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    Therapeutic agents
    191.
    发明专利
    Therapeutic agents 未知

    公开(公告)号：GB201321733D0

    公开(公告)日：2014-01-22

    申请号：GB201321733

    申请日：2013-12-09

    Applicant: UCB PHARMA SA

    Abstract: A series of substituted pyrazolo[1,5-a]pyridine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

    Therapeutic agents
    192.
    发明专利
    Therapeutic agents 未知

    公开(公告)号：GB201321732D0

    公开(公告)日：2014-01-22

    申请号：GB201321732

    申请日：2013-12-09

    Applicant: UCB PHARMA SA

    Abstract: A series of substituted imidazo[l,2-b][l,2,4]triazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

    Injector
    199.
    发明专利
    Injector 未知

    公开(公告)号：GB201314381D0

    公开(公告)日：2013-09-25

    申请号：GB201314381

    申请日：2013-08-12

    Applicant: UCB PHARMA SA

    Abstract: Provided is a manual drive unit for use with a cassette unit comprising a cassette unit housing containing there within a syringe comprising a barrel for containing a volume of a liquid drug formulation; a hollow needle at a front end of the barrel, the hollow needle defining a needle tip for dispensing of the liquid drug formulation; and a plunger that is axially movable within the barrel. The manual drive unit comprises a manual drive unit housing defining a docking cavity and a needle delivery aperture, wherein said docking cavity is arranged for docking receipt of the cassette unit at a docking position; and received by the manual drive unit housing and axially movable relative thereto, a manually operable drive transfer element for transferring axial drive to the plunger of the syringe for moving the plunger into the barrel of the syringe to eject at least part of the volume of liquid drug formulation.

    SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES
    200.
    发明专利
    SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES 未知

    公开(公告)号：CA2865261A1

    公开(公告)日：2013-08-29

    申请号：CA2865261

    申请日：2013-02-22

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE

    IPC: C07K16/00

    Abstract: The present disclosure provides an asymmetric mixed antibody comprising two heavy chains or heavy chain fragments each comprising at least a variable region, a hinge region and a CH1 domain, wherein a first heavy chain or fragment thereof is a class IgG4 and has: a the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, and wherein the second heavy chain or fragment thereof is characterised in that part or all of the chain has a different amino acid sequence to said first heavy chain in at least the region outside the variable region (for example the constant region), formulations comprising the same, therapeutic used of both of the above, and processes for preparing the antibodies and formulation.

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