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    PROCESS FOR THE REMOVAL OF NITROPHENOLIC COMPOUNDS IN THE PRODUCTION OF NITROBENZENE
    201.
    发明申请
    PROCESS FOR THE REMOVAL OF NITROPHENOLIC COMPOUNDS IN THE PRODUCTION OF NITROBENZENE 审中-公开
    硝基苯酚化合物在硝基苯生产中的去除方法

    公开(公告)号：WO2014122596A4

    公开(公告)日：2015-02-26

    申请号：PCT/IB2014058814

    申请日：2014-02-05

    Applicant: CUF QUÍMICOS IND S A

    Inventor： FRANÇA GOMES RIBEIRO ALEJANDRO ,  MARTINS DA SILVA DULCE CRISTINA ,  DOS SANTOS GAUD NCIO BAPTISTA CRISTINA MARIA

    IPC: C07C201/16 ,  C02F1/00

    CPC classification number: C07C201/16 ,  C02F1/26 ,  C02F2101/345 ,  C02F2101/38 ,  C07C205/06 ,  C07C205/23 ,  C07C205/24

    Abstract: The present application describes a process for the removal of undesirable by-products, namely organic acids, nitrophenols, in particular dinitrophenol and/or trinitrophenol, in nitrated streams, namely in processes for the production of mononitrobenzene by benzene nitration. Namely, it describes a process for the removal of nitrophenolic impurities/compounds, namely dinitrophenol and/or trinitrophenol, in particular dinitrophenol and trinitrophenol or trinitrophenol, from a product stream comprising mononitrobenzene, with an alkaline washing procedure, in a continuous, counter-current mode, preferably in a multistage, in particular 1-2-3... n stages, mixing/decanter system, wherein the alkaline washing comprises the following steps: a mixing stage of a stream comprising a nitrated aromatic compound in the presence of nitrophenols, with a stream comprising an alkaline solution with an ammonia concentration up to 0.5 % (m/m); a liquid-liquid extraction of the resulting mixture, with recovery of the organic phase.

    Abstract translation: 本申请描述了在硝化流中，即通过苯硝化生产单硝基苯的方法中除去不期望的副产物，即有机酸，硝基苯酚，特别是二硝基苯酚和/或三硝基苯酚的方法。 即，它描述了从包含单硝基苯的产物流中以硝酸苯酚和/或三硝基苯酚，特别是二硝基苯酚和/或三硝基苯酚，以碱性洗涤方法连续逆流除去硝基苯酚和/或三硝基苯酚的方法。 模式，优选多级，特别是1-2-3 ...阶段，混合/滗析器系统，其中碱洗涤包括以下步骤：在硝基苯酚存在下包含硝化芳族化合物的流的混合阶段 ，其中包含氨浓度高达0.5％（m / m）的碱性溶液的流; 对所得混合物进行液 - 液萃取，同时回收有机相。

    PROCESS FOR THE REMOVAL OF NITROPHENOLIC COMPOUNDS IN THE PRODUCTION OF NITROBENZENE
    202.
    发明申请
    PROCESS FOR THE REMOVAL OF NITROPHENOLIC COMPOUNDS IN THE PRODUCTION OF NITROBENZENE 审中-公开
    硝基苯酚化合物在硝基苯生产中的去除方法

    公开(公告)号：WO2014122596A3

    公开(公告)日：2014-12-24

    申请号：PCT/IB2014058814

    申请日：2014-02-05

    Applicant: CUF QUÍMICOS IND S A

    Inventor： FRANÇA GOMES RIBEIRO ALEJANDRO ,  MARTINS DA SILVA DULCE CRISTINA ,  DOS SANTOS GAUD NCIO BAPTISTA CRISTINA MARIA

    IPC: C07C201/16 ,  C02F1/00

    CPC classification number: C07C201/16 ,  C02F1/26 ,  C02F2101/345 ,  C02F2101/38 ,  C07C205/06 ,  C07C205/23 ,  C07C205/24

    Abstract: The present application describes a process for the removal of undesirable by-products, namely organic acids, nitrophenols, in particular dinitrophenol and/or trinitrophenol, in nitrated streams, namely in processes for the production of mononitrobenzene by benzene nitration. Namely, it describes a process for the removal of nitrophenolic impurities/compounds, namely dinitrophenol and/or trinitrophenol, in particular dinitrophenol and trinitrophenol or trinitrophenol, from a product stream comprising mononitrobenzene, with an alkaline washing procedure, in a continuous, counter-current mode, preferably in a multistage, in particular 1-2-3... n stages, mixing/decanter system, wherein the alkaline washing comprises the following steps: a mixing stage of a stream comprising a nitrated aromatic compound in the presence of nitrophenols, with a stream comprising an alkaline solution with an ammonia concentration up to 0.5 % (m/m); a liquid-liquid extraction of the resulting mixture, with recovery of the organic phase.

    Abstract translation: 本申请描述了在硝化流中，即通过苯硝化生产单硝基苯的方法中除去不期望的副产物，即有机酸，硝基苯酚，特别是二硝基苯酚和/或三硝基苯酚的方法。 即，它描述了从包含单硝基苯的产物流中以硝酸苯酚和/或三硝基苯酚，特别是二硝基苯酚和/或三硝基苯酚，以碱性洗涤方法连续逆流除去硝基苯酚和/或三硝基苯酚的方法。 模式，优选多级，特别是1-2-3 ...阶段，混合/滗析器系统，其中碱洗涤包括以下步骤：在硝基苯酚存在下包含硝化芳族化合物的流的混合阶段 ，其中包含氨浓度高达0.5％（m / m）的碱性溶液的流; 对所得混合物进行液 - 液萃取，同时回收有机相。

    REMOVAL OF NON-AROMATIC IMPURITIES FROM A NITRATION PROCESS
    205.
    发明申请
    REMOVAL OF NON-AROMATIC IMPURITIES FROM A NITRATION PROCESS 审中-公开
    从硝化过程中去除非芳香污染物

    公开(公告)号：WO2012110839A1

    公开(公告)日：2012-08-23

    申请号：PCT/IB2011/000306

    申请日：2011-02-17

    Applicant: NORAM INTERNATIONAL LIMITED ,  GUENKEL, Alfred, A. ,  BERRETTA, Sergio

    Inventor： GUENKEL, Alfred, A. ,  BERRETTA, Sergio

    IPC: C07C201/08 ,  C07C201/16 ,  C07C205/06

    CPC classification number: C07C201/16 ,  Y02P20/582 ,  C07C205/06 ,  C07C205/12

    Abstract: A method and apparatus for removing non-aromatic impurities from non- nitrated aromatic reactant in a nitration production process, in which process an aromatic reactant is nitrated (100) to produce a nitrated aromatic product using a molar excess of the aromatic reactant, and non-nitrated aromatic reactant is recovered (102) from the produced nitrated aromatic product and is recycled (104) for use in the nitration production process. A portion of the removed excess non-nitrated aromatic reactant is diverted (106) and subjected to nitration (108). The nitrated stream may be further processed by separating out the spent acids (1 10) and the non-aromatic impurities (116). These streams may be sent (114, 118) to a suitable location in the nitration production train.

    Abstract translation: 一种用于在硝化生产过程中从非硝化芳族反应物除去非芳族杂质的方法和装置，其中芳族反应物被硝化（100）以产生使用摩尔过量的芳族反应物的硝化芳族产物， 硝酸芳香族反应物（102）从所生产的硝化芳香族产物中回收（102）并循环使用（104），用于硝化生产过程。 去除的过量非硝化芳族反应物的一部分被转移（106）并进行硝化（108）。 可以通过分离废酸（110）和非芳族杂质（116）来进一步处理硝化物流。 这些流可以被发送（114,118）到硝化生产列车中的合适位置。

    METHOD FOR CONTINUOUSLY PRODUCING NITROBENZENE
    206.
    发明申请
    METHOD FOR CONTINUOUSLY PRODUCING NITROBENZENE 审中-公开
    工艺硝基苯连续生产

    公开(公告)号：WO2012013678A3

    公开(公告)日：2012-04-26

    申请号：PCT/EP2011062833

    申请日：2011-07-26

    Applicant: BAYER MATERIALSCIENCE AG ,  KNAUF THOMAS ,  MERKEL MICHAEL ,  RAUSCH ANDREAS KARL ,  LEHNER PETER ,  MUENNIG JUERGEN

    Inventor： KNAUF THOMAS ,  MERKEL MICHAEL ,  RAUSCH ANDREAS KARL ,  LEHNER PETER ,  MUENNIG JUERGEN

    IPC: C07C201/08 ,  C07C201/16 ,  C07C205/06

    CPC classification number: C07C201/14 ,  C07C201/08 ,  C07C201/16 ,  C07C209/36 ,  C07C205/06 ,  C07C211/46

    Abstract: The invention relates to a continuous method for producing nitrobenzene by nitriding benzene by means of nitric acid or mixtures of nitric acid and sulfuric acid to form raw nitrobenzene, washing the raw nitrobenzene by means of at least one acidic, alkaline, and neutral wash, respectively, wherein a prepurified nitrobenzene is obtained, comprising at least light boilers, optionally medium boilers, and high boilers and salts in addition to nitrobenzene, wherein the prepurified nitrobenzene is further purified by separating light boilers in a distillation apparatus by evaporating the light boilers and separating nitrobenzene from the further purified nitrobenzene thus obtained in a distillation apparatus by partially evaporating nitrobenzene, wherein pure nitrobenzene is removed from the distillation apparatus in gaseous form and then condensed, and wherein the non-evaporated part of the further purified nitrobenzene is fed back into the wash at an arbitrary point.

    Abstract translation: 本发明涉及一种连续方法用于通过用硝酸或硝酸与硫酸的混合物的粗硝基苯苯的硝化生产硝基苯的，洗涤的粗硝基苯装置中的至少每一个酸性，碱性和中性衣物，其特征在于，预纯化的硝基苯得到的 是，可选地至少低沸，介质锅炉和高沸点物和它们的盐，其中，所述预纯化硝基苯进一步除去在蒸馏设备中低沸物纯化通过蒸发从这样获得的纯化进一步硝基苯低沸点和硝基苯的分离在含有硝基苯 由硝基苯的部分蒸发，蒸馏装置，其中纯硝基苯以气态形式抽出到蒸馏装置，然后冷凝，和的未蒸发部分中一个硝基苯进一步纯化 洗涤的任何部分被返回。

    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES
    207.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES 审中-公开
    包含单体的药物组合物

    公开(公告)号：WO2011109635A1

    公开(公告)日：2011-09-09

    申请号：PCT/US2011/027051

    申请日：2011-03-03

    Applicant: NEONC TECHNOLOGIES INC. ,  CHEN, Thomas ,  LEVIN, Daniel ,  PUPPALI, Satish

    Inventor： CHEN, Thomas ,  LEVIN, Daniel ,  PUPPALI, Satish

    IPC: A01N43/78

    CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w) The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w) The purified monoterpene can be used to treat a disease such as cancer The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    Abstract translation: 本发明提供纯化大于约98.5％（w / w）的单萜或倍半萜的方法。该方法包括使单萜（或倍半萜烯）衍生以产生单萜（或倍半萜烯）衍生物的步骤，将 单萜（或倍半萜烯）衍生物和从衍生物中释放单萜（或倍半萜烯）本发明的范围还包括药物组合物，其包含纯度大于约98.5％的单萜（或倍半萜烯）（w / w ）纯化的单萜可用于治疗诸如癌症的疾病。目前的单萜（或倍半萜烯）可以单独施用，或者可以与辐射或其它治疗剂如化学治疗剂共同施用。

    WASHING SYSTEM FOR NITROAROMATIC COMPOUNDS
    208.
    发明申请
    WASHING SYSTEM FOR NITROAROMATIC COMPOUNDS 审中-公开
    硝基化合物洗涤系统

    公开(公告)号：WO2011021057A1

    公开(公告)日：2011-02-24

    申请号：PCT/IB2009/006570

    申请日：2009-08-18

    Applicant: NORAM INTERNATIONAL LIMITED ,  BERRETTA, Sergio

    Inventor： BERRETTA, Sergio

    IPC: C02F1/02 ,  C02F9/00 ,  C07C201/06 ,  C07C201/16 ,  C07C205/06

    CPC classification number: C07C201/16 ,  C02F1/04 ,  C02F1/20 ,  C02F2101/38 ,  C02F2209/06 ,  C07C205/06

    Abstract: A method of removing alkalinity and salt from a nitroaromatic product downstream of water washing to remove mineral acids and alkaline washing to remove salts of organic acids, comprises washing the product stream with an acidic aqueous solution, prior to the step of removing excess organic reactant, by steam stripping or distillation. Acid removed from the stripper or column is recycled back for use in the acidic washing. The acidic washing is done instead of the neutral washing step of the prior art. It removes residual salt and decreases the level of entrained colloidal water in the nitroaromatic product.

    Abstract translation: 一种从水洗下游的硝基芳族化合物产物中去除碱度和盐的方法，以除去无机酸和碱洗涤以除去有机酸的盐，包括在除去过量有机反应物的步骤之前用酸性水溶液洗涤产物流， 通过汽提或蒸馏。 从汽提塔或塔中除去的酸被循环使用，用于酸洗。 进行酸性洗涤代替现有技术的中性洗涤步骤。 它去除残留的盐并降低硝基芳族产物中夹带的胶体水的含量。

    METHOD OF CONTINUOUSLY AND SELECTIVELY SEPARATING CLATHRATE AND APPARATUS THEREFOR
    210.
    发明申请
    METHOD OF CONTINUOUSLY AND SELECTIVELY SEPARATING CLATHRATE AND APPARATUS THEREFOR 审中-公开
    连续分离分离方法及其设备

    公开(公告)号：WO01064606A1

    公开(公告)日：2001-09-07

    申请号：PCT/JP2000/009073

    申请日：2000-12-21

    IPC: C07B63/00 ,  C07C7/152 ,  C07C17/395 ,  C07C201/16 ,  C07D215/06 ,  C07B63/02

    CPC classification number: C07D215/06 ,  C07B63/00 ,  C07C7/152 ,  C07C17/395 ,  C07C201/16 ,  C07C2602/42 ,  C07C25/02 ,  C07C25/10 ,  C07C205/06 ,  C07C15/08 ,  C07C15/24 ,  C07C13/21 ,  C07C13/39

    Abstract: In a reaction system having at least two liquid-liquid interfaces between an aqueous phase, which comprises an organic phase of a material containing the compound to be separated and an aqueous solution of a clathrate complexing agent, and an organic phase comprising an extraction solvent, the above compound is incorporated into the aqueous phase via the formation of a clathrate complex of the compound and the above clathrate complexing agent and, at the same time, the compound to be separated is incorporated into the organic phase of the extraction solvent via the dissociation of the above-described clathrate complex. The procedures as described above are carried out by using, for example, a square U-shape tube or an H-shape tube provided with a bottom plate. It is preferable to use, for example, highly water-soluble branched cyclodextrins as the clathrate complexing agent.

    Abstract translation: 在具有包含含有待分离化合物的材料的有机相和包合络合剂的水溶液的水相和包含萃取溶剂的有机相的水相之间具有至少两个液 - 液界面的反应体系中， 通过形成化合物和上述包合物络合剂的包合络合物将上述化合物引入水相中，同时通过解离将待分离的化合物引入萃取溶剂的有机相中 的上述包合物复合物。 上述方法通过使用例如方形U形管或设有底板的H形管来进行。 优选使用高水溶性支链环糊精作为包合物络合剂。

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