公开(公告)号：AU2003299691B2

公开(公告)日：2008-06-05

申请号：AU2003299691

申请日：2003-12-18

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： LAZAR JEFF ,  CARTER RICHARD B ,  BURCH RONALD

IPC: A61K31/05 ,  A61K9/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K36/81 ,  A61K45/06 ,  A61K47/10 ,  C07C231/02 ,  C07C233/20

Abstract: The present invention is directed to methods for attenuating pain associated with a surgical site or an open wound by administration of single doses of a capsaicinoid formulation in proximity to a surgical site or wound opening.

公开(公告)号：AU2005309586A1

公开(公告)日：2006-06-01

申请号：AU2005309586

申请日：2005-11-23

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： ANDERSON TIMOTHY A ,  BURCH RONALD ,  LAZAR JEFF

IPC: A61K31/04

公开(公告)号：WO2006058140A3

公开(公告)日：2007-01-04

申请号：PCT/US2005042578

申请日：2005-11-23

Applicant: ALGORX PHARMACEUTICALS INC ,  BURCH RONALD ,  ANDERSON TIMOTHY A ,  LAZAR JEFF

Inventor： BURCH RONALD ,  ANDERSON TIMOTHY A ,  LAZAR JEFF

IPC: A61K31/04

CPC classification number: A61K47/26 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/16 ,  A61K36/81 ,  A61K47/36 ,  A61K47/38

Abstract: The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 µg to 10,000µg.

Abstract translation: 本发明提供辣椒素类凝胶制剂和方法，其通过在有需要的人或动物的手术部位施用一定剂量的辣椒素凝胶来减轻人或动物的部位的手术前和手术后疼痛， 减轻手术部位的手术后疼痛，辣椒素的剂量范围为100μg〜10,000μg。

公开(公告)号：WO2004092122A3

公开(公告)日：2005-12-29

申请号：PCT/US2004010745

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC ,  MCILVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BURCH RONALD ,  CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  ZHANG HEPING

Inventor： MCILVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BURCH RONALD ,  CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  ZHANG HEPING

IPC: A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

CPC classification number: C07C231/02 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  A61K2300/00 ,  C07C57/03 ,  C07C233/20

Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.

Abstract translation: 本发明提供了通过利用反应几何形式从合成反应开始设定并通过整个合成过程进行的方法来合成辣椒素和/或辣椒素样化合物的反式异构体的方法。

公开(公告)号：NZ540769A

公开(公告)日：2009-03-31

申请号：NZ54076903

申请日：2003-12-18

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： BURCH RONALD ,  CARTER RICHARD B ,  LAZAR JEFF

IPC: A61K9/00 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K36/81 ,  A61K45/06 ,  A61K47/10 ,  C07C231/02 ,  C07C233/20 ,  A61K35/78 ,  A61K9/50 ,  A61K9/08 ,  A61P23/00 ,  A61P25/00

Abstract: Disclosed is the use of a capsaicinoid for the preparation of an injectable, implantable, or infiltratable composition for attenuating pain associated with osteoarthritis, rheumatoid arthritis, tendonitis, bursitis, orthopedic disorders, laparoscopic cholecystectomy, chronic post-herniorrhapy, a surgical site or an open wound, a body space, traumatic pain associated with an injury, or neuropathic pain, said composition comprising a dose of a capsaicinoid for administration in an amount effective to produce a selective, highly localized destruction or incapacitation of C-fiber and A-delta fibers at a joint afflicted with osteoarthritis, rheumatoid arthritis, or in a discrete localized area responsible for the initiation of pain due to tendonitis, bursitis, orthopedic disorder, laparoscopic cholecystectomy, chronic post-herniorrhapy, a surgical site or an open wound, a body space, traumatic pain associated with an injury, or neuropathic pain without eliciting an effect outside the joint or said discrete area, and thereby attenuating pain emanating from the joint, the effective dose being from 1 - 5000 micrograms of capsaicin or a therapeutically equivalent dose of a capsaicinoid other than capsaicin when said dose is injected or implanted into the joint, and the dose ranging from 1 - 15,000 micrograms of capsaicin or a therapeutically equivalent dose of a capsaicinoid other than capsaicin when said dose is infiltrated into a surgical site or open wound.

公开(公告)号：AU2004230915A1

公开(公告)日：2004-10-28

申请号：AU2004230915

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： MCILVAIN SHARON ,  RAMIYA PREMCHANDRAN H ,  CARTER RICHARD B ,  ANDERSON THIMOTHY A ,  BURCH RONALD ,  CHEN WEI

IPC: A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.

公开(公告)号：CA2510181A1

公开(公告)日：2004-07-15

申请号：CA2510181

申请日：2003-12-18

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： CARTER RICHARD B ,  BURCH RONALD ,  LAZAR JEFF

IPC: A61K9/00 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K36/81 ,  A61K45/06 ,  A61K47/10 ,  C07C231/02 ,  C07C233/20 ,  A61K35/78

Abstract: The present invention provides compositions and methods for relieving pain a t a site in a human or animal in need thereof by administering at a site in a human or animal in need thereof a dose of capsaicinoid.

公开(公告)号：CA2510181C

公开(公告)日：2011-03-08

申请号：CA2510181

申请日：2003-12-18

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： BURCH RONALD ,  CARTER RICHARD B ,  LAZAR JEFF

IPC: A61K31/165 ,  A61K9/00 ,  A61K31/05 ,  A61K31/16 ,  A61K31/5415 ,  A61K31/551 ,  A61K36/81 ,  A61K45/06 ,  A61K47/10 ,  C07C231/02 ,  C07C233/20

Abstract: The present invention provides compositions and methods for relieving pain at a site in a human or animal in need thereof by administering at a site in a human or animal in need thereof a dose of capsaicinoid.

公开(公告)号：EA011708B1

公开(公告)日：2009-04-28

申请号：EA200500986

申请日：2003-12-18

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： BURCH RONALD ,  CARTER RICHARD B ,  LAZAR JEFF

IPC: A61K31/045 ,  A61K9/00 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K36/81 ,  A61K45/00 ,  A61K45/06 ,  A61K47/10 ,  A61P29/02 ,  C07C231/02 ,  C07C233/20

Abstract: Настоящееизобретениеотноситсяк композициями способамдляоблегченияболив участкеорганизмачеловекаилиживотногопосредствомвведенияинъецируемой, имплантируемойилиинфильтрируемойкомпозиции, содержащейдозусинтетическоготранс-капсаицинав количестве, эффективномдляденервацииданногоучасткабезоказаниядействиявнеотдельногоместоположения, идляослабленияболи, исходящейизуказанногоучастка, причемданнаядозанаходитсяв пределахприблизительноот 1 до 5000 мкгсинтетическоготранс-капсаицинас чистотойпоменьшеймереприблизительно 95%, гдеуказаннуюдозуинъецируютилиимплантируютв отдельныйучастокорганизмачеловекаилиживотного, иданнаядозаварьируетприблизительноот 1 до 15000 мкгсинтетическоготранс-капсаицинас чистотойпоменьшеймереприблизительно 95%, гдеуказаннуюдозуинфильтрируютв участокхирургическоговмешательстваилив открытуюрану.

公开(公告)号：CA2596194A1

公开(公告)日：2006-06-01

申请号：CA2596194

申请日：2005-11-23

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： LAZAR JEFF ,  ANDERSON TIMOTHY A ,  BURCH RONALD

IPC: A61K31/04