-
公开(公告)号:TWD170507S
公开(公告)日:2015-09-11
申请号:TW104300034
申请日:2015-01-07
Applicant: 四國計測工業股份有限公司 , SHIKOKU INSTRUMENTATION CO., LTD. , 國立大學法人 鹿兒島大學 , KAGOSHIMA UNIVERSITY
Designer: 福田賢司 , FUKUDA, KENJI , 水田敬 , MIZUTA, KEI
-
公开(公告)号:TW201341716A
公开(公告)日:2013-10-16
申请号:TW102112822
申请日:2013-04-11
Applicant: 日本國立大學法人鹿兒島大學 , KAGOSHIMA UNIVERSITY
Inventor: 水田敬 , MIZUTA, KEI
IPC: F21V29/00 , F21Y101/02
CPC classification number: F21V29/51 , F21V29/006 , F21V29/15 , F21V29/507 , F21Y2115/10
Abstract: 本發明提供一種散熱裝置(1),其具有框體(2)、配置於框體(2)內部的發熱體(5)及將自發熱體(5)產生的熱輸送至框體(2)的面狀熱管(4),面狀熱管(4)具有受熱部與排熱部,以受熱部而與發熱體(5)導熱地接觸,並以排熱部而與框體(2)導熱地接觸,並且排熱部以外之部位遠離框體(2)。
Abstract in simplified Chinese: 本发明提供一种散热设备(1),其具有框体(2)、配置于框体(2)内部的发热体(5)及将自发热体(5)产生的热输送至框体(2)的面状热管(4),面状热管(4)具有受热部与排热部,以受热部而与发热体(5)导热地接触,并以排热部而与框体(2)导热地接触,并且排热部以外之部位远离框体(2)。
-
公开(公告)号:TW200902063A
公开(公告)日:2009-01-16
申请号:TW097105308
申请日:2008-02-15
Applicant: 國立大學法人熊本大學 KUMAMOTO UNIVERSITY , 國立大學法人鹿兒島大學 KAGOSHIMA UNIVERSITY , 志野試驗股份有限公司 SHINO-TEST CORPORATION
Inventor: 安東由喜雄 ANDO, YUKIO , 丸山征郎 MARUYAMA, IKURO , 山田吾 YAMADA, SHINGO
CPC classification number: C07K16/24 , C07K2317/21 , C07K2317/23 , C07K2317/76
Abstract: 以往,欲得到不與HMGB-2結合而與HMGB-1專一性結合且親和性高之抗體並不容易。在此情形中,本案發明人等成功地藉由使用特定胜作為抗原,而取得對於HMGB-1之反應强過於對HMGB-2之反應的抗體。又,本案發明人等發現上述抗體對於HMGB-1具中和活性。本案發明人等,成功地證實上述抗體對於類澱粉變性(amyloidosis)之疾病模型動物投予之結果,可得顯著治療效果。
Abstract in simplified Chinese: 以往,欲得到不与HMGB-2结合而与HMGB-1专一性结合且亲和性高之抗体并不容易。在此情形中,本案发明人等成功地借由使用特定胜作为抗原,而取得对于HMGB-1之反应强过于对HMGB-2之反应的抗体。又,本案发明人等发现上述抗体对于HMGB-1具中和活性。本案发明人等,成功地证实上述抗体对于类淀粉变性(amyloidosis)之疾病模型动物投予之结果,可得显着治疗效果。
-
公开(公告)号:TW200846366A
公开(公告)日:2008-12-01
申请号:TW097105310
申请日:2008-02-15
Applicant: 學校法人福岡大學 FUKUOKA UNIVERSITY , 國立大學法人鹿兒島大學 KAGOSHIMA UNIVERSITY , 志野試驗股份有限公司 SHINO-TEST CORPORATION
Inventor: 安波洋一 YASUNAMI, YOHICHI , 丸山征郎 MARUYAMA, IKURO , 山田吾 YAMADA, SHINGO
CPC classification number: C07K16/24 , A61K2039/505 , C07K2317/76
Abstract: 本發明之目的係提供一種有效方法,能抑制器官移植時引起之排斥反應。特別是,能抑制對治療糖尿病有用之胰島移植後的排斥反應。經由本發明,抗HMGB-1之抗體顯然可抑制胰島移植時之排斥反應,促進移植胰島之生著。此外,本發明亦提供一種含有抗HMGB-1抗體之器官移植排斥抑制劑。
Abstract in simplified Chinese: 本发明之目的系提供一种有效方法,能抑制器官移植时引起之排斥反应。特别是,能抑制对治疗糖尿病有用之胰岛移植后的排斥反应。经由本发明,抗HMGB-1之抗体显然可抑制胰岛移植时之排斥反应,促进移植胰岛之生着。此外,本发明亦提供一种含有抗HMGB-1抗体之器官移植排斥抑制剂。
-
公开(公告)号:US20240181035A1
公开(公告)日:2024-06-06
申请号:US18285970
申请日:2022-04-08
Inventor: Kenta YAMATO , Takeshi MIYATA , Takahiro KUSAKABE , Jae Man LEE , Akitsu MASUDA
CPC classification number: A61K39/12 , A61K35/64 , A61P31/20 , A61P37/04 , C12N15/86 , A61K2039/515 , A61K2039/542 , C12N2710/14022 , C12N2710/14034 , C12N2710/14043 , C12N2710/14052 , C12N2710/14071
Abstract: A method of easily producing an immunogenic pupa for oral administration and a pupa for oral administration produced by the method are provided. The method is a method of producing a pupa for oral administration, including a step of infecting a larva or pupa of an insect capable of being baculovirus-infected with a recombinant baculovirus having DNA encoding an antigen protein introduced therein and freeze-drying a pupa having pupated from the infected larva or the infected pupa.
-
公开(公告)号:US11896635B2
公开(公告)日:2024-02-13
申请号:US16758019
申请日:2018-11-08
Applicant: KAGOSHIMA UNIVERSITY
Inventor: Ken-ichiro Kosai , Nobuhiro Ijichi
IPC: C12N7/00 , A61K35/761 , A61P35/04 , C12N15/86 , C12N15/861
CPC classification number: A61K35/761 , A61P35/04 , C12N15/86 , C12N15/861
Abstract: The present invention is based on a novel concept for finding the optimum expression level of a therapeutic gene for inducing the largest therapeutic effect without any adverse reaction. An object of the present invention is to develop an immuno-viral therapeutic vector exerting the optimal therapeutic effect while ensuring high safety. The present invention provides, for example, an oncolytic virus comprising an immunity-inducing gene operably linked to the downstream of E2F promoter or a promoter having an activity equivalent thereto, wherein at least one promoter for nucleic acids encoding an element essential for viral replication or assembly is replaced with a promoter for an organ specific highly expressed factor or with a promoter for a cancer cell specific highly expressed factor.
-
公开(公告)号:US11873337B2
公开(公告)日:2024-01-16
申请号:US17255784
申请日:2019-06-26
Applicant: Kyowa Kirin Co., Ltd. , KAGOSHIMA UNIVERSITY
Inventor: Nobuaki Takahashi , Ryosuke Nakano , Sayaka Maeda , Takenao Yamada , Yuji Ito
CPC classification number: C07K16/2803 , A61K2039/505 , C07K2317/14 , C07K2317/31 , C07K2317/33 , C07K2317/565
Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.
-
28.
公开(公告)号:US11432742B2
公开(公告)日:2022-09-06
申请号:US16489311
申请日:2018-03-01
Applicant: Kagoshima University
Inventor: Tomonori Iwasaki , Youichi Yamasaki
Abstract: A nasal-cavity model generator (41) extracts pixels having pixel density values within a specific range from three-dimensional image data on a nasal cavity of a subject contained in DICOM data (21), and generates a nasal cavity model (50), which is a three-dimensional model of the nasal cavity, based on three-dimensional image data composed of the extracted pixels. A nasal-cavity resistance calculator (42) calculates a nasal cavity resistance (51) through fluid analysis using the nasal cavity model (50) generated by the nasal-cavity model generator (41). An adjuster (43) adjusts the specific range of the pixel density values of the pixels to be extracted for generation of the nasal cavity model (50) by the nasal-cavity model generator (41) such that the nasal cavity resistance (51) calculated by the nasal-cavity resistance calculator (42) is equal to a nasal cavity resistance (52) actually measured with a nasal-cavity draft gauge.
-
公开(公告)号:US20220241736A1
公开(公告)日:2022-08-04
申请号:US17612772
申请日:2020-05-18
Applicant: Kagoshima University
Inventor: Takashi Goshima , Yudai Mikuni
IPC: B01F23/233 , B01F33/452 , B01F27/93 , B01F27/053
Abstract: A bubble formation apparatus (500) includes: a rotor (100); a container (200) in which the rotor (100) is housed together with a liquid (LQ) and a gas (GS); and a rotary device (300) that causes rotation of the rotor (100) with the rotor (100) being pressed against an inner lower surface (221) that is the inner surface of the container (200). A bubble is formed by periodically repeating pressurization and depressurization of a mixture of the gas (GS) and the liquid (LQ) in a gap between the inner lower surface (221) and a portion, pressed against the inner lower surface (221), of the rotor (100) due to the rotation of the rotor (100) by the rotary device (300).
-
公开(公告)号:US20220184081A1
公开(公告)日:2022-06-16
申请号:US17430557
申请日:2020-02-12
Applicant: KAGOSHIMA UNIVERSITY
Inventor: Takashi KURIHARA , lchiro TAKASAKl , Naoki TOYOOKA , Hiroaki GOUDA
IPC: A61K31/519 , A61K31/4178 , A61P17/04
Abstract: This invention relates to an antipruritic agent of formula (I) or (II), wherein R1 is a hydrogen atom, a C1-6-alkyl group, a C1-6-alkoxy group, a C2-6-alkenyloxy group, a halogen atom, a C1-6-haloalkyl group, a C1-6-haloalkoxy group, or a substituted or unsubstituted phenyl group; R2 is a hydrogen atom, a C1-6-alkyl group, a C1-6-alkoxy group, a C2-6-alkenyloxy group, a halogen atom, a C1-6-haloalkyl group, a C1-6-haloalkoxy group, or a substituted or unsubstituted phenyl group; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.
-
-
-
-
-
-
-
-
-