a measurement time period. A temporal intensity distribution of the pulsed pump radiation beam is selected such that in the measurement time period a signal to background ratio is greater than a signal to background ratio achieved using a single pulse of the pulsed pump radiation beam. The signal to background ratio is a ratio of: (a) signals generated at the surface by reflections of acoustic waves from the feature to (b) background signals generated at the surface by reflections of acoustic waves which have not reflected from the feature.

公开(公告)号：WO2018111099A1

公开(公告)日：2018-06-21

申请号：PCT/NL2017/050831

申请日：2017-12-12

Applicant: STICHTING VUMC ,  STICHTING VU

Inventor： SMIT, August Benjamin ,  HOOZEMANS, Jeroen Joseph Maria ,  HONDIUS, David Carolus ,  KWAKKEL, Johanna Maria

IPC: A61K51/10 ,  G01N33/50 ,  G01N33/68

CPC classification number: A61K51/1018 ,  G01N33/5088 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/52

Abstract: The invention relates to biomarkers and diagnostic methods for determining the presence and/or risk of cerebral amyloid angiopathy (CAA) as well as to methods for screening for treatments for CAA.

公开(公告)号：WO2017102406A1

公开(公告)日：2017-06-22

申请号：PCT/EP2016/079770

申请日：2016-12-05

Applicant: STICHTING VU ,  UNIVERSITEIT VAN AMSTERDAM ,  STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN ,  ASML NETHERLANDS B.V.

Inventor： WITTE, Stefan, Michiel ,  EIKEMA, Kjeld, Sijbrand, Eduard

IPC: G03F7/20

CPC classification number: G03F9/7042 ,  G01B15/00 ,  G01N23/2055 ,  G03F7/70625 ,  H05G2/008

Abstract: Lensless imaging metrology using soft x-rays (EUV) radiation to reconstruct a three-dimensional product structure on the substrate. The coherent radiation is scattered by the structure and plural diffraction patterns are captured. Data describing the three-dimensional strucure are reconstructed using numerical phase retrieval algorithms based on the plural diffraction patterns corresponding to different wavelengths or to coherent radiation pulses with varying time delays.

Abstract translation: 使用软X射线（EUV）辐射来重建基底上的三维产品结构的无透镜成像测量。 相干辐射被该结构散射并捕获多个衍射图案。 描述三维结构的数据使用基于对应于不同波长的多个衍射图案的数值相位检索算法或具有变化的时间延迟的相干辐射脉冲重建。

公开(公告)号：WO2016129994A1

公开(公告)日：2016-08-18

申请号：PCT/NL2016/050079

申请日：2016-02-04

Applicant: STICHTING VU

Inventor： BIEBRICHER, Andreas Sebastian ,  CANDELLI, Andrea ,  HELLER, Iddo ,  LAURENS, Niels ,  PETERMAN, Erwin Johannes Gerard ,  WUITE, Gijs Jan Lodewijk

IPC: B01L3/00 ,  G02B21/32

CPC classification number: G02B21/32 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0654 ,  B01L2400/0454 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6439 ,  G02B21/16 ,  G02B21/18 ,  G02B21/361 ,  G02B26/0816 ,  G02B27/106 ,  G02B27/141 ,  G02B27/283

Abstract: The present disclosure relates to an apparatus (100) and method for controlling a plurality of simultaneously active optical traps (OT1,OT2,OT3). In one method, trapping beams (TB1,TB2,TB3) are provided and redirected for individually controlling a respective position (X,Y) of optical traps (OT1,OT2,OT3) formed by focusing of the redirected trapping beams in a sample volume (SV). Light (L11,L20) from the sample volume (SV) corresponding to the optical traps is received. A path of a detector beam (AB) is overlapped with one of the trapping beams (TB3), wherein the detector beam has a distinct wavelength (λA) from that of the overlapping trapping beam (TB3). In one channel, the light from the sample volume is filtered according to wavelength, and only the filtered light having the wavelength (λA) of the detector beam (AB) is measured.

Abstract translation: 本发明涉及一种用于控制多个同时有效的光阱（OT1，OT2，OT3）的装置（100）和方法。 在一种方法中，提供俘获光束（TB1，TB2，TB3）并重定向，以单独控制通过将重定向捕获光束聚焦在样本体积中形成的光学陷阱（OT1，OT2，OT3）的相应位置（X，Y） （SV）。 从与光阱相对应的样品体积（SV）接收光（L11，L20）。 检测器光束（AB）的路径与捕获光束（TB3）中的一个重叠，其中检测器光束具有与重叠捕获光束（TB3）的不同波长（λA）。 在一个通道中，根据波长对来自样品体积的光进行滤波，并且仅测量具有检测器束（AB）的波长（λA）的滤波光。

公开(公告)号：WO2016122320A1

公开(公告)日：2016-08-04

申请号：PCT/NL2016/050064

申请日：2016-01-27

Applicant: STICHTING VU-VUMC ,  STICHTING VUMC

Inventor： VAN DER VLIET, Johannes Jelle ,  DE GRUIJL, Tanja Denise ,  VERHEUL, Hendrik Marinus Willem ,  DE BRUIN, Renée Cornelia Gerarda ,  LAMERIS, Roland

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  C07K16/2833 ,  C07K16/30 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/75

Abstract: The invention relates to compounds, in particular polypeptides that specifically bind to the non-classical MHC protein CD1d and modulate CD1d-mediated biological functions. The invention in particular relates to such compounds and polypeptides comprising or consisting of at least one single domain antibody, and wherein at least one single domain antibody specifically binds to CD1d. Also provided is for methods and use employing such compounds, polypeptides and/or single-domain antibodies.

Abstract translation: 本发明涉及化合物，特别是与非经典MHC蛋白质CD1d特异性结合并调节CD1d介导的生物功能的多肽。 本发明特别涉及包含至少一个单结构域抗体或由至少一个单结构域抗体组成的这样的化合物和多肽，并且其中至少一个单结构域抗体特异性结合CD1d。 还提供了使用这种化合物，多肽和/或单域抗体的方法和用途。

公开(公告)号：WO2016079194A1

公开(公告)日：2016-05-26

申请号：PCT/EP2015/076989

申请日：2015-11-18

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  STICHTING VU-VUMC

Inventor： NAVIS, Anna Catharina ,  LEENDERS, Wilhelmus Petrus Johannes ,  WÜRDINGER, Thomas

IPC: C12Q1/68

CPC classification number: G01N33/5748 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/574 ,  G01N33/74 ,  G01N2333/71

Abstract: The present invention relates to the fields of medicine and molecular diagnostics. In particular, it relates to a novel method for the treatment, prevention and/or delay of cancer and to a diagnostic method involving detection of a novel auto-active and intracellular mutant of MET.

Abstract translation: 本发明涉及药物和分子诊断领域。 特别涉及用于治疗，预防和/或延缓癌症的新方法以及涉及检测MET的新型自身活性和细胞内突变体的诊断方法。

公开(公告)号：WO2014200341A1

公开(公告)日：2014-12-18

申请号：PCT/NL2014/050377

申请日：2014-06-11

Applicant: STICHTING VU-VUMC

Inventor： PETERMAN, Erwin Johannes Gerard ,  WUITE, Gijs Jan Lodewijk ,  SITTERS, Gerrit ,  KAMSMA, Douwe

IPC: G02B21/32 ,  B82Y35/00

CPC classification number: C12Q1/6837 ,  G01N29/0681 ,  G02B21/32

Abstract: A molecular manipulation system for investigating molecules,having a sample holder constructed to hold a sample comprising a plurality of molecules attached on one side to a surface in the sample holder and on another side attached to a microbead of a plurality of microbeads. The system having; an acoustic wave generator to generate an acoustic wave exerting a force on the microbeads in the sample; anda detector device to detect a response of the plurality of microbeads in the sample on the force exerted by the acoustic wave to investigate the molecules attached to the microbeads.

Abstract translation: 一种用于调查分子的分子操纵系统，具有样品架，其被构造成将包含附着在一侧的多个分子的样品保持在样品保持器中的表面上，另一侧附着在多个微珠的微珠上。 系统有 声波发生器，用于产生在样品中的微珠上施加力的声波; 以及检测器装置，用于检测样品中的多个微珠对由声波施加的力的响应，以研究附着于微珠的分子。