ONE STEP SYNTHESIS OF CORE/SHELL NANOCRYSTAL QUANTUM DOTS
    22.
    发明申请
    ONE STEP SYNTHESIS OF CORE/SHELL NANOCRYSTAL QUANTUM DOTS 审中-公开
    一步合成核/壳纳米晶量

    公开(公告)号:WO2014089743A1

    公开(公告)日:2014-06-19

    申请号:PCT/CN2012/086294

    申请日:2012-12-10

    Abstract: Compositions and one-step synthesis of core/shell nanocrystal quantum dots are provided. A method of making the nanocrystal includes mixing at least one cationic precursor, at least one anionic precursor, and at least one solvent to form a mixture, heating the mixture, precipitating the mixture to form a nanocrystal precipitate, and isolating the nanocrystal precipitate. The formed nanocrystal comprises an outer shell encapsulating an inner core and exhibits substantial crystallinity, monodispersity, and reproducibility.

    Abstract translation: 提供核/壳纳米晶体量子点的组成和一步合成。 制备纳米晶体的方法包括将至少一种阳离子前体,至少一种阴离子前体和至少一种溶剂混合以形成混合物,加热混合物,使混合物沉淀形成纳米晶体沉淀物,并分离纳米晶体沉淀物。 形成的纳米晶体包括封装内核的外壳,并显示出显着的结晶度,单分散性和再现性。

    REVERSIBLY WATER-SOLUBLE NANOCRYSTALS CAPPED BY NUCLEOTIDES AND/OR NUCLEOSIDES
    30.
    发明申请
    REVERSIBLY WATER-SOLUBLE NANOCRYSTALS CAPPED BY NUCLEOTIDES AND/OR NUCLEOSIDES 审中-公开
    由核酸和/或核苷酸引起的可逆性水溶性纳米晶体

    公开(公告)号:WO2013107041A1

    公开(公告)日:2013-07-25

    申请号:PCT/CN2012/070659

    申请日:2012-01-20

    CPC classification number: G01N33/5005 B82Y30/00 C07H19/10 C07H19/20

    Abstract: A general, facile, and reversible nanocrystal (NCs) phase transfer protocol via ligand exchange using nucleotides and/or nucleosides is provided to generate reversibly water-soluble nanocrystals. This phase transfer strategy can be employed on a wide variety of chemically synthesized nanostructured materials including semiconductors, metal oxides and noble metals with different sizes and shapes. The nucleotide/nucleoside-capped nanocrystals can disperse homogeneously in aqueous or alcohol media retaining, for example, high photoluminescence quantum yields. The disclosed water-soluble nanocrystals have excellent colloidal and photoluminescent stability independent on the pH and ionic strength, minimal hydrodynamic size, and are stable in cells and suitable for in vitro cell labeling, cell tracking, and other bioimaging applications.

    Abstract translation: 提供通过使用核苷酸和/或核苷的配体交换的通用的,容易的和可逆的纳米晶体(NCs)相转移方案以产生可逆的水溶性纳米晶体。 该相转移策略可用于各种化学合成的纳米结构材料,包括半导体,金属氧化物和具有不同尺寸和形状的贵金属。 核苷酸/核苷封端的纳米晶体可以均匀分散在水或醇介质中,保持例如高光致发光量子产率。 所公开的水溶性纳米晶体具有优异的胶体和光致发光稳定性,独立于pH和离子强度,最小的流体动力学尺寸,并且在细胞中是稳定的并且适用于体外细胞标记,细胞跟踪和其它生物成像应用。

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