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    225.
    发明专利
    未知

    公开(公告)号：AT263148T

    公开(公告)日：2004-04-15

    申请号：AT00987278

    申请日：2000-11-21

    Applicant: MORPHOCHEM AG

    Inventor： MUELLER THOMAS ,  ANSORGE MARKUS

    IPC: A61P31/04 ,  A61P31/10 ,  C07D201/00 ,  C07D231/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

    Abstract: The invention relates to a process for the preparation of heterocycles, characterised in that the following components:i) a propargyl derivative of the general structural formula Ia wherein Het is an optionally substituted hetero atom and A is a substituted or unsubstituted aromatic entity, a substituted or unsubstituted aromatic heterocycle, a substituted or unsubstituted vinyl arene and/or a derivative thereof, an olefin, an alkyne, an acceptor group or a nitrile;(ii) a compound of the general structural formula II,wherein B is an electron-deficient substituted or unsubstituted aromatic entity with or without an acceptor group, an electron-deficient substituted or unsubstituted heteroaromatic entity with or without an acceptor group, an electron-deficient olefin and/or alkyne, a metal complex, and X is a leaving group;(iii) a nucleophile of the general structural formula III,wherein Y and/or Z, each independently of the other, is an amino group, thio group (mercapto group), seleno group, telluro group, hydroxy group (alcohol group), imido group, carbonyl group, thiocarbonyl group, selenocarbonyl group, tellurocarbonyl group; C is a substituted or unsubstituted C atom, a substituted or unsubstituted or annelated CC double bond or single bond and n=0-10, preferably 1-5, preferably are reacted in a one-pot reaction by cyclocondensation to form 4- to 10-membered, preferably 5- to 7-membered, heterocyclic, aromatic or non-aromatic ring systems.

    227.
    发明专利
    未知

    公开(公告)号：ES2188891T3

    公开(公告)日：2003-07-01

    申请号：ES97902722

    申请日：1997-02-05

    Applicant: DSM NV ,  DU PONT

    Inventor： GUIT RUDOLF PHILIPPUS MARIA ,  FRENTZEN YVONNE HELENE

    IPC: C07D201/00 ,  C07D201/08 ,  C07D201/16 ,  C07D223/10

    Abstract: Process to separate epsi-caprolactam from an aqueous mixture containing epsi-caprolactam and at least 0.5 wt % oligomers, wherein the separation is performed by extraction using an organic extraction agent. The aqueous mixture may be obtained in a process to prepare epsi-caprolactam starting from 6-aminocapronitrile or in a process to prepare epsi-caprolactam starting from 6-aminocaproic acid.

    228.
    发明专利
    未知

    公开(公告)号：AT239702T

    公开(公告)日：2003-05-15

    申请号：AT99910210

    申请日：1999-02-05

    Applicant: DUPHAR INT RES

    Inventor： DEN HARTOG JACOBUS A J ,  VISSER GERBEN M ,  VAN STEEN BARTHOLOMEUS J ,  TULP MARTINUS T M ,  RONKEN ERIC ,  KRUSE CORNELIS G

    IPC: A61K31/4709 ,  A61K31/496 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D201/00 ,  C07D215/38 ,  C07D401/12 ,  C07D405/12

    Abstract: The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R1)n represents 1 or 2 substituents, which can be the same or different, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)amino, or two groups R1 at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R2)p represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R2)p is a methylene bridge or ethylene bridge, R3 is hydrogen or methyl, and (R)m represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)amino, on the understanding that R1 cannot represent o-OCH3 when X is nitrogen, (R2)p and R3 are hydrogen, m is 0 and n is 1

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