公开(公告)号：AU2010299640B2

公开(公告)日：2016-02-25

申请号：AU2010299640

申请日：2010-09-23

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

IPC: C12N9/50 ,  C12P21/00

Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a. a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b. a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c. a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated Deg P gene and optionally a polynucleotide sequence encoding a protein of interest.

公开(公告)号：SG182279A1

公开(公告)日：2012-08-30

申请号：SG2012047668

申请日：2011-01-13

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell comprises a non-recombinant wild-type chromosomal Tsp gene.

公开(公告)号：SG10201807560XA

公开(公告)日：2018-10-30

申请号：SG10201807560X

申请日：2012-07-13

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

Abstract: BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC The present invention provides a recombinant gram-negative bacterial cell comprising and expression vector comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen binding fragment thereof specifically binding to CD154.

公开(公告)号：AU2017200545B2

公开(公告)日：2018-10-25

申请号：AU2017200545

申请日：2017-01-27

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

IPC: C07K16/24 ,  C12N9/48 ,  C12N15/70 ,  C12P21/02

Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell comprises a non recombinant wild-type chromosomal Tsp gene. 8846157 1 (GHMailers- P90772 A[ J 1 27-Jn-17

公开(公告)号：BR112013032871A2

公开(公告)日：2017-01-24

申请号：BR112013032871

申请日：2012-07-13

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  ELLIS MARK

IPC: C07K16/28 ,  C12N15/70

Abstract: 1/1 resumo “cepa hospedeira bacteriana que expressa dsbc recombinante” a presente invenção fornece uma célula bacteriana gram-negativa recombinante que compreende um vetor de expressão que compreende um polinucleotídeo recombinante que codifica dsbc e um ou mais polinucleotídeos que codificam um anticorpo ou um fragmento de ligação de antígeno deste que liga-se especificamente a cd154.

公开(公告)号：AU2011206586B2

公开(公告)日：2016-10-27

申请号：AU2011206586

申请日：2011-01-13

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

IPC: C07K16/24 ,  C12N9/48 ,  C12N15/70 ,  C12P21/02

Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell comprises a non-recombinant wild-type chromosomal Tsp gene.

公开(公告)号：SG10201606462WA

公开(公告)日：2016-09-29

申请号：SG10201606462W

申请日：2010-09-23

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a. a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b. a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c. a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity ; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated Deg P gene and optionally a polynucleotide sequence encoding a protein of interest.

公开(公告)号：AU2016201536A1

公开(公告)日：2016-03-24

申请号：AU2016201536

申请日：2016-03-09

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

IPC: C12N9/50 ,  C12P21/00

Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a. a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b. a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c. a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity ; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated Deg P gene and optionally a polynucleotide sequence encoding a protein of interest. 7493670_1 (GHMatters) P89876.AU.1

公开(公告)号：IN202DEN2014A

公开(公告)日：2015-06-05

申请号：IN202DEN2014

申请日：2014-01-09

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

IPC: C07K16/28 ,  C12N15/70

Abstract: The present invention provides a recombinant gram negative bacterial cell comprising and expression vector comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen binding fragment thereof specifically binding to CD154.

公开(公告)号：AU2012283388A1

公开(公告)日：2014-01-09

申请号：AU2012283388

申请日：2012-07-13

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

IPC: C07K16/28 ,  C12N15/70

Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector, comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen binding fragment thereof specifically binding to CD154.