公开(公告)号：WO2010120389A2

公开(公告)日：2010-10-21

申请号：PCT/US2010001166

申请日：2010-04-19

Applicant: AXXIA PHARMACEUTICALS LLC ,  POLLOCK WAYNE C ,  GROOSMAN STUART A ,  OWENS ALBERT H JR

Inventor： POLLOCK WAYNE C ,  GROOSMAN STUART A ,  OWENS ALBERT H JR

IPC: A61K47/34 ,  A61K9/00 ,  A61K31/485 ,  B29C47/06

CPC classification number: A61K9/0024 ,  A61K31/485 ,  A61K47/34 ,  B29C45/00 ,  B29L2031/753

Abstract: The subject invention relates to implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.

Abstract translation: 本发明涉及用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。

公开(公告)号：WO2010045527A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060950

申请日：2009-10-16

Applicant: WATERS TECHNOLOGIES CORPORATION ,  OEHRLE, Stuart, A.

Inventor： OEHRLE, Stuart, A.

IPC: C07D457/00

CPC classification number: C07D457/00 ,  Y10T436/10 ,  Y10T436/145555

Abstract: The present invention is directed to methods and kits for the determining the presence or absence of ergot alkaloids in sample which use chromatographic instrumentation and columns operating at a pressure of 4,000 to 15,000 psi and columns with 1 - 3 micron particle size to produce results by mass spectroscopy in approximately four minutes.

Abstract translation: 本发明涉及用于确定样品中麦角生物碱的存在或不存在的方法和试剂盒，其使用色谱仪器和在4,000至15,000psi的压力下操作的色谱柱和具有1-3微米粒度的柱以产生质量结果 大约四分钟。

公开(公告)号：WO2009155321A1

公开(公告)日：2009-12-23

申请号：PCT/US2009/047616

申请日：2009-06-17

Applicant: TRANSPORT PHARMACEUTICALS, INC. ,  FRIDEN, Phillip, M. ,  KIM, Hyun, D. ,  STAFF, Kirsten ,  BROWN, Marc, B. ,  JONES, Stuart, A.

Inventor： FRIDEN, Phillip, M. ,  KIM, Hyun, D. ,  STAFF, Kirsten ,  BROWN, Marc, B. ,  JONES, Stuart, A.

IPC: A01N43/82 ,  A61K31/41

CPC classification number: A61K33/24 ,  A61K9/0009 ,  A61N1/30

Abstract: Pharmaceutical formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of gallium to at least one body surface are described and methods for administering gallium to a body surface via iontophoresis. In one embodiment, the body surface is human skin.

Abstract translation: 本发明描述了适用于离子电渗疗法的药物制剂，其提供镓至少一个身体表面的增强的离子电渗疗法输送，以及通过离子电渗法向人体表面施用镓的方法。 在一个实施例中，身体表面是人皮肤。

公开(公告)号：WO2009051819A1

公开(公告)日：2009-04-23

申请号：PCT/US2008/011908

申请日：2008-10-17

Applicant: AXXIA PHARMACEUTICALS, LLC ,  POLLOCK, Wayne, C. ,  GROSSMAN, Stuart, A. ,  OWENS, Albert, H.

Inventor： POLLOCK, Wayne, C. ,  GROSSMAN, Stuart, A. ,  OWENS, Albert, H.

IPC: A61F2/00

CPC classification number: B29C47/06 ,  A61K9/0024 ,  A61K31/485 ,  A61K47/34 ,  B29C45/0001 ,  B29C47/0016 ,  B29C47/0021 ,  B29K2105/0035

Abstract: Implants are disclosed for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.

Abstract translation: 公开了用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。

公开(公告)号：WO2009032107A2

公开(公告)日：2009-03-12

申请号：PCT/US2008/010119

申请日：2008-08-27

Applicant: MCLEAN, Stuart, A. ,  MEEHAN, Harriet ,  JACOBS, Phillip, R. ,  GREENWALD, JR., Charles, M. ,  EDWARDS, Mark ,  STEINER, Don, P.

Inventor： MCLEAN, Stuart, A. ,  MEEHAN, Harriet ,  JACOBS, Phillip, R. ,  GREENWALD, JR., Charles, M. ,  EDWARDS, Mark ,  STEINER, Don, P.

IPC: G06F17/30

CPC classification number: G06F17/3061

Abstract: A method of automatically sending an alert message when the status of one or more documents has changed is disclosed. The method includes receiving, by a computer system, instructions from a user to monitor the status of a first type of information for a first selected document. The method further includes monitoring, by the computer system, the status of the first type of information for the first selected document. The method also includes, when the status of the first type of information for the first selected document has changed, sending, by the computer system, an alert message to the user to indicate that the status of the document has changed.

Abstract translation: 公开了当一个或多个文档的状态已经改变时自动发送警报消息的方法。 该方法包括由计算机系统接收来自用户的指令以监视第一选定文档的第一类型的信息的状态。 该方法还包括由计算机系统监视用于第一选定文档的第一类型的信息的状态。 该方法还包括当第一所选文档的第一类型的信息的状态已经改变时，计算机系统向用户发送警告消息以指示文档的状态已经改变。

公开(公告)号：WO2008144232A3

公开(公告)日：2009-01-29

申请号：PCT/US2008062922

申请日：2008-05-07

Applicant: UNIV JOHNS HOPKINS ,  THERATAXIS LLC ,  RAGHAVAN RAGHU ,  GROSSMAN STUART A

Inventor： RAGHAVAN RAGHU ,  GROSSMAN STUART A

IPC: A61B5/05

CPC classification number: A61B34/10 ,  A61B6/461 ,  A61B6/481 ,  A61B6/501 ,  A61B90/00 ,  A61B2034/101 ,  A61B2034/252 ,  A61N2005/1021 ,  G06F19/321 ,  G06T7/0012 ,  G06T2207/30016 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

Abstract: A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.

Abstract translation: 一种用于提供关于神经系统疾病的治疗的生理状况和效果的信息的治疗模拟器，包括计算机以及被配置为与所述计算机一起操作的应用。 该应用能够：从脑获得放射成像; 从大脑内感兴趣的区域内的放射成像获得解剖信息; 构建评估感兴趣区域的生理状态的生理状态模型; 利用解剖信息和生理状态模型确定颗粒物质的间质流的来源并获得间质流的路径的流体电导率; 并创建颗粒物质的流动模型，其使用间隙流和流体电导率来评估流动速率和间隙压力变化。

公开(公告)号：WO2008144232A2

公开(公告)日：2008-11-27

申请号：PCT/US2008/062922

申请日：2008-05-07

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  THERATAXIS, LLC ,  RAGHAVAN, Raghu ,  GROSSMAN, Stuart, A.

Inventor： RAGHAVAN, Raghu ,  GROSSMAN, Stuart, A.

IPC: A61B19/00 ,  G06G7/48 ,  A61N1/00 ,  A61B5/05

CPC classification number: A61B34/10 ,  A61B6/461 ,  A61B6/481 ,  A61B6/501 ,  A61B90/00 ,  A61B2034/101 ,  A61B2034/252 ,  A61N2005/1021 ,  G06F19/00 ,  G06F19/321 ,  G06T7/0012 ,  G06T2207/30016 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

Abstract: A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.

Abstract translation: 一种用于提供关于神经系统疾病的治疗的生理状况和效果的信息的治疗模拟器，包括计算机以及被配置为与所述计算机一起操作的应用。 该应用能够：从脑获得放射成像; 从大脑内感兴趣的区域内的放射成像获得解剖信息; 构建评估感兴趣区域的生理状态的生理状态模型; 利用解剖信息和生理状态模型确定颗粒物质的间质流的来源并获得间质流的路径的流体电导率; 并创建颗粒物质的流动模型，其使用间隙流和流体电导率来评估流动速率和间隙压力变化。

公开(公告)号：WO2008121268A1

公开(公告)日：2008-10-09

申请号：PCT/US2008/003873

申请日：2008-03-25

Applicant: MERCK & CO., INC. ,  FRENKL, Tara ,  GREEN, Stuart, A. ,  MACINTYRE, Euan ,  MILLS, Sander, G.

Inventor： FRENKL, Tara ,  GREEN, Stuart, A. ,  MACINTYRE, Euan ,  MILLS, Sander, G.

IPC: A01N43/42 ,  A61K31/47

CPC classification number: A61K31/47 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention concerns compositions for the treatment of Lower Urinary Tract Symptoms (LUTS), and especially LUTS which results from benign prostatic hypertrophy. The compositions of the invention comprise a Beta-3 agonist described below, optionally in combination with a 5-alpha reductase inhibitor, or an NK-1 antagonist or an alpha-1 adrenergic antagonist or an anti-muscarinic agent. The invention also includes compositions comprising a beta-3 agonist and two additional active agents selected from a 5-alpha reductase inhibitor, an NK-1 antagonist, an alpha-1 adrenergic antagonist or an anti-muscarinic agent.

Abstract translation: 本发明涉及用于治疗下尿路症状（LUTS）的组合物，特别是由良性前列腺肥大引起的LUTS。 本发明的组合物包含下述的β-3激动剂，任选地与5-α还原酶抑制剂或NK-1拮抗剂或α-1肾上腺素能拮抗剂或抗毒蕈碱剂组合。 本发明还包括包含β-3激动剂和选自5-α还原酶抑制剂，NK-1拮抗剂，α-1肾上腺素能拮抗剂或抗毒蕈碱剂的另外的活性剂的组合物。

公开(公告)号：WO2008100260A1

公开(公告)日：2008-08-21

申请号：PCT/US2007/004165

申请日：2007-02-15

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. ,  SCOFIELD, Stuart, A. ,  SHIVJI, Shane

Inventor： SCOFIELD, Stuart, A. ,  SHIVJI, Shane

IPC: B41J3/407

CPC classification number: B41J3/4071

Abstract: A method of printing on an optical disc (110) using a printing device (300) including automated detection of the optical disc (110), the method includes, with a sensor (200) of the printing device (300), optically detecting the optical disc (110) to determine whether the optical disc (110) is installed properly for printing in a carrier (100) that is inserted into the printing device (300). A system for printing on an optical disc (110), the system includes a printing device (300); a carrier (100) configured to hold the optical disc (110) while the printing device (300) prints on the disc (110); and a sensor (200) of the printing device (300) configured to optically detect whether the optical disc (110) is installed in the carrier (100) properly for printing.

Abstract translation: 使用包括光盘（110）的自动检测的打印装置（300）在光盘（110）上进行打印的方法，所述方法包括：利用所述打印装置（300）的传感器（200）光学地检测 光盘（110），以确定光盘（110）是否适当地安装在打印在插入打印设备（300）的载体（100）中。 一种用于在光盘（110）上打印的系统，所述系统包括打印装置（300）; 配置为在打印装置（300）打印在盘（110）上时保持光盘（110）的载体（100）; 以及所述打印装置（300）的传感器（200）被配置为光学地检测所述光盘（110）是否适当地安装在所述载体（100）中用于打印。

公开(公告)号：WO2008028038A2

公开(公告)日：2008-03-06

申请号：PCT/US2007/077240

申请日：2007-08-30

Applicant: LUTNICK, Howard ,  HERSCH, Stuart, A. ,  ROSE, Laurence

Inventor： LUTNICK, Howard ,  HERSCH, Stuart, A. ,  ROSE, Laurence

IPC: G06Q40/00

CPC classification number: G06Q30/06 ,  G06Q40/06 ,  G06Q40/08

Abstract: A method comprising receiving at least one document that is associated with a life insurance policy; assigning a respective value to each of the at least one document, in which the value indicates a level of importance; determining a summation of the at least one document; determining an indication for the life insurance policy, in which the indication is based on the summation of the at least one document and at least one of the values; and displaying the indication.

Abstract translation: 一种方法，包括接收与人寿保险相关联的至少一个文档; 向所述至少一个文档中的每一个分配相应的值，其中所述值表示重要程度; 确定所述至少一个文档的总和; 确定人身保险政策的指示，其中所述指示基于所述至少一个文档的总和和所述值中的至少一个; 并显示指示。