公开(公告)号：US20170122961A1

公开(公告)日：2017-05-04

申请号：US15317619

申请日：2015-06-19

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Olof Karlsson

IPC: G01N33/68 ,  G01N21/552

CPC classification number: G01N33/6827 ,  G01N21/274 ,  G01N21/553 ,  G01N2201/127

Abstract: The invention relates to a method for normalization of a label-free system for calibration-free concentration analysis. The method comprises (1) providing a solution containing a control macromolecular particle of a known concentration at a pH lower than the pI of the macromolecular particle and a low ionic strength; (2) contacting the solution with a negatively charged optical sensor surface at a first flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a first sensorgram; (3) contacting the solution with the optical sensor surface at a second flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a second sensorgram; and (4) fitting the sensorgrams to a binding equation to determine a measured concentration of the control; wherein the optical sensor surface is not immobilized with a ligand for the control and the contacting steps are performed under mass transport limitations. Also provided is a kit for performing the method, as well as a method for determining a concentration of an analyte.

公开(公告)号：US09625390B2

公开(公告)日：2017-04-18

申请号：US15194630

申请日：2016-06-28

Applicant: MannKind Corporation

Inventor： Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

IPC: G01J3/44 ,  G01N21/65 ,  G01G9/00 ,  G01N15/06

CPC classification number: G01N21/65 ,  G01G9/00 ,  G01N15/06 ,  G01N2201/06113 ,  G01N2201/121 ,  G01N2201/127

Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.

公开(公告)号：US09603561B2

公开(公告)日：2017-03-28

申请号：US14260755

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20170074732A1

公开(公告)日：2017-03-16

申请号：US14725365

申请日：2015-05-29

Applicant: Charles P. Marsh ,  Kyle B. Ford ,  Nassim E. Ajarni ,  Michael Collins

Inventor： Charles P. Marsh ,  Kyle B. Ford ,  Nassim E. Ajarni ,  Michael Collins

IPC: G01L1/24 ,  G01N21/64

CPC classification number: G01L1/24 ,  G01N21/645 ,  G01N21/6489 ,  G01N2021/6417 ,  G01N2201/06113 ,  G01N2201/127

Abstract: The pressure-detecting system utilizes a nanocomposite sensor with quantum dots embedded in a matrix. Under pressure, both the quantum dots and the matrix fluoresce when illuminated by a laser. A spectroscope detects the intensity of each fluorescence and sends the information to a data processor. The data processor calculates a ratio using the intensities. Comparing this ratio to ratios stored in a data object in a database provides a value for the pressure detected by the sensor. The data object contains multiple ratios, each correlated to a specific pressure during a calibration process for the sensor. This calibration process subjected the sensor to known pressures, with the resultant ratios calculated and stored in the data object, correlated to the appropriate pressures.

Abstract translation: 压力检测系统利用纳米复合传感器，量子点嵌入矩阵中。 在压力下，当激光照射时，量子点和基体均发出荧光。 分光镜检测每个荧光的强度，并将信息发送到数据处理器。 数据处理器使用强度来计算比率。 将此比率与存储在数据库中的数据对象中的比率进行比较，为传感器检测到的压力提供一个值。 数据对象包含多个比率，每个比率与传感器校准过程中的特定压力相关。 该校准过程使传感器达到已知压力，其中所得到的比率被计算并存储在数据对象中，与适当的压力相关。

公开(公告)号：US09562849B2

公开(公告)日：2017-02-07

申请号：US14538827

申请日：2014-11-12

Applicant: REBELLION PHOTONICS, INC.

Inventor： Robert Timothy Kester ,  Nathan Adrian Hagen

IPC: H01L25/00 ,  G01N21/3504 ,  H04N5/33 ,  H04N3/09 ,  H04N5/365 ,  G01J3/02 ,  G01J3/36 ,  G01J5/52 ,  G01J3/28 ,  G01J5/00 ,  G01J5/08 ,  G01J3/26 ,  G01J5/20 ,  G01N21/17

CPC classification number: G01J5/522 ,  G01J3/0208 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0297 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J5/0014 ,  G01J5/0806 ,  G01J5/0834 ,  G01J5/0862 ,  G01J5/20 ,  G01J2003/2826 ,  G01J2003/283 ,  G01J2005/0048 ,  G01J2005/0077 ,  G01N21/3504 ,  G01N2021/1793 ,  G01N2021/3531 ,  G01N2201/06106 ,  G01N2201/068 ,  G01N2201/127 ,  H04N3/09 ,  H04N5/33 ,  H04N5/332 ,  H04N5/365 ,  H04N5/3651 ,  H04N5/3655

Abstract: Various embodiments disclosed herein describe a divided-aperture infrared spectral imaging (DAISI) system that is adapted to acquire multiple IR images of a scene with a single-shot (also referred to as a snapshot). The plurality of acquired images having different wavelength compositions that are obtained generally simultaneously. The system includes at least two optical channels that are spatially and spectrally different from one another. Each of the at least two optical channels are configured to transfer IR radiation incident on the optical system towards an optical FPA unit comprising at least two detector arrays disposed in the focal plane of two corresponding focusing lenses. The system further comprises at least one temperature reference source or surface that is used to dynamically calibrate the two detector arrays and compensate for a temperature difference between the two detector arrays.

Abstract translation: 本文公开的各种实施例描述了分光孔径红外光谱成像（DAISI）系统，其适于用单次拍摄（也称为快照）获取场景的多个IR图像。 通常同时获得具有不同波长成分的多个获取图像。 该系统包括在空间上和光谱上彼此不同的至少两个光学通道。 所述至少两个光学通道中的每一个被配置为将入射在所述光学系统上的IR辐射转移到包括设置在两个对应的聚焦透镜的焦平面中的至少两个检测器阵列的光学FPA单元。 该系统还包括用于动态地校准两个检测器阵列并补偿两个检测器阵列之间的温度差的至少一个温度参考源或表面。

公开(公告)号：US20170003166A1

公开(公告)日：2017-01-05

申请号：US14788561

申请日：2015-06-30

Applicant: Agilent Technologies, Inc.

Inventor： Andrew Ghetler ,  Adam Kleczewski ,  Richard P. Tella

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/10

CPC classification number: G01J3/0297 ,  G01J3/10 ,  G01J3/108 ,  G01J3/2823 ,  G01J3/42 ,  G01N21/274 ,  G01N21/276 ,  G01N21/3563 ,  G01N21/4785 ,  G01N21/55 ,  G01N2201/101 ,  G01N2201/1042 ,  G01N2201/127

Abstract: A method and apparatus for obtaining reference samples during the generation of a mid-infrared (MW) image without requiring that the sample being imaged be removed is disclosed. A tunable MIR laser generates a light beam that is focused onto a specimen on a specimen stage that moves the specimen in a first direction. An optical assembly includes a scanning assembly having a focusing lens and a mirror that moves in a second direction, different from the first direction, relative to the stage such that the focusing lens maintains a fixed distance between the focusing lens and the specimen stage. A light detector measures an intensity of light leaving the point on the specimen. A controller forms an image from the measured intensity. A reference stage is positioned such that the mirror moves over the reference stage in response to a command so that the controller can also make a reference measurement.

Abstract translation: 公开了在生成中红外（MW）图像期间获得参考样本而不需要去除被成像的样品的方法和装置。 可调谐的MIR激光产生聚焦在样品台上的试样上的光束，该试样台沿第一方向移动试样。 光学组件包括具有聚焦透镜和反射镜的扫描组件，所述聚焦透镜和反射镜相对于所述平台在与第一方向不同的第二方向上移动，使得聚焦透镜在聚焦透镜和样品台之间保持固定的距离。 光检测器测量离开样品点的光的强度。 控制器根据测量的强度形成图像。 定位参考台，使得反射镜响应于命令而在参考平台上移动，使得控制器也可进行参考测量。

公开(公告)号：US20160363755A1

公开(公告)日：2016-12-15

申请号：US14734320

申请日：2015-06-09

Applicant: General Electric Company

Inventor： Zhangyi Zhong ,  Chun Zhan ,  Kang Zhang ,  Daniel Curtis Gray

IPC: G02B21/24 ,  G01N21/88 ,  G01B9/02 ,  G01N21/95 ,  G02B7/28 ,  G02B21/00

CPC classification number: G02B21/245 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02063 ,  G01B9/02091 ,  G01N21/8851 ,  G01N21/9501 ,  G01N2201/127 ,  G02B7/28 ,  G02B21/0016 ,  G02B21/0032 ,  G02B21/0056

Abstract: Methods and systems for autofocusing of an imaging system are presented. Provided is an imaging system and an optical interferometry system for generating one or more images corresponding to a target region in a subject. The method provides calibration information that identifies a focal position of the optical interferometry system corresponding to a determined focal position of the imaging system. A subsequent focal position of the imaging system is determined for generating a desired image corresponding to at least one of another target region in the subject and another position of the target region relative to the imaging system based on the calibration information.

Abstract translation: 介绍了一种用于自动对焦成像系统的方法和系统。 提供了一种成像系统和光学干涉测量系统，用于产生与被摄体中的目标区域相对应的一个或多个图像。 该方法提供校准信息，其标识对应于成像系统的确定的焦点位置的光学干涉测量系统的焦点位置。 确定成像系统的随后的焦点位置，用于基于校准信息来生成对应于被摄体中的另一目标区域中的至少一个与目标区域相对于成像系统的另一位置的期望图像。

公开(公告)号：US09506855B2

公开(公告)日：2016-11-29

申请号：US14376324

申请日：2013-02-04

Applicant: University of Cincinnati ,  The United States of America as Represented by the Secretary of the Air Force

Inventor： Ian Papautsky ,  Li Shen ,  Joshua Hagen ,  Morley Stone

IPC: G01N21/25 ,  G01J3/46 ,  G01N21/27 ,  G01N21/78 ,  G01N21/29

CPC classification number: G01N21/25 ,  G01J3/46 ,  G01N21/278 ,  G01N21/293 ,  G01N21/78 ,  G01N2201/061 ,  G01N2201/127 ,  G01N2201/13

Abstract: Described herein is a method, system and computer program for analyzing a colorimetric assay that includes obtaining an image of the assay, optionally correcting for ambient lighting conditions in the image, converting the intensity data for at least one of the red channel, the green channel, or the blue channel to a first data point, recalling a predetermined standardized curve, comparing the first data point with the standardized curve, and identifying the value for the assay parameter from the standardized curve.

Abstract translation: 本文描述了一种用于分析比色测定法的方法，系统和计算机程序，其包括获得测定图像，可选地校正图像中的环境光照条件，转换红色通道，绿色通道中的至少一个的强度数据 或蓝色通道移动到第一数据点，回忆预定的标准化曲线，将第一数据点与标准化曲线进行比较，并从标准化曲线识别测定参数的值。

公开(公告)号：US20160338585A1

公开(公告)日：2016-11-24

申请号：US15227839

申请日：2016-08-03

Applicant: ADOM, Advanced Optical Technologies Ltd

Inventor： Yoel Arieli ,  Yoel Cohen ,  Shlomi Epstein ,  Dror Arbel ,  Ra'anan Gefen

IPC: A61B3/10 ,  G01N21/27 ,  A61B3/00 ,  A61B3/15 ,  G02B3/08 ,  G01B11/06 ,  G01B9/02

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/1005 ,  A61B3/152 ,  G01B9/02021 ,  G01B9/02025 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/0209 ,  G01B11/06 ,  G01B11/0625 ,  G01B11/0675 ,  G01B2290/45 ,  G01N21/274 ,  G01N2201/066 ,  G01N2201/127 ,  G02B3/08

Abstract: A system and method are described for performing tear film structure measurement. A broadband light source illuminates the tear film. A spectrometer measures respective spectra of reflected light from at least one point of the tear film. A color camera performs large field of view imaging of the tear film, so as to obtain color information for all points of the tear film imaged by the color camera. A processing unit calibrates the camera at the point measured by the spectrometer so that the color obtained by the camera at the point matches the color of the spectrometer at the same point. The processing unit determines, from the color of respective points of the calibrated camera, thicknesses of one or more layers of the tear film at the respective points. Other applications are also described.

Abstract translation: 描述了进行泪膜结构测量的系统和方法。 宽带光源照亮泪膜。 光谱仪测量来自泪膜的至少一个点的反射光的各个光谱。 彩色照相机对泪膜进行大视野成像，以获得由彩色照相机成像的泪膜的所有点的颜色信息。 处理单元在由光谱仪测量的点处校准相机，使得在该点处由相机获得的颜色与同一点处的光谱仪的颜色匹配。 处理单元根据校准的相机的各个点的颜色确定各个点处的泪膜的一层或多层的厚度。 还描述了其它应用。

公开(公告)号：US09494527B2

公开(公告)日：2016-11-15

申请号：US13713864

申请日：2012-12-13

Applicant: Step Ahead Innovations, Inc.

Inventor： James E. Clark

IPC: G01N21/15 ,  G01N21/88 ,  G01N21/77 ,  C02F1/00 ,  G01N33/18 ,  G01N21/85 ,  F21V8/00 ,  G01N21/78 ,  G01N31/22 ,  A01K63/04 ,  G01N21/64

CPC classification number: G01N21/77 ,  A01K63/04 ,  C02F1/008 ,  C02F2103/42 ,  C02F2209/005 ,  C02F2209/006 ,  C02F2209/008 ,  C02F2209/06 ,  C02F2209/14 ,  C02F2209/15 ,  C02F2209/18 ,  G01N21/15 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8507 ,  G01N21/88 ,  G01N31/22 ,  G01N33/18 ,  G01N2021/758 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/127 ,  G02B6/0001 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/175383 ,  Y10T436/193333 ,  Y10T436/207497 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Cleaning systems for optics of optical readers to periodically clean one or more surfaces of the optics of matter that may deposit on surface(s) and that might interfere with the performance of the reader. In an example, the cleaning system is used on a chemical indicator apparatus that includes one or more chemical indicators that are read by an optical reader having an optic. During use, the chemical indicator apparatus is moved relative optic during a reading mode. A cleaning element is engaged with the chemical indicator apparatus so as to have a neutral position in which it cannot contact the optic during the reading mode. When it is desired to clean the optic, the chemical indicator apparatus is moved in a manner that causes the cleaning element to move from the neutral position to a deployed position in which it contacts the optic in a manner that cleans the optic as the apparatus continues to be moved.

Abstract translation: 用于光学读取器的光学系统的清洁系统周期性地清洁可能沉积在表面上并且可能干扰读取器的性能的物质光学元件的一个或多个表面。 在一个示例中，清洁系统用于化学指示器装置，其包括由具有光学元件的光学读取器读取的一个或多个化学指示器。 在使用期间，在读取模式期间，化学指示器装置相对于光学元件移动。 清洁元件与化学指示器装置接合，以便具有在读取模式期间其不能接触光学元件的中性位置。 当需要清洁光学元件时，化学指示器装置以使得清洁元件从中立位置移动到展开位置的方式移动，在该展开位置中，该化学指示器装置以与装置相连的方式清洁光学元件的方式移动 被移动