公开(公告)号：WO2019213130A2

公开(公告)日：2019-11-07

申请号：PCT/US2019/029991

申请日：2019-04-30

Applicant: LEIDOS, INC.

Inventor： CHRISTIAN, Noah, Peter

IPC: H01J49/00

Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

公开(公告)号：WO2018218137A1

公开(公告)日：2018-11-29

申请号：PCT/US2018/034625

申请日：2018-05-25

Applicant: LEIDOS, INC.

Inventor： GUTIERREZ, Gabriel M. ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy ,  PANNUCCI, James

IPC: C07K14/705 ,  A61K38/17

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

公开(公告)号：AU2018273958A1

公开(公告)日：2020-01-02

申请号：AU2018273958

申请日：2018-05-25

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY ,  PANNUCCI JAMES

IPC: C07K14/705 ,  A61K38/17

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

公开(公告)号：AU2012201079B2

公开(公告)日：2013-03-28

申请号：AU2012201079

申请日：2012-02-24

Applicant: UNIV GEORGETOWN ,  LEIDOS INC

Inventor： CURRIE JOHN F ,  PARANJAPE MAKARAND ,  PECK CARL C ,  WHITE ROBERT C ,  SCHNEIDER THOMAS W

IPC: A61B5/00 ,  G01N1/10 ,  G01N33/48 ,  G01N33/53 ,  G01N37/00

Abstract: Abstract The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for: (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector. 0 0m fm At ArA \ x " CDOh n - -0 C) - E -0

公开(公告)号：AU2006225209B8

公开(公告)日：2010-04-01

申请号：AU2006225209

申请日：2006-10-03

Applicant: UNIV GEORGETOWN ,  LEIDOS INC

Inventor： PECK CARL C ,  WHITE ROBERT C ,  PARANJAPE MAKARAND ,  SCHNEIDER THOMAS W ,  CURRIE JOHN F

IPC: A61B5/00 ,  G01N33/48 ,  G01N1/10 ,  G01N33/53 ,  G01N37/00

Abstract: The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.

公开(公告)号：AU2018410849B2

公开(公告)日：2025-02-27

申请号：AU2018410849

申请日：2018-02-28

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

IPC: A61K38/10 ,  A61K38/16 ,  A61K48/00 ,  A61P17/00 ,  A61P17/02 ,  A61P31/00 ,  A61P31/04 ,  A61P35/00 ,  A61Q5/00 ,  A61Q19/02 ,  C12N15/00

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor programmed death 1 (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

公开(公告)号：MX2024006834A

公开(公告)日：2024-06-19

申请号：MX2024006834

申请日：2020-10-30

Applicant: LEIDOS INC

Inventor： CHRISTIAN NOAH PETER

IPC: H01J49/04 ,  G01N33/82 ,  H01J49/16 ,  H01J49/20 ,  H01J49/24 ,  H01J49/30 ,  H01J49/48

Abstract: Un montaje de espectrómetro de masas de baja energía incluye al menos un componente de ionización, un analizador electrostático, un montaje de lente, un montaje de imán y al menos un detector ubicado en un mismo plano que la entrada al montaje de imán para detectar los iones de muestra desviados y/o fragmentos de iones de muestra, incluidos iones o fragmentos de iones indicativos del metabolito de vitamina D dentro de la muestra.

公开(公告)号：AU2023274139A1

公开(公告)日：2023-12-21

申请号：AU2023274139

申请日：2023-11-29

Applicant: LEIDOS INC

Inventor： NOAH PETER CHRISTIAN

IPC: H01J49/04

Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

公开(公告)号：MX2020011575A

公开(公告)日：2021-01-20

申请号：MX2020011575

申请日：2019-04-30

Applicant: LEIDOS INC

Inventor： CHRISTIAN NOAH PETER

IPC: H01J49/04

Abstract: Un montaje de espectrómetro de masas de baja energía incluye al menos un componente de ionización, un analizador electrostático, un montaje de lente, un montaje de imán y al menos un detector ubicado en un mismo plano que la entrada al montaje de imán para detectar los iones de muestra desviados y/o fragmentos de iones de muestra, incluidos iones o fragmentos de iones indicativos del metabolito de vitamina D dentro de la muestra.

公开(公告)号：CA3222677A1

公开(公告)日：2019-11-07

申请号：CA3222677

申请日：2019-04-30

Applicant: LEIDOS INC

Inventor： CHRISTIAN NOAH PETER

Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.