公开(公告)号：JP5683107B2

公开(公告)日：2015-03-11

申请号：JP2009520956

申请日：2007-07-17

Applicant: ウォーターズ テクノロジーズ コーポレイションWaters Technologies Corporation ,  ウォーターズ テクノロジーズ コーポレイションWaters Technologies Corporation

Inventor： キンバー， ディ． フォーゲルマン， ,  キンバー， ディ． フォーゲルマン， ,  ビィンセント， エル． ウォルレイ， ,  ビィンセント， エル． ウォルレイ， ,  ピーター， エム． サリバン， ,  ピーター， エム． サリバン，

IPC: G01N30/84 ,  G01N30/02

CPC classification number: B01D11/0203 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0484 ,  B01D15/40 ,  B01D19/0021 ,  B01D19/0052 ,  Y10T137/3003 ,  G01N30/80

公开(公告)号：WO2023089315A1

公开(公告)日：2023-05-25

申请号：PCT/GB2022/052914

申请日：2022-11-17

Applicant: WATERS TECHNOLOGIES CORPORATION ,  FORRESTERS IP LLP

Inventor： FEKETE, Szabolcs ,  FOGWILL, Michael ,  LAUBER, Matthew

IPC: G01N30/32 ,  B01D15/16

Abstract: There is provided a method of operating a liquid chromatography arrangement, the liquid chromatography arrangement comprising: a solvent pump (10) arranged to flow a liquid solvent over a liquid chromatography column (14); a restrictor (20) arranged to restrict the liquid solvent from leaving the liquid chromatography column; and a liquid pump (12) arranged to provide liquid flow between the liquid chromatography column (14) and the restrictor (20), the method comprising: flowing the liquid solvent through the liquid chromatography column (14) using the solvent pump (10); and controlling a liquid pressure within the liquid chromatography column by providing a liquid flow between the liquid chromatography column (14) and the restrictor (20) using the liquid pump (12).

公开(公告)号：WO2023026251A1

公开(公告)日：2023-03-02

申请号：PCT/IB2022/058018

申请日：2022-08-26

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： XU, MingCheng ,  BROUSMICHE, Darryl W. ,  WYNDHAM, Kevin ,  WALSH, Daniel P. ,  LAWRENCE, Nicole L.

IPC: B01J20/28

Abstract: In various embodiments, the present disclosure pertains to organic polymer core-shell particles that comprise a non-porous organic polymer core (i.e., having a pore volume of less than 0.1 cc/g) and a porous organic polymer shell (i.e., having a pore volume of greater than 0.1 cc/g), in which the porous organic polymer shell has a pore size ranging from 100 Å to 3000 Å. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such organic polymer core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such organic polymer core-shell particles and (b) flowing a mobile phase through the column.

公开(公告)号：WO2022245566A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/028299

申请日：2022-05-09

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MACKINNON, Peter ,  JACKSON, Michael R.

IPC: G01N30/34

Abstract: Disclosed is a liquid chromatography system and mixer (100) for use therein that includes a first split 106 connected to an inlet (102), the first split branching the flow of fluid from the inlet into a first path (108) and a second path (110); a second split (112) connected to an outlet of the first path, the second split branching the first path into a third path (114) and a fourth path (116); and a third split (118) connected to an outlet of the second path, the third split branching the second path into a fifth path (120) and a sixth path (122). The first path and the second path are offset by a first predetermined volume, the third path and the fourth path are offset by a second predetermined volume, and the fifth path and the sixth path are also offset by the second predetermined volume.

公开(公告)号：WO2022229904A1

公开(公告)日：2022-11-03

申请号：PCT/IB2022/053969

申请日：2022-04-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LAWRENCE, Nicole L. ,  BROUSMICHE, Darryl W. ,  FIELD, Jessica ,  WALSH, Daniel P.

IPC: B01J20/28 ,  B01D15/30 ,  B01D15/32 ,  B01D15/34 ,  B01D15/36 ,  B01D15/38 ,  B01J20/32 ,  B01J39/05 ,  B01J39/07 ,  B01J41/05 ,  B01J41/07 ,  B01J20/289 ,  B01J20/288

Abstract: In some aspects, the present disclosure pertains to chromatographic materials that comprise (a) a bulk material and (b) a zwitterionic polymer covalently linked to a surface of the bulk material, in which the zwitterionic polymer comprises one or more monomer residues that comprise an amide or urea moiety, a positively charged moiety, and a negatively charged moiety. Other aspects of the present disclosure pertain to chromatographic separation devices that comprise such chromatographic materials, to chromatographic methods that employ such chromatographic separation devices, and to kits that contain (i) such chromatographic materials and (ii) one or more chromatographic devices for containing such materials.

公开(公告)号：WO2022212504A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022546

申请日：2022-03-30

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： FOGWILL, Michael O. ,  CORMIER, Sylvain G.

IPC: F04B13/02 ,  F04B23/02 ,  F04B23/06 ,  F04B49/06 ,  G01N30/02 ,  F04B2201/0209 ,  F04B2205/09 ,  F04B49/065 ,  G01N2030/326 ,  G01N30/32

Abstract: The exemplary embodiments control solvent pumps so that system flow is constant. One or more controllers may control the flow rate produced by the pumps over time. The one or more controllers control a first pump so that, as the first pump is refilling, a second pump maintains a sufficient flow rate to compensate for the lost flow due to the refilling event. In some exemplary embodiments, the one or more controllers control the timing of the refilling event for the first event such that the refilling event overlaps with the equilibrating of the chromatography column with solvent(s) from the second pump. Similarly, the one or more controllers control the timing of the refilling event for the second pump such that the refilling event overlaps with the equilibrating of the chromatography column.

公开(公告)号：WO2022175728A1

公开(公告)日：2022-08-25

申请号：PCT/IB2021/053914

申请日：2021-05-07

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： ZHANG, Ximo ,  KOZA, Stephan M. ,  YU, Ying Qing ,  CHEN, Weibin

IPC: G01N33/68

Abstract: The present disclosure relates to a method of characterizing proteins in a sample. The method includes: removing non-ionic surfactant from the sample via denaturing size-exclusion chromatography to form a denatured sample; eluting the denatured sample via liquid chromatography to collect fractions of the sample, wherein the fractions of the sample include a protein fraction; lyophilizing the protein fraction to increase protein concentration; reconstituting the lyophilized protein fraction with a buffer comprising a surfactant to denature the protein; digesting the denatured protein fraction with an enzyme; and analyzing the digested protein fraction.

公开(公告)号：WO2022169710A1

公开(公告)日：2022-08-11

申请号：PCT/US2022/014555

申请日：2022-01-31

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： RAYMOND, Timothy M. ,  MACKINNON, Peter ,  JACKSON, Michael R.

IPC: G01N30/30 ,  G01N30/34 ,  G01N30/88

Abstract: Described is a solvent manager for a liquid chromatography system. The solvent manager includes a temperature control module, a plurality of solvent reservoirs, a gradient proportioning valve and a degasser. The temperature control module maintains a substantially constant temperature of one or more of the plurality of solvent reservoirs, gradient proportioning valve and degasser. The temperature control module may include a thermal chamber having an enclosure with a thermally controlled internal environment and may also include an active thermal element such as one or more heaters. The enclosure may surround at least one of the plurality of solvent reservoirs, gradient proportioning valve and degasser. The temperature control module reduces the negative effects on solvent composition that result from temperature-dependent changes in solvent viscosities and solvent densities. Such changes affect the retention times of analytes eluted from the chromatographic column.

公开(公告)号：WO2022064447A1

公开(公告)日：2022-03-31

申请号：PCT/IB2021/058741

申请日：2021-09-24

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： DELANO, Mathew ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  NGUYEN, Jennifer M.

IPC: G01N30/60

Abstract: The present disclosure relates to a method of reducing degradation of sample components in a liquid chromatography system. The method utilizes a masked metal frit to prevent or reduce metal surfaces from becoming catalytically active. The masked metal frit is a metal based frit that includes a coating on its exterior surfaces to mask or prevent contact between the organic solvents (and/or any analyte or other related solvent) and the underlying metal. The coating is a vapor deposited inorganic-organic hybrid coating, such as a vapor deposited C2 coating.

公开(公告)号：WO2022061026A1

公开(公告)日：2022-03-24

申请号：PCT/US2021/050732

申请日：2021-09-16

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： TUNC SARISOZEN, Yeliz ,  LAWRENCE, Nicole L. ,  BROUSMICHE, Darryl W. ,  SCHMUDLACH, Andrew Wyatt ,  LAUBER, Matthew A.

IPC: B01J20/286 ,  B01J20/32 ,  B01J20/28 ,  B01D15/20 ,  B01D15/34

Abstract: The present disclosure is directed to stationary phase materials (e.g., porous inorganic-organic hybrid particles) for performing size exclusion chromatography. Embodiments of the present disclosure feature hydroxy-terminated polyethylene glycol surface modified stationary phase materials.