公开(公告)号：WO2007035559A3

公开(公告)日：2007-03-29

申请号：PCT/US2006/036156

申请日：2006-09-18

Applicant: CLEVELAND STATE UNIVERSITY ,  GAO, Zhiqiang ,  MIKLOSOVIC, Robert ,  RADKE, Aaron ,  ZHOU, Wankun ,  ZHENG, Qing

Inventor： GAO, Zhiqiang ,  MIKLOSOVIC, Robert ,  RADKE, Aaron ,  ZHOU, Wankun ,  ZHENG, Qing

IPC: G06F11/00

Abstract: Controller scaling and parameterization (2900) are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also apply to state feedback and state observer based controllers, as well as linear active disturbance rejection (ADRC) controllers. Parameterization simplifies the use of ADRC. A discrete extended state observer (DESO) and a generalized extended state observer (GESO) are described. They improve the performance of the ESO and therefore ADRC. A tracking control algorithm is also described that improves the performance of the ADRC controller. A general algorithm is described for applying ADRC to multi-input multi-output systems. Several specific applications of the control systems and processes are disclosed.

公开(公告)号：WO2003075977A3

公开(公告)日：2003-09-18

申请号：PCT/US2003/006797

申请日：2003-03-05

Applicant: CLEVELAND STATE UNIVERSITY ,  ANNAPRAGADA, Annanth ,  BHAVANE, Rohan

Inventor： ANNAPRAGADA, Annanth ,  BHAVANE, Rohan

IPC: A61K9/127

Abstract: The invention provides a drug delivery vehicle for inhalation by a patient. The drug delivery vehicle comprises biocompatible particles between 0.1 and 1.0 microns in diameter, that are loaded with one or more drugs and which are crosslinked together to form agglomerates. The agglomerates can also provide for delivery of contrast-enhancing agents for clinical imaging. The invention also provides methods of making the inventive agglomerates, pharmaceutical compositions comprising the agglomerates, and methods for delivering drugs or contrast-enhancing agents to a patient by inhalation of pharmaceutical compositions containing the agglomerates.

公开(公告)号：WO2012083036A3

公开(公告)日：2012-06-21

申请号：PCT/US2011/065191

申请日：2011-12-15

Applicant: CLEVELAND STATE UNIVERSITY ,  NAYFEH, Taysir, H. ,  WIEDERHOLT, Anita, M.

Inventor： NAYFEH, Taysir, H. ,  WIEDERHOLT, Anita, M.

IPC: D01F9/12 ,  B82B1/00

Abstract: Nano-composite structures are formed by pre-loading carbon nanotubes (CNTs) into at least one of a plurality of channels running the length of a cartridge, placing the pre-loaded cartridge in a piston chamber of a die-casting machine, creating a vacuum therein, and filing the piston chamber with molten metal to soak the pre-loaded cartridge and fill empty cartridge channels. Pressure is applied via the piston to eject the carbon nanotubes and molten metal from the cartridge channels and inject the nano-composite mixture into a rod-shaped die cavity. The internal diameter of the cavity is equal to or less than the final diameter of the nozzle. The nano-composite mixture is cooled to form a solid nano- composite rod having the first predetermined diameter, wherein the carbon nanotubes are aligned in a non-random manner. Furthermore, drawing down the nano-composite rod to smaller diameter wire further disperses the nanotubes along the length of the wire.

公开(公告)号：WO2008070318A2

公开(公告)日：2008-06-12

申请号：PCT/US2007/082251

申请日：2007-10-23

Applicant: CLEVELAND STATE UNIVERSITY ,  BAYACHOU, Mekki ,  PEIRIS, Pubudu

Inventor： BAYACHOU, Mekki ,  PEIRIS, Pubudu

IPC: G01N27/44

CPC classification number: G01N33/0037 ,  Y02A50/245

Abstract: Electrodes comprising ruthenium oxide nanoparticles are disclosed. The ruthenium oxide nanoparticles are located within the electrode or as a coating thereon. The electrode is especially suited for measuring the presence and/or concentration of nitric oxide in a sample.

Abstract translation: 公开了包含氧化钌纳米颗粒的电极。 氧化钌纳米颗粒位于电极内或作为其上的涂层。 电极特别适用于测量样品中一氧化氮的存在和/或浓度。

公开(公告)号：WO2005034844A3

公开(公告)日：2005-04-21

申请号：PCT/US2004/021487

申请日：2004-07-01

Applicant: CLEVELAND STATE UNIVERSITY ,  KALAFATIS, Michael

Inventor： KALAFATIS, Michael

IPC: A61K38/00

Abstract: Disclosed are an amino acid sequence of the human blood clotting factor Va, peptides containing such sequence, and additional peptides of interest that significantly inhibit thrombin generation. Also disclosed are pharmaceutical compositions containing these peptides and related therapeutic methods for inhibiting thrombin generation and treating blood coagulation disorders.

公开(公告)号：WO2018191496A1

公开(公告)日：2018-10-18

申请号：PCT/US2018/027300

申请日：2018-04-12

Applicant: CLEVELAND STATE UNIVERSITY

Inventor： SAWICKI, Jerzy T. ,  LAUBSCHER, Curt A. ,  FARRIS, Ryan J. ,  ETHERIDGE, Steven J-S

IPC: A61H1/02 ,  A61H3/00 ,  F16H7/08 ,  F16H7/02

CPC classification number: A61H3/00 ,  A61H1/024 ,  A61H1/0244 ,  A61H2001/0248 ,  A61H2201/0107 ,  A61H2201/1207 ,  A61H2201/1215 ,  A61H2201/1436 ,  A61H2201/1454 ,  A61H2201/1463 ,  A61H2201/1472 ,  A61H2201/149 ,  A61H2201/164 ,  A61H2201/1642 ,  A61H2201/165 ,  A61H2201/1671 ,  A61H2201/1673 ,  A61H2201/5005 ,  A61H2201/5058 ,  A61H2201/5064 ,  A61H2201/5084 ,  A61H2205/106 ,  A61H2205/108 ,  F16H7/023 ,  F16H7/08 ,  F16H19/005 ,  F16H2007/087 ,  F16H2007/0891

Abstract: An actuating device for orthosis including a housing, a motor, a transmission disposed in the housing, and an actuating arm. The transmission is operatively connected to the motor such that the motor provides power to the transmission. The transmission includes a first stage, a second stage, and a third stage. The first stage has a first sprocket, a second sprocket, and a first drive belt tensioned between the first sprocket and the second sprocket. The first sprocket is attached to a shaft of the motor. The second stage has a third sprocket, a fourth sprocket, and a second drive belt tensioned by the third sprocket and the fourth sprocket. The third sprocket is attached to the second sprocket of the first stage. The third stage has a fifth sprocket, a sixth sprocket, and a third drive belt tensioned by the fifth sprocket and the sixth sprocket. The fifth sprocket is attached to the fourth sprocket of the second stage. The transmission additionally includes a first shaft and a second shaft. The second sprocket, the third sprocket, and the sixth sprocket are attached to the first shaft, and the fourth sprocket and the fifth sprocket are attached to the second shaft. The actuating arm is operatively connected to the sixth sprocket of the third stage of the transmission such that the power provided to the transmission by the motor causes the actuating arm to provide an output torque.

公开(公告)号：WO2017123722A1

公开(公告)日：2017-07-20

申请号：PCT/US2017/013144

申请日：2017-01-12

Applicant: CLEVELAND STATE UNIVERSITY

Inventor： LEE, Moo-Yeal

IPC: B33Y10/00 ,  C12M3/00 ,  C12N5/00 ,  C12N5/077 ,  C12N5/09 ,  G01N33/50

CPC classification number: C12N11/04 ,  C12N5/00 ,  C12Q1/02 ,  G01N33/5005

Abstract: A method of creating a miniature multicellular biological construct and a method for studying cellular environments using the miniature multicellular biological construct is provided. The method for making the miniature multicellular biological construct includes suspending cells in a hydrogel, depositing the cell-suspension into a microwell, gelling the cell-suspension, and incubating the cell-suspension. The method for studying cellular environments includes imaging the miniature multicellular biological construct.

Abstract translation: 提供了一种产生微型多细胞生物构建体的方法和使用该微型多细胞生物构建体研究细胞环境的方法。 制造微型多细胞生物构建体的方法包括将细胞悬浮在水凝胶中，将细胞悬液沉积到微孔中，胶凝细胞悬液并孵育细胞悬液。 研究细胞环境的方法包括对微型多细胞生物构建体进行成像。

公开(公告)号：WO2010011851A1

公开(公告)日：2010-01-28

申请号：PCT/US2009/051567

申请日：2009-07-23

Applicant: CLEVELAND STATE UNIVERSITY ,  YAU, Siu-Tung

Inventor： YAU, Siu-Tung

IPC: C25B11/02

CPC classification number: H01M4/8878 ,  H01G11/26 ,  H01G11/48 ,  H01G11/86 ,  H01M4/9008 ,  H01M4/9075 ,  H01M4/9083 ,  H01M8/1009 ,  H01M8/16 ,  Y02E60/13 ,  Y02E60/527

Abstract: The invention provides an electrode and an electrochemical device including the electrode. The electrode comprises a spatial confining structure such as grooves and an active compound such as glucose oxidase (GOx). The grooves spatially confines GOx, and stabilizes its enzymatic activity. Also provided is a method of stabilizing the activity of an active compound such as GOx. The invention can be widely used in development of an energy-generation device such as a fuel cell, a memory, an electrochemical reactor, a supercapacitor, a biosensor and a medical device thereof such as artificial pancreas, and a sensor such as detector of redox reactant.

Abstract translation: 本发明提供一种电极和包括该电极的电化学装置。 电极包括诸如凹槽的空间限制结构和诸如葡萄糖氧化酶（GOx）的活性化合物。 凹槽在空间上限制GOx，并稳定其酶活性。 还提供了稳定活性化合物如GOx的活性的方法。 本发明可广泛用于人造胰腺等燃料电池，记忆体，电化学反应器，超级电容器，生物传感器及其医疗装置等发电装置的开发，以及诸如氧化还原检测器的传感器 反应物。

公开(公告)号：WO2006104477A1

公开(公告)日：2006-10-05

申请号：PCT/US2005/009871

申请日：2005-03-24

Applicant: CLEVELAND STATE UNIVERSITY ,  GUO, Baochuan ,  SUN, Xiyuan

Inventor： GUO, Baochuan ,  SUN, Xiyuan

IPC: C12Q1/68

CPC classification number: G01N33/6803

Abstract: Various methods and strategies are disclosed for detecting human tumors, and specifically colorectal tumors. Methods are also disclosed for detecting truncation mutations in a large background of wild-type DNA. And, methods for detecting AP mutations in a large background of wild-type DNA are also disclosed.

Abstract translation: 公开了用于检测人类肿瘤，特别是结肠直肠肿瘤的各种方法和策略。 还公开了用于在野生型DNA的大背景中检测截短突变的方法。 并且还公开了在野生型DNA的大背景中检测AP突变的方法。

公开(公告)号：WO2004069490A1

公开(公告)日：2004-08-19

申请号：PCT/US2003/013275

申请日：2003-04-28

Applicant: CLEVELAND STATE UNIVERSITY ,  GAO, Zhiqiang

Inventor： GAO, Zhiqiang

IPC: B25J9/16

CPC classification number: G05B13/024 ,  G05B5/01 ,  G05B11/42 ,  G05B13/042 ,  G05B15/02 ,  G05B19/416 ,  G05B2219/33347

Abstract: Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also applies to state feedback and state observer based controllers, as well as linear active disturbance rejection controllers.

Abstract translation: 描述控制器缩放和参数化。 可以通过使用缩放和参数化来改进的技术包括但不限于控制器设计，调整和优化。 这里描述的缩放和参数化方法适用于基于传递函数的控制器，包括PID控制器。 参数化方法也适用于状态反馈和基于状态观察器的控制器，以及线性有源扰动抑制控制器。