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    Device for and Method of Measurement of Chemical Agents Quantity in Gas Medium
    211.
    发明申请
    Device for and Method of Measurement of Chemical Agents Quantity in Gas Medium 审中-公开
    气体介质中化学试剂量的测量装置和方法

    公开(公告)号：US20080225285A1

    公开(公告)日：2008-09-18

    申请号：US12046063

    申请日：2008-03-11

    Applicant: Mochkin V. Sergeevich

    Inventor： Mochkin V. Sergeevich

    IPC: G01J3/00

    CPC classification number: G01J3/457 ,  G01J3/4338 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/3133 ,  G01N2021/399

    Abstract: Measurement device for chemical agents quantity contained in a gas medium having a source of monochromatic radiation with a wavelength which changes in accordance with time law that is supplied through an optical brancher to an optical modulator, and then into a gas medium to be measured and further into a photoreceiver, whose signal is supplied into a computing block, while another part of the radiation from the optical brancher is supplied into a gas correlating filter, and the radiation which passed through the gas correlating filter is supplied to the auxiliary photoreceivers, whose signal is supplied to the solving block of standard comparison for controlling the optical modulator and the computing block, so that on the photoreceiver, a radiation is supplied only from spectral lines or bands of radiation of the chemical agents to be measured, and signals from a part of spectral radiation in spectral lines and bands which coincide with a spectral lines of bands of absorption of foreign gasses are filtered out.

    Abstract translation: 包含在具有单色辐射源的气体介质中的测量装置，其具有根据通过光学分支器供应到光学调制器的时间定律而变化的波长，然后进入待测量的气体介质 将其信号提供到计算块中的光接收器，而来自光分支器的另一部分辐射被提供给气体相关滤波器，并且通过气体相关滤波器的辐射被提供给辅助光接收器，其信号 被提供给用于控制光调制器和计算块的标准比较的求解块，使得在光接收器上，仅从待测量的化学试剂的光谱线或辐射带提供辐射，并且从部分 光谱辐射在频谱线和带中与吸收带的谱线一致 外界气体被过滤掉。

    FLUORESCENCE CORRELATION SPECTROSCOPY INSTRUMENT AND METHOD OF USING THE SAME
    212.
    发明申请
    FLUORESCENCE CORRELATION SPECTROSCOPY INSTRUMENT AND METHOD OF USING THE SAME 审中-公开
    荧光相关光谱仪及其使用方法

    公开(公告)号：US20070291254A1

    公开(公告)日：2007-12-20

    申请号：US11834168

    申请日：2007-08-06

    Applicant: David Wolf ,  Dylan Bulseco

    Inventor： David Wolf ,  Dylan Bulseco

    IPC: G01N21/00

    CPC classification number: G01N21/6428 ,  G01J3/4406 ,  G01J3/457 ,  G01N21/645 ,  G01N33/582 ,  G01N2021/6417 ,  G01N2021/6482 ,  G01N2021/6484

    Abstract: Disclosed is a portable fluorescence correlation spectroscopy instrument that includes an excitation source, at least one of a light focusing element positioned to receive light emitted by the excitation source, a detector for detecting light, the detector positioned to receive light emitted by a sample excited by the excitation source, and a correlator coupled to the detector, the correlator for processing data received at the detector and providing data including autocorrelation data, crosscorrelation data, or a combination thereof.

    Abstract translation: 公开了一种便携式荧光相关光谱仪器，其包括激发源，定位成接收由激发源发射的光的光聚焦元件中的至少一个，用于检测光的检测器，被定位成接收由由 激励源和耦合到检测器的相关器，相关器，用于处理在检测器处接收的数据，并提供包括自相关数据，互相关数据或其组合的数据。

    Method of characterizing fluorescent molecules or other particles using generating functions
    213.
    发明授权
    Method of characterizing fluorescent molecules or other particles using generating functions 有权
    使用生成函数表征荧光分子或其他颗粒的方法

    公开(公告)号：US06927401B1

    公开(公告)日：2005-08-09

    申请号：US09869581

    申请日：2000-04-29

    Applicant: Kaupo Palo

    Inventor： Kaupo Palo

    IPC: G01J3/443 ,  G01J3/28 ,  G01J3/44 ,  G01J3/447 ,  G01J3/457 ,  G01N21/64

    CPC classification number: G01J3/4406 ,  G01J3/457 ,  G01J2003/2866 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/6421 ,  G01N2021/6463

    Abstract: A method for characterizing fluorescent molecules or other particles in samples comprising the steps of: a) monitoring fluctuating intensity of fluorescence emitted by the molecules or other particles in at least one measurement volume of a non-uniform spatial brightness profile by measuring numbers of photon counts in primary time intervals by a single or more photon detectors, b) determining at least one distribution of numbers of photon counts, {circumflex over (P)}(n), from the measured numbers of photon counts, c) determining physical quantities characteristic to said particles by fitting the distribution of numbers of photon counts {circumflex over (P)}(n),  wherein the fitting procedure involves calculation of a theoretical distribution function of the number of photon counts P(n) through its generating function, defined as G ⁡ ( ξ → ) = ∑ n ⁢ ξ → n ⁢ P ⁡ ( n ) .

    Abstract translation: 用于表征样品中的荧光分子或其他颗粒的方法，包括以下步骤：a）通过测量光子计数来监测在非均匀空间亮度分布的至少一个测量体积中由分子或其它颗粒发射的荧光的波动强度 通过单个或多个光子检测器在主要时间间隔中，b）从所测量的光子计数中确定光子计数数目P（n）的至少一个分布，c）通过拟合所述粒子的特征来确定所述粒子的特征量 光子计数P（n）的分布，其中拟合过程包括通过其生成函数计算光子计数数P（n）的理论分布函数，定义为 G ⁡ （ Σ n > - > n P >⁡ （ n ） / MROW>

      Gas leak detector
      216.
      发明授权
      Gas leak detector 有权
      气体检漏仪

      公开(公告)号：US06680778B2

      公开(公告)日：2004-01-20

      申请号：US10007080

      申请日：2001-11-08

      Applicant: Michele Hinnrichs ,  Robert Hinnrichs

      Inventor： Michele Hinnrichs ,  Robert Hinnrichs

      IPC: G01N2100

      CPC classification number: G01N21/3504 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/2823 ,  G01J3/457 ,  G01N2021/1793 ,  G01N2021/1795

      Abstract: A remote sensing method for detecting and analyzing gases, vapors and flame plumes using an imaging spectrometer. The spectrometric instrument uses Image Multispectral Sensing (IMSS) technology, enhanced by advanced imaging processing techniques and micro-miniature circuitry. These enhancements provide a portable instrument with the capability to remotely detect and image gases, including gas leaks. The technology also provides an analysis of the gas including chemical species and concentrations. The instrument can also remotely detect, image and analyze flames and plumes in the same manner, providing an analysis of the chemical species and concentrations in the flame. Advanced image processing techniques are used to provide gas and plume images and analysis to the operator. These processing algorithms are implemented in micro-miniature circuits such as digital signal processors (DSP's) and field programmable gate arrays (FPGA's) to provide a field portable instrument.

      Abstract translation: 一种使用成像光谱仪检测和分析气体，蒸汽和火焰羽流的遥感方法。 光谱仪使用图像多光谱传感（IMSS）技术，通过先进的成像处理技术和微型微型电路进行增强。 这些增强功能为便携式仪器提供远程检测和图像气体（包括气体泄漏）的能力。 该技术还提供了包括化学物质和浓度在内的气体分析。 仪器还可以以相同的方式远程检测，成像和分析火焰和羽流，从而对火焰中的化学物质和浓度进行分析。 高级图像处理技术用于向操作员提供气体和羽流图像和分析。 这些处理算法在诸如数字信号处理器（DSP）和现场可编程门阵列（FPGA）的微型电路中实现，以提供现场便携式仪器。

      Tunable filter
      217.
      发明授权
      Tunable filter 有权
      可调滤波器

      公开(公告)号：US06650810B1

      公开(公告)日：2003-11-18

      申请号：US09639063

      申请日：2000-08-15

      Applicant: Robert A. Lieberman ,  John D Prohaska ,  Lothar U Kempen

      Inventor： Robert A. Lieberman ,  John D Prohaska ,  Lothar U Kempen

      IPC: G02B634

      CPC classification number: G01J3/457 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/4338 ,  G02B6/02133 ,  G02B6/02138 ,  G02B6/022 ,  G02B6/124 ,  G02F1/0115 ,  G02F2201/307

      Abstract: A tunable optical filter for simulating the waveband spectrums of selected substances. The filter includes an optical waveguide with a core material for transmitting light energy and a nominal core refractive index for the core material. Predetermined periodic variations are formed in the core material of the optical waveguide between the input and output ends that alter the core refractive index of the waveguide at the location of the periodic variations. Depending upon the periodic variations, the waveguide produces a predetermined reference waveband spectrum output that matches the waveband spectrum of a selected substance. A modulator is coupled to the waveguide to selectively modulate the periodic variations to intermittently shift the reference waveband spectrum output to fine tune the filter and reduce signal noise. The filter is useful as a reference cell for correlation spectroscopy, DIAL LIDAR, equipment calibration, and other uses where a predetermined or known waveband spectrum is useful or desirable.

      Abstract translation: 一种用于模拟所选物质的波段频谱的可调光滤波器。 滤波器包括具有用于透射光能的芯材料和用于芯材料的标称芯折射率的光波导。 在输入和输出端之间的光波导的芯材中形成预定的周期性变化，其改变在周期性变化的位置处的波导的纤芯折射率。 根据周期性变化，波导产生与选定物质的波段频谱相匹配的预定参考波段频谱输出。 调制器耦合到波导以选择性地调制周期性变化，以间歇地移动参考波段频谱输出以微调滤波器并降低信号噪声。 滤波器可用作相关光谱参考单元，DIAL LIDAR，设备校准以及预定或已知波段频谱是有用或期望的其它用途。

      Scanning fluorescent systems for various diagnostic
      218.
      发明授权
      Scanning fluorescent systems for various diagnostic 失效

      公开(公告)号：US06618138B2

      公开(公告)日：2003-09-09

      申请号：US09973996

      申请日：2001-10-09

      Applicant: Jed Khoury

      Inventor： Jed Khoury

      IPC: G01J340

      CPC classification number: G01N21/6456 ,  A61B5/0059 ,  A61B5/7257 ,  G01J3/28 ,  G01J3/457 ,  G01N2021/6423

      Abstract: An angularly multiplexed store contains filters derived from prior examination of input image reference samples, a spectrum analyzer produces spectral data representing the frequency spectrum of the input image under examination, a computer produces an encoded map of the spectral data representing the input image frequency spectrum. The encoded map is transformed, inputted into the store while close match spectral correlation light beams emerge from the multiplexed store, each having an emerging angle associated with that filter within the multiplexed store producing a close match with the first transform. An array of light beam detectors and a display present images having colors that indicate the nature of the input image such as a type of cancer. An associated memory-retro-reflector arrangement displays characters naming the materials making up the input image such as types of abnormal tissue. The disclosed apparatus can have significant application in medicine, food industry, spectroscopy, material science and other various areas.

      Spatially-multiplexed imaging microscope
      220.
      发明授权
      Spatially-multiplexed imaging microscope 失效
      空间多路成像显微镜

      公开(公告)号：US5923036A

      公开(公告)日：1999-07-13

      申请号：US797713

      申请日：1997-02-11

      Applicant: Thomas J. Tague, Jr. ,  Norman Mortensen ,  Michael K. Bellamy

      Inventor： Thomas J. Tague, Jr. ,  Norman Mortensen ,  Michael K. Bellamy

      IPC: G01J3/28 ,  G01J3/457 ,  G02B21/24 ,  G01N21/35

      CPC classification number: G01J3/2846 ,  G01J3/2823 ,  G01J3/457 ,  G02B21/24

      Abstract: An infrared imaging microscope uses spatial encoding to divide an sample being examined into a plurality of pixel regions. The spatial encoding is provided by a digitally controlled mask, which is preferably a multiple mirror array, and which masks the imaging radiation directed from a radiation source to the sample. The signal reflected or transmitted from the sample is detected using a single-element detector. As the mask pattern provided by the mask changes, the output signal of the detector is monitored, and the spectroscopic composition of each of the pixel regions is resolved using a spatial decoding method, such as a Hadamard transform. The digital control of the mask allows fast, easily-implemented changes to the masking pattern, and provides a low processing load relative to imaging devices that use multiple-element detectors. The invention may be implemented in a stand-alone microscope, or as a probe in which most of the elements of the device are located in a main housing, while the mask is located in a remote probe housing connected to the main housing by fiber optic cables. This allows reflective-mode scanning of free-standing objects. In one alternative embodiment, a multiple-element detector is used with the digitally-controlled mask. In this embodiment, visible light is spatially encoded by the mask along with the imaging radiation. By masking the visible light in this manner, visual examination of the sample allows correlation between the area of the sample being examined and the output of the appropriate element of the detector.

      Abstract translation: 红外成像显微镜使用空间编码将待检样本分成多个像素区域。 空间编码由数字控制的掩模提供，其优选地是多反射镜阵列，并且将从辐射源引导的成像辐射掩蔽到样品。 使用单元件检测器检测从样品反射或发射的信号。 当由掩模提供的掩模图案改变时，监测检测器的输出信号，并且使用诸如Hadamard变换的空间解码方法来解析每个像素区域的分光组成。 掩模的数字控制允许对掩模图案的快速，容易实现的改变，并且相对于使用多元件检测器的成像装置提供低处理负载。 本发明可以在独立的显微镜中或作为探针中实现，其中装置的大多数元件位于主壳体中，而掩模位于通过光纤连接到主壳体的远程探测器壳体中 电缆 这允许对独立物体进行反射模式扫描。 在一个替代实施例中，多元素检测器与数字控制掩模一起使用。 在该实施例中，可见光与成像辐射一起由掩模进行空间编码。 通过以这种方式掩蔽可见光，样本的目视检查允许正在检查的样品的面积与检测器的适当元件的输出之间的相关性。

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