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公开(公告)号：US09955676B2
公开(公告)日：2018-05-01
申请号：US14620141
申请日：2015-02-11
Applicant: Macau University of Science and Technology
Inventor： Liang Liu , Ting Li , Kam Wai Wong , Zhihong Jiang , Hua Zhou
IPC: A01K67/027 , C12N15/00 , A61K49/00 , G01N33/573 , A61K31/70 , G01N33/574
CPC classification number: A01K67/0278 , A01K2207/12 , A01K2227/105 , A01K2267/01 , A01K2267/0368 , A61K49/0008 , G01N33/573 , G01N33/574 , G01N2333/91215 , G01N2800/102 , G01N2800/44
Abstract: The present invention provides an in vivo platform for identifying and determining therapeutic or prophylactic activity of test compounds in delay-type hypersensitivity (DTH) and other inflammatory or cancerous diseases mediated by activation of IKK-βC46A mutants. The in vivo platform of the present invention is a non-human transgenic mammal, e.g., a mouse model, with a site directed mutagenesis at a cysteine residue replaced by alanine in IKK-β protein kinase. The site directed mutagenesis is introduced by a specially designed targeting vector containing a transversion in exon 3 of the Ikbkb genes encoding the IKK-β. The present invention also provides methods for generating the transgenic mammal and for determining and identifying compounds that can inhibit activation of IKK-βC46A mutants.
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公开(公告)号：US09935462B2
公开(公告)日：2018-04-03
申请号：US15007486
申请日：2016-01-27
Applicant: Macau University of Science and Technology
Inventor： Xiaodong Li
CPC classification number: H02J3/38 , H02J3/32 , H02J3/386 , H02J7/34 , H02M3/33584 , Y02E10/763 , Y02E10/766 , Y02E70/30
Abstract: A method for controlling an operation of a converter circuit adapted to regulate power transfer between a first voltage source and a second voltage source includes detecting a first voltage level of the first voltage source and a second voltage level of the second voltage source; calculating a power value based on the detected first voltage level and the detected second voltage level; comparing the calculated power value with a reference power value; and determining switching time of one or more switches in the converter circuit based on a compared result so as to regulate power transfer between the first voltage source and the second voltage source.
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公开(公告)号：US09927816B2
公开(公告)日：2018-03-27
申请号：US15153778
申请日：2016-05-13
Applicant: Macau University of Science and Technology
Inventor： Zhiwu Li , Oussama Karoui , Anis Koubaa , Mohamed Khalgui , Emna Guerfala , Eduardo Tovard , Naiqi Wu
CPC classification number: G05D1/0295 , B60K31/00 , B60W30/14 , G05D1/0027 , G05D1/0212 , G05D1/0278 , G05D2201/0213 , G08G1/22
Abstract: A method for operating a follower vehicle in a vehicle platoon includes determining, during operation, whether the follower vehicle is operating in a normal state or an abnormal state based on an operation condition of a component of the follower vehicle, or a communication between the follower vehicle and a preceding vehicle in the vehicle platoon. The method further includes selecting a first control mode if the follower vehicle is in the normal state and a second control mode if the follower vehicle is in the abnormal state so as to control movement of the follower vehicle using the selected control mode. In the first control mode, the follower vehicle uses communication data received from the preceding vehicle in the vehicle platoon to control its movement. In the second control mode, the follower vehicle uses data obtained by one or more of its sensors to control its movement.
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24.发明申请公开(公告)号：US20170329925A1
公开(公告)日：2017-11-16
申请号：US15150580
申请日：2016-05-10
Applicant: Macau University of Science and Technology
Inventor： Yong Liang , Hua Chai , Zi-yi Yang , Xiao-Ying Liu
Abstract: A system and a method for determining an estimated survival time of a subject with a medical condition utilizes the novel RS-AFT model and is especially suitable and highly advantageous for survival analysis based on microarray gene expression data because of its exceptional performance of gene selection, stable noise resistance, and high prediction precision.
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25.发明申请公开(公告)号：US20170329913A1
公开(公告)日：2017-11-16
申请号：US15150732
申请日：2016-05-10
Applicant: Macau University of Science and Technology
Inventor： Yong Liang , Hai-Hui Huang , Xiao-Ying Liu
Abstract: A method and a system for determining an association of at least one biological feature with a medical condition utilizes the novel L1/2 penalized network-constraint regression model to achieve an improved biological analysis, in particular by solving high-dimensional problems. The method and the system of the present invention attain high accuracy and preciseness.
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Patent Agency Ranking
26.发明申请公开(公告)号：US20170329912A1
公开(公告)日：2017-11-16
申请号：US15150608
申请日：2016-05-10
Applicant: Macau University of Science and Technology
Inventor： Yong Liang , Hai-Hui Huang , Xiao-Ying Liu
Abstract: A system and a method for determining an association of one or more biological features with a medical condition provides empirical results and simulations confirming that the involvement of both L1/2-regularized logistic regression and L2-regularized logistic regression in the regression model is highly competitive against usual approaches like Lasso, L1/2, SCAD-L2, and Elastic net in analyzing high dimensional and low sample sizes data.
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27.发明申请公开(公告)号：US20170281702A1
公开(公告)日：2017-10-05
申请号：US15089687
申请日：2016-04-04
Applicant: Macau University of Science and Technology
Inventor： Jing-Rong Wang , Zhi-Hong Jiang , Qi-Tong Feng , Guo-Yuan Zhu , Wei-Na Gao , Zifeng Yang , Nanshan Zhong
IPC: A61K36/19 , A61K31/7056 , A61K31/192 , A61K31/404 , A61K31/047 , A61K31/191 , A61K31/538 , A61K31/517
CPC classification number: A61K36/19 , A61K31/404 , A61K31/538 , A61K31/567 , A61K2236/15 , A61K2236/17 , A61K2236/33 , A61K2236/55
Abstract: The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.
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公开(公告)号：US20170279298A1
公开(公告)日：2017-09-28
申请号：US15078367
申请日：2016-03-23
Applicant: Macau University of Science and Technology
Inventor： Zhiwu Li , Zhongyuan Jiang , Naiqi Wu , Mengchu Zhou
CPC classification number: H02J9/06 , G01R31/40 , H02J3/28 , H02J13/001 , H02J2003/007 , Y02E60/722 , Y02E60/723 , Y02E60/76 , Y04S10/14 , Y04S10/16 , Y04S10/40 , Y04S40/22
Abstract: A power transmission system includes a plurality of electrical substations and a plurality of transmission lines arranged to connect the plurality of electrical substations to form a power transmission network; and a controller system arranged to control a power transmission within the power transmission network. The controller system includes: a detection module arranged to detect an occurrence of a fault in at least one faulty electrical substation of the plurality of electrical substations; and a restoration module arranged to at least temporally maintain an output power of the at least one faulty electrical substation; and wherein at least one of the plurality of electrical substations is operable to facilitate maintaining of the output of the at least one faulty electrical substation upon the detection of the occurrence of the fault.
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公开(公告)号：US09769849B2
公开(公告)日：2017-09-19
申请号：US14840139
申请日：2015-08-31
Applicant: Macau University of Science and Technology
Inventor： Li Feng
CPC classification number: H04W74/0816 , H04W84/12
Abstract: A method for enabling one or more nodes to communicate with an access point (AP) according to a CSMA/CA protocol is provided. In one embodiment of the method, when the individual node enters into a state of having at least one packet of data to be transmitted to the AP, the individual node waits for a non-zero deterministic delay so that any packet arrived during the delay is allowed to be aggregated and transmitted upon one transmission opportunity, thereby improving channel utilization. The delay is determined such that a predicted system throughput is maximized. It is found that the system throughput is significantly affected by the relationship between the delay and the number of the one or more nodes. Hence, the delay is advantageously determined according to the number of the one or more nodes. After the delay expires, the individual node initiates a contending procedure.
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公开(公告)号：US09744145B1
公开(公告)日：2017-08-29
申请号：US15406798
申请日：2017-01-16
Applicant: Macau University of Science and Technology
Inventor： Liang Liu , Lai-Han Elaine Leung , Xiao-Jun Yao , Run-Ze Li
IPC: A61K31/18
CPC classification number: A61K31/18
Abstract: This invention provides a method of treating lung cancer including administering a therapeutically effective amount of a compound of 0089-0022 formula I to a subject in need thereof. The compound activates pyruvate kinase M2 isoform (PKM2) to treat the lung cancer. In one example, the lung cancer is Non-Small Cell Lung Cancer (NSCLC).
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