公开(公告)号：WO1994014370A1

公开(公告)日：1994-07-07

申请号：PCT/US1993009597

申请日：1993-10-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  YIM, Jeffrey, B.

IPC: A61B05/02

CPC classification number: A61B5/14539 ,  A61B5/1455

Abstract: A system (10) for in vivo measuring chemical and physical parameters of a patient's blood includes a probe (12), a sensing system (14), and flush interference warning devices (20). The system measures pH, pCO2, and temperature values, and determines a base excess value using the measured pH and pCO2. The time rate of change of the base excess value is also determined, as is the time rate of change of temperature. The warning devices are activated, indicating that the measured parameters are likely affected by the presence of flush solution flowing past the probe, when either: (a) the base excess value is less than a predefined threshold base excess; (b) the absolute value of the time rate of change of the base excess value is greater than a predefined threshold time rate of change of base excess; or, (c) the absolute value of the time rate of change of temperature is greater than a predefined threshold time rate of change of temperature.

Abstract translation: 用于体内测量患者血液的化学和物理参数的系统（10）包括探针（12），感测系统（14）和冲洗干扰警告装置（20）。 该系统测量pH，pCO2和温度值，并使用测量的pH和pCO2确定碱度过量值。 还要确定基础过剩值的时间变化率，以及温度变化的时间速率。 警告装置被激活，表明测量的参数可能受到流过探头的冲洗液的存在的影响，当时：（a）基础过量值小于预定义的阈值基础过剩; （b）基本超额值的时间变化率的绝对值大于基准过剩的预定阈值时间变化率; 或者，（c）温度变化时间率的绝对值大于预定的阈值时间温度变化率。

公开(公告)号：WO1994013199A1

公开(公告)日：1994-06-23

申请号：PCT/US1993011807

申请日：1993-12-07

Applicant: SUNSHINE MEDICAL INSTRUMENTS, INC.

Inventor： SUNSHINE MEDICAL INSTRUMENTS, INC. ,  KUPERSCHMIDT, Vladimir

IPC: A61B05/02

CPC classification number: A61B5/14558 ,  A61B5/7207 ,  G01N21/21

Abstract: A method and apparatus for non-invasive measurement of blood glucose concentration based on producing a polarized-modulated laser beam, measuring a phase difference introduced, e.g., by a finger (F) or a ear lobule (E) of a subject, measuring the phase difference between a reference signal (SR) and a probe/measurement signal (SP, SM), and processing the obtained data which are then presented as blood glucose concentration. Apparatus includes an infrared laser source (22), a polarized frequency shifter (24) which produces a polarized-modulated infrared laser beam, a piezoelectric transducer (26) for driving the polarizing frequency shifter (24), and an optical transducer (30) with a glucose measuring head (32). The latter has an optical input for receiving the laser beam and a balanced receiver (62). The probe beam, after passing through the finger, is converted into a probe electrical signal, the reference beam is converted into a reference electrical signal, the probe and reference electrical signals are compared, and the obtained phase difference is processed by an electronic signal processing unit (34) which presents the results in the form of blood glucose concentration. Alternate embodiments based on measurement of circular dichroism caused by the presence of glucose in blood are included. The polarized frequency shifter may be crystal optic or fiber-optic based.

Abstract translation: 一种用于通过产生偏振调制的激光束来非血管测量血糖浓度的方法和装置，测量例如由受试者的手指（F）或耳小叶（E）引入的相位差，测量 参考信号（SR）和探针/测量信号（SP，SM）之间的相位差，并且处理所获得的数据，然后呈现为血糖浓度。 装置包括：红外激光源（22），产生偏振调制的红外激光束的偏振变频器（24），用于驱动偏振变频器（24）的压电换能器（26）;以及光学变换器（30） 与葡萄糖测量头（32）。 后者具有用于接收激光束的光学输入和平衡接收器（62）。 探测光束在通过手指之后被转换成探针电信号，将参考光束转换为参考电信号，比较探针和参考电信号，并且通过电子信号处理处理获得的相位差 单位（34），以血糖浓度的形式呈现结果。 包括由血液中存在葡萄糖引起的圆二色性测量的替代实施方案。 偏振移频器可以是晶体光学或基于光纤的。

公开(公告)号：WO1993019665A1

公开(公告)日：1993-10-14

申请号：PCT/HU1993000006

申请日：1993-02-08

Applicant: RICHTER GEDEON VEGYÉSZETI GYAR RT. ,  BODO, Mihály ,  NAGY, István ,  PEREDI, János ,  THUROCZY, György ,  OZSVALD, László

Inventor： RICHTER GEDEON VEGYÉSZETI GYAR RT.

IPC: A61B05/02

CPC classification number: A61B5/4884 ,  A61B5/0002 ,  A61B5/0205

Abstract: During the process, arterial blood circulation parameters are measured and recorded and diagnoses are made on the basis of the results. The essence of the process consists in: a) asking the patient questions about his/her neurological state and recording the answers; b) measuring and recording by means of instruments the patient's electrical brain activity, the rheographical pulse waves in the head and members and the electrical activity of the heart ; c) evaluating the data from the verbal and instrumental findings together and, on this basis, making the diagnosis. The device for implementing the process is fitted with a computer (2) and an essential feature is that the computer (2) is connected via a data transmission channel (6) to a patient interface unit (1) which comprises the converter channels (3a-3c) for recording and transmitting the human physiological parameters, a data collection unit (4) and a mains supply unit (5), while the computer (2) has a patient-related adapter board (5a).

公开(公告)号：WO1993012716A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011027

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HUGHES, Timothy, J.

IPC: A61B05/02

CPC classification number: A61B5/0275 ,  A61B5/028 ,  A61B5/7203 ,  A61B5/7257

Abstract: A method for compensating the determination of cardiac output for a baseline blood temperature drift, or other long-term noise. The method is applicable to the continuous monitoring of cardiac output, which is carried out by modifying the temperature of blood within a heart (12) using a periodically varying electrical current that is applied to a heater (22) disposed on the outer surface of a catheter (14) inserted within the heart. A temperature sensor (24) disposed near a distal end (18) of the catheter monitors the temperature of blood leaving the heart, producing a blood temperature signal that periodically varies in a manner corresponding to the input signal. Alternatively, the temperature of blood within the heart can be modified by heat exchange with a fluid circulated within a heat exchanger (16) on the catheter, so that heat is transferred between the fluid and blood.

公开(公告)号：WO1993012714A1

公开(公告)日：1993-07-08

申请号：PCT/US1992010965

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HUGHES, Timothy, J.

IPC: A61B05/02

CPC classification number: A61B5/028

Abstract: A method and apparatus for continuously monitoring cardiac output based upon phase shift between an input signal and a temperature signal indicative of change in blood temperature leaving the heart. In a preferred embodiment of a cardiac output monitoring system (10), a catheter (14) is provided with an electrical resistance heater (22). An electrical current having a sinusoidal wave form with a period of from 30 to 60 seconds is applied to the heater, causing power to be dissipated into the blood within a patient's heart (12). A temperature sensor (24) disposed near the catheter produces a signal indicative of the temperature of blood leaving the heart. The temperature signal and the signal corresponding to the electrical power dissipated in the heater are filtered at a frequency φ corresponding to the frequency of the applied electrical current. The amplitude of the input power, the amplitude of the temperature signal, and their phase difference are used in calculating cardiac output.

公开(公告)号：WO1993010705A1

公开(公告)日：1993-06-10

申请号：PCT/US1991008941

申请日：1991-11-27

Applicant: INNERSPACE, INC.

Inventor： INNERSPACE, INC. ,  BECKMAN, Bruce

IPC: A61B05/02

CPC classification number: A61B5/14553 ,  A61B5/031

Abstract: A catheter assembly for measuring a fluid pressure in a body cavity includes an optical converter (39) responsive to an electrical power source for energizing a light-emitting diode (45) which has drift characteristics which vary in response to temperature. An optical sensor (72) is adapted to receive the light from the light-emitting diode and to provide a measurement signal indicative of the fluid pressure in the cavity. This measurement signal has undesirable characteristics related to the thermal drift characteristics of the diode. A detection circuit (93, 109) detects the measurement signal and provides an output signal indicative of fluid pressure in the cavity. A special filter (63) is included in this detection circuit which has optical characteristics that substantially offset the undesirable characteristics of the measurement signal, so that the output signal is substantially independent of the temperature of the diode. A power conversion (36) circuit enables the assembly to be energized by an excitation voltage which is provided in several different forms by various monitors.

Abstract translation: 用于测量体腔内的流体压力的导管组件包括响应于电源的光学转换器（39），用于激励具有随温度变化的漂移特性的发光二极管（45）。 光学传感器（72）适于接收来自发光二极管的光并提供指示空腔中的流体压力的测量信号。 该测量信号具有与二极管的热漂移特性相关的不期望的特性。 检测电路（93,109）检测测量信号，并提供指示空腔中的流体压力的输出信号。 该检测电路中包括一个特殊的滤波器（63），其具有基本上抵消测量信号的不良特性的光学特性，使得输出信号基本上与二极管的温度无关。 电源转换（36）电路使得组件能够被各种监视器以几种不同形式提供的激励电压激励。

公开(公告)号：WO1993005703A1

公开(公告)日：1993-04-01

申请号：PCT/US1991006785

申请日：1991-09-20

Applicant: MATSUMURA, Kenneth, N.

IPC: A61B05/02

CPC classification number: A61B5/01 ,  A61B5/0404 ,  A61B5/0468 ,  A61B5/14532 ,  A61B5/681 ,  A61B10/0012 ,  A61B2010/0019 ,  A61M5/14248 ,  G01K13/002 ,  G06F19/00 ,  Y02A90/26

Abstract: A device for computer-assisted monitoring of body temperature and for detection of ovulation, for detection and treatment of life-threatening cardiac ischemia and arrythmia, and for detection and correction of abnormal elevation of glucose.

Abstract translation: 一种用于计算机辅助监测体温和检测排卵的装置，用于检测和治疗危及生命的心脏缺血和心律失常，以及用于检测和纠正葡萄糖异常升高的装置。

公开(公告)号：WO1991017699A1

公开(公告)日：1991-11-28

申请号：PCT/JP1990000623

申请日：1990-05-17

Applicant: TOMITA, Mitsuei

IPC: A61B05/02

CPC classification number: A61B5/0225 ,  A61B5/02208 ,  A61B5/02225

Abstract: A pressure cuff (200; 500) is fastened to the brachium to cause ischemia in the brachium by a blood impediment bladder (210; 520) of the cuff. A sound wave sensor (110) and a pressure sensor (120) are provided in the rear bladder (230; 530) on the downstream side of the blood impediment bladder to detect Korotkoff sound and pulse wave. The standard internal pressure in the pressure cuff is controlled by an air pump and a leak valve controlled by the CPU (130; 430; 640). By monitoring the Korotkoff sound or the pulse wave, the standard internal pressure in the pressure cuff can be maintained at a diastolic pressure. The pulse wave obtained in the brachium at the time of this pressure approximates to the aortic wave. This approximate aortic wave is displayed together with the Korotkoff sound and its envelope curve, and an output that gives information on the trouble of the blood circulation in the circulatory organ system is performed.

Abstract translation: 压力袖带（200; 500）被紧固到所述手套上，以通过所述袖带的血液阻塞囊（210; 520）引起所述胎体中的缺血。 声波传感器（110）和压力传感器（120）设置在血液阻挡气囊的下游侧的后囊（230; 530）中，以检测Korotkoff声和脉搏波。 压力袖带中的标准内部压力由空气泵和由CPU（130; 430; 640）控制的泄漏阀控制。 通过监测Korotkoff声音或脉搏波，压力袖带中的标准内部压力可以保持在舒张压。 在该压力时在臂中获得的脉搏波接近主动脉波。 该近似的主动脉波与Korotkoff声音及其包络线一起显示，并且输出一个关于循环器官系统中的血液循环问题的信息的输出。

公开(公告)号：WO1990012537A1

公开(公告)日：1990-11-01

申请号：PCT/SE1990000244

申请日：1990-04-09

Applicant: RADI MEDICAL SYSTEMS AB ,  STENOW, Erik ,  TENERZ, Lars ,  ÖBERG, Åke

Inventor： RADI MEDICAL SYSTEMS AB

IPC: A61B05/02

CPC classification number: A61B5/0275 ,  A61B5/0261

Abstract: The invention refers to a method and an apparatus which in situ measure the flow in a blood vessel mean (9). A local disturbance of the optical properties of the blood is performed at the measuring place. The disturbance is optically detected by means of an optical conduit (1) introduced into the vessel, the field of view of the conduit being directed towards the central portion of the vessel. The detected optical signal is used to form a measure of the flow. The device comprises a conduit introduced into the vessel up to the measuring place. A fibre optical light conductor (7) is provided within the conduit. According to the invention the end surface of the light conductor is bevelled to look into the central portion of the blood vessel. A light detector (7) is provided in the proximal end of the light conductor and detects the local disturbance of the optical properties of the blood. The disturbance may be brought about by introducing a fluorescent substance into the blood or by making use of the autofluorescence of the blood. Disturbances may also be brought about by locally producing microbubbles in the blood upstreams of the measuring position or by locally disturbing the orientation of the blood corpuscles.

Abstract translation: 本发明涉及一种原位测量血管平均流量（9）的方法和装置。 在测量地点进行血液光学性质的局部干扰。 通过引入到容器中的光学导管（1）光学检测干扰，导管的视野指向容器的中心部分。 检测到的光信号用于形成流量的度量。 该装置包括导入容器中直到测量位置的导管。 光纤光导体（7）设置在导管内。 根据本发明，光导体的端面被倾斜以观察血管的中心部分。 在光导体的近端设有光检测器（7），并检测局部的血液光学性质的干扰。 可以通过将荧光物质引入血液中或通过利用血液的自发荧光来实现干扰。 也可能通过在测量位置上游的血液中局部产生微泡或通过局部扰动血小板的取向而引起干扰。

公开(公告)号：WO1990006721A1

公开(公告)日：1990-06-28

申请号：PCT/JP1989001242

申请日：1989-12-12

Applicant: COLIN ELECTRONICS CO., LTD. ,  NIWA, Minoru

Inventor： COLIN ELECTRONICS CO., LTD.

IPC: A61B05/02

CPC classification number: A61B5/021 ,  A61B5/02208

Abstract: When a pulse wave is counted by pressing a pulse wave sensor to the artery of a living body, required detection accuracy of the pulse wave cannot be obtained from time to time due to a factor resulting from the living body itself as well as due to the pressing condition of the pulse wave sensor. In the case of such a factor resulting from the living body itself, no effect can be obtained even if the pressing condition of the pulse wave sensor is changed, and the condition for counting the pulse wave from a radial artery can be improved by changing the bending angle of a wrist, for example. The present invention comtemplates to detect automatically that detection accuracy of the pulse wave cannot be obtained due to a factor resulting from the living body itself. The present invention judges whether or not the detection accuracy of the pulse wave is abnormal due to a factor resulting from the living body itself, on the basis of a first pressing force width where the change of the amplitude of the pulse wave counted during the change process of the pressing force of the pulse wave sensor is below a predetermined value and a second pressing force width where the change of the minimum value of the pulse wave counted during the change process of the pressing force of the pulse wave sensor with the pressing force is below a predetermined value, and an abnormality signal representing the abnormality is outputted.