公开(公告)号：WO1997035511A1

公开(公告)日：1997-10-02

申请号：PCT/EP1997001076

申请日：1997-03-04

Applicant: INSTITUT FÜR DIABETESTECHNOLOGIE, GEMEINNÜTZIGE FORSCHUNGS- UND ENTWICKLUNGSGESELLSCHAFT MBH AN DER UNIVERSITÄT ULM ,  PFEIFFER, Margret +hf ,  HOSS, Udo

Inventor： INSTITUT FÜR DIABETESTECHNOLOGIE, GEMEINNÜTZIGE FORSCHUNGS- UND ENTWICKLUNGSGESELLSCHAFT MBH AN DER UNIVERSITÄT ULM ,  PFEIFFER, Margret +hf ,  PFEIFFER, Ernst, Friedrich +di

IPC: A61B05/00

CPC classification number: A61B5/14865 ,  A61B5/14528 ,  A61B5/686

Abstract: The invention relates to a process and arrangement for determining the concentration of a metabolite in bio-tissues (10) in which a perfusion solution (20) is taken to a microdialysis probe (12) in the tissue (10) and drawn off after enrichment with the metabolite as a dialysis flow. Under the effect of an enzyme (34), the metabolite is oxidised by oxygen and an electrode signal dependent upon the concentration of one of the reactants in the oxidation reaction is used as a measure for the metabolite concentration. In order to prevent the undesirable incomplete oxidation of the metabolite, especially during temperature fluctuations, according to the invention the dialysate flow is enriched with oxygen in an oxygen-permeable reaction channel (38) before reaching the measuring point (14).

Abstract translation: 馈送到灌注溶液（20）和衍生的由富集与代谢物作为透析液流动，本发明涉及一种方法，以及用于确定在生物组织（10）的代谢物的浓度的装置，布置成一个在所述幅材（10）微透析探针（12） 是。 下形成酶（34）的作用，所述代谢物被氧化杜赫氧气，并推导作为氧化反应依赖电极的信号的反应物的浓度的代谢物的浓度的量度。 为了防止特别是令人不安的随温度变化的代谢物的不完全氧化，根据本发明，提供的是，透析液流在氧可透过的反应通道（38）富含到达测量点（14）与氧气之前。

公开(公告)号：WO1997034521A1

公开(公告)日：1997-09-25

申请号：PCT/US1997003801

申请日：1997-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PEZZANITI, J., Larry ,  LINDBERG, John, M.

IPC: A61B05/00

CPC classification number: A61B5/14558 ,  G01N21/21

Abstract: An apparatus (8) and a process of determining the concentration of an optically active compound in a biological sample are provided. The process measures the entire polarization state of the sample and compares the measured polarization state of the sample to the polarization state of a sample having a known concentration of that compound. The polarization state of the sample is measured after manipulating the polarization state of light entering and leaving the sample and detecting the light leaving the sample. The apparatus (8) contains a source of light (10), a sample holder (14) for holding the biological sample, a detector (18), a first polarization manipulator (12) between the light source (10) and the sample holder (14), a second polarization manipulator (16) between the sample holder (14) and an analyzer (20) to correlate detected signals with concentration of the optically active compound.

Abstract translation: 提供了一种设备（8）和确定生物样品中光学活性化合物浓度的方法。 该过程测量样品的整个极化状态，并将样品的测量的偏振状态与具有该化合物的已知浓度的样品的偏振状态进行比较。 在处理进入和离开样品的光的偏振状态并检测离开样品的光之后测量样品的偏振状态。 所述装置（8）包含光源（10），用于保持所述生物样品的样品保持器（14），在所述光源（10）和所述样品架之间的检测器（18），第一偏振机械手（12） （14），所述样品保持器（14）和分析器（20）之间的第二偏振操纵器（16），用于将检测到的信号与所述光学活性化合物的浓度相关联。

公开(公告)号：WO1997032517A1

公开(公告)日：1997-09-12

申请号：PCT/US1997003204

申请日：1997-03-05

Applicant: SYMBIOSIS CORPORATION ,  TURKEL, David ,  GORDON, David, P. ,  GALLAGHER, Thomas, A. ,  SCARFONE, Frank, A. ,  SOLAR, Matthew, S. ,  COHEN, Herbert

Inventor： SYMBIOSIS CORPORATION

IPC: A61B05/00

CPC classification number: A61B10/02 ,  A61B10/0045 ,  A61B2010/0216 ,  A61B2017/2911 ,  A61B2017/2923 ,  A61B2017/320012

Abstract: A protected microbiological sampling brush assembly includes a sampling brush (12) mounted on the distal end of a control wire (14), an inner catheter (18) which houses the brush (12), an outer catheter (22) which houses the inner catheter (18), and an elastomeric tip (24) which is rigidly attached to the distal end of the outer catheter (22).

Abstract translation: 受保护的微生物采样刷组件包括安装在控制线（14）的远端上的采样刷（12），容纳刷子（12）的内导管（18），容纳内部的内导管 导管（18）和刚性地附接到外导管（22）的远端的弹性体顶端（24）。

公开(公告)号：WO1997031567A1

公开(公告)日：1997-09-04

申请号：PCT/US1997002789

申请日：1997-02-25

Applicant: MEDICOMP OF VIRGINIA, INC.

Inventor： MEDICOMP OF VIRGINIA, INC. ,  GOLTRA, Peter, S.

IPC: A61B05/00

CPC classification number: G06F19/325 ,  A61B5/00 ,  G06F19/00 ,  G16H40/63 ,  Y10S128/924 ,  Y10S706/924

Abstract: A method and apparatus for helping health care professionals create clinical protocols or assist in direct entry of medical finding into a chart by intelligently prompting a health care professional with medical findings associated with at least one medical finding which has already been entered in the protocol, is disclosed (fig. 2). First of all, at least one medical finding for a patient is inputted into the system (10) wherein each findings is assigned a point of value for each diagnosis within a knowledge base (22). A total number of points for each diagnosis is then totalled for all the findings which have been entered into the system (10). The possible diagnoses are then ranked in descending point total and predetermined plurality of the highest ranked diagnoses are selected. Once the higher ranked diagnoses have been selected, the health care professional is prompted with additional findings associated with the selected diagnoses which have not yet been inputted into the clinical protocol.

Abstract translation: 一种帮助卫生保健专业人员创建临床协议或协助直接将医疗查询输入图表的方法和设备，通过智能地促使卫生保健专业人员获得与至少一项已经在协议中输入的医疗结果相关的医学发现，是 披露（图2）。 首先，向系统（10）输入至少一个患者的医疗结果，其中每个发现被分配了知识库（22）内的每个诊断的一个有价值的点。 对于已经输入系统的所有发现，每个诊断的总分数总计（10）。 然后将可能的诊断排在下降点总数中，并且选择预定多个最高排名的诊断。 一旦选择了更高等级的诊断，医疗保健专业人员将提供与所选择的诊断相关的其他发现，这些诊断尚未被输入到临床方案中。

公开(公告)号：WO1997029678A3

公开(公告)日：1997-08-21

申请号：PCT/IL1997000060

申请日：1997-02-14

Applicant: BIOSENSE INC. ,  OSADCHY, Daniel ,  FRIED, Shlomo ,  BEN-HAIM, Shlomo ,  FENSTER, Maier

Inventor： BIOSENSE INC.

IPC: A61B05/00

公开(公告)号：WO1997027801A1

公开(公告)日：1997-08-07

申请号：PCT/US1997001815

申请日：1997-01-31

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  ORAEVSKY, Alexander, A. ,  JACQUES, Steven, L. ,  ESENALIEV, Rinat, O.

IPC: A61B05/00

CPC classification number: G01N21/1702 ,  A61B5/0095 ,  A61B5/1459 ,  A61B8/08 ,  A61B2017/00128 ,  A61F9/008 ,  A61F2009/00851 ,  A61F2009/00897 ,  A61K49/225

Abstract: The present invention provides a system and principles of laser photo-acoustic imaging and tomography. The basis for laser photo-acoustic tomography is the time resolved detection of laser induced transient stress waves, selectively generated in absorbing tissues of diagnostic interest. Such a technique allows to visualize absorbed light distribution in turbid biological tissues irradiated by short laser pulses. Laser photo-acoustic tomography can be used for detection of tissue pathological changes that result in increased concentration of various tissue chromophore such as hemoglobin or development of enhanced micro-circulation in diseased tissue. The invented technology combines the advantages of pulsed laser excitation with time resolved detection of acoustic transients. The invented technology can be used for determination of optical heterogeneities in biological tissues. These heterogeneities include blood vessels, tissue layers, abnormal tissues and damaged tissues with further reconstruction of 3D tomographic images of human organs or portions thereof.

Abstract translation: 本发明提供了激光光声成像和层析成像的系统和原理。 激光光声层析成像的基础是激光诱发瞬态应激波的时间分辨检测，在诊断感兴趣的吸收组织中有选择性地产生。 这种技术允许可视化由短激光脉冲照射的混浊生物组织中的吸收光分布。 激光光声层析成像可用于组织病理学变化的检测，导致各种组织发色团的浓度增加，如血红蛋白或病变组织中增强的微循环的发展。 本发明的技术将脉冲激光激发的优点与声学瞬态的时间分辨检测相结合。 本发明技术可用于确定生物组织中的光学异质性。 这些异质性包括血管，组织层，异常组织和受损组织，进一步重建人体器官或其部分的3D断层图像。

公开(公告)号：WO1997027800A1

公开(公告)日：1997-08-07

申请号：PCT/US1997001450

申请日：1997-02-05

Applicant: DIASENSE, INC. ,  RABER, Peter, E. ,  CUPP, James ,  FOWLER, Raymond

Inventor： DIASENSE, INC.

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: Disclosed is a probe (2) suitable for use in the non-invasive sensing of glucose concentrations in the body of a patient. The probe (2) includes at least three radiation receiving fibers (16) extending between a probe body (12) and a spectrograph (8), and spaced apart from each other in a substantially uniform manner and aligned in a predetermined fixed pattern at the probe body (12). A radiation transmitting means (10) conducts radiation from a radiation source (4) and extends from the radiation source (4) to the probe body (12). The radiation transmitting means (10) is formed in the probe (2) into a ring to conduct radiation in a ring shaped area immediately surrounding each of the receiving fibers (16). The radiation transmitting means (10) and the receiving fibers (16) terminate at the probe body (12) in a unitary structure having an outer surface configured for contacting the skin of a patient. The ring passes radiation from the radiation source (4) into the patient in the areas immediately surrounding each receiving fiber (16). The receiving fibers (16) detect the radiation passing back out of the patient and pass this detected radiation to the spectrograph (8).

Abstract translation: 公开了适合用于非侵入性感测患者体内葡萄糖浓度的探针（2）。 探针（2）包括在探针主体（12）和光谱仪（8）之间延伸的至少三个辐射接收光纤（16），并且以基本上均匀的方式彼此间隔开并且以预定的固定图案对准 探针体（12）。 辐射透射装置（10）从辐射源（4）传导辐射并从辐射源（4）延伸到探针体（12）。 辐射传递装置（10）在探针（2）中形成为环，以在紧邻围绕每个接收纤维（16）的环形区域中传导辐射。 辐射传递装置（10）和接收纤维（16）以一体式结构终止在探针体（12）处，其具有被配置为接触患者皮肤的外表面。 该环将辐射源（4）的辐射传递到紧邻每个接收光纤（16）周围的区域中的患者体内。 接收光纤（16）检测从患者返回出来的辐射，并将该检测到的辐射传递到光谱仪（8）。

公开(公告)号：WO1997027799A1

公开(公告)日：1997-08-07

申请号：PCT/US1997001018

申请日：1997-01-23

Applicant: HEARTPORT, INC.

Inventor： HEARTPORT, INC. ,  DONLON, Brian, S. ,  PETERS, William, S. ,  GARRISON, Michi, E. ,  ROSENMAN, Daniel, C. ,  STEVENS, John, H.

IPC: A61B05/00

CPC classification number: A61B17/00234 ,  A61B17/0057 ,  A61B17/0218 ,  A61B17/0293 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/06061 ,  A61B17/122 ,  A61B17/29 ,  A61B17/2909 ,  A61B17/3417 ,  A61B17/3421 ,  A61B18/1492 ,  A61B90/36 ,  A61B90/50 ,  A61B2017/00053 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00278 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/00907 ,  A61B2017/00946 ,  A61B2017/0237 ,  A61B2017/0243 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0496 ,  A61B2017/2912 ,  A61B2017/2926 ,  A61B2017/2927 ,  A61B2017/2932 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2017/3405 ,  A61B2017/3492 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00291 ,  A61B2018/00363 ,  A61B2018/00392 ,  A61B2018/00577 ,  A61B2018/00982 ,  A61B2090/061 ,  A61B2090/306 ,  A61F2/2427 ,  A61F2/2496 ,  A61F7/10 ,  A61F2007/0001 ,  A61F2007/0054 ,  A61F2007/101 ,  A61M1/3621 ,  A61M25/1011 ,  A61M39/0247 ,  A61M2025/028 ,  A61M2039/027 ,  A61M2039/0279 ,  A61M2202/047 ,  A61M2205/3344 ,  A61M2205/3355 ,  A61M2205/366 ,  Y10S623/902

Abstract: Systems and methods are disclosed for performing less invasive surgical procedures within the heart. A method for less invasive repair or replacement of a cardiac valve (216) comprises placing an instrument (290) through an intercostal access port (212) and through a penetration in a wall of a vessel in communication with the heart, advancing the instrument (290) into the heart, using the instrument (290) to perform a surgical intervention on a cardiac valve (216) in the heart under visualization through an intercostal access port. The surgeons hands are kept outside of the chest during each step. The surgical intervention may comprise replacing the cardiac valve with a prosthetic valve, wherein the native valve is removed using a tissue removal instrument (206), the native valve annulus is sized with a specialized sizing device (216), a prosthetic valve is introduced through an intercostal access port (212) and through the penetration in the vessel, and the prosthetic valve is secured at the native valve position, all using instruments positioned through intercostal access ports without placing the hands inside the chest. Systems and devices for performing these procedures are also disclosed.

Abstract translation: 公开了用于在心脏内执行较少侵入性外科手术的系统和方法。 用于较少侵入性修复或更换心脏瓣膜（216）的方法包括将器械（290）穿过肋间进入口（212）并通过与心脏连通的血管壁穿透，推进器械 290）进入心脏，使用仪器（290）通过肋间进入端口在可视化的心脏内的心脏瓣膜（216）上执行手术干预。 在每一步中，外科医生的手都保持在胸前。 外科手术可以包括用假性瓣膜替换心脏瓣膜，其中使用组织去除器具（206）去除所述天然瓣膜，所述天然瓣膜通过专门的上浆装置（216）来定尺寸，通过引入人工瓣膜 肋间进入口（212），并穿过容器内的穿透，并且人造瓣膜固定在天然瓣膜位置，所有这些都使用通过肋间进入口定位的器械，而不将手放在胸部内。 还公开了用于执行这些程序的系统和装置。

公开(公告)号：WO1997025913A1

公开(公告)日：1997-07-24

申请号：PCT/US1996003319

申请日：1996-03-21

Applicant: SPECTRX, INC.

Inventor： SPECTRX, INC. ,  EPPSTEIN, Jonathon, A. ,  SAMUELS, Mark, A. ,  IGNOTZ, Keith, D. ,  NEWMAN, Gregory, J.

IPC: A61B05/00

CPC classification number: A61B5/1495 ,  A61B5/0059 ,  A61B2560/0233

Abstract: A disposable calibration device (45) is used to calibrate a measurement system (3) which transmits radiation (39) to a material or tissue (40) in order to effect measurements with a spectrometer (10). The disposable calibration device includes a structure with a window through which radiation (39) can be transmitted, as well as a removable calibration target (270) arranged on the window and capable of returning a portion of the radiation for calibrating the measurement system. The removable calibration target (270) can be peeled off of the window or the perimeter of an opening to allow a measurement to be made on the material or tissue (40). Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the measurement system.

Abstract translation: 一次性校准装置（45）用于校准将辐射（39）传输到材料或组织（40）的测量系统（3），以便用光谱仪（10）进行测量。 一次性校准装置包括具有可以透射辐射（39）的窗口的结构以及布置在窗口上并且能够返回一部分辐射以校准测量系统的可移除校准目标（270）。 可拆卸校准目标（270）可以从窗口或开口的周边剥离，以允许在材料或组织（40）上进行测量。 一旦测量完成，可以丢弃一次性校准装置，并且可以在测量系统上插入新的校准装置。

公开(公告)号：WO1997024979A1

公开(公告)日：1997-07-17

申请号：PCT/US1997000390

申请日：1997-01-09

Applicant: SMITHKLINE BEECHAM CORPORATION ,  EPITOPE, INC. ,  BEZEK, Edward, Anthony ,  LIVINGOOD, Sharon, Louise ,  GOLDSTEIN, Andrew, Sherman ,  BERGERON, Charles, Edward ,  LOGAN, Douglas

Inventor： SMITHKLINE BEECHAM CORPORATION ,  EPITOPE, INC.

IPC: A61B05/00

CPC classification number: A61B10/0051 ,  B01L3/5029 ,  B01L3/50825 ,  B01L3/5635 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0832

Abstract: A device for collecting substances for testing comprises a vial having a first, generally open end, engageable by a removable closure member, and a second, generally closed end. A removable closure member is provided having first and second ends. The first and second ends of the closure member are engageable with the first end of the vial. An absorbent member is preferably attached to the removable closure member and is receivable in the vial whereby the absorbent member is located outside of the vial prior to use, with the first end of the vial being secured to the second end of the closure member to provide a handle, and after use, the second end of the closure member is removed from the first end of the vial, the closure member is inverted, the absorbent member is inserted into the vial and the first end of the closure member is removably engaged to the first end of the vial.

Abstract translation: 用于收集用于测试的物质的装置包括具有第一通常敞开的端部的小瓶，可由可移除的关闭构件接合，以及第二，大致封闭的端部。 提供具有第一端和第二端的可移除封闭构件。 封闭构件的第一和第二端可与小瓶的第一端接合。 吸收体优选地附接到可移除的关闭构件并且可接收在小瓶中，由此吸收构件在使用之前位于小瓶的外部，其中小瓶的第一端固定到关闭构件的第二端以提供 手柄，并且在使用后，关闭构件的第二端从小瓶的第一端移除，关闭构件被倒置，吸收构件插入小瓶中，并且关闭构件的第一端可移除地接合到 小瓶的第一端。