A RACEMIC SHIKONIN NAPHTHAZARINE PARENT NUCLEUS HYDROXYMETHYLATED SODIUM SULFONATE DERIVATIVE

    公开(公告)号:LU507992B1

    公开(公告)日:2025-02-13

    申请号:LU507992

    申请日:2024-08-13

    Inventor: CUI JIAHUA

    Abstract: The invention relates to a racemic shikonin naphthazarine parent nucleus hydroxymethylated sodium sulfonate derivative, which belongs to the pharmaceutical field. The derivative has the structural formula depicted in formula (I): wherein R is an alkane, olefin or aromatic group containing 1-6 carbon atoms. The racemic shikonin naphthazarine parent nucleus hydroxymethylated sodium sulfonate derivative of the invention features a novel structure and excellent water solubility. In vitro experiments have demonstrated that these compounds have significant antitumor activity. Additionally, they exhibit strong antibacterial activity against both Gram-positive and Gram-negative bacteria.

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