公开(公告)号：WO1997034521A1

公开(公告)日：1997-09-25

申请号：PCT/US1997003801

申请日：1997-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PEZZANITI, J., Larry ,  LINDBERG, John, M.

IPC: A61B05/00

CPC classification number: A61B5/14558 ,  G01N21/21

Abstract: An apparatus (8) and a process of determining the concentration of an optically active compound in a biological sample are provided. The process measures the entire polarization state of the sample and compares the measured polarization state of the sample to the polarization state of a sample having a known concentration of that compound. The polarization state of the sample is measured after manipulating the polarization state of light entering and leaving the sample and detecting the light leaving the sample. The apparatus (8) contains a source of light (10), a sample holder (14) for holding the biological sample, a detector (18), a first polarization manipulator (12) between the light source (10) and the sample holder (14), a second polarization manipulator (16) between the sample holder (14) and an analyzer (20) to correlate detected signals with concentration of the optically active compound.

Abstract translation: 提供了一种设备（8）和确定生物样品中光学活性化合物浓度的方法。 该过程测量样品的整个极化状态，并将样品的测量的偏振状态与具有该化合物的已知浓度的样品的偏振状态进行比较。 在处理进入和离开样品的光的偏振状态并检测离开样品的光之后测量样品的偏振状态。 所述装置（8）包含光源（10），用于保持所述生物样品的样品保持器（14），在所述光源（10）和所述样品架之间的检测器（18），第一偏振机械手（12） （14），所述样品保持器（14）和分析器（20）之间的第二偏振操纵器（16），用于将检测到的信号与所述光学活性化合物的浓度相关联。

公开(公告)号：WO1997028428A1

公开(公告)日：1997-08-07

申请号：PCT/US1997000949

申请日：1997-01-30

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LINDBERG, John, M. ,  HEINZ, Robert, E.

IPC: G01J03/457

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/457 ,  G01J2003/1286 ,  G01J2003/2836 ,  G01J2003/2866

Abstract: The present invention provides a programmable filter for use as a standard in correlation spectrometers. Also provided is the use of the programmable standard in a process for determining the concentration of an optically absorbing compound. Also provided is a method and apparatus for noninvasively determining the concentration of an optically absorbing biological sample which incorporates the programmable standard of the invention. In one embodiment the programmable standard (20) contains a dispersive element (106a) and a transmissive spatial light modulator (108). Because the position of each light beam correlates to its wavelength, spatial filter (108) controllably and selectively attenuates desired wavelengths of the input beam.

Abstract translation: 本发明提供了一种用于相关光谱仪中的标准的可编程滤波器。 还提供了在用于确定光学吸收化合物的浓度的方法中使用可编程标准品。 还提供了用于非侵入性地确定结合了本发明的可编程标准的光学吸收生物样品的浓度的方法和装置。 在一个实施例中，可编程标准（20）包含色散元件（106a）和透射空间光调制器（108）。 由于每个光束的位置与其波长相关，所以空间滤波器（108）可控地选择性地衰减输入光束的期望波长。

公开(公告)号：WO1994009507A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009599

申请日：1993-10-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GUTCHECK, Robert, A. ,  LINDBERG, John, M. ,  VUREK, Gerald, G.

IPC: H01J05/16

CPC classification number: G02B6/4204 ,  G01D5/268 ,  G01N21/7703 ,  G01N2021/772 ,  G01N2021/7786 ,  G01N2201/062 ,  G02B6/4202 ,  H01S5/02415

Abstract: An optical distribution system incorporating an improved luminescent based optical fiber sensor incorporating a signal generating component (32) for generating a first optical signal, a signal separating component (49) for delivering said first optical signal to the sensor, delivering a second returned optical signal to an associated signal detector (42), and including signal interference means to separate said first and second signals and minimize cross-talk therebetween. A sensor optical fiber connects to a sensor tip (37) to the signal separating component. The signal detector receives a returned signal from the signal separating component and transmits it to a signal-measuring component of the distribution system.

Abstract translation: 一种包含改进的基于发光的光纤传感器的光分配系统，其包括用于产生第一光信号的信号产生部件（32），用于将所述第一光信号传送到传感器的信号分离部件（49），传送第二返回光信号 并且包括用于分离所述第一信号和第二信号的信号干扰装置，并使它们之间的串扰减至最小。 传感器光纤连接到信号分离部件的传感器尖端（37）。 信号检测器从信号分离部件接收返回的信号并将其发送到分配系统的信号测量部件。

公开(公告)号：EP0891151B1

公开(公告)日：2004-06-09

申请号：EP97914986.1

申请日：1997-03-12

Applicant: Abbott Laboratories

Inventor： PEZZANITI, J., Larry ,  LINDBERG, John, M.

IPC: A61B5/00 ,  G01N21/21

CPC classification number: A61B5/14558 ,  G01N21/21

公开(公告)号：EP0877919A1

公开(公告)日：1998-11-18

申请号：EP97903884.0

申请日：1997-01-30

Applicant: Abbott Laboratories

Inventor： LINDBERG, John, M. ,  HEINZ, Robert, E.

IPC: G01J3 ,  G01N21

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/457 ,  G01J2003/1286 ,  G01J2003/2836 ,  G01J2003/2866

Abstract: The present invention provides a programmable filter for use as a standard in correlation spectrometers. Also provided is the use of the programmable standard in a process for determining the concentration of an optically absorbing compound. Also provided is a method and apparatus for noninvasively determining the concentration of an optically absorbing biological sample which incorporates the programmable standard of the invention. In one embodiment the programmable standard (20) contains a dispersive element (106a) and a transmissive spatial light modulator (108). Because the position of each light beam correlates to its wavelength, spatial filter (108) controllably and selectively attenuates desired wavelengths of the input beam.

公开(公告)号：EP1139862A1

公开(公告)日：2001-10-10

申请号：EP99966375.0

申请日：1999-12-16

Applicant: ABBOTT LABORATORIES

Inventor： JENG, Tzyy-Wen ,  YEH, Shu-Jen ,  LINDBERG, John, M. ,  PEZZANITI, Joseph, Larry ,  KHALIL, Omar, S. ,  OOSTA, Gary, M. ,  HANNA, Charles, F. ,  STALDER, Arnold, F. ,  SZUTS, Ete Z.

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: A method and apparatus for measuring the concentration of an analyte of interest, e.g. glucose, in blood non-invasively. The method and apparatus of this invention can also be adapted to allow a portion of a body part to be engorged with blood to bring about greater accuracy in optical measurements. In the method of this invention, at least two similar, but not identical, measurements are made concurrently. For example, two similar, but not identical, wavelengths of electromagnetic radiation can be used. The two wavelengths should not be overlapping to allow maximum non-identity. By making measurements concurrently, each measurement channel in the system experiences variations as they occur substantially simultaneously in all channels. By selecting one of the channels as a reference channel and by normalizing the optical measurements of the other channels to this reference channel, the variations common to all channels are eliminated. Removing these common variations from the optical measurements by normalization, such as by calculating ratios of the measurement of each of the measuring channels to that of the reference channel, will allow the actual changes of the signal for a specific analyte of interest to be measured.

公开(公告)号：EP0891151A1

公开(公告)日：1999-01-20

申请号：EP97914986.0

申请日：1997-03-12

Applicant: Abbott Laboratories

Inventor： PEZZANITI, J., Larry ,  LINDBERG, John, M.

IPC: G01N33 ,  A61B5 ,  G01N21

CPC classification number: A61B5/14558 ,  G01N21/21

Abstract: An apparatus (8) and a process of determining the concentration of an optically active compound in a biological sample are provided. The process measures the entire polarization state of the sample and compares the measured polarization state of the sample to the polarization state of a sample having a known concentration of that compound. The polarization state of the sample is measured after manipulating the polarization state of light entering and leaving the sample and detecting the light leaving the sample. The apparatus (8) contains a source of light (10), a sample holder (14) for holding the biological sample, a detector (18), a first polarization manipulator (12) between the light source (10) and the sample holder (14), a second polarization manipulator (16) between the sample holder (14) and an analyzer (20) to correlate detected signals with concentration of the optically active compound.