公开(公告)号：WO1997023162A1

公开(公告)日：1997-07-03

申请号：PCT/US1996019315

申请日：1996-12-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HUGHES, Timothy, J.

IPC: A61B05/029

CPC classification number: A61B5/028 ,  A61B5/7257 ,  G01K7/25

Abstract: A method and apparatus for correcting thermal drift in cardiac output measurements based upon a temperature signal indicative of the change in temperature of blood leaving the heart is disclosed. In a first preferred embodiment of a cardiac output monitoring system (10), the catheter (14) is provided with an electrical resistance heater (22). An electrical current having a sinusoidal waveform with a period of from 30 to 60 seconds is applied to the heater, causing power to be dissipated into the blood within a patient's heart (12). A temperature sensor (24) disposed near a distal end of the catheter produces a signal indicative of the temperature of blood leaving the heart. The temperature signal and the signal corresponding to the electrical power dissipated in the heater (an input signal) are filtered at a frequency omega n corresponding to the frequency of the applied electrical current, i.e., the frequency of the input signal. An output signal indicative of the temperature of the blood leaving the heart corrected for the effects of thermal drift is then calculated. The blood temperature output signal is first split into two equal overlapping time periods. The two signals are then filtered separately to produce two partially independent output signals in the frequency domain. These two frequency domain output signals are then combined into a single corrected frequency domain output signal with the effects of thermal drift removed. The amplitude of the input power, the amplitude of the temperature signal corrected for thermal drift, and their phase difference are then used in calculating cardiac output.

Abstract translation: 公开了一种基于指示离开心脏的血液温度变化的温度信号来校正心输出量测量中的热漂移的方法和装置。 在心输出量监测系统（10）的第一优选实施例中，导管（14）设置有电阻加热器（22）。 将具有30至60秒周期的正弦波形的电流施加到加热器，使得电力消散到患者心脏（12）内的血液中。 设置在导管的远端附近的温度传感器（24）产生指示离开心脏的血液的温度的信号。 对应于在加热器（输入信号）中消耗的电功率的温度信号和信号以与所施加的电流的频率即输入信号的频率相对应的频率ωn被滤波。 然后计算表示为热漂移的影响而校正的离开心脏的血液的温度的输出信号。 首先将血液温度输出信号分为两个等重叠时间段。 然后分别对两个信号进行滤波，以在频域中产生两个部分独立的输出信号。 然后将这两个频域输出信号组合成单个校正的频域输出信号，并消除热漂移的影响。 输入功率的振幅，热漂移校正的温度信号的振幅及其相位差用于计算心输出量。

公开(公告)号：WO1992022240A1

公开(公告)日：1992-12-23

申请号：PCT/US1992005038

申请日：1992-06-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HUGHES, Timothy, J.

IPC: A61B05/02

CPC classification number: A61B5/028 ,  A61B5/029

Abstract: A heated catheter for monitoring cardiac output. Displaced from a distal end of a heated catheter (30) is a resistive heater (32) that heats blood flowing within a heart muscle (10). The resistive heater is mounted on the catheter so that when the catheter is inserted into the heart, the resistive heater is disposed in the right ventricle. A temperature sensor (34) is disposed downstream of the resistive heater, in or proximate the pulmonary artery during use. A differential amplifier (40, 70) provides an electrical current to the resistive heater that varies as a function of the difference between the temperature of the resistive heater, measured by a temperature sensor (35), and a predetermined temperature. In another embodiment of the invention, a resistive heater (90) has a resistance that varies with temperature. The resistive heater comprises one arm of a bridge circuit (85). A differential amplifier (110) provides an electrical current to the bridge circuit in response to the voltage developed across the bridge circuit.

公开(公告)号：WO1994002066A1

公开(公告)日：1994-02-03

申请号：PCT/US1993006598

申请日：1993-07-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GALLUP, David, A. ,  HUGHES, Timothy, J. ,  SPERINDE, John

IPC: A61B05/029

CPC classification number: A61B5/028 ,  A61B5/1459

Abstract: A multi-lumen multi-purpose catheter (10) which incorporates optical filaments (33) and an optical coupler (30) for use with an external apparatus for determining the oxygen concentration in the blood of a patient under critical care conditions, as well as incorporating therein a heater coil (55) useable with a second external apparatus for measurement of continuous cardiac output. The catheter (10) also includes a thermistor (54) and at least one injectate port (64) for enabling the user to also conduct thermal dilution readings and obtain intermittent measurements of cardiac output. The combination of a thermal dilution catheter with an SV02 catheter and a continuous cardiac output catheter gives the multipurpose catheter (10) substantial versatility as well as providing the user with a versatile cardiac catheter device which enables him to conduct multiple evaluations of disparate blood-related parameters which require the use of separate apparatuses.

Abstract translation: 一种多腔多用途导管（10），其包含光学灯丝（33）和光耦合器（30），用于与外部设备一起使用，用于确定危重护理条件下患者血液中的氧浓度，以及 其中结合有可用于测量连续心输出量的第二外部设备的加热器线圈（55）。 导管（10）还包括热敏电阻（54）和至少一个注射口（64），用于使使用者能够进行热稀释读数并获得心输出量的间歇测量。 热稀释导管与SV02导管和连续心输出导管的组合使得多用途导管（10）具有实质的多功能性，并为使用者提供通用的心脏导管装置，使得他能够进行与血液相关的不同的评估 需要使用单独设备的参数。

公开(公告)号：WO1993012716A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011027

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HUGHES, Timothy, J.

IPC: A61B05/02

CPC classification number: A61B5/0275 ,  A61B5/028 ,  A61B5/7203 ,  A61B5/7257

Abstract: A method for compensating the determination of cardiac output for a baseline blood temperature drift, or other long-term noise. The method is applicable to the continuous monitoring of cardiac output, which is carried out by modifying the temperature of blood within a heart (12) using a periodically varying electrical current that is applied to a heater (22) disposed on the outer surface of a catheter (14) inserted within the heart. A temperature sensor (24) disposed near a distal end (18) of the catheter monitors the temperature of blood leaving the heart, producing a blood temperature signal that periodically varies in a manner corresponding to the input signal. Alternatively, the temperature of blood within the heart can be modified by heat exchange with a fluid circulated within a heat exchanger (16) on the catheter, so that heat is transferred between the fluid and blood.

公开(公告)号：WO1993012714A1

公开(公告)日：1993-07-08

申请号：PCT/US1992010965

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HUGHES, Timothy, J.

IPC: A61B05/02

CPC classification number: A61B5/028

Abstract: A method and apparatus for continuously monitoring cardiac output based upon phase shift between an input signal and a temperature signal indicative of change in blood temperature leaving the heart. In a preferred embodiment of a cardiac output monitoring system (10), a catheter (14) is provided with an electrical resistance heater (22). An electrical current having a sinusoidal wave form with a period of from 30 to 60 seconds is applied to the heater, causing power to be dissipated into the blood within a patient's heart (12). A temperature sensor (24) disposed near the catheter produces a signal indicative of the temperature of blood leaving the heart. The temperature signal and the signal corresponding to the electrical power dissipated in the heater are filtered at a frequency φ corresponding to the frequency of the applied electrical current. The amplitude of the input power, the amplitude of the temperature signal, and their phase difference are used in calculating cardiac output.

公开(公告)号：EP0618780A1

公开(公告)日：1994-10-12

申请号：EP93901168.0

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： HUGHES, Timothy, J.

IPC: A61B5

CPC classification number: A61B5/028

Abstract: Procédé et appareil de surveillance continue du débit cardiaque, se basant sur le décalage de phase entre un signal d'entrée et un signal de température indiquant une variation de la température du sang sortant du coeur. Selon un mode préféré de réalisation d'un système de surveillance du débit cardiaque (10), un cathéter (14) est pourvu d'un dispositif de chauffage à résistance (22). Un courant électrique présentant une forme d'onde sinusoïdale et une période comprise entre 30 et 60 secondes est appliqué au dispositif de chauffage, de sorte que l'énergie est dissipée dans le sang à l'intérieur du coeur d'un patient (12). Un détecteur de température (24), placé auprès du cathéter, produit un signal indiquant la température du sang sortant du coeur. Le signal de température et le signal correspondant à l'énergie électrique dissipée dans le dispositif de chauffage sont filtrés à une fréquence omega correspondant à la fréquence du courant électrique appliqué. L'amplitude de la puissance d'entrée, l'amplitude du signal de température et leur différence de phase sont utilisées pour calculer le débit cardiaque.

公开(公告)号：EP0597881B2

公开(公告)日：2003-03-12

申请号：EP92914564.7

申请日：1992-06-12

Applicant: ABBOTT LABORATORIES

Inventor： HUGHES, Timothy, J.

IPC: A61B5/028

CPC classification number: A61B5/028 ,  A61B5/029

公开(公告)号：EP0868145A1

公开(公告)日：1998-10-07

申请号：EP96942883.0

申请日：1996-12-05

Applicant: ABBOTT LABORATORIES

Inventor： HUGHES, Timothy, J.

IPC: A61B5 ,  A61M25 ,  G01K7

CPC classification number: A61B5/028 ,  A61B5/7257 ,  G01K7/25

Abstract: A method and apparatus for correcting thermal drift in cardiac output measurements based upon a temperature signal indicative of the change in temperature of blood leaving the heart is disclosed. In a first preferred embodiment of a cardiac output monitoring system (10), the catheter (14) is provided with an electrical resistance heater (22). An electrical current having a sinusoidal waveform with a period of from 30 to 60 seconds is applied to the heater, causing power to be dissipated into the blood within a patient's heart (12). A temperature sensor (24) disposed near a distal end of the catheter produces a signal indicative of the temperature of blood leaving the heart. The temperature signal and the signal corresponding to the electrical power dissipated in the heater (an input signal) are filtered at a frequency φn corresponding to the frequency of the applied electrical current, i.e., the frequency of the input signal. An output signal indicative of the temperature of the blood leaving the heart corrected for the effects of thermal drift is then calculated. The blood temperature output signal is first split into two equal overlapping time periods. The two signals are then filtered separately to produce two partially independent output signals in the frequency domain. These two frequency domain output signals are then combined into a single corrected frequency domain output signal with the effects of thermal drift removed. The amplitude of the input power, the amplitude of the temperature signal corrected for thermal drift, and their phase difference are then used in calculating cardiac output.

公开(公告)号：EP0652727A1

公开(公告)日：1995-05-17

申请号：EP93917160.0

申请日：1993-07-14

Applicant: ABBOTT LABORATORIES

Inventor： GALLUP, David, A. ,  HUGHES, Timothy, J. ,  SPERINDE, John

IPC: A61B5

CPC classification number: A61B5/028 ,  A61B5/1459

Abstract: A multi-lumen multi-purpose catheter (10) which incorporates optical filaments (33) and an optical coupler (30) for use with an external apparatus for determining the oxygen concentration in the blood of a patient under critical care conditions, as well as incorporating therein a heater coil (55) useable with a second external apparatus for measurement of continuous cardiac output. The catheter (10) also includes a thermistor (54) and at least one injectate port (64) for enabling the user to also conduct thermal dilution readings and obtain intermittent measurements of cardiac output. The combination of a thermal dilution catheter with an SV02 catheter and a continuous cardiac output catheter gives the multipurpose catheter (10) substantial versatility as well as providing the user with a versatile cardiac catheter device which enables him to conduct multiple evaluations of disparate blood-related parameters which require the use of separate apparatuses.

公开(公告)号：EP0618780B1

公开(公告)日：2000-03-22

申请号：EP93901168.0

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： HUGHES, Timothy, J.

IPC: A61B5/028 ,  A61B5/02

CPC classification number: A61B5/028