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公开(公告)号：WO2009037222A1
公开(公告)日：2009-03-26
申请号：PCT/EP2008/062234
申请日：2008-09-15
Applicant: F. HOFFMANN-LA ROCHE AG , BOLIN, David Robert , CAI, Jianping , CHEUNG, Adrian Wai-Hing , GOODNOW JR., Robert Alan , HAMILTON, Matthew Michael , LI, Shiming , MCDERMOTT, Lee Apostle , YUN, Weiya
Inventor： BOLIN, David Robert , CAI, Jianping , CHEUNG, Adrian Wai-Hing , GOODNOW JR., Robert Alan , HAMILTON, Matthew Michael , LI, Shiming , MCDERMOTT, Lee Apostle , YUN, Weiya
IPC: C07D401/14 , C07D403/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/437 , A61K31/416 , A61K31/404 , A61P3/00
CPC classification number: C07D413/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。
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公开(公告)号：WO2007059113A2
公开(公告)日：2007-05-24
申请号：PCT/US2006044154
申请日：2006-11-14
Applicant: CYTOKINETICS INC , COLLIBEE SCOTT , BERGNES GUSTAVE , HAMILTON MATTHEW RICHARD , MORGAN BRADLEY P , MORGANS DAVID J JR
Inventor： COLLIBEE SCOTT , BERGNES GUSTAVE , HAMILTON MATTHEW RICHARD , MORGAN BRADLEY P , MORGANS DAVID J JR
IPC: A61K31/4245
CPC classification number: C07D211/82
Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.
Abstract translation: 公开了用于治疗细胞增殖性疾病的化合物。
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公开(公告)号：WO2005035514A2
公开(公告)日：2005-04-21
申请号：PCT/US2004033367
申请日：2004-10-08
Applicant: VERTEX PHARMA , HADIDA RUAH SARA S , SINGH ASHVANI K , MILLER MARK T , HAMILTON MATTHEW , GROOTENHUIS PETER D J
Inventor： HADIDA RUAH SARA S , SINGH ASHVANI K , MILLER MARK T , HAMILTON MATTHEW , GROOTENHUIS PETER D J
IPC: A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/11 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C307/00 , C07C311/16 , C07C311/17 , C07C323/60 , C07D209/42 , C07D213/82 , C07D215/54 , C07D215/56 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D307/87 , C07D333/32 , C07D333/70 , C07D407/12 , C07D307/00
CPC classification number: C07D307/87 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C311/16 , C07C311/17 , C07C323/60 , C07C2601/08 , C07D209/42 , C07D213/82 , C07D215/54 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D333/32 , C07D333/70 , C07D407/12
Abstract: The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein R , n, B, R , R , R , A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula (I), useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
Abstract translation: 本发明提供可用作ABC转运蛋白活性调节剂的式（I）化合物或其药学上可接受的盐，其中R b，n，B，R c，R d，R e， A和Z一般在下面的类和子类中进行描述。 本发明还提供与式（I）相关的药物组合物，方法和试剂盒，其可用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。
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24.发明申请PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 审中-公开作为ATP结合蛋白转运蛋白的调节剂的吡嗪衍生物
公开(公告)号：WO2004111014A1
公开(公告)日：2004-12-23
申请号：PCT/US2004/017673
申请日：2004-06-04
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , MAKINGS, Lewis, R. , SINGH, Ashvani, K. , MILLER, Mark, T. , HADIDA RUAH, Sarah, S. , GROOTENHUIS, Peter , HAMILTON, Matthew , HAZELWOOD, Anna, R. , HUANG, Liming
Inventor： MAKINGS, Lewis, R. , SINGH, Ashvani, K. , MILLER, Mark, T. , HADIDA RUAH, Sarah, S. , GROOTENHUIS, Peter , HAMILTON, Matthew , HAZELWOOD, Anna, R. , HUANG, Liming
IPC: C07D239/90
CPC classification number: C07D239/36 , C07D239/42 , C07D239/90 , C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/10 , C07D513/04
Abstract: The present invention relates to compounds of Formula (I) as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Abstract translation: 本发明涉及作为ATP结合盒（“ABC”）转运体或其片段的调节剂的式（I）化合物，包括囊性纤维化跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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25.发明申请CHITOSAN COVALENTLY LINKED WITH SMALL MOLECULE INTEGRIN ANTAGONIST FOR TARGETED DELIVERY 审中-公开CHITOSAN共同连接小分子整合剂ANAGONIST用于定向递送
公开(公告)号：WO2013110681A1
公开(公告)日：2013-08-01
申请号：PCT/EP2013/051279
申请日：2013-01-24
Applicant: F. HOFFMANN-LA ROCHE AG , CHIN, Jayne , GOODNOW Jr., Robert, Alan , HAMILTON, Matthew, Michael , SIDDURI, Achyutharao
Inventor： CHIN, Jayne , GOODNOW Jr., Robert, Alan , HAMILTON, Matthew, Michael , SIDDURI, Achyutharao
CPC classification number: A61K31/722 , A61K47/60 , A61K47/61 , C08B37/003
Abstract: The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X 1 , X 4 , R 1 , R 2 , and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (α4ß1) and alpha-V-beta-3 (α Vß3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.
Abstract translation: 本发明涉及式I的壳聚糖聚合物衍生物及其药学上可接受的盐和酯，其中Y，X 1，X 4，R 1，R 2和n在详细描述和权利要求书中定义。 式I的壳聚糖聚合物衍生物与α-4-β-1（α4β1）和α-V-β-3（αVβ3）整联蛋白二聚体结合或结合，并且可用于递送制剂中以递送药物，核酸， 或其他治疗性化合物施用于表达这种整联蛋白的组织或细胞。
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Patent Agency Ranking26.发明申请INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING LFA-1 审中-公开用于指定递送至表达LFA-1的细胞的整合拮抗剂
公开(公告)号：WO2013110679A1
公开(公告)日：2013-08-01
申请号：PCT/EP2013/051273
申请日：2013-01-24
Applicant: F. HOFFMANN-LA ROCHE AG , GOODNOW JR., Robert Alan , HAMILTON, Matthew Michael , KOWALCZYK, Agnieszka , SIDDURI, Achyutharao
Inventor： GOODNOW JR., Robert Alan , HAMILTON, Matthew Michael , KOWALCZYK, Agnieszka , SIDDURI, Achyutharao
CPC classification number: C07D403/12 , A61K47/54 , A61K47/545 , A61K47/60 , C07C327/06 , C07C381/00 , C07D207/36 , C07D207/46 , C07D213/71 , C07H21/02
Abstract: The invention relates to compounds of formula (I), wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula I for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to LFA-1 integrin antagonists to target cells expressing LFA-1.
Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 2和n在详细描述和权利要求书中定义。 特别地，本发明涉及式I化合物，其用于制备和递送缀合的部分，例如与LFA-1整联蛋白拮抗剂连接至靶细胞的小分子，肽，核酸，荧光部分和聚合物 表达LFA-1。
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公开(公告)号：WO2013030138A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066567
申请日：2012-08-27
Applicant: F. HOFFMANN-LA ROCHE AG , CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
Inventor： CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P29/00
CPC classification number: C07D487/04
Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
Abstract translation: 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中所述变量如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：WO2012122478A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028484
申请日：2012-03-09
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA , SADOWSKY, Michael J. , KHORUTS, Alexander , WEINGARDEN, Alexa R. , HAMILTON, Matthew J.
CPC classification number: A61K35/37 , A61K9/0053 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K35/24 , A61K35/74 , A61K35/741 , A61K35/742 , A61K45/06 , A61K47/08 , A61K47/26 , A61K2035/11 , Y02A50/473 , Y02A50/475 , A61K2300/00
Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
Abstract translation: 本发明提供了包含人类粪便提取物的组合物和使用这些组合物的方法，包括用于替代或补充或修饰受试者的结肠微生物群的方法，以及用于治疗受试者的结肠微生物群的疾病，病理状况和/或医源性病症的方法 结肠。
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29.发明申请INDOLE AND INDAZOLE DERIVATIVES AS GLYCOGEN SYNTHASE ACTIVATORS 审中-公开作为GLYCOGEN SYNTHASE激活剂的吲哚和吲哚衍生物
公开(公告)号：WO2011057959A1
公开(公告)日：2011-05-19
申请号：PCT/EP2010/066868
申请日：2010-11-05
Applicant: F. HOFFMANN-LA ROCHE AG , BOLIN, David, Robert , HAMILTON, Matthew, Michael , MCDERMOTT, Lee, Apostle , YI, Lin
Inventor： BOLIN, David, Robert , HAMILTON, Matthew, Michael , MCDERMOTT, Lee, Apostle , YI, Lin
IPC: C07D209/08 , C07D231/56 , A61K31/404 , A61K31/416
CPC classification number: C07D209/08 , C07D231/56
Abstract: Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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公开(公告)号：WO2007060140A3
公开(公告)日：2007-09-13
申请号：PCT/EP2006068611
申请日：2006-11-17
Applicant: HOFFMANN LA ROCHE , BOLIN DAVID ROBERT , CHEUNG ADRIAN WAI-HING , FIROOZNIA FARIBORZ , HAMILTON MATTHEW MICHAEL , LI SHIMING , MCDERMOTT LEE APOSTLE , QIAN YIMIN , YUN WEIYA
Inventor： BOLIN DAVID ROBERT , CHEUNG ADRIAN WAI-HING , FIROOZNIA FARIBORZ , HAMILTON MATTHEW MICHAEL , LI SHIMING , MCDERMOTT LEE APOSTLE , QIAN YIMIN , YUN WEIYA
IPC: C07D413/12 , A61K31/42 , A61P25/00 , C07D413/14 , C07D417/12 , C07D417/14
CPC classification number: C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。
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