公开(公告)号：US4072705A

公开(公告)日：1978-02-07

申请号：US656711

申请日：1976-02-09

Applicant: Andre Mieville

Inventor： Andre Mieville

IPC: C07C69/736 ,  A61K31/12 ,  A61K31/22 ,  C07C45/00 ,  C07C45/45 ,  C07C45/46 ,  C07C45/64 ,  C07C45/67 ,  C07C49/83 ,  C07C49/84 ,  C07C49/86 ,  C07C51/00 ,  C07C59/125 ,  C07C59/68 ,  C07C59/70 ,  C07C59/84 ,  C07C59/90 ,  C07C67/00 ,  C07C69/712 ,  C07C201/00 ,  C07C205/35 ,  C07C205/45 ,  C07C217/80 ,  C07C219/06 ,  C07C233/00 ,  C07C233/25 ,  C07C233/33 ,  C07C233/43 ,  C07C233/54 ,  C07C235/24 ,  C07C327/22 ,  C07D213/30 ,  C07D213/67 ,  C07D217/00 ,  C07D295/088 ,  C07D295/185 ,  C07D307/38 ,  C07D307/46 ,  C07D307/56 ,  C07D307/80 ,  C07D317/22 ,  C07D333/20 ,  C07D333/22 ,  C07D333/28 ,  C07C69/76

CPC classification number: C07D213/30 ,  C07C205/35 ,  C07C205/45 ,  C07C327/00 ,  C07C45/45 ,  C07C45/46 ,  C07C45/64 ,  C07C45/673 ,  C07C49/83 ,  C07C49/84 ,  C07C49/86 ,  C07C59/68 ,  C07C59/90 ,  C07D213/67 ,  C07D295/088 ,  C07D295/185 ,  C07D307/46 ,  C07D307/56 ,  C07D307/80 ,  C07D317/22 ,  C07D333/22 ,  C07D333/28

Abstract: Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.

Abstract translation: 其中A为低级烷基或取代或未取代的苯基，噻吩基，呋喃基，吲哚基或硫代吗啉基的式（II）化合物为氢或低级烷基，Y为氢， 羟基，醚化的羟基，取代的氨基或N-连接的杂环基，X 0是O或OCH 2 CH 2 O，R'表示氢，低级烷基或乙酰基; 和其酸加成盐在药物中作为降血糖，降血胆固醇血症和胆碱剂或在制备这些药剂中是新颖的和有用的。

公开(公告)号：US4062886A

公开(公告)日：1977-12-13

申请号：US596690

申请日：1975-07-16

Applicant: Sam R. Turner

Inventor： Sam R. Turner

IPC: C07C65/36 ,  C07C67/00 ,  C07C69/76 ,  C07C201/00 ,  C07C205/57 ,  C07C205/61 ,  C07C231/00 ,  C07C235/84 ,  C07C253/00 ,  C07C255/40 ,  C07C255/56 ,  C07D203/10 ,  C07D303/16 ,  C08F20/12 ,  C08F20/54 ,  G03G5/06 ,  G03G5/07 ,  C07C79/46

CPC classification number: C07C205/61 ,  C07C65/36 ,  C07D203/10 ,  C07D303/16 ,  C08F20/12 ,  C08F20/54 ,  G03G5/0609 ,  G03G5/0618 ,  G03G5/0625 ,  G03G5/071 ,  G03G5/075 ,  C07C2103/18

Abstract: Disclosed are monomers of the formula: ##STR1## WHEREIN R is ##STR2## R' is hydrogen or methyl; R" is alkyl of 1-10 carbon atoms;X and Y are independently selected from the group consisting of NO.sub.2, halogen, cyano and --CF.sub.3 ;Z is oxygen or dicyanomethylene;a and a' can range from 0-3; andn is 1-10.These monomers can be readily polymerized to polymers suitable for use in electrophotographic imaging members and methods.

Abstract translation: 公开了下式的单体：其中R是氢或甲基; R“是1-10个碳原子的烷基; X和Y独立地选自NO 2，卤素，氰基和-CF 3; Z是氧或二氰基亚甲基; A和A从0-3的范围; 和N是1-10。

公开(公告)号：US4057590A

公开(公告)日：1977-11-08

申请号：US761565

申请日：1977-01-24

Applicant: Walter A. Gay

Inventor： Walter A. Gay

IPC: C07C67/00 ,  C07C201/00 ,  C07C205/12 ,  C07C79/12

CPC classification number: C07C201/08

Abstract: Process for making highly pure pentachloronitrobenzene (PCNB) by the nitration of pentachlorobenzene (PENTA).

Abstract translation: 通过硝基五氯苯（PENTA）制备高纯度五氯硝基苯（PCNB）的方法。

公开(公告)号：US4042604A

公开(公告)日：1977-08-16

申请号：US686365

申请日：1976-05-14

Applicant: Heinz Eilingsfeld ,  Dietrich Lach

Inventor： Heinz Eilingsfeld ,  Dietrich Lach

IPC: C07C205/47 ,  C07C67/00 ,  C07C201/00 ,  C09B1/00 ,  C07C79/37

CPC classification number: C07C225/34

Abstract: A process for the isolation of mixtures of 1,5-dinitroanthraquinone and 1,8-dinitroanthraquinone which have a high content of .alpha.,.alpha.'-dinitroanthraquinones by heating a suspension of the crude dinitroanthraquinone mixture in certain organic liquids at from 60.degree. to 200.degree. C until solution equilibrium has been set up, and separating the undissolved material from the solution. The undissolved material contains more than 90% and as a rule more than 95% by weight of 1,5-dinitroanthraquinone and 1,8-dinitroanthraquinone. The pure mixture of 1,5-dinitroanthraquinone and 1,8-dinitroanthraquinone may be used for the manufacture of dyes.

Abstract translation: 通过在60°至200°的某些有机液体中加热粗二硝基蒽醌混合物的悬浮液，分离具有高α，α'-二硝基蒽醌含量的1,5-二硝基蒽醌和1,8-二硝基蒽醌的混合物的方法 直到溶液平衡已经建立，并将未溶解的材料与溶液分离。 未溶解的材料含有超过90％且通常超过95重量％的1,5-二硝基蒽醌和1,8-二硝基蒽醌。 1,5-二硝基蒽醌和1,8-二硝基蒽醌的纯混合物可用于制备染料。

公开(公告)号：US4039589A

公开(公告)日：1977-08-02

申请号：US495847

申请日：1974-08-08

Applicant: Edit Toth ,  Jozsef Torley ,  Szabolcs Szeberenyi ,  Eva Palosi ,  Laszlo Szporny ,  Sandor Gorog ,  Csilla Meszaros

Inventor： Edit Toth ,  Jozsef Torley ,  Szabolcs Szeberenyi ,  Eva Palosi ,  Laszlo Szporny ,  Sandor Gorog ,  Csilla Meszaros

IPC: A61K31/445 ,  A61K31/045 ,  A61K31/047 ,  A61K31/065 ,  A61K31/085 ,  A61K31/135 ,  A61P1/16 ,  C07C20060101 ,  C07C27/00 ,  C07C29/00 ,  C07C29/17 ,  C07C29/38 ,  C07C33/02 ,  C07C33/025 ,  C07C33/24 ,  C07C33/28 ,  C07C33/34 ,  C07C33/38 ,  C07C33/46 ,  C07C37/20 ,  C07C39/11 ,  C07C39/21 ,  C07C43/20 ,  C07C43/23 ,  C07C65/01 ,  C07C67/00 ,  C07C201/00 ,  C07C205/19 ,  C07C205/57 ,  C07C205/59 ,  C07C215/32 ,  C07C215/68 ,  C07C215/74 ,  C07C217/48 ,  C07C217/56 ,  C07C217/76 ,  C07C217/82 ,  C07C219/34 ,  C07C229/64 ,  C07C233/22 ,  C07C233/25 ,  C07C233/29 ,  C07C233/43 ,  C07C233/54 ,  C07C233/73 ,  C07C233/75 ,  C07C255/49 ,  C07C255/53 ,  C07C255/59 ,  C07C319/20 ,  C07C323/19 ,  C07C327/20 ,  C07D295/12 ,  C07D295/135 ,  C07C31/16

CPC classification number: C07D295/135 ,  C07C255/00 ,  C07C29/40 ,  C07C323/00 ,  C07C41/30 ,  C07C65/01

Abstract: A compound of the formula: ##STR1## wherein Z is ethyl or vinyl,R.sub.1 and R.sub.2 are hydrogen, lower alkyl, lower alkenyl or trihalomethyl,R.sub.3 and R.sub.4 are hydrogen, lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl or phenyl, andR.sub.5 is lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl, or phenyl with the proviso that where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, R.sub.5 is not methyl attached to the 4-position of the benzene ring, or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof is disclosed as effective in the regulation of the liver microsomal enzyme system.

Abstract translation: 下式的化合物：其中Z是乙基或乙烯基，R 1和R 2是氢，低级烷基，低级烯基或三卤甲基，R 3和R 4是氢，低级烷基，低级烯基，三卤代甲基，环戊基，苄基或苯基， 并且R 5为低级烷基，低级烯基，三卤甲基，环戊基，苄基或苯基，条件是其中R 1，R 2，R 3和R 4各自为氢，R 5不与甲苯的4-位相连， 公开了其药学上可接受的酸加成盐或季铵盐在肝微粒体酶体系的调节中是有效的。

公开(公告)号：US4038278A

公开(公告)日：1977-07-26

申请号：US603235

申请日：1975-08-08

Applicant: Sachiyuki Hamano ,  Takaharu Nakamura

Inventor： Sachiyuki Hamano ,  Takaharu Nakamura

IPC: A61K31/12 ,  A61K31/13 ,  A61K31/135 ,  A61K31/21 ,  A61K31/505 ,  A61P25/04 ,  A61P29/00 ,  C07C67/00 ,  C07C201/00 ,  C07C205/45 ,  C07C225/22 ,  C07C313/00 ,  C07C317/24 ,  C07D239/42 ,  C07D239/26

CPC classification number: C07D239/42

Abstract: New 4-aminopyrimidium derivatives of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents a hydrogen atom or a lower alkyl group, and R.sub.3 and R.sub.4 each represents a hydrogen or halogen atom, a lower alkyl, a lower alkoxyl, a lower alkoxycarbonyl, a lower alkylsulfonyl, nitro or amino group, and X represents a halogen atom, as well as a process for the preparation thereof. The compounds are useful as anti-inflammatory, analgesic agents without producing gastrointestinal trouble.

公开(公告)号：US4021498A

公开(公告)日：1977-05-03

申请号：US639019

申请日：1975-12-09

Applicant: Verner Alexanderson ,  James Bryant Trecek ,  Cornelius Marsden Vanderwaart

Inventor： Verner Alexanderson ,  James Bryant Trecek ,  Cornelius Marsden Vanderwaart

IPC: C07B43/02 ,  C07B31/00 ,  C07C67/00 ,  C07C201/00 ,  C07C201/08 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C205/47 ,  C07C79/10 ,  C07C79/12

CPC classification number: C07C201/08

Abstract: An adiabatic process for the mononitration of nitratable aromatic hydrocarbons and halo substituted aromatic hydrocarbons which yield a mononitration product containing less than 500 ppm. of dinitrated product is disclosed.

Abstract translation: 产生含有小于500ppm的单硝化产物的可硝化芳族烃和卤代烃芳族烃单硝化的绝热方法。 的硝酸盐产品被公开。

公开(公告)号：US3996289A

公开(公告)日：1976-12-07

申请号：US557297

申请日：1975-03-11

Applicant: Horst Meyer

Inventor： Horst Meyer

IPC: C07C205/44 ,  A61K31/04 ,  A61K31/11 ,  C07B41/06 ,  C07C20060101 ,  C07C27/00 ,  C07C47/54 ,  C07C51/16 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07D211/82

CPC classification number: C07C205/44 ,  C07C201/12

Abstract: 2-NITROBENZALDEHYDE, A VALUABLE CHEMICAL INTERMEDIATE, IS PREPARED THROUGH THE OXIDATION OF AN ALKALI METAL SALT OF 2-NITROPHENYLPYRUVIC ACID WITH POTASSIUM PERMANGANATE IN AN ALKALINE MEDIUM. Advantageously the requisite starting material is prepared directly by the reaction of 2-nitrotoluene and a diester of oxalic acid in the presence of an alcoholate and is then subjected to the oxidation without isolation. In a preferred embodiment the oxidation reaction mixture is acidified to convert the manganese-(IV) oxide to soluble maganese-(II) salts with concurrent conversion of oxalic acid to carbon dioxide. The process is industrially attractive in terms of the high yield, the availability of starting material and the ease of the manipulative steps involved.

Abstract translation: 2-NITROBENZALDEHYDE，一种有价值的化学中间体，是通过在碱性介质中用硫酸钾处理2-硝基戊酸的碱金属盐来制备的。 有利的是，必需的原料直接通过在醇化物存在下由2-硝基甲苯与草酸二酯的反应制备，然后在不分离的条件下进行氧化。 在优选的实施方案中，将氧化反应混合物酸化以将锰（IV）氧化物转化为可溶性的锰 - （II）盐，同时将草酸转化为二氧化碳。 该方法在高产率，起始材料的可用性和所涉及的操纵步骤的容易性方面在工业上具有吸引力。

公开(公告)号：US3984565A

公开(公告)日：1976-10-05

申请号：US541421

申请日：1975-01-16

Applicant: Derek Richard Buckle ,  Harry Smith ,  Barrie Christian Charles Cantello

Inventor： Derek Richard Buckle ,  Harry Smith ,  Barrie Christian Charles Cantello

IPC: C07C205/45 ,  A61K31/24 ,  C07C13/465 ,  C07C67/00 ,  C07C201/00 ,  C07C201/08 ,  C07C205/54 ,  C07D307/88 ,  C07D307/89 ,  A61K31/335

CPC classification number: C07D307/88 ,  C07C205/54 ,  C07D307/89 ,  Y10S514/826

Abstract: A pharmaceutical composition is produced which is useful for treating allergic conditions in humans which comprises an anti-allergenic amount of a compound of the formula: ##SPC1##Or a pharmaceutically acceptable salt or ester thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is hydrogen, alkyl, alkoxy, aryl, aralkyl or halogen or any two of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 taken together, with the carbon atoms to which they are attached, form a phenyl, cyclohexyl or cyclohexenyl ring, in combination with a pharmaceutically acceptable carrier.

Abstract translation: 制备可用于治疗人类过敏症状的药物组合物，其包含抗过敏量的下式化合物：

公开(公告)号：US3984488A

公开(公告)日：1976-10-05

申请号：US580505

申请日：1975-05-23

Applicant: Barton Milligan

Inventor： Barton Milligan

IPC: C07C67/00 ,  C07C201/00 ,  C07C205/11 ,  C07C205/12 ,  C07C205/58 ,  C07C79/12

CPC classification number: C07C201/12

Abstract: This invention relates to an improvement in an process for dinitrating 3-nitrobenzotrifluoride and 4-hal0-3-nitrobenzotrifluoride compounds wherein the mononitrobenzotrifluoride composition is contacted with a mixture comprising sulfuric and nitric acid. The improvement constituting the basis of this invention comprises carrying out the dinitration with the sulfuric acid being present in at least a catalytic proportion but not exceeding about 65 mole percent in said mixture.

Abstract translation: 本发明涉及三硝基三氟甲苯和4-卤代-3-硝基三氟甲苯化合物的二硝化方法的改进，其中一硝基三氟甲苯组合物与包含硫酸和硝酸的混合物接触。 构成本发明基础的改进包括以所述混合物中至少催化比例但不超过约65摩尔％的硫酸进行二硝化。