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    PROCESS ANALYSIS UNIT
    263.
    发明申请
    PROCESS ANALYSIS UNIT 有权
    过程分析单元

    公开(公告)号：US20120198921A1

    公开(公告)日：2012-08-09

    申请号：US13392098

    申请日：2010-07-28

    Applicant: Ulrich Lundgreen ,  Aria Farjam

    Inventor： Ulrich Lundgreen ,  Aria Farjam

    IPC: G01N33/00 ,  G01N21/00

    CPC classification number: G01N21/8507 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2400/0481 ,  F04B43/082 ,  F04B43/12 ,  G01N21/05 ,  G01N21/11 ,  G01N21/78 ,  G01N33/18 ,  G01N35/1095 ,  G01N2001/4016 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/054 ,  G01N2021/8411 ,  G01N2201/0218 ,  G01N2201/024

    Abstract: A process analysis unit includes a base module and an exchangeable cartridge module. The base module comprises at least one independent pump drive, and an analyte sensor without a fluidic measuring section. The cartridge module comprises a liquid reservoir tank, a sample taking device, at least one drive-less pump mechanism configured as a peristaltic membrane pump, a fluidic measuring section for the analyte sensor, and a plastic material plate with groove-like microfluidic channels configured to connect the liquid reservoir tank, the at least one drive-less pump mechanism, and a measuring section. The drive-less pump mechanism is driven pneumatically and pumps a liquid from the liquid reservoir tank. When the cartridge module is connected to the base module, the at least one drive-less pump mechanism is connected to and is driven by the at least one independent pump drive, and the fluidic measuring section is connected to the analyte sensor.

    Abstract translation: 过程分析单元包括基本模块和可更换盒式模块。 基本模块包括至少一个独立的泵驱动器和不具有流体测量部分的分析物传感器。 盒式模块包括液体储存罐，取样装置，配置为蠕动膜泵的至少一个无驱动泵机构，用于分析物传感器的流体测量部分，以及配置有凹槽状微流体通道的塑料材料板 连接储液箱，至少一个无驱动泵机构和测量部。 无驱动泵机构被气动地驱动，并从液体储存罐泵送液体。 当墨盒模块连接到基座模块时，至少一个无驱动泵机构连接到并由至少一个独立泵驱动器驱动，并且流体测量部分连接到分析物传感器。

    Calibrator for fluorosensor
    266.
    发明授权
    Calibrator for fluorosensor 有权
    氟传感器校准器

    公开(公告)号：US07416701B2

    公开(公告)日：2008-08-26

    申请号：US11299784

    申请日：2005-12-13

    Applicant: Eugene Tokhtuev ,  Anatoly Skirda ,  Viktor Slobodyan ,  Christopher Owen

    Inventor： Eugene Tokhtuev ,  Anatoly Skirda ,  Viktor Slobodyan ,  Christopher Owen

    IPC: G01N21/64 ,  G01N21/66 ,  G01N15/06 ,  G01N33/00 ,  C12Q1/68

    CPC classification number: G01N21/645 ,  G01N21/15 ,  G01N21/276 ,  G01N21/278 ,  G01N21/6486 ,  G01N21/8507 ,  G01N33/1826 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6478 ,  G01N2201/0218 ,  G01N2201/024 ,  G01N2201/0627 ,  G01N2201/0693 ,  Y10T29/49 ,  Y10T29/49002 ,  Y10T436/108331

    Abstract: A multichannel fluorosensor includes an optical module and an electronic module combined in a watertight housing with an underwater connector. The fluorosensor has an integral calibrator for periodical sensitivity validation of the fluorosensor. The optical module has one or several excitation channels and one or several emission channels that use a mutual focusing system. To increase efficiency, the excitation and emission channels each have a micro-collimator made with one or more ball lenses. Each excitation channel has a light emitting diode and an optical filter. Each emission channel has a photodiode with a preamplifier and an optical filter. The electronic module connects directly to the optical module and includes a lock-in amplifier, a power supply and a controller with an A/D converter and a connector. The calibrator provides a response proportional to the excitation intensity, and matches with spectral parameter of fluorescence for the analyzed fluorescent substance.

    Abstract translation: 多通道氟传感器包括光学模块和组合在具有水下连接器的防水壳体中的电子模块。 氟传感器具有用于氟传感器周期灵敏度验证的积分校准器。 光学模块具有一个或多个激发通道和使用相互聚焦系统的一个或多个发射通道。 为了提高效率，激发和发射通道各自具有由一个或多个球透镜制成的微型准直器。 每个激励通道都有一个发光二极管和一个滤光器。 每个发射通道具有带有前置放大器和光学滤波器的光电二极管。 电子模块直接连接到光模块，包括锁定放大器，电源和带有A / D转换器和连接器的控制器。 校准器提供与激发强度成比例的响应，并与分析的荧光物质的荧光光谱参数相匹配。

    Method and apparatus for verifying proper operation of a photometric device, such as a cell density probe
    268.
    发明授权
    Method and apparatus for verifying proper operation of a photometric device, such as a cell density probe 有权
    用于验证诸如细胞密度探针的测光装置的正确操作的方法和装置

    公开(公告)号：US07180594B2

    公开(公告)日：2007-02-20

    申请号：US10856885

    申请日：2004-05-27

    Applicant: Paul C. Williams

    Inventor： Paul C. Williams

    IPC: G01N21/00 ,  G01J3/42

    CPC classification number: G01N21/534 ,  G01N21/274 ,  G01N21/4785 ,  G01N21/8507 ,  G01N2021/8535 ,  G01N2201/0218 ,  G01N2201/024 ,  G01N2201/1242 ,  G01N2201/12746

    Abstract: An in-situ technique is provided for automatically verifying proper operation of a photometric device, such as a cell density probe (CDP). The CDP has a first detector and a second detector. The first detector senses light that is transmitted from a light source of the CDP. The second detector senses light that has passed through an optical gap at a tip of the CDP, wherein the sensed light has been reduced in intensity due to light absorption. Electrical current provided to the light source is reduced, and the resultant values of a light characteristic (such as intensity) are sensed. These values from the detectors are compared against one or more predicted values. If the CDP is operating properly, the values from the detectors will be consistent with the predicted values. If there is a malfunction in the CDP, then the values from the detectors will be inconsistent with the predicted values.

    Abstract translation: 提供了用于自动验证诸如细胞密度探针（CDP）的光度测量装置的正确操作的原位技术。 CDP具有第一检测器和第二检测器。 第一检测器感测从CDP的光源传输的光。 第二检测器感测已经通过CDP顶端的光学间隙的光，其中感测的光由于光吸收而被强度降低。 降低了提供给光源的电流，并且感测出光特性（如强度）的合成值。 来自检测器的这些值与一个或多个预测值进行比较。 如果CDP正常工作，检测器的值将与预测值一致。 如果CDP出现故障，则检测器的值将与预测值不一致。

    Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
    269.
    发明申请
    Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector 有权
    具有将多个光模块耦合到公共检测器的光纤束的多重荧光检测装置

    公开(公告)号：US20060223172A1

    公开(公告)日：2006-10-05

    申请号：US11174755

    申请日：2005-07-05

    Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

    Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

    IPC: C12M1/34 ,  G01N21/66

    CPC classification number: G01J3/4406 ,  G01J3/0218 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/024

    Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system is described that includes a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of optical modules. Each of the optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of optical modules conveys the fluorescent light from the multiple optical modules to a single detector.

    Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，描述了包括数据采集装置和耦合到数据采集装置的检测装置的系统。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个光学模块。 每个光学模块被光学配置以激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个光学模块的光纤束将来自多个光学模块的荧光传送到单个检测器。

    Modular optical detector system
    270.
    发明授权
    Modular optical detector system 有权
    模块化光学检测器系统

    公开(公告)号：US06998598B2

    公开(公告)日：2006-02-14

    申请号：US10633794

    申请日：2003-08-04

    Applicant: Brent A. Horn ,  Ronald F. Renzi

    Inventor： Brent A. Horn ,  Ronald F. Renzi

    IPC: H01J3/14 ,  H01J40/14 ,  H01J5/16

    CPC classification number: G01N30/74 ,  B01L3/5027 ,  G01N21/645 ,  G01N2201/024

    Abstract: A modular optical detector system. The detector system is designed to detect the presence of molecules or molecular species by inducing fluorescence with exciting radiation and detecting the emitted fluorescence. Because the system is capable of accurately detecting and measuring picomolar concentrations it is ideally suited for use with microchemical analysis systems generally and capillary chromatographic systems in particular. By employing a modular design, the detector system provides both the ability to replace various elements of the detector system without requiring extensive realignment or recalibration of the components as well as minimal user interaction with the system. In addition, the modular concept provides for the use and addition of a wide variety of components, including optical elements (lenses and filters), light sources, and detection means, to fit particular needs.

    Abstract translation: 模块化光学检测器系统。 探测器系统设计用于通过用激发辐射诱导荧光并检测发射的荧光来检测分子或分子物质的存在。 因为该系统能够精确地检测和测量皮摩尔浓度，所以它理想地适用于通常用于微量化学分析系统和特别是毛细管色谱系统。 通过采用模块化设计，检测器系统提供了替换检测器系统的各种元件的能力，而不需要对组件进行大量的重新对准或重新校准，以及最小化与系统的用户交互。 此外，模块化概念提供了各种组件的使用和添加，包括光学元件（透镜和滤光片），光源和检测装置，以适应特殊需要。

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