公开(公告)号：EP3417276A1

公开(公告)日：2018-12-26

申请号：EP17709821.7

申请日：2017-02-14

Applicant: Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis

Inventor： RUERS, Theodoor Jacques Marie ,  KHO, Esther ,  STERENBORG, Henricus Josephus Cornelus Maria

IPC: G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  A61B5/00 ,  G01J3/00 ,  G01N33/02 ,  G01N33/12 ,  G01N33/18

CPC classification number: G01N21/314 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/0091 ,  A61B5/441 ,  A61B5/4869 ,  A61B5/4872 ,  A61B5/4875 ,  A61B5/7239 ,  A61B2505/05 ,  A61B2576/00 ,  G01J3/2823 ,  G01J3/42 ,  G01J2003/1213 ,  G01J2003/1221 ,  G01J2003/2826 ,  G01J2003/425 ,  G01N21/4738 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/02 ,  G01N33/025 ,  G01N33/12 ,  G01N2021/3133 ,  G01N2021/3137 ,  G01N2021/3174 ,  G01N2201/103 ,  G01N2201/1053

Abstract: In a method and apparatus (400), a property of an optically diffuse medium comprising a first optical absorber having a first concentration and a second optical absorber having a second concentration is determined. A surface area (406) of the medium is imaged at multiple wavelengths around an isosbestic wavelength of the first absorber and the second absorber. A reflectance spectrum of the medium at the surface area at the multiple wavelengths is determined. A derivative of the determined reflectance spectrum around the isosbestic wavelength is determined. From the derivative, a concentration ratio of the first concentration and the second concentration is estimated.

公开(公告)号：EP3268726A1

公开(公告)日：2018-01-17

申请号：EP16709557.9

申请日：2016-03-08

Applicant: Renishaw Plc.

Inventor： SMITH, Timothy ,  BLACKWELL-WHITEHEAD, Richard, John

IPC: G01N21/65 ,  G01J3/44 ,  G01J3/06 ,  G02B21/00

CPC classification number: G01J3/44 ,  G01J3/06 ,  G01J2003/064 ,  G01N21/65 ,  G01N2201/103 ,  G01N2201/1045 ,  G01N2201/1087 ,  G02B21/002

Abstract: A transmission Raman spectroscopy apparatus has a light source for generating a light profile on a sample, a photodetector having at least one photodetector element, collection optics arranged to collect Raman scattered light transmitted through the sample and direct the Raman light onto the at least one photodetector element and a support for supporting the sample. The support and light source are arranged such that the light profile can be moved relative to the sample in order that the at least one photodetector element receives Raman scattered light generated for different locations of the light profile on the sample.

公开(公告)号：EP2746748B1

公开(公告)日：2017-12-06

申请号：EP12823870.6

申请日：2012-07-11

Applicant: Olympus Corporation

Inventor： TANABE, Tetsuya ,  YAMAGUCHI, Mitsushiro

IPC: G01N21/64 ,  G02B21/00 ,  G01N15/14 ,  G01N21/51

CPC classification number: G01N21/64 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N21/51 ,  G01N21/6408 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2201/103 ,  G01N2201/105 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/008

Abstract: In the scanning molecule counting method which detects light of a light-emitting particle in a sample solution using a confocal or multiphoton microscope, there is provided an optical analysis technique enabling the scanning in a sample solution with moving a light detection region in a broader area or along a longer route while making the possibility of detecting the same light-emitting particle as different particles as low as possible and remaining the size or shape of the light detection region unchanged as far as possible. In the inventive optical analysis technique, there are performed detecting light from the light detection region and generating time series light intensity data during moving the position of the light detection region along the second route whose position is moved along the first route in a sample solution, and thereby, the signal indicating light from each light-emitting particle existing in a predetermined route is individually detected using the time series light intensity data.

公开(公告)号：EP2829901A1

公开(公告)日：2015-01-28

申请号：EP13763578.5

申请日：2013-02-20

Applicant: Sharp Kabushiki Kaisha

Inventor： WATANABE, Yukio

IPC: G02B21/00 ,  G01N21/64 ,  G02B21/02

CPC classification number: G01N21/645 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/06113 ,  G01N2201/10 ,  G01N2201/103 ,  G01N2201/105 ,  G02B19/0028 ,  G02B19/0076 ,  G02B19/008 ,  G02B19/0085 ,  G02B21/0076 ,  G02B2207/113

Abstract: Even when the distance from an objective lens to a sample differs, the distribution of light from the sample can be detected accurately.
A first lens 23 for converting light from the objective lens into parallel light is composed of a concave lens part 32 having a concave curved face 32c in a center portion of a flat face 32a, and a convex lens part 33 having a convex curved face 33c around a flat face 33b. Further, the first lens 23 includes first and second regions for diverging light through the flat face 33b and the concave curved face 32c and a third region for collecting light through the convex curved face 33c and the concave curved face 32c. When the sample is placed on a sample table while being sealed in a two-dimensional electrophoresis substrate, light totally reflected by a side surface of the objective lens is caused to enter the second region. In contrast, when the sample is directly placed on the sample table, the light is caused to enter the third region. As a result, in any of the cases, the rays of light d emitted from the first lens 23 are nearly parallel to one another, and are nearly parallel to the optical axis.

Abstract translation: 即使从物镜到样本的距离不同，也可以准确地检测来自样品的光的分布。 用于将来自物镜的光转换成平行光的第一透镜23由在平坦面32a的中心部分具有凹曲面32c的凹透镜部32和具有凸曲面33c的凸透镜部33 围绕平面33b。 此外，第一透镜23包括用于使光通过平面33b和凹曲面32c发散的第一和第二区域，以及用于通过凸曲面33c和凹曲面32c收集光的第三区域。 当样品被放置在样品台上同时密封在二维电泳基片中时，由物镜的侧面全反射的光进入第二区域。 相反，当将样品直接放置在样品台上时，使光进入第三区域。 结果，在任何情况下，从第一透镜23发射的光线d几乎彼此平行，并且几乎平行于光轴。

公开(公告)号：EP2746748A1

公开(公告)日：2014-06-25

申请号：EP12823870.6

申请日：2012-07-11

Applicant: Olympus Corporation

Inventor： TANABE, Tetsuya ,  YAMAGUCHI, Mitsushiro

IPC: G01N21/64

CPC classification number: G01N21/64 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N21/51 ,  G01N21/6408 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2201/103 ,  G01N2201/105 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/008

Abstract: In the scanning molecule counting method which detects light of a light-emitting particle in a sample solution using a confocal or multiphoton microscope, there is provided an optical analysis technique enabling the scanning in a sample solution with moving a light detection region in a broader area or along a longer route while making the possibility of detecting the same light-emitting particle as different particles as low as possible and remaining the size or shape of the light detection region unchanged as far as possible. In the inventive optical analysis technique, there are performed detecting light from the light detection region and generating time series light intensity data during moving the position of the light detection region along the second route whose position is moved along the first route in a sample solution, and thereby, the signal indicating light from each light-emitting particle existing in a predetermined route is individually detected using the time series light intensity data.

公开(公告)号：EP2154516A1

公开(公告)日：2010-02-17

申请号：EP09166941.6

申请日：2009-07-31

Applicant: Fondazione Bruno Kessler ,  Art-test Di Luciano Marras E Anna Pelagotti S.N.C.

Inventor： The designation of the inventor has not yet been filed

IPC: G01N23/08 ,  G01N21/88 ,  G01V5/00

CPC classification number: G01N23/083 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/55 ,  G01N2021/3155 ,  G01N2201/10 ,  G01N2201/103

Abstract: A method and apparatus of analyzing a body, wherein a first radiation (X rays) transmitted through the body and a second radiation (visible, IR and/or ultraviolet radiation) reflected by the body surface are detected at each point of a series of investigated points. The data collected for each scanning point are processed so as to maintain the correspondence between the images obtained using the different techniques.

Abstract translation: 一种分析身体的方法和装置，其中通过身体透射的第一辐射（X射线）和由身体表面反射的第二辐射（可见的，IR和/或紫外辐射）在一系列被研究的每个点处被检测 点。 对每个扫描点收集的数据进行处理，以保持使用不同技术获得的图像之间的对应关系。

公开(公告)号：EP1810006A1

公开(公告)日：2007-07-25

申请号：EP05810637.8

申请日：2005-11-11

Applicant: SMCS Limited

Inventor： HUNTER, Christopher

IPC: G01N21/25

CPC classification number: G01J3/50 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0235 ,  G01N21/25 ,  G01N2201/10 ,  G01N2201/103

Abstract: There is disclosed a colour assessment apparatus comprising a sample carrier, magnifying optics to capture light from defined locations of a sample located on the sample carrier, means for analyzing the light captured by the magnifying optics to measuring colour values of the defined locations of the sample, means for automatically displacing the optical means relative to the sample carrier in order to the apparatus to scan a succession of locations of the sample and to measure colour values of the sample for each location, memory means for storing a table of location information correlated with colour value information, means for inputting a colour value of a reference sample, and means for analyzing the table so as to determine locations of any colour values from the sample that match the colour value of the reference sample.

Abstract translation: 公开了一种颜色评估设备，其包括样本载体，放大光学器件以从位于样本载体上的样本的限定位置捕获光，用于分析由放大光学器件捕获的光以测量样本的限定位置的颜色值的装置 ，用于使所述光学装置相对于所述样本载体自动移位的装置，以便所述装置扫描所述样本的一系列位置并且为每个位置测量所述样本的颜色值;存储装置，用于存储与所述样本相关的位置信息的表格 颜色值信息，用于输入参考样本的颜色值的装置以及用于分析该表格以便确定来自样本的与参考样本的颜色值匹配的任何颜色值的位置的装置。

公开(公告)号：EP1475627A2

公开(公告)日：2004-11-10

申请号：EP04010474.7

申请日：2004-05-03

Applicant: Mitutoyo Corporation

Inventor： Gladnick, Paul G. ,  Wasserman, Richard M. ,  Saylor, Barry E. ,  Delaney, Mark L.

IPC: G01N21/88 ,  G06T7/00

CPC classification number: G01N21/8806 ,  G01N2021/8835 ,  G01N2021/8838 ,  G01N2021/8887 ,  G01N2201/0694 ,  G01N2201/103 ,  G01N2201/117 ,  G06T1/0007 ,  G06T7/0004 ,  G06T2207/30164 ,  G06T2207/30241

Abstract: A precision machine vision inspection system and method for increased inspection throughput. The vision inspection system includes a movable stage for scanning and measuring selected workpiece features. In prior systems, conventional interspersing of image processing and inspection operations with image acquisition operations required stopping and starting the stage motion during image acquisition, necessitating associated delays or wait-states in various operations. Such delays are avoided in this invention by acquiring images continuously, with a timing that is independent of image inspection operations, so that delays and wait-states are avoided. In addition, continuous stage motion is combined with a strobe lighting feature during the image acquisition operations to acquire blur-free images at a high rate. Improved image acquisition and image analysis routines including these features are created and stored by the system.

Abstract translation: 精密机器视觉检测系统和方法，提高检测吞吐量。 视觉检查系统包括用于扫描和测量所选择的工件特征的可移动台。 在现有系统中，图像处理和检查操作与图像采集操作的传统散布需要在图像采集期间停止和启动阶段运动，从而在各种操作中需要相关的延迟或等待状态。 在本发明中通过以与图像检查操作无关的定时连续地获取图像来避免这种延迟，从而避免延迟和等待状态。 此外，在图像采集操作期间，连续舞台运动与闪光灯照明特征相结合，以高速率获得无模糊图像。 包括这些功能的改进的图像采集和图像分析程序由系统创建和存储。

公开(公告)号：EP0557558B1

公开(公告)日：1997-06-18

申请号：EP92103406.2

申请日：1992-02-27

Applicant: MITSUI MINING & SMELTING CO., LTD.

Inventor： Moriya, Kazuo ,  Tsuzura, Takayuki

IPC: G01N21/88

CPC classification number: G01N21/9501 ,  G01N21/8806 ,  G01N2021/8838 ,  G01N2021/8845 ,  G01N2021/8887 ,  G01N2201/0696 ,  G01N2201/103

公开(公告)号：EP0458199A2

公开(公告)日：1991-11-27

申请号：EP91107982.0

申请日：1991-05-16

Applicant: NTN CORPORATION

Inventor： Saruta, Masahiro ,  Sagisaka, Tetsuji ,  Maeda, Kazunari ,  Yashiki, Takumi

IPC: G01N21/88 ,  B23K26/00 ,  G02F1/13

CPC classification number: G05B19/401 ,  B23K26/0853 ,  G01N21/88 ,  G01N2021/9513 ,  G01N2201/103 ,  G02F1/1309 ,  G05B2219/45165 ,  G05B2219/50064

Abstract: A laser processing device includes a Z stage (4) movable in the up and down directions with respect to a XY stage (3) movable in the X, Y directions on which an object to be processed is provided. The surface of the object to be processed is image-sensed by a CCD camera (7) through a lens of an electrically-driven revolver (5) attached to the Z stage, which is projected in a monitor (40). When a defect of the object is displayed in the monitor (40), a laser beam is radiated to a defective portion of the object from a laser head (9) provided in the Z stage and the defective portion is removed.

Abstract translation: 本发明提供一种激光加工装置，该激光加工装置具有能够相对于在设置有被加工物的X方向，Y方向移动的XY载物台（3）沿上下方向移动的Z载物台（4）。 被加工物体的表面通过安装在Z台上的电动旋转器（5）的镜头由CCD照相机（7）进行图像检测，该电子旋转器（5）投影到监视器（40）中。 当在监视器（40）中显示物体的缺陷时，激光束从设置在Z台上的激光头（9）照射到物体的缺陷部分，并且去除缺陷部分。