公开(公告)号：EP0553279A1

公开(公告)日：1993-08-04

申请号：EP91920372.0

申请日：1991-10-15

Applicant: ML TECHNOLOGY VENTURES, L.P.

Inventor： MARIANIK, Charles, G., J. ,  ZARATE, Carlos, E. ,  LEVY, Gilbert, M.

IPC: G01J3

CPC classification number: G01J3/02 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/12 ,  G01J2003/1278 ,  G01J2003/1286 ,  G01N2201/067

Abstract: Un monochromateur à accès sélectif est décrit. Ce dispositif ne contient pas d'éléments mécaniques et élimine la nécessité de balayer séquentiellement les longueurs d'ondes de la lumière contenue dans un spectre lumineux pour sélectionner une ou des longueur(s) d'ondes voulues dans le spectre. Le dispositif comprend des moyens de commutation de grande vitesse (16), permet de sélectionner simultanément des longueurs d'ondes et des largeurs de bande multiples, et possède la capacité de corriger la non-linéarité dans des prismes, causée par la dispersion non-linéaire ou de second ordre de la lumière.

公开(公告)号：EP0468487A3

公开(公告)日：1992-04-29

申请号：EP91112449.3

申请日：1991-07-24

Applicant: SHOWA DENKO KABUSHIKI KAISHA

Inventor： Tokieda, Tsunemi, c/o SHOWA DENKO K.K. ,  Ishida, Norio

IPC: G01J4/04 ,  G01N21/21

CPC classification number: G01J4/04 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2201/067 ,  G01N30/74

Abstract: In a detection apparatus, a linearly polarized light beam polarized in a polarizer (62) is converted by being transmitted through a Pockels cell (60), driven by an alternative voltage, into an alternative linearly polarized light beam and a circularly polarized light beam, which is transmitted through a sample solution flowing through a flow cell (68). The transmitted light beam is separated into two polarized light components, and an intensity thereof is measured to obtain a signal proportional to an angle of rotation by the sample solution. A signal corresponding to an angle of rotation caused by an optical rotary power of the sample solution is obtained by subtracting the signal obtained during irradiation of the circularly polarized light from the signal obtained during irradiation of the linearly polarized light. The sample solution (18) is infused into an optical path of the flow cell (68) under a condition where mean velocity is 0.5 to 5 m/sec.

公开(公告)号：EP0468487A2

公开(公告)日：1992-01-29

申请号：EP91112449.3

申请日：1991-07-24

Applicant: SHOWA DENKO KABUSHIKI KAISHA

Inventor： Tokieda, Tsunemi, c/o SHOWA DENKO K.K. ,  Ishida, Norio

IPC: G01J4/04 ,  G01N21/21

CPC classification number: G01J4/04 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2201/067 ,  G01N30/74

Abstract: In a detection apparatus, a linearly polarized light beam polarized in a polarizer (62) is converted by being transmitted through a Pockels cell (60), driven by an alternative voltage, into an alternative linearly polarized light beam and a circularly polarized light beam, which is transmitted through a sample solution flowing through a flow cell (68). The transmitted light beam is separated into two polarized light components, and an intensity thereof is measured to obtain a signal proportional to an angle of rotation by the sample solution. A signal corresponding to an angle of rotation caused by an optical rotary power of the sample solution is obtained by subtracting the signal obtained during irradiation of the circularly polarized light from the signal obtained during irradiation of the linearly polarized light. The sample solution (18) is infused into an optical path of the flow cell (68) under a condition where mean velocity is 0.5 to 5 m/sec.

Abstract translation: 在一检测装置，在一个偏振器偏振（62）的线偏振光束由被反通过普克尔斯盒（60）mitted，通过在交流电压驱动，变成在备选线性偏振光束和圆偏振光束转换， 这是通过流过流单元（68）的样品溶液反式mitted。 反式mitted光束被分成两个偏振光分量，和强度的测量其在由样品溶液的旋转角，以获得一个信号成比例。 的信号，以通过向样品溶液的光学旋转功率引起的旋转角度相对应的是通过减去线性偏振光的照射期间得到的信号的圆偏振光的照射期间得到的信号中获得。 将样品溶液（18），其中平均流速为0.5〜5米/秒的条件下注入到流动池（68）的光路中。

公开(公告)号：EP0337054A3

公开(公告)日：1991-01-16

申请号：EP89100386.5

申请日：1989-01-11

Applicant: Hartmann & Braun Aktiengesellschaft

Inventor： Zöchbauer, Michael ,  Fabinski, Walter

IPC: G01J3/26 ,  G01N21/45

CPC classification number: G01N21/31 ,  G01J3/26 ,  G01N2201/067

Abstract: Interferometrische Einrichtung zum Nachweis einer Substanz mit strukturiertem Absorptionsspektrum mit einer Strahlungsquelle (L), in deren Strahlengang die zu untersuchende Substanz (K), ein Interferenzfilter, dessen Dicke den Abstand der Interferenz­linien bestimmt und ein Detektor (D) angeordnet sind. Das Inter­ferenzfilter ist ein elektrisch abstimmbares Filter (E) mit einer Platte aus elektrooptischem Material (P) und teildurch­lässig verspiegelten Stirnseiten (S).

Abstract translation: 一种用于通过具有待检测物质（K）的辐射源（L）检测具有结构化吸收光谱的物质的干涉装置，其厚度确定干涉线的间距的干涉滤光器和其中的检测器（D） 光束路径。 干涉滤光器是包含电光材料板（P）和部分吸收金属化端面（S）的电可调滤光器（E）。 ... ...

公开(公告)号：US12071664B2

公开(公告)日：2024-08-27

申请号：US17939760

申请日：2022-09-07

Applicant: Pacific Biosciences of California, Inc.

Inventor： Adrian Fehr ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

IPC: C12Q1/6874 ,  B01L3/00 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  G01N21/75 ,  G01N21/77 ,  G01N33/543 ,  G02B6/122

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G02B6/1226 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  Y10T436/143333

Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

公开(公告)号：US20240272066A1

公开(公告)日：2024-08-15

申请号：US18438513

申请日：2024-02-11

Applicant: Zhenhong Yu ,  James William Assif

Inventor： Zhenhong Yu ,  James William Assif

IPC: G01N21/17

CPC classification number: G01N21/1702 ,  G01N2201/067 ,  G01N2201/0691

Abstract: The present disclosure is directed to a photoacoustic excitation device comprising an amplitude modulator to control emitted light beam.

公开(公告)号：US20190170649A1

公开(公告)日：2019-06-06

申请号：US16210311

申请日：2018-12-05

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Yuichi WAKAMOTO ,  Koseki KOBAYASHI

IPC: G01N21/65 ,  G01J3/44 ,  G01L1/24 ,  C12Q1/6816

CPC classification number: G01N21/65 ,  C12Q1/6816 ,  G01J3/44 ,  G01L1/242 ,  G01N2021/0143 ,  G01N2201/067

Abstract: An objective cell is irradiated with laser beam of a predetermined wavelength. Only Stokes light is selected out of detected light including reflected light and scattered light of the laser beam, and a Raman scattering spectrum is obtained by dispersion of the selected Stokes light. A transcriptome of the objective cells is estimated, based on the Raman scattering spectrum. It is preferable to estimate the transcriptome of the objective cells, based on N-dimensional Raman data obtained by dimensional reduction of the Raman scattering spectrum. This configuration only needs to irradiate the objective cell with the laser beam and does not require to destroy the objective cell. As a result, this enables the transcriptome of the cell to be estimated in a short time period without destroying the cell.

公开(公告)号：US20170285063A1

公开(公告)日：2017-10-05

申请号：US15485261

申请日：2017-04-12

Applicant: United States of America, as represented by the Secretary of the Army

Inventor： Bradley W. Libbey ,  James D. Perea

IPC: G01P3/36

CPC classification number: G01P3/36 ,  G01H9/00 ,  G01H9/002 ,  G01N21/1702 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/0683 ,  G01N2201/12

Abstract: A laboratory system has demonstrated the measurement of three degrees of vibrational freedom simultaneously using a single beam through heterodyne speckle imaging. The random interference pattern generated by the illumination of a rough surface with coherent light can be exploited to extract information about the surface motion. The optical speckle pattern is heterodyne mixed with a coherent reference. The recorded optical data is then processed to extract three dimensions of surface motion. Axial velocity is measured by demodulating the received time-varying intensity of high amplitude pixels. Tilt, a gradient of surface velocity, is calculated by measuring speckle translation following reconstruction of the speckle pattern from the mixed signal.

公开(公告)号：US09702812B2

公开(公告)日：2017-07-11

申请号：US14706743

申请日：2015-05-07

Applicant: Theodore Peter Rakitzis

Inventor： Theodore Peter Rakitzis

IPC: G01N21/19 ,  G01J4/02 ,  G01J4/04 ,  G01N21/21 ,  G01J4/00

CPC classification number: G01N21/19 ,  G01J4/02 ,  G01J4/04 ,  G01J2004/001 ,  G01N21/21 ,  G01N2201/06113 ,  G01N2201/0636 ,  G01N2201/067

Abstract: A polarimeter for measuring chirality of a material comprising an optical ring cavity comprising a plurality of reflective elements configured to promote bi-directional propagation of a laser beam within the cavity, a laser-emitting device configured to introduce a first input laser beam and a second input laser beam into the ring cavity, and a Faraday rotator and a phase compensator configured to suppress a birefringent background as the first and second laser beams pass through the ring cavity, wherein the plurality of mirrors, Faraday rotator, and phase compensator are configured such that light from the first and second laser beams passes through a chiral material located within the cavity a sufficient number of times for a measurement of optical rotary dispersion (ORD) and circular dichroism (CD) of light transmitted through the chiral material to be obtained. Particular implementations include monolithic ring cavities or microresonators or use of intra-cavity gain media.

公开(公告)号：US20170156646A1

公开(公告)日：2017-06-08

申请号：US15239309

申请日：2016-08-17

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: A61B5/145 ,  A61B5/1455 ,  G01N33/49 ,  G01N21/49 ,  G01N21/359 ,  G01N33/483

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.