公开(公告)号：IL150511A

公开(公告)日：2006-12-10

申请号：IL15051102

申请日：2002-07-01

Applicant: PROCTER & GAMBLE

IPC: A61K31/663 ,  A61K31/675 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00 ,  C07F9/58

Abstract: The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.

公开(公告)号：SA1598B1

公开(公告)日：2006-11-25

申请号：SA01220066

申请日：2001-04-18

Applicant: PROCTER & GAMBLE

Inventor： CAZER FREDERICK DANA ,  PARRY GREGORY EUGENE ,  BILLINGS DENNIS MICHAEL ,  FUREY NANCY LEE REDMAN -

IPC: A61K31/663 ,  A61K31/675 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00 ,  C07F9/58

Abstract: الملخص: يبينهذاالإختراعنصفخامسهيدرات hemipentahydrate وأحاديهيدرات monohydrate ٣- بيريديل-١-هيدروكسىإثيليدين -١،١- حمضفوسفونيكمكررصوديوم،3-pyridyl-1 -hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrateوطرقلتحضيرنصفخامسهيدرات hemipentahydrate وأحاديهيدرات monohydrate عنطريقالتحكمفيدرجةحرارةتكوينالأنويةومعدلالتبلور crystallization كمايبينتركيباتصيدلية pharmaceutical compositions تحتويعلىواحدةمنأوكلمنأشكالالهيدرات hydrate forms.

公开(公告)号：AU784307B2

公开(公告)日：2006-03-09

申请号：AU3473601

申请日：2001-02-01

Applicant: PROCTER & GAMBLE

Inventor： CAZER FREDRICK DANA ,  PERRY GREGORY EUGENE ,  BILLINGS DENNIS MICHAEL ,  REDMAN-FUREY NANCY LEE

IPC: A61K31/663 ,  C07F9/58 ,  A61K31/675 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00

Abstract: The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.

公开(公告)号：PL378027A1

公开(公告)日：2006-02-20

申请号：PL37802704

申请日：2004-01-20

Applicant: UCB FARCHIM SA

Inventor： ATES CELAL ,  CAVOY EMILE ,  BOUVY DIDIER

IPC: C07D295/14 ,  A61K31/495 ,  C07D201/00 ,  C07D271/06 ,  C07D271/07 ,  C07D295/15

公开(公告)号：NO20053910L

公开(公告)日：2005-10-21

申请号：NO20053910

申请日：2005-08-22

Applicant: UCB FARCHIM SA

Inventor： ATES CELAL ,  CAVOY EMILE ,  BOUVY DIDIER

IPC: C07D201/00 ,  C07D271/06 ,  C07D271/07 ,  C07D295/15 ,  C07D295/14 ,  A61K31/495

Abstract: The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds

公开(公告)号：SI1218005T1

公开(公告)日：2005-08-31

申请号：SI200030619

申请日：2000-09-07

Applicant: SMITHKLINE BEECHAM CORP

Inventor： MANLEY PETER J ,  MILLER WILLIAM H ,  UZINSKAS IRENE N

IPC: A61K31/4375 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  C07D201/00 ,  C07D213/36 ,  C07D213/74 ,  C07D401/08 ,  C07D413/08 ,  C07D413/12 ,  C07D417/08 ,  C07D417/12 ,  C07D471/04

公开(公告)号：MY119968A

公开(公告)日：2005-08-30

申请号：MYPI20010386

申请日：2001-01-30

Applicant: PROCTER & GAMBLE

Inventor： DANA CAZER FREDERICK ,  EUGENE PERRY GREGORY ,  MICHAEL BILLINGS DENNIS ,  LEE REDMAN-FUREY NANCY

IPC: A61K31/663 ,  A61K31/675 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00 ,  C07F9/58

Abstract: THE PRESENT INVENTION DISCLOSES 3-PYRIDYL-L-HYDROXYETHYLIDENE-L, L-BISPHOSPHONIC ACID SODIUM HEMIPENTAHYDRATE AND MONOHYDRATE, METHODS OF PREPARING THE HEMIPENTAHYDRATE OR MONOHYDRATE THROUGH CONTROL OF THE NUCLEATION TEMPERATURE AND RATE OF CRYSTALLIZATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING ONE OR BOTH OF THE HYDRATE FORMS.

公开(公告)号：DE69829867D1

公开(公告)日：2005-05-25

申请号：DE69829867

申请日：1998-09-10

Applicant: YEDA RES & DEV ,  JOHN HOPKINS UNIVERSITY BALTIM

Inventor： BACHI MARIO ,  POSNER H ,  KORSHIN EDWARD

IPC: C07D319/02 ,  C07D201/00

Abstract: PCT No. PCT/IL98/00440 Sec. 371 Date May 11, 2000 Sec. 102(e) Date May 11, 2000 PCT Filed Sep. 10, 1998 PCT Pub. No. WO99/12900 PCT Pub. Date Mar. 18, 19992,3-Dioxabicyclo[3.3.1]nonane derivatives, carrying, at position 4, a sulfur-containing functionality selected from the group consisting of sulfonyl, sulfinyl and sulfenyl, adhered to C(4) vie methylene group, represented by structural formula (A) wherein: X is hydrogen, hydroxy, alkoxy, optionally substituted by alkoxy or acyloxy, aralkoxy optionally substituted by alkoxy or aryloxy, and M is hydrogen, hydroxy, alkoxy, alkenyloxy, acyloxy, optionally substituted by acyl or acyloxy, aralokoxy, arylalkenyloxy, oxalyloxy substituted by alkoxy, di(alkyl)amino or alkyl(aryl)amino, di(aralalkyl)amino or carbonyloxy substituted by arloxy, di(alkyl)amino, di(aralkyl)amino and alkyl(aryl)amino; or X and M together represent a carbon-carbon bond or an oxygen atom; L is hydrogen or L and M together represent a carbon-carbon bond; and either Z is a radical R-S(=O)n- and Y is hydrogen, or Y is R-S(=O)n- and Z is hydrogen, wherein R is alkyl optionally substituted by alkoxy or alkoxycarbonyl, cycloalkyl, or aryl or araklkyl optionally substituted by alkyl, halogen or CF3; and n is 0, 1, or 2, are useful for the prevention and/or treatment of malaria.

公开(公告)号：CA2521925A1

公开(公告)日：2004-10-28

申请号：CA2521925

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  BURCH RONALD ,  RAMIYA PREMCHANDRAN H ,  CHEN WEI ,  MCILVAIN SHARON

IPC: C07C233/22 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carri ed through the entire synthesis process.

公开(公告)号：CA2518707A1

公开(公告)日：2004-09-30

申请号：CA2518707

申请日：2004-03-10

Applicant: CIBA SC HOLDING AG

Inventor： DALVI PRAMOD V ,  ADAM JEAN-MARIE ,  EKKUNDI VADIRAJ SUBBANNA ,  BACHER JEAN-PIERRE ,  TIWARI SANDIP

IPC: C07D20060101 ,  C07D201/00 ,  C07D207/26 ,  C07D211/46 ,  C07D233/70 ,  C07D263/42 ,  C07D315/00 ,  C09B23/01 ,  C09B23/04 ,  C09B23/10 ,  C09B55/00 ,  C09D7/00

Abstract: Compounds of formula (1) wherein R1 is hydrogen, hydroxy, halogen, nitro, cyano, amino, carboxy, carboxylic ester, sulfo, sulfonic ester, carboxylic amide, sulfonic amide, alkoxy, aryloxy, alkylthio or arylthio, X is -0-, -S- , - NH- or -N(alkyl)-, Y is hydrogen or carboxylic ester, Z is =C- or =N-, T is =C- or =N-, R2 is hydrogen, alkyl or CN, n is 0 or 1, when Z is =N- then n is 0 , m is 0 or 1, when T is =N- then m is 0, A is a heterocyclic or linear or polycondensed aromatic group which is unsubstituted or substituted by hydrox y alkyl, halogen, nitro, cyano, amino, acylarnino, carboxylic ester, sulfonic ester, carboxylic amide, sulfonic amide, alkoxy, aryloxy, alkylthio, arylthi o or phenyl, or A together with T and R2 can form an allycyclic or heterocycli c ring, their preparation and their use in the production of coloured plastics or polymeric colour particles.