公开(公告)号：AU2008100746A4

公开(公告)日：2008-09-11

申请号：AU2008100746

申请日：2008-08-09

Applicant: HAMILTON MATTHEW ,  HOPE KIRSTI

Inventor： HOPE KIRSTI ,  HAMILTON MATTHEW

IPC: G01B3/02

公开(公告)号：AU2002364547A1

公开(公告)日：2003-11-11

申请号：AU2002364547

申请日：2002-12-09

Applicant: HAMILTON MATTHEW

Inventor： KINNIER ALEX ,  HAMILTON MATTHEW ,  WALTERS RUSSEL

IPC: B05D1/18 ,  B05D5/04 ,  B05D5/06 ,  B41M1/30 ,  B41M1/34 ,  B41M3/00 ,  B32B7/00 ,  G03C11/08

Abstract: It is an object of the present invention to provide novel signs and visual displays produced by different behavior of liquids applied to hydrophilic and hydrophobic surfaces on patterned surfaces. It is also an object of the present invention to provide articles baring logos and alphanumeric text produced by application of liquids to patterned material surfaces. There is further provided a method for producing novel signs and visual displays by producing patterned hydrophobic and hydrophilic surfaces. Also provided are processes for producing patterned surfaces.

公开(公告)号：AU2016388305A1

公开(公告)日：2017-08-24

申请号：AU2016388305

申请日：2016-01-20

Applicant: VALDERRABANO VICTOR ,  NUNLEY JAMES ,  DEORIO JAMES ,  EASLEY MARK ,  HAMILTON MATTHEW ,  DIEP PHONG

Inventor： VALDERRABANO VICTOR ,  NUNLEY JAMES ,  DEORIO JAMES ,  EASLEY MARK ,  HAMILTON MATTHEW ,  DIEP PHONG

IPC: A61F2/42

公开(公告)号：WO2018157230A1

公开(公告)日：2018-09-07

申请号：PCT/CA2017/050531

申请日：2017-05-02

Applicant: HAMILTON, Matthew

Inventor： HAMILTON, Matthew ,  CAMPBELL-CORREA, Jennifer ,  HILL, Stephen ,  PECKHAM, Jordan ,  RUMBOLT, Chuck ,  HAAS, Wally

IPC: G09F9/33 ,  G02B27/22 ,  H04N13/04

Abstract: The present disclosure relates to a directional pixel for a high-angular resolution, wide field of view, multiple view display. The design teaches a directional pixel comprising a substrate, one or more pixel driving circuits, one or more nano- or micro-scale subpixels, and one or more directional optical guiding surfaces, wherein each of said one or more subpixels is comprised of a light emitting device emitting a light beam and an optical microcavity housing said light emitting device. The optical microcavity is comprised of a plurality of reflective surfaces to specifically manipulate and tune said light beam, wherein one or more of said reflective surfaces is a light propagating reflective surface which propagates said light beam out of said microcavity, and said light propagating reflective surface is connected to said one or more directional optical guiding surfaces to direct said light beam at a specific angle. A high-angular resolution, multiple-view light-field display is created by deploying a plurality of directional pixels into a directional pixel array system.

公开(公告)号：WO2013110680A1

公开(公告)日：2013-08-01

申请号：PCT/EP2013/051275

申请日：2013-01-24

Applicant: F. HOFFMANN-LA ROCHE AG ,  GOODNOW Jr., Robert, Alan ,  HAMILTON, Matthew, Michael ,  SIDDURI, Achyutharao

Inventor： GOODNOW Jr., Robert, Alan ,  HAMILTON, Matthew, Michael ,  SIDDURI, Achyutharao

IPC: A61K47/48 ,  A61P35/00 ,  A61P29/00

CPC classification number: A61K47/545 ,  A61K47/54 ,  A61K47/60

Abstract: The invention relates to compounds of formula I: wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula I for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to VLA-4 integrin antagonists to target cells expressing VLA-4.

Abstract translation: 本发明涉及式I化合物：其中R1，R2和n在详细描述和权利要求书中定义。 特别地，本发明涉及式I化合物，其用于制备和递送缀合的部分，例如小分子，肽，核酸，荧光部分和与VLA-4整联蛋白拮抗剂连接至靶细胞的聚合物 表达VLA-4。

公开(公告)号：WO2013110578A1

公开(公告)日：2013-08-01

申请号：PCT/EP2013/051082

申请日：2013-01-22

Applicant: F. HOFFMANN-LA ROCHE AG ,  GOODNOW JR., Robert Alan ,  HAMILTON, Matthew Michael ,  KOWALCZYK, Agnieszka ,  SIDDURI, Achyutharao

Inventor： GOODNOW JR., Robert Alan ,  HAMILTON, Matthew Michael ,  KOWALCZYK, Agnieszka ,  SIDDURI, Achyutharao

IPC: A61K47/48 ,  A61P35/00 ,  A61P29/00

CPC classification number: C07D277/593 ,  A61K47/48061 ,  A61K47/48092 ,  A61K47/48215 ,  A61K47/545 ,  A61K47/549 ,  A61K47/60 ,  C07C237/52 ,  C07C327/32 ,  C07D207/452 ,  C07D239/14 ,  C07D417/12

Abstract: The invention relates to compounds of formula (I): wherein R 1 , R 2 , and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3.

Abstract translation: 本发明涉及式（I）的化合物：其中R 1，R 2和n在详细描述和权利要求书中定义。 特别地，本发明涉及用于制备和递送缀合部分的式（I）化合物，所述共轭部分例如小分子，肽，核酸，荧光部分和与α-V-β- 3整合素拮抗剂靶向表达α-V-β-3的细胞。

公开(公告)号：WO2007056341A1

公开(公告)日：2007-05-18

申请号：PCT/US2006/043289

申请日：2006-11-08

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  HADIDA RUAH, Sara ,  HAMILTON, Matthew ,  MILLER, Mark ,  GROOTENHUIS, Peter, D., J. ,  BEAR, Brian ,  MCCARTHY, Jason ,  ZHOU, Jinglan

Inventor： HADIDA RUAH, Sara ,  HAMILTON, Matthew ,  MILLER, Mark ,  GROOTENHUIS, Peter, D., J. ,  BEAR, Brian ,  MCCARTHY, Jason ,  ZHOU, Jinglan

IPC: C07D405/12 ,  C07D405/14 ,  C07D213/75 ,  A61K31/5585 ,  A61K31/4418 ,  A61P11/00

CPC classification number: C07D405/12 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：WO2011057956A1

公开(公告)日：2011-05-19

申请号：PCT/EP2010/066857

申请日：2010-11-05

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David, Robert ,  HAMILTON, Matthew, Michael ,  MCDERMOTT, Lee, Apostle ,  QIAN, Yimin

Inventor： BOLIN, David, Robert ,  HAMILTON, Matthew, Michael ,  MCDERMOTT, Lee, Apostle ,  QIAN, Yimin

IPC: C07D261/20 ,  C07D403/12 ,  A61P3/10 ,  A61K31/423

CPC classification number: C07D261/20 ,  C07D403/12

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。

公开(公告)号：WO2010056506A1

公开(公告)日：2010-05-20

申请号：PCT/US2009/062154

申请日：2009-10-27

Applicant: VIA PHARMACEUTICALS, INC. ,  BOLIN, David, R. ,  CHEUNG, Adrian, Wai-hing ,  HAMILTON, Matthew, Michael ,  MARCOPULOUS, Nicholas ,  McDERMOTT, Lee, Apostle ,  QIAN, Yimin

Inventor： BOLIN, David, R. ,  CHEUNG, Adrian, Wai-hing ,  HAMILTON, Matthew, Michael ,  MARCOPULOUS, Nicholas ,  McDERMOTT, Lee, Apostle ,  QIAN, Yimin

IPC: C12Q1/48

CPC classification number: C07D401/04 ,  C07D213/75 ,  C07D213/82 ,  C07D277/46 ,  C07D277/82 ,  C07D295/155 ,  C07D295/185 ,  C07D295/205 ,  C07D333/54 ,  C07D401/12

Abstract: Provided herein are compounds of the formula (I): were Rl is phenyl, R2 is hyrogen, halogen or lower alkyl,X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a-4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of triglicerides, such as, for example, obesity, type Il diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供了式（I）的化合物：R1是苯基，R2是氢，卤素或低级烷基，X是氮上的碳，R3是异喹啉， - 氨基或a-4-至6-元杂环烷基环 其药学上可接受的盐，其作为DGAT抑制剂是有活性的，因此可用于治疗与三联嘧啶的异常代谢相关的疾病，例如肥胖症，II型糖尿病和代谢综合征。

公开(公告)号：WO2005026137A3

公开(公告)日：2005-07-21

申请号：PCT/US2004029206

申请日：2004-09-07

Applicant: VERTEX PHARMA ,  MILLER MARK T ,  HADIDA RUAH SARA S ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

Inventor： MILLER MARK T ,  HADIDA RUAH SARA S ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

IPC: A61K31/426 ,  A61K31/427 ,  A61P43/00 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including CF Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。