Abstract:
An instrument includes a plurality of spaced-apart reaction regions (40) and a light source (10) comprising more than one individual light source. The light source is capable of illuminating more than one of the plurality of reaction regions with excitation beams (25). The individual light sources are arranged in groups and different groups of individual light sources are configured to emit different excitation frequencies. Each group of individual light sources is configured to provide excitation beams that illuminate one or more of the plurality of reaction regions simultaneously.
Abstract:
Die Erfindung betrifft eine Anordnung zur orts- und wellenlängenaufgelösten Erfassung von Lichtstrahlung, die von mindestens einer OLED (1) oder LED emittiert wird. Zwischen einer Elektrode (3,4), einer OLED oder LED und einem Substrat ist ein Mehrschichtsystem (2), das mit alternierend übereinander ausgebildeten Schichten aus einem Material mit höherem und niedrigerem optischen Brechungsindex n gebildet ist, angeordnet. Dabei tritt von der mindestens einen OLED oder LED Lichtstrahlung mit mehreren unterschiedlichen Wellenlängen λ1, ⋋2, ⋋3,...⋋n so aus dem Mehrschichtsystem aus. Lichtstrahlung, die mit unterschiedlichen Wellenlängen λ1, ⋋2, λ3,...⋋n mit definierten Winkeln austritt, trifft nach mindestens einfacher Brechung an einem optischen Element (10,11) oder nach Reflexion an einer Schicht oder einem Schichtsystem eines Sensors (12) auf mindestens ein Detektorarray (9, 9.1), so auf, dass Lichtstrahlung mit einer Wellenlänge λ1, ⋋2, ⋋3,... oder ⋋n auf jeweils ein Detektorelement des Detektorarrays auftrifft. Die Detektorelemente des Detektorarrays sind diskret zueinander angeordnet.
Abstract:
Cell culturing and tracking systems using an array of organic light emitting diodes (OLEDs) to illuminate cells and/or other particles in a cell chamber are described. Compared to conventional light sources, the OLED array consumes very little energy and emits a small amount of waste heat, so it may be disposed near or on the cell chamber. For instance, it can be printed on one side of the cell chamber itself. In addition, the OLED array may be patterned into pixels or sub-pixels (individual OLEDs), each of which is as small as or smaller than an individual cell or particle. Because the pixels are so small, OLED illumination can be used to acquire images with a spatial resolution equal to or better than the cell or particle cell. As a result, the OLED array can be used to track, monitor, identify, and manipulate individual cells within the cell culture.
Abstract:
Chlorophyll fluorescence may be studied in response to a variety of environmental cues or conditions by growing phototrophic organisms under actinic illumination. Such illumination may be punctuated or disrupted to gain information about the photosynthetic properties or performance of the phototrophic organism. Instruments or devices for carrying out the method are also described.
Abstract:
Die Erfindung betrifft ein Verfahren und mindestens eine Anordnung zur Detektion von biologischen und/oder chemischen Substanzen. Ein aus einer gepumpten Lichtenergiequelle erzeugter Lichtstrahl bzw. ein Lichtbündel mit einer Anregungswellenlänge λ Α wird so auf ein Trägersubstrat gelenkt, und auf dem sich eine optische Funktionsstruktur in Form eines organischen Leuchtmittels befindet, auf dem wiederum die zu detektierende/n Substanz/en in geeigneter Form aufgebracht wird, so dass die in Folge der Absorbtion veränderten beugungsoptischen Eigenschaften erzeugte Differenzwellenlänge λ ΔΑ bzw. X R mittels eines geeigneten Empfängers erfasst wird, und über eine damit gekoppelte Auswerteeinheit auf Basis eines Datenvergleichssystems die Detektion der Substanzen vorgenommen wird. In bevorzugter Weise ist der organische Leuchtstoff mindestens ein organischer Distributed Feedback Laser (DFB-Laser). Das Verfahren und eine spezielle Anordnung kann auch zur Detektion einer bestimmten Substanz über einzelne Laserpixel (2P) genutzt werden.
Abstract:
Device to detect at least an analyte, comprising a transparent substrate (2), having a first surface (3) with which a light source (7) is associated, and a second surface (4) on which a plurality of biological protein probes (12) are disposed, a layer (6) of polymer being interposed between said second surface (4) and said biological protein probes (12). A marker (fluorophore) is associated with said analyte, having determinate characteristics of fluorescence and/or phosphorescence correlated to the emission wavelength of the light source (7). Said light source (7) is suitable to emit a light radiation in a range of wavelengths equal to 400-550 nm, inside which range the absorption peak of said marker (fluorophore) used is comprised. The value of the distance ("s") between the wavelength corresponding to the absorption peak of the marker (fluorophore) and the wavelength corresponding to the emission peak of fluorescence (phosphorescence) is comprised between 25 and 150 nm.
Abstract:
In one aspect, the invention provides an optical sensor (100) comprising a flexible substrate (2) and an optical element (3, 3') being positioned on the substrate. The flexible substrate comprises deformations (5) affecting the optical element and the deformations are provided in a substrate deformation zone (4, 4') at least partly surrounding the optical element. It is an object of the present invention to provide an optical sensor configuration compatible with roll-to-roll manufacturing.
Abstract:
In one aspect, the invention provides an optical sensor comprising a flexible substrate and an optical element being positioned on the substrate. The flexible substrate comprises deformations affecting the optical element and the deformations are provided in a substrate deformation zone at least partly surrounding the optical element. It is an object of the present invention to provide an optical sensor configuration compatible with roll-to-roll manufacturing.
Abstract:
A biosensor platform for a biosensor adapted to detect one or more predetermined target analytes in a sample, the platform comprising a waveguide (202) for transporting, preferably by substantially total internal reflection, light emitted by a light source, at least one light source (204) comprising an organic light emitting diode (OLED), for incoupling light to the waveguide, said light source being arranged on said waveguide, a binding site (214) comprising immobilized bio-recognition material capable of binding to the target analytes, said binding site positioned relative to the waveguide such that evanescent field triggered by the light propagating in the waveguide extend to the binding site, a microfluidic layer (206) comprising one or more microfluidic cavities for conveying the sample past said binding site so as to enable at least part of the target analytes of the sample to bind to the immobilized biorecognition material, wherein said biosensor platform is further configured to enable, when said at least part of the target analytes are bound to the immobilized biorecognition material, fluorescent markers associated with the bound target or other analytes to be excited by the evanescent field so as to emit fluorescence detectable by a detector. The platform may be manufactured using a roll-to-roll technique, for example.