公开(公告)号：WO2006091421A3

公开(公告)日：2006-12-14

申请号：PCT/US2006005084

申请日：2006-02-13

Applicant: IDEXX LAB INC ,  O'CONNOR JR THOMAS PATRICK

Inventor： O'CONNOR JR THOMAS PATRICK

IPC: G01N33/50

CPC classification number: G01N33/56911 ,  G01N2469/20

Abstract: The invention provides compositions and methods for the detection and quantification of Ehrlichia ewingii, Ehrlichia ewingii antibodies, antibody fragments, and polypeptides.

Abstract translation: 本发明提供了用于检测和定量艾氏弧菌，艾氏杆菌抗体，抗体片段和多肽的组合物和方法。

公开(公告)号：WO2005019796A3

公开(公告)日：2006-11-23

申请号：PCT/US2004025073

申请日：2004-08-04

Applicant: IDEXX LAB INC

Inventor： SELLERS JAMES M ,  TAYLOR HAYDN B ,  KUBA LAWRENCE M

IPC: B01L99/00 ,  G01N21/00 ,  B01L9/00 ,  G01N35/00 ,  G01N35/02

CPC classification number: B01L9/52 ,  B01L2200/025 ,  B01L2300/0803 ,  B01L2300/0822 ,  G01N35/00029 ,  G01N35/025 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00138

Abstract: A slide cartridge (1) for use with a chemical analyzer includes an upper ring (2) and a lower ring (4) secured together but rotatable with respect to each other. The upper and lower rings define a plurality of reaction chambers (6) between them, which receive dry analyte test slides (8). A gear track formed in the underside of the lower ring engages a pinion gear (28) attached to a stepping motor (30) of the chemical analyzer in order to rotate the slide cartridge. The slide cartridge is rotated under a sample fluid metering device (68), which deposits a sample fluid on the test slides through a plurality of spotter ports (66) formed in the upper ring, and above a reflectometer (22), which performs a colorimetric measurement on the spotted test slides through viewing windows (18) formed in the lower ring of the slide cartridge.

Abstract translation: 用于化学分析器的滑动盒（1）包括固定在一起但可相对于彼此旋转的上环（2）和下环（4）。 上下环在它们之间限定多个反应室（6），其接收干燥的分析物测试载片（8）。 形成在下环的下侧的齿轮轨道接合附接到化学分析仪的步进电动机（30）的小齿轮（28），以便旋转滑动盒。 滑动盒在样品流体计量装置（68）下旋转，样品流体计量装置（68）将样品流体通过形成在上部环中的多个检测口（66）和反射计（22）的上方沉积在测试载片上，该反射计执行 通过形成在滑动盒的下环中的观察窗（18），在点样测试滑块上进行比色测量。

公开(公告)号：WO2005025488A3

公开(公告)日：2005-05-12

申请号：PCT/US2004011823

申请日：2004-04-16

Applicant: IDEXX LAB INC ,  MURTHY YERRAMILLI V S N ,  SUVA ROBERT H

Inventor： MURTHY YERRAMILLI V S N ,  SUVA ROBERT H

IPC: A61K9/00 ,  A61K31/65 ,  A61K31/655 ,  A61K31/704 ,  A61K47/12 ,  A61K47/14 ,  A61K47/44

CPC classification number: A61K31/704 ,  A61K9/0019 ,  A61K31/65 ,  A61K31/655 ,  A61K47/12 ,  A61K47/14 ,  A61K47/44

Abstract: The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water immiscible solvent. In one embodiment the compositions are provided as injectable compositions. The lipophilic counterion may be a saturated or unsaturated C8-C22 fatty acid, and preferably may be a saturated or unsaturated C10-C18 fatty acid. The compositions are released over time when administered to a mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for periods of up to 15 days or even longer. Many compounds can be administered according to the present invention, including, but not limited to, tilmicosin, oxytetracycline, fluoxetine, roxithromycin, and turbinafine.

Abstract translation: 本发明提供用于延长释放时间并降低药理活性化合物的毒性的组合物和方法。 所述化合物包含药理活性化合物的盐与亲脂性抗衡离子和药学上可接受的与水不混溶的溶剂。 在一个实施方案中，组合物作为可注射组合物提供。 亲油抗衡离子可以是饱和或不饱和的C 8 -C 22脂肪酸，优选可以是饱和或不饱和的C 10 -C 18脂肪酸。 当给予哺乳动物时，组合物随时间释放。 因此，本发明使得能够提供活性化合物的受控剂量给药长达15天甚至更长时间。 根据本发明可以施用许多化合物，包括但不限于替米考星，土霉素，氟西汀，罗红霉素和头孢噻吩。

公开(公告)号：WO0058730A9

公开(公告)日：2002-07-11

申请号：PCT/US0007965

申请日：2000-03-24

Applicant: IDEXX LAB INC ,  CARPENTER CHARLES R

Inventor： CARPENTER CHARLES R

IPC: G01N33/543 ,  C12M1/34 ,  C12Q1/25 ,  G01N21/78 ,  G01N33/483 ,  G01N33/533 ,  G01N33/536 ,  G01N33/558 ,  G01N33/577

CPC classification number: G01N33/558 ,  Y10S435/81 ,  Y10S435/91

Abstract: A disposable, dry chemistry analytical system is disclosed which is broadly useful for the detection of a variety of analytes present in biological fluids such as whole blood, serum, plasma, urine and cerebral spinal fluid. The invention discloses the use of the reaction interface that forms between two liquids converging from opposite directions within a bibulous material. The discovery comprises a significant improvement over prior art disposable, analytical reagent systems in that the detectable reactant zone is visually distinct and separate from the unreacted reagents allowing for the use of reaction indicators exhibiting only minor changes as well as extremely high concentrations of reactants. In addition, staged, multiple reagents can be incorporated. Whole blood can be used as a sample without the need for separate cell separating materials. Finally, the invention is useful for the detection of analytes in a broad variety of materials such as milk, environmental samples, and other samples containing target analytes.

Abstract translation: 公开了一次性干燥化学分析系统，其广泛用于检测生物流体如全血，血清，血浆，尿液和脑脊液中存在的各种分析物。 本发明公开了在吸水材料内从两相反方向汇合的两种液体之间形成的反应界面的应用。 该发现包括相对于现有技术的一次性分析试剂系统的显着改进，因为可检测的反应物区域在视觉上是不同的并且与未反应的试剂分离，允许使用仅显示微小变化的反应指示剂以及极高浓度的反应物。 此外，可以并入分阶段的多种试剂。 全血可用作样品，不需要单独的细胞分离材料。 最后，本发明可用于检测多种材料中的分析物，例如牛奶，环境样品和含有目标分析物的其它样品。

公开(公告)号：WO2014063051A3

公开(公告)日：2014-06-26

申请号：PCT/US2013065681

申请日：2013-10-18

Applicant: IDEXX LAB INC

Inventor： LEUTENEGGER CHRISTIAN ,  ANGELICHIO MICHAEL JOHN

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q2600/166 ,  C12Q2537/143 ,  C12Q2545/107 ,  C12Q2563/185

Abstract: The invention provides components and methods for polymerase chain reaction assays. The assays minimize both handling of material and time spent running samples. For example, a single internal positive control (SPC) polynucleotide pair can provide a means to ensure proper nucleic acid purification for both RNA and DNA test targets. Additionally, standard cycling conditions for ali diagnostic tests allow the user to run both RNA and DNA targets side-by-side.

Abstract translation: 本发明提供了用于聚合酶链式反应测定的组分和方法。 分析可以最大限度地减少材料处理和运行样品所花费的时间 例如，单个内部阳性对照（SPC）多核苷酸对可以提供确保针对RNA和DNA测试靶标的适当核酸纯化的手段。 此外，阿里诊断测试的标准循环条件允许用户同时运行RNA和DNA目标。

公开(公告)号：WO2009143080A3

公开(公告)日：2010-02-25

申请号：PCT/US2009044399

申请日：2009-05-18

Applicant: IDEXX LAB INC ,  DIVERGENCE INC ,  ELSEMORE DAVID ALLEN ,  FLYNN LAURIE A ,  GENG JINMING ,  CRAWFORD MICHAEL

Inventor： ELSEMORE DAVID ALLEN ,  FLYNN LAURIE A ,  GENG JINMING ,  CRAWFORD MICHAEL

IPC: G01N33/53 ,  G01N33/569

CPC classification number: G01N33/543 ,  C07K14/4354 ,  C07K16/18 ,  C12Q1/6888 ,  G01N33/5308

Abstract: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

Abstract translation: 本文公开了用于检测粪便样品中蛔虫存在或不存在的方法，装置，试剂盒和组合物。 本发明的方法，装置，试剂盒和组合物可以用于确认来自哺乳动物的粪便样品中是否存在蛔虫，所述蛔虫样品也可能被钩虫，鞭虫和心丝虫中的一种或多种感染。 可以确认哺乳动物中蛔虫的存在或不存在，例如，为了选择治疗哺乳动物和/或为了确定哺乳动物是否已经在治疗后已经除去感染的目的的最佳方法 已经启动

公开(公告)号：WO2009039414A3

公开(公告)日：2010-01-07

申请号：PCT/US2008077079

申请日：2008-09-19

Applicant: IDEXX LAB INC ,  O'CONNOR THOMAS PATRICK ,  KRAH EUGENC REGIS ,  SLAUENWHITE JILL M

Inventor： O'CONNOR THOMAS PATRICK ,  KRAH EUGENC REGIS ,  SLAUENWHITE JILL M

IPC: C07K14/00

CPC classification number: C07K16/1246 ,  C07K14/29 ,  G01N33/56911 ,  G01N2333/29

Abstract: The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.

Abstract translation: 本发明提供了用于检测查菲埃里希体的方法和组合物。

公开(公告)号：WO2009143079A2

公开(公告)日：2009-11-26

申请号：PCT/US2009044397

申请日：2009-05-18

Applicant: IDEXX LAB INC ,  DIVERGENCE INC ,  ELSEMORE DAVID ALLEN ,  FLYNN LAURIE A ,  CRAWFORD MICHAEL

Inventor： ELSEMORE DAVID ALLEN ,  FLYNN LAURIE A ,  CRAWFORD MICHAEL

IPC: C12Q1/70 ,  C07K14/00 ,  C07K16/18 ,  C12M1/00 ,  G01N33/53

CPC classification number: C12Q1/6888 ,  C07K14/4354 ,  C07K16/18 ,  G01N33/5308

Abstract: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a mammalian sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

Abstract translation: 本文公开了用于检测哺乳动物样品中蛔虫存在或不存在的方法，装置，试剂盒和组合物。 本发明的方法，装置，试剂盒和组合物可以用于确认来自哺乳动物的粪便样品中是否存在蛔虫，所述蛔虫样品也可能被钩虫，鞭虫和心丝虫中的一种或多种感染。 可以确认哺乳动物中蛔虫的存在或不存在，例如，为了选择治疗哺乳动物和/或为了确定哺乳动物是否已经在治疗后已经除去感染的目的的最佳方法 已经启动

公开(公告)号：WO2009039413A2

公开(公告)日：2009-03-26

申请号：PCT/US2008077078

申请日：2008-09-19

Applicant: IDEXX LAB INC ,  O'CONNOR THOMAS PATRICK ,  SLAUENWHITE JILL M

Inventor： O'CONNOR THOMAS PATRICK ,  SLAUENWHITE JILL M

IPC: C07K2/00 ,  C07K16/12 ,  C07K16/18 ,  G01N33/53

CPC classification number: C07K16/1246 ,  C07K14/195 ,  G01N33/56911 ,  G01N2333/29

Abstract: The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.

Abstract translation: 本发明提供了用于检测埃里希利（Ehrlichia chaffeensis）的方法和组合物。

公开(公告)号：WO2007097889A2

公开(公告)日：2007-08-30

申请号：PCT/US2007002694

申请日：2007-02-01

Applicant: IDEXX LAB INC ,  MURTHY YERRAMILLI V S N

Inventor： MURTHY YERRAMILLI V S N

IPC: A61K31/496 ,  A61K31/4709

CPC classification number: A61K31/4709 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/08 ,  A61K31/496 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/40

Abstract: The invention relates to pharmaceutical compositions comprising (i) a fluoroquinolone, (ii) a salt formed between a carboxylate anion and a divalent metal cation, (iii) a liquid comprising an organic solvent selected from the group consisting of glycerol, propylene glycol, glycerol formal, and (iv) optionally water. The invention further relates to methods of treating or preventing a condition in an animal comprising administering to the animal in need thereof a pharmaceutical composition of the invention.

Abstract translation: 本发明涉及药物组合物，其包含（i）氟喹诺酮，（ii）在羧酸根阴离子和二价金属阳离子之间形成的盐，（iii）包含选自甘油，丙二醇，甘油 （iv）任选的水。 本发明还涉及治疗或预防动物病症的方法，其包括向有需要的动物施用本发明的药物组合物。